Translational pediatrics最新文献

{"title":"Advances in magnetic resonance imaging for the assessment of paediatric focal epilepsy: a narrative review.","authors":"Luigi Vincenzo Pastore, Enrico De Vita, Sniya Valsa Sudhakar, Ulrike Löbel, Kshitij Mankad, Asthik Biswas, Luigi Cirillo, Suresh Pujar, Felice D'Arco","doi":"10.21037/tp-24-166","DOIUrl":"https://doi.org/10.21037/tp-24-166","url":null,"abstract":"<p><strong>Background and objective: </strong>Epilepsy affects approximately 50 million people worldwide, with 30-40% of patients not responding to medication, necessitating alternative therapies such as surgical intervention. However, the accurate localization of epileptogenic lesions, particularly in pediatric magnetic resonance imaging (MRI)-negative drug-resistant epilepsy, remains a challenge. This paper reviews advanced neuroimaging techniques aimed at improving the detection of such lesions to enhance surgical outcomes.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, focusing on advanced MRI sequences, focal epilepsy, and the integration of artificial intelligence (AI) in the diagnostic process.</p><p><strong>Key content and findings: </strong>New MRI sequences, including magnetization prepared 2 rapid gradient echo (MP2RAGE), edge-enhancing gradient echo (EDGE), and fluid and white matter suppression (FLAWS), have demonstrated enhanced capabilities in detecting subtle epileptogenic lesions. Quantitative MRI techniques, notably magnetic resonance fingerprinting (MRF), alongside innovative post-processing methods, are emphasized for their effectiveness in delineating cortical malformations, whether used alone or in combination with ultra-high field MRI systems. Furthermore, the integration of AI in radiology is progressing, providing significant support in accurately localizing lesions, and potentially optimizing pre-surgical planning.</p><p><strong>Conclusions: </strong>While advanced neuroimaging and AI offer significant improvements in the diagnostic process for epilepsy, some challenges remain. These include long acquisition times, the need for extensive data analysis, and a lack of large, standardized datasets for AI validation. However, the future holds promise as research continues to integrate these technologies