Translational pediatrics最新文献

{"title":"The distribution patterns and clinical significance of serum immunoglobulin E in children with chalazion in Hubei, China.","authors":"Hua Yuan, Nan Ma, Songhua Mei, Ming Sun, Yixuan Wu, Yun Xiang, Shilian Li, Hong Jie","doi":"10.21037/tp-2024-565","DOIUrl":"10.21037/tp-2024-565","url":null,"abstract":"<p><strong>Background: </strong>Chalazion is common in children which can lead to cosmetically disfiguring, ptosis, astigmatism, and affect the quality of life. The aim of this study was to investigate the distribution patterns of serum total immunoglobulin E (T-IgE) and specific immunoglobulin E (sIgE) levels in children with chalazia, further to explore the clinical significance of immunoglobulin E (IgE) in the development of chalazion.</p><p><strong>Methods: </strong>This retrospective cross-sectional study enrolled children with chalazion or allergic conjunctivitis (AC) in Hubei, China, from June 2020 to December 2021. The food and inhaled sIgE were summarized. Meanwhile, the correlations between serum T-IgE, the numbers of positive sIgE, grades of sIgE, and the stages of chalazion in children were analyzed.</p><p><strong>Results: </strong>A total of 224 children with chalazion were included, among whom 98 (43.8%) were males, with average age of 3.5±2.0 years (range, 0.5 to 11.2 years). Compared to AC, the sIgE positive rate of epithelial materials of dogs was higher in chalazia children (9.4% <i>vs</i>. 0.6%, P=0.001). The positive rate of food allergens-sIgE in preschool children with chalazion (71.4%) was higher than that in school children (50.0%) (P=0.008). Furthermore, the numbers and the grade of sIgE had a positive correlation with the stages of chalazia, respectively (R=0.269, 0.245, P<0.001). Moreover, there was also a positive correlation between T-IgE and the stages of chalazia (R=0.238, P=0.001).</p><p><strong>Conclusions: </strong>Compared to AC, children with chalazion are more sensitive to the epithelial materials of dogs in Hubei province. Meanwhile, children with high level of T-IgE and more positive allergens-sIgE associated with more severe stage of chalazia.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"893-899"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplanted oligodendrocyte progenitor cells improve neurological defects in a rat model of preterm white-matter injury during the sequela phase.","authors":"Hui Yang, Weipeng Liu, Qian Wang, Zhaoyan Wang, Jie Zhou, Fang Liu, Fan Zhang, Jialan Liang, Suqing Qu, Zuo Luan","doi":"10.21037/tp-2025-175","DOIUrl":"10.21037/tp-2025-175","url":null,"abstract":"<p><strong>Background: </strong>Preterm white-matter injury (PWMI), frequently occurring in preterm infants, is a major factor contributing to long-term neurological impairment and is a prevalent form of brain injury in this population. Therapies for this condition mainly target the acute phase, often leaving the chronic sequelae phase untreated. This study aimed to examine how transplanted human oligodendrocyte progenitor cells (hOPCs) differentiate and their therapeutic effectiveness in a rat model of PWMI sequelae.</p><p><strong>Methods: </strong>Hypoxia-ischemia was induced in neonatal rats at 3 days after birth and was followed by intracerebral transplantation of hOPCs (5×10⁵ cells in 4 µL) 3 weeks later. Neurobehavioral assessment was performed using the Morris water maze test 9-10 weeks after transplantation. After cardiac perfusion, pathological staining, immunohistochemical (IHC) analysis, and transmission electron microscopy (TEM) were conducted.</p><p><strong>Results: </strong>Transplanted hOPCs remained viable in the brains of rats with PWMI sequelae for up to 13 weeks. They were found to be extensively dispersed in the damaged white matter and traversed along the corpus callosum toward the opposite hemisphere. About 83.34%±3.81% of the transplanted cells underwent differentiation to become oligodendrocyte lineage cells, among which about 77.15%±3.06% matured into oligodendrocytes that myelinated axons. IHC staining and TEM analyses showed that the myelin basic protein fluorescence intensity and myelin thickness were increased, pathological staining indicated that white-matter fiber injury was ameliorated, and the results of the Morris water maze test suggested that the cognitive function and neurobehavioral performance of the rats receiving transplanted hOPCs were restored.</p><p><strong>Conclusions: </strong>Transplanted hOPCs promoted remyelination, reduced white-matter injury, and improved neurobehavioral outcomes in PWMI rats during the sequela phase, suggesting that transplantation of hOPCs may be an effective therapeutic approach for children with neurological deficits associated with PWMI.