Translational pediatrics最新文献

{"title":"Rotavirus vaccination is a protective factor for adverse outcomes in primary intussusception: a single-center retrospective study.","authors":"Min Du, Lihong Shang, Xin Li, Rongna Huang, Haibo Yao, Sheng Yang, Sujing Zhao, Libing Zhang, Xiaoli Xie","doi":"10.21037/tp-24-109","DOIUrl":"10.21037/tp-24-109","url":null,"abstract":"<p><strong>Background: </strong>The clinical features and prognosis of intussusception in children vaccinated against rotavirus were undefined. Hence, we conducted the study to explore the clinical characteristics and outcomes of primary intussusception patients who received rotavirus vaccine.</p><p><strong>Methods: </strong>A single-center retrospective study was performed in 327 primary intussusception patients between January 2019 and December 2021. Of these, 168 were vaccinated against rotavirus and 159 were not, the latter serving as the control group. Data on patients' clinical characteristics, commonly used inflammatory biomarkers, treatment, and outcomes were collected and evaluated.</p><p><strong>Results: </strong>Most of the vaccination group received pentavalent rotavirus vaccine produced by Merck, USA (89.88%). There were no differences in demographic characteristics, time from onset to hospital attendance, clinical symptoms and signs between the vaccination group and the control group. The success rate of air enema reduction in the vaccination group was higher than that in the control group (98.21% <i>vs</i>. 88.68%, q=0.01). The vaccination group had lower rates of surgery and complication (1.79% <i>vs</i>. 11.32%, q=0.008; 2.98% <i>vs</i>. 12.58%, q=0.006). Both platelet-lymphocyte ratio (PLR) and C-reactive protein (CRP) levels were lower in the vaccinated group (q=0.02, q=0.004). Higher CRP level [odds ratio (OR): 1.635; 95% confidence interval (CI): 1.248-2.143; P=0.006] and the longer time from onset to hospital attendance (OR: 3.040; 95% CI: 2.418-12.133; P=0.01) were associated with increased adverse events. Rotavirus vaccination (OR: 0.527; 95% CI: 0.103-0.751; P=0.02) was associated with a reduction in the probability of adverse events.</p><p><strong>Conclusions: </strong>Adverse events such as surgery and complications were lower in the vaccination group. Rotavirus vaccination was an independent protective factor for adverse events in patients with primary intussusception.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"877-888"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The SafeBoosC-III trial and the future of cerebral oximetry-guided interventions in preterm infants-time to pause and reset?","authors":"Krishna Dummula, Vishal Pandey, Venkatesh Sampath","doi":"10.21037/tp-24-89","DOIUrl":"10.21037/tp-24-89","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"1017-1021"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of foodborne salmonellosis serotypes and drug resistance in children in Chenzhou City of China from 2017 through 2022.","authors":"Yong Zhou, Bin Liao, Huilong Fang, Huiwen Zeng, Cuimei Chen, Zheng-Hang Huan, Wen Zheng, Xun Liu","doi":"10.21037/tp-24-120","DOIUrl":"10.21037/tp-24-120","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;i&gt;Salmonella&lt;/i&gt; is a significant pathogens of foodborne illness. The widespread use of antibiotics in clinical practice and animal husbandry has resulted in increasing drug resistance of &lt;i&gt;Salmonella&lt;/i&gt;. In this study, we examined the serotype distribution and drug resistance of &lt;i&gt;Salmonella&lt;/i&gt; in pediatric patients with diarrhea in Chenzhou City to provide a basis for the scientific control and rational use of antibiotics in clinical practice in relation to &lt;i&gt;Salmonellosis&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Stool &lt;i&gt;Salmonella spp&lt;/i&gt;. were collected from patients younger than 18 years of age who met the definition for foodborne illness at two sentinel hospitals from 2017 through 2022 tested &lt;i&gt;Salmonella&lt;/i&gt;, and a descriptive analysis of the epidemiologic characteristics. &lt;i&gt;Salmonella&lt;/i&gt; strains isolated from the stool underwent serology and drug-sensitivity tests. The following 14 antibiotics were used for the drug-sensitivity tests: ampicillin (AMP), ampicillin/sulbactam (AMS), cefazolin (CFZ), cefoxitin, cefotaxime, ceftazidime, imipenem (IPM), tetracycline (TET), nalidixic acid, ciprofloxacin, chloramphenicol (CHL), gentamicin, trimethoprim/sulfamethoxazole (SXT), and azithromycin.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Samples from 1,263 pediatric with diarrhea, and &lt;i&gt;Salmonella&lt;/i&gt; was detected in 221 (17.5%) of these patients. Positive test results were principally observed in the second and third quarters of each year, accounting for 21.1% and 19.6% of the cases, respectively. The infection rates of infants aged less than 12 months and toddlers aged 1-3 years with diarrhea were the highest at 21.3% and 17.8%, respectively. The 221 &lt;i&gt;Salmonella&lt;/i&gt; strains were divided into 32 serotypes, of which &lt;i&gt;Salmonella&lt;/i&gt; Typhimurium (&lt;i&gt;S.&lt;/i&gt; Typhimurium) was the dominant strain (79.2%). The resistance rates to TET (86.9%), AMP (75.6%), AMS (58.4%), CFZ (55.7%), CHL (54.3%), and SXT (45.2%) predominated, and the differences in the drug-resistance rates to 1&lt;sup&gt;st&lt;/sup&gt;-, 2&lt;sup&gt;nd&lt;/sup&gt;-, and 3&lt;sup&gt;rd&lt;/sup&gt;-generation cephalosporins were high (2.3-55.7%). Only 0.9% of the strains were resistant to IPM. The multidrug resistance (MDR) rate was 76.5% (169/221), and 48.9% (108/221) of the strains were resistant to five or more classes of antibiotics, of which the most common drug-resistance profile was AMP-AMS-TET-CHL-CFZ-SXT, accounting for 10.9% of Salmonella strains (24/221).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Foodborne salmonellosis tended to occur during the summer and autumn in children, and infants and toddlers were more likely to develop salmonellosis than children in the other age groups. The dominant &lt;i&gt;Salmonella&lt;/i&gt; serotype was &lt;i&gt;S&lt;/i&gt;. Typhimurium. The drug-resistance rate of the tested strains was high, and the MDR problem was severe. We recommend that in the treatment of salmonellosis, antibiotics be selected rationally based on the drug-resistance status of local &lt;i&gt;Salmonella&lt;/i&gt; resistanc","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"921-930"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor outcome in congenital mesoblastic nephroma with <i>TPM3::NTRK1</i> fusion: a case report from multi-disciplinary treatment to molecular tumor board.","authors":"Mengjiao Sun, Ji Chen, Yao Xue, Yongji Deng, David Van Mater, Laura S Hiemcke-Jiwa, Peng Wu, Yongjun Fang","doi":"10.21037/tp-24-126","DOIUrl":"10.21037/tp-24-126","url":null,"abstract":"<p><strong>Background: </strong>Congenital mesoblastic nephroma (CMN) is a rare renal tumor with good prognosis in children; however, cellular CMN is a special subtype with poor prognosis. The <i>ETV6</i> fusion gene has been found in some cellular CMNs, whereas CMNs with <i>TPM3::NTRK1</i> fusion gene have not been reported. This study aims to share the progression and treatment of a case of CMNs with <i>TPM3::NTRK1</i> fusion gene, in order to provide experience for the diagnosis and treatment of such specific diseases.</p><p><strong>Case description: </strong>We report a case of CMN with <i>TPM3::NTRK1</i> fusion gene and a 3-year course of disease that originated during the fetal period. The child experienced rapid tumor progression 22 months after birth, followed by tumor recurrence 3 months after complete resection of CMN. Although traditional chemotherapy could not prevent the tumor progression. The tropomyosin receptor kinase (TRK) inhibitor larotrectinib resulted in significant inhibitory effects on metastatic lesions in the lungs, liver, and peritoneum. However, the patient ultimately died as the tumor became resistant to larotrectinib.