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"1019-1032"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the pathogenesis of idiopathic pediatric acute pancreatitis by combining intestinal microbiome and metabolome.","authors":"Feng Liu, Ying Sun, Jizhong Wang, Jianghua Zhan","doi":"10.21037/tp-2024-571","DOIUrl":"10.21037/tp-2024-571","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Idiopathic pediatric acute pancreatitis (IPAP) represents a significant health threat to children and adolescents, yet its underlying pathogenesis remains poorly understood, necessitating further research to elucidate its mechanisms. This study aims to explore the roles of intestinal microbiota, short-chain fatty acids (SCFAs), and serum metabolites in the pathogenesis of IPAP, as well as to assess the therapeutic potential of acetic acid intervention in this condition.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Fecal and serum samples from 22 cases of IPAP (excluding biliary origin) and 10 healthy controls were collected and analyzed. Intestinal microbial was characterized using 16S ribosomal RNA (16S rRNA) sequencing, while SCFAs and serum metabolites were quantified by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Omics analysis was employed to identify microbial-metabolite regulation and regulatory networks and potential disease biomarkers. To evaluate the therapeutic efficacy of acetic acid in acute pancreatitis (AP), AP was induced in animal models by intraperitoneal injection of caerulein (50 µg/kg; once daily for seven days), followed by oral administration of acetic acid (10 mL/kg, once daily) in 4-, 6-, and 8-week models. Pancreatic and ileum tissues were examined for histopathological changes, serum enzymes levels, and intestinal barrier integrity.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The results of 16S rRNA sequencing revealed significant differences in the composition and abundance of intestinal microbial communities between the control (Con) and IPAP groups. Pathogenic bacteria, such as &lt;i&gt;f_Tannerellaceae&lt;/i&gt; and &lt;i&gt;c_Bacteroidia&lt;/i&gt;, as well as certain symbiotic bacteria, were significantly enriched in the IPAP group. SCFAs metabolome analysis indicated that acetic acid, as a key intermediate metabolite, may play a regulatory role in the pathogenesis of IPAP. The construction of a microbial-metabolite regulatory network demonstrated that microorganisms such as &lt;i&gt;g_Monoglobus&lt;/i&gt; and &lt;i&gt;g_Morganella&lt;/i&gt; were closely associated with SCFAs, including acetic acid, suggesting that the development of IPAP is influenced by upstream and downstream regulatory mechanisms. Furthermore, significant associations were identified between serum metabolites and gut microbes. For instance, (4E,15E)-bilirubin and creatinine showed significant positive correlations with &lt;i&gt;g_Bacteroides&lt;/i&gt; (P&lt;0.01). Similarly, 1,2-ethanediol monoricinoleate was significantly positively correlated with &lt;i&gt;g_Hungatella&lt;/i&gt; (P&lt;0.01), while pubescenol and tecastemizole were significantly positively correlated with &lt;i&gt;g_Parabacteroides&lt;/i&gt; (P&lt;0.01). Animal experiments demonstrated that pancreatic and intestinal tissue damage was alleviated to varying degrees following treatment. Compared to the disease model group, the acetic acid treatment group exhibited significantly reduced serum levels of D-lactic acid, amylase, and lipase, along with a","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"855-870"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood penetrating intracranial injury by non-metallic objects: a case report of three pediatric cases.","authors":"Qi Li, Rong Fu","doi":"10.21037/tp-2024-550","DOIUrl":"10.21037/tp-2024-550","url":null,"abstract":"<p><strong>Background: </strong>Despite being relatively rare, pediatric penetrating intracranial injuries entail substantial risks of secondary complications such as intracranial hemorrhage, infection, and mortality.</p><p><strong>Case description: </strong>This case report describes three pediatric cases of penetrating intracranial injury caused by non-metallic objects, including two bamboo chopsticks and one pencil. In all cases, the patients presented with facial or orbital entry points and underwent prompt clinical evaluation, including computed tomography (CT) scans to assess foreign body location, injury trajectory, and potential complications. Tailored craniotomy approaches were selected based on imaging findings: pterional or subfrontal craniotomies were employed to access and safely extract the foreign bodies. Intraoperatively, great care was taken to avoid further neurological damage, and the dural defects were repaired using grafts and fibrin glue. Postoperatively, all patients received broad-spectrum antibiotics and sodium valproate to prevent infections and seizures, respectively. In two cases, postoperative fever and elevated white blood cell counts suggested intracranial infection, prompting escalation or adjustment of antibiotics, including ceftriaxone and meropenem. No cerebrospinal fluid (CSF) leakage or long-term neurological sequelae were observed. Follow-up evaluations conducted up to three years post-surgery revealed preserved cognitive and sensory functions without signs of epilepsy or delayed complications.