</p><p><strong>Conclusions: </strong>CMN, is a rare pediatric renal tumor that warrant prompt surgical management. A watchful waiting approach may allow for aggressive growth of metastatic disease, as seen in this case of cellular CMN with <i>TPM3::NTRK1</i> fusion gene, TRK inhibitors can play significant roles in the treatment of CMN with <i>TPM3::NTRK1</i> fusion gene, but we still need to pay attention to the phenomenon of drug resistance to larotrectinib caused by site mutations of TRKA.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"976-986"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world experience of thrombopoietin receptor agonists in pediatric immune thrombocytopenia: a report from a Chinese tertiary children's hospital.","authors":"Junjie Fan, Jing Chen, Li Gao, Yuanyuan Tian, Yina Sun, Yanhua Yao, Shihong Zhan, Shaoyan Hu","doi":"10.21037/tp-24-48","DOIUrl":"10.21037/tp-24-48","url":null,"abstract":"<p><strong>Background: </strong>Primary immune thrombocytopenia (ITP) is the most common bleeding disorder in children. There are approximately 20% pediatric ITP patients respond poor to corticosteroids as first-line treatment. Recently thrombopoietin receptor agonists (TPO-RAs) have been used to treat refractory ITP and have achieved certain therapeutic effects. To investigate the efficacy and safety of TPO-RAs in the treatment of pediatric ITP, we conducted this real-world study.</p><p><strong>Methods: </strong>Fifty-three pediatric patients with ITP who did not respond well to corticosteroids were treated with TPO-RAs. Clinical data, including therapeutic response rate, changes in platelet (PLT) count, and adverse events (AEs) were collected.</p><p><strong>Results: </strong>Of the 51 evaluable patients, 37 (72.5%) responded to TPO-RAs. Patients aged >4 years had a higher response rate than those aged ≤4 years (81.1% <i>vs.</i> 50.0%, P=0.04). There was no effect of sex, duration of disease, prior therapy, <i>Mycoplasma pneumoniae</i> (MP) immunoglobulin M (IgM) positivity, antinuclear antibody (ANA) positivity, CD4/CD8 ratio or baseline PLT count on the response rate (P>0.05). Other than 10 patients with PLT counts that exceeded the upper limit of normal, AEs were sporadic, including increased aminotransferase levels, cough, headache, and vomiting.</p><p><strong>Conclusions: </strong>TPO-RAs exhibited good clinical efficacy in pediatric ITP patients who failed to respond to first-line treatment, especially patients aged >4 years, and the side effects were minor.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"889-896"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acral persistent papular mucinosis: a rare child case report and literature review.","authors":"Mei-Yun Ding, Hai-Liang Zuo, Yan Sun, Jian-Cheng Zhang, Yong Yang, Fu-Jiang Ma, Xiao-Li Hu, Jiang-Hua Zhan","doi":"10.21037/tp-23-607","DOIUrl":"10.21037/tp-23-607","url":null,"abstract":"<p><strong>Background: </strong>Acral persistent papular mucinosis (APPM) is a rare idiopathic subtype of localized lichen myxedematosus. To date, there have been less than 41 APPM cases reported worldwide, however, almost all patients were older than 18 years of age. A 7-year-old child was first reported in this paper.</p><p><strong>Case description: </strong>A 7-year-old boy was admitted to our hospital with a solitary skin-colored papule on the radial side of the middle segment of his right index finger. The patient wanted to know the exact diagnosis and remove it because the flexion movement of the middle segment had been affected. Thus, a surgery was performed. Histopathological examination of a biopsy specimen obtained from the papule on the radial side of the middle segment of his right index finger showed a focal and well-circumscribed deposit of mucin in the papillary and middermis. The deposit never extended deeply into the reticular dermis. Mucin spared a subepidermal area in the papillary dermis. Alcian blue stains can highlight the mucin. The papule was histologically diagnosed as an APPM and excised surgically. The wound gradually healed after the operation, and no obvious recurrence, scar or other discomfort was observed during follow-up so far.</p><p><strong>Conclusions: </strong>To the best of our knowledge, this is the rare case of a child APPM presenting as a solitary papule affecting the flexion movement of the middle segment. Since it is a rare disease, we report this case to contribute to future research on the diagnosis and pathogenesis of APPM.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"987-993"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage treatment of ruxolitinib for refractory adenovirus-associated hemophagocytic syndrome post-haploidentical allogeneic stem cell transplantation: a case report.","authors":"Jian Li, Qizi Wu, Xuemei Guo, Liucheng Rong, Yongjun Fang","doi":"10.21037/tp-24-27","DOIUrl":"10.21037/tp-24-27","url":null,"abstract":"<p><strong>Background: </strong>Hemophagocytic lymphohistiocytosis (HLH) is a rare complication following hematopoietic stem cell transplantation (HSCT). Currently, there is a lack of consensus recommendations for the treatment of post-transplant HLH. This case report emphasizes the successful utilization of ruxolitinib as a salvage therapy for HLH post-HSCT. The aim is to provide valuable insights into the optimal management of this rare and complex complication.</p><p><strong>Case description: </strong>We present a case study of an 11-year-old male patient diagnosed with severe aplastic anemia who received a haploidentical HSCT. On the 86th day post-transplantation, the patient developed recurrent fever, hepatomegaly, hypertriglyceridemia, severe pancytopenia, and elevated levels of inflammatory factors and ferritin. Hemophagocytosis was observed in the bone marrow, and subsequent DNA next-generation sequencing identified adenovirus type C infection, leading to a diagnosis of adenovirus-associated HLH. After unsuccessful treatment attempts with cidofovir, dexamethasone, immunoglobulin, plasmapheresis, and etoposide, ruxolitinib was administered. Remarkably, the patient's clinical symptoms rapidly improved, and his test results gradually normalized with ruxolitinib therapy. The adenovirus viral load became undetectable by the 180th day. With continuous remission, ruxolitinib was discontinued on the 137th day post-transplantation, and a 15-month follow-up examination showed no relapse.</p><p><strong>Conclusions: </strong>We present a case of adenovirus-related secondary HLH (sHLH) post-HSCT, which was effectively treated with ruxolitinib. Our case highlights the potential of ruxolitinib as a therapeutic option for patients with viral infections and sHLH. Nonetheless, the safety and efficacy of this innovative treatment should be evaluated in forthcoming large-scale clinical trials.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"994-1000"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Specific reference interval for high-sensitivity cardiac troponin I among healthy children in Wuhan, China.","authors":"Qinzhen Cai, Mei Liu, Zhen Xie, Mo Wu, Lun Zhao, Wenbin Tuo, Si Xie, Yun Xiang, Hong Sun, Chunhui Yuan, Cong Yao, Jun Wang","doi":"10.21037/tp-24-98","DOIUrl":"10.21037/tp-24-98","url":null,"abstract":"<p><strong>Background: </strong>Troponin (Tn) is of an important biomarker for the diagnosis and prognosis of myocardial injury and for evaluating the severity of cardiac involvement due to other systemic diseases in children. Unfortunately, high-sensitivity cardiac troponin I (hs-cTnI) specific reference intervals (RIs) are extremely limited. This study aimed to establish a preliminary pediatric hs-cTnI RI for newborns, children, and adolescents in Wuhan, China.</p><p><strong>Methods: </strong>A total of 1,355 healthy participants (1 day to 19 years) were recruited from a cross-sectional study implemented in Wuhan Children's Hospital from September 2022 to August 2023. Serum hs-cTnI levels were detected via the Mindray automated chemiluminescence immunoassay analyzer (CL-6000i). Specific serum hs-cTnI RIs were established according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The RIs were defined by the nonparametric median (P50), and 2.5^th, 97.5^th [P50 (P2.5-P97.5)] intervals.