</p><p><strong>Conclusions: </strong>Notably, there were no occurrences of postoperative CSF fistula or epilepsy seizures, and intracranial infections were effectively managed. By documenting these three cases of pediatric intracranial penetrating brain injury, it is evident that accurate diagnosis and immediate surgical intervention are imperative in mitigating secondary brain injury and minimizing the risk of infection or hemorrhage.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"1039-1049"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of endotracheal tube design of different brands are related to proper endotracheal tube position in pediatrics: a descriptive study.","authors":"Jirawat Wankijcharoen, Pramuk Khamman, Kittipott Thusneyapan, Adisak Kasemassawachanont, Karnkawin Patharateeranart, Ramida Amornsitthiwat, Terasut Numwong, Chairat Turbpaiboon, Nophanan Chaikittisilpa, Taniga Kiatchai","doi":"10.21037/tp-2025-71","DOIUrl":"10.21037/tp-2025-71","url":null,"abstract":"<p><strong>Background: </strong>Vocal cord markings (VCmarkings) on endotracheal tubes (ETTs) are designed to guide the proper tube placement depth. However, endobronchial intubation and cuff placement in the subglottic region still occur even when intubation depths are guided by the VCmarking. This study aimed to examine the characteristics of ETTs related to proper placement depth across different sizes and brands, including the designs of the VCmarking, cuff locations, and outer diameters (ODs).</p><p><strong>Methods: </strong>This descriptive study examined uncuffed and cuffed tubes from seven brands with inner diameters (IDs) ranging from 3.0 to 8.5 mm that were marketed in Thailand between March and August 2022. The seven brands included: 1, Ruschelit; 2, Shiley; 3, Curity; 4, Portex; 5, Unomedical; 6, Fornia; 7, Microcuff. Mark-Tip, Mark-Cuff, and Cuff-Tip distances were measured on each tube. ODs were measured between non-cuff area and the deflated cuff level.</p><p><strong>Results: </strong>A total of 98 tubes were included in the study (27 uncuffed tubes from four brands and 71 cuffed tubes from seven brands). VCmarkings were present in 79 (80.6%) tubes, while 37 tubes had more than one marking. For tubes of the same size, the Mark-Tip distances ranged from 10.0 to 40.3 mm, the Mark-Cuff distances varied from 1.2 to 30.4 mm, and the Cuff-Tip distances ranged from 10.7 to 21.2 mm. Minimal variation was observed in the OD at non-cuffed area, whereas the OD at the deflated cuff level added between 0.1 and 2.6 mm thickness to the OD of the non-cuffed area.</p><p><strong>Conclusions: </strong>We observed variations in the tube characteristics which affect intubation depth (Mark-Tip, Mark-Cuff, and Cuff-Tip distances), and OD at the deflated cuff level among different brands of tubes with the same size specifications.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"824-833"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram to predict extubation failure in infants born before 32 gestational weeks: a single-center retrospective study.","authors":"Han Zhang, Yunjie Zhang, Fangfei Tao, Yongfeng Wu, Zhou Jiang","doi":"10.21037/tp-2025-43","DOIUrl":"10.21037/tp-2025-43","url":null,"abstract":"<p><strong>Background: </strong>Identification of factors associated with extubation failure (EF) may contribute to the optimization of the timing of extubation, prevention of reintubation, and enhancement of clinical outcomes in preterm infants. This study aimed to analyze the risk factors for EF in preterm infants born before 32 gestational weeks and develop a predictive nomogram for EF.</p><p><strong>Methods: </strong>This retrospective study was based on data of preterm infants born before 32 gestational weeks between January 2020 and December 2024 who received mechanical ventilation within 24 hours after birth. These infants were divided into a training set and a validation set according to the time of birth. Risk factors were screened using univariable analysis, least absolute shrinkage and selection operator regression was used for variable screening, a predictive model was built using binary logistic analysis, and a nomogram was constructed. Calibration curve, the area under the receiver operating characteristic curve (AUC), and decision curve analysis (DCA) were applied to assess the discrimination, accuracy, and clinical practicability of the nomogram, respectively.</p><p><strong>Results: </strong>A total of 178 infants were included in the study and EF rate was 30.9%. Postmenstrual age at extubation, fraction of inspired oxygen before extubation and hemodynamically significant patent ductus arteriosus before extubation were identified as independent factors for predicting EF. A nomogram constructed based on these independent factors can be used for predicting EF. The AUC values of the training set and the validation set were 0.834 and 0.851. Calibration curves revealed significant agreement between the nomogram model and actual observations. The results of the DCA analysis indicated that this model offered good clinical benefits.</p><p><strong>Conclusions: </strong>The prediction model can accurately estimate the risk of EF in preterm infants born before 32 gestational weeks.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"776-787"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of naked-eye 3D technology in mitigating myopia progression among children.","authors":"Zongyue Lv, Zhengyang Tao, Hang Chu, Guorui Hu, Zhixing Xu, Hui Zhong, Zefeng Kang, Hongwei Deng","doi":"10.21037/tp-2024-523","DOIUrl":"10.21037/tp-2024-523","url":null,"abstract":"<p><strong>Background: </strong>With the gradual development of display technology, naked-eye 3D technology has gradually come into people's view, and its impact on binocular vision has also attracted attention. This study examines the efficacy of visual perceptual training utilizing naked-eye 3D technology in the prevention and control of myopia progression among children.</p><p><strong>Methods: </strong>A total of 110 children (220 eyes), aged 6 to 12 years, who visited Shenzhen Eye Hospital between April 5, 2023 and June 1, 2024, and presented with a spherical equivalent (SE) of 0 to -1.50 diopters (D) following cycloplegic refraction, were included. Participants were non-randomly assigned to one of three groups: the 0.01% atropine group, the visual perceptual training group, and the control group. Changes in SE, axial length, and visual function across the three groups were assessed following a three-month treatment period.</p><p><strong>Results: </strong>Among the 110 participants, 81 (73.6%) completed the 3-month follow-up, with 30 in the 0.01% atropine group, 28 in the visual perceptual training group, and 23 in the control group. Following baseline equalization through entropy rebalancing weighting, a significant difference in binocular SE progression was observed between the visual perceptual training group and the control group {right eye SE difference: 0.386 D [95% confidence interval (CI), 0.153-0.619], P<0.001; left eye SE difference: 0.244 D (95% CI, 0.016-0.472), P=0.03}. No significant differences in axial length changes were observed among the three groups. Improvements in accommodation flexibility were recorded in the visual perceptual training group: 2.5 cycles per minute (cpm) for the right eye (95% CI, 1.318-3.682, P<0.001), 1.75 cpm for the left eye (95% CI, 0.580-2.920, P=0.006), and 2.279 cpm for both eyes (95% CI, 0.807-3.755, P=0.005). All visual perceptual indices demonstrated statistically significant improvements after three months of training.</p><p><strong>Conclusions: </strong>Visual perceptual training employing naked-eye 3D technology is effective in decelerating myopia progression, improving binocular vision, and enhancing accommodation flexibility among children.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"628-638"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To screen or not to screen: the importance of early detection of pectus excavatum.","authors":"Elise J van Polen, Nicky Janssen, Jean H T Daemen, Aimée J P M Franssen, Eric P de Groot, Lori M van Roozendaal, Karel W E Hulsewé, Yvonne L J Vissers, Erik R de Loos","doi":"10.21037/tp-2025-2","DOIUrl":"10.21037/tp-2025-2","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"529-532"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of cystatin C for Kawasaki disease with coronary artery aneurysm.","authors":"Kaizhi Liang, Danyan Su, Yusheng Pang","doi":"10.21037/tp-2024-516","DOIUrl":"10.21037/tp-2024-516","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular and kidney diseases are interconnected through shared biological mechanisms. However, research on renal function in Kawasaki disease (KD) remains insufficient. This study focused on coronary artery aneurysm (CAA), a severe cardiac consequence of KD, aiming to examine the predictive value of cystatin C (Cys C) and other common laboratory indicators before and after intravenous immunoglobulin (IVIG) treatment on KD with CAA.