</p><p><strong>Results: </strong>Of the 1,355 pediatric participants, serum hs-cTnI concentrations of 1,332 children were measured. The serum overall P50 and 95% interval range (P2.5-P97.5) of serum hs-cTnI was 0.41 (0.00, 44.31) ng/L. This was higher in males of 0.47 (0.00, 44.90) ng/L than in females of 0.36 (0.00, 44.17) ng/L (P<0.01). Age- and sex-specific differences in hs-cTnI levels were observed. The levels were highly variable in children under 1 year of age (especially in newborns), deriving a P50 (P2.5-P97.5) of 22.06 (1.04, 154.22) ng/L, and gradually narrowed and decreased with increasing age, with a markedly lower established P50 (P2.5-P97.5) of 0.36 (0.00, 2.16) ng/L. However, the levels began to increase slightly at the age of 9-12 years and reached a small peak at the age range of 15 to 18 years in males with 0.71 (0.03, 3.29) ng/L, while females were less affected by puberty. Sex- and age-specific RIs for hs-cTnI were established: 5 age-specific RIs in males, 1 day-1 month: 30.16 (8.67, 171.81) ng/L; >1-12 months: 13.20 (0.63, 61.91) ng/L; >1-15 years: 0.36 (0.00, 1.86) ng/L; >15-18 years: 0.71 (0.03, 3.29) ng/L; >18-19 years: 0.52 (0.00, 1.92) ng/L; and 4 age-specific RIs in females, 1 day-1 month: 43.93 (18.82, 146.38) ng/L; >1-12 months: 5.22 (0.92, 42.54) ng/L; >1-6 years: 0.54 (0.00, 2.74) ng/L; >6-19 years: 0.23 (0.00, 1.56) ng/L.</p><p><strong>Conclusions: </strong>This study preliminarily established age- and sex-specific serum hs-cTnI RIs using the Mindray CL-6000i system in healthy children in Wuhan, China.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"908-920"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and depressive symptoms in youth.","authors":"Katherine E Spring, Amanda E Staiano","doi":"10.21037/tp-24-44","DOIUrl":"10.21037/tp-24-44","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"1007-1011"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond borders: an appraisal of the global congenital cardiac surgery workforce.","authors":"Jeevan Francis, Edward Peng, Antonio F Corno","doi":"10.21037/tp-24-38","DOIUrl":"10.21037/tp-24-38","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) is the most common congenital abnormality worldwide. Patients in resource-constrained environments experience higher levels of mortality and morbidity from CHD. Many studies have quantified the incidence of CHD in resource-constrained environments and compared these to availability of surgeons per population. However, no study to date has compiled and created a repository of the global paediatric cardiac surgical workforce. We aimed to quantify the number and details of the congenital cardiac surgeons globally, compare the population of under 15's in each respective countries, and address the workforce gaps that currently exist within paediatric cardiac surgery.</p><p><strong>Methods: </strong>Cardiothoracic Surgery Network (CTSNet) was searched in 2021 to extrapolate the current paediatric cardiac surgical workforce. The data was evaluated with the current literature to address current gaps in workforce planning and sustainability to produce this appraisal.</p><p><strong>Results: </strong>A total of 4,027 congenital cardiac surgeons were identified from CTSNet with 75% residing in high-income countries (HICs) or upper-middle-income countries (UMICs) despite these income groups only accounting for 16% of the world population. Despite similar incidence and prevalence of CHD globally, we found an unequal distribution in the availability of congenital cardiac surgeons worldwide.</p><p><strong>Conclusions: </strong>The disparity in the availability of surgeons between HICs and low-middle-income countries (LMICs) is a global health issue that will require serous thought and planning to resolve. The high proportion of preventable deaths from CHD cases is a regrettable figure that governments and medical organisations should further strive to decrease. Education and proactive investments in training up local teams in LMICs will allow for sustainability in global congenital cardiac surgery.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 6","pages":"897-907"},"PeriodicalIF":1.5,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141564436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}