</p><p><strong>Methods: </strong>Based on patients' coronary status, 122 KD individuals were categorized in this retrospective analysis. After comparing the clinical and laboratory information of the patients with KD, multivariate logistic regression analysis was employed to identify independent risk factors for CAA development among them. Additionally, the predictive values of these parameters in CAA development of KD were assessed by receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>In this study, 28 patients (23.0%, 28/122) had CAA, including 12 who had coronary artery regression (9.8%, 12/122). The parameters with P<0.10 in the difference analysis, namely polymorphous exanthem, changes in the extremities, plateletocrit and Cys C before IVIG, prealbumin >107.2 mg/L and prognostic nutritional index >54.7 after IVIG, were included in multivariate logistic regression analysis. Finally, binary logistic regression analysis identified the pre-IVIG Cys C [odds ratio, 10.183; 95% confidence interval (CI): 1.158-89.525] as an independent risk factor for developing CAA among KD patients. In addition, the 0.71 Cys C cut-off value sampled within five days had a 100% sensitivity and a 42.9% specificity (area under the ROC curve =0.752, 95% CI: 0.577-0.928, P=0.03).</p><p><strong>Conclusions: </strong>Higher pre-IVIG Cys C levels may be associated with increased CAA risk, but further large-scale prospective studies are needed to confirm its predictive utility. Furthermore, Cys C acquired within five days of disease onset may theoretically provide better prediction power for the CAA development in KD.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"545-558"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-specific reference intervals for anti-Müllerian hormone during childhood in Chinese population: a cross-sectional study of 2,450 healthy children.","authors":"Yu Shang, Cong Yao, Mo Wu, Tian Chen, Yuxuan Tao, Wenbin Tuo, Chunhui Yuan, Liping Li, Chengdong Qiu, Jiaying Liang, Wei Luo, Alessandro Boscarelli, Antonio F Corno, Yun Xiang, Jun Wang, Qinzhen Cai","doi":"10.21037/tp-2025-104","DOIUrl":"10.21037/tp-2025-104","url":null,"abstract":"<p><strong>Background: </strong>Anti-Müllerian hormone (AMH) serves as a reliable biomarker of testicular function in males and ovarian function in females. However, reference intervals (RIs) for AMH in Chinese pediatric populations are scarce. This study aimed to establish age- and sex-specific RIs for AMH in healthy Chinese children and explore its correlation with six sex hormones.</p><p><strong>Methods: </strong>A cross-sectional study conducted from September 2022 to August 2023 recruited 2,450 healthy participants aged 1 day-19 years. Serum AMH levels were measured using the CL-6000i automated chemiluminescence immunoassay analyzer (Mindray, Shenzhen, China). RIs were established following Clinical and Laboratory Standards Institute (CLSI) guidelines and were defined according to the nonparametric median (P50), the 2.5th (P2.5) and 97.5th (P97.5) percentiles and 95% interval range (P2.5-P97.5).</p><p><strong>Results: </strong>In males, serum AMH levels were high at birth [1 d-1 m: 46.49 (2.89, 120.15) ng/mL], increased markedly from 1 to 12 months [94.75 (0.49, 248.73) ng/mL], and then continuously declined until 18 years of age [15-18 years: 5.33 (0.83, 13.72) ng/mL)], followed by a slight increase between 18 and 19 years of age [6.79 (2.22, 17.32) ng/mL]. In females, serum AMH levels were low within the first month after birth [0.27 (0.01, 88.7) ng/mL], gradually increased thereafter, peaked at 9 years of age [1 m-9 y: 2.32 (0.45, 103.99) ng/mL], underwent a slight decline between 9 and 15 years [2.49 (0.51, 60.00) ng/mL], and reached a plateau from 15 to 19 years [3.44 (1.13, 10.32) ng/mL]. Age- and sex-specific RIs for AMH were determined. There were four age-specific RIs in males including 1 day-1 month (P50 46.49 ng/mL; 95% interval range, 2.89-120.15 ng/mL), >1 month-3 years (P50 92.20 ng/mL; 95% interval range, 1.05-232.77 ng/mL), >3-12 years (P50 44.97 ng/mL; 95% interval range, 1.50-121.97 ng/mL), and >12-19 years (P50 6.23 ng/mL; 95% interval range, 1.94-16.14 ng/mL). Similarly, there were four age-specific RIs in females, including1 day-1 month (P50 0.27 ng/mL; 95% interval range, 0.01-88.7 ng/mL), >1 month-9 years (P50 2.32 ng/mL; 95% interval range, 0.45-103.99 ng/mL), >9-15 years (P50 2.49 ng/mL; 95% interval range, 0.51-60.00 ng/mL), and >15-19 years (P50 3.44 ng/mL; 95% interval range, 1.13-10.32 ng/mL).</p><p><strong>Conclusions: </strong>In this study, we established age- and sex-specific serum AMH RIs using the Mindray CL-6000i system in healthy children in Wuhan, China. AMH exhibits significant fluctuations across the various stages of growth and development in both genders. This will aid in providing clinicians with a decision-making tool and broaden its application in pediatric care.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"683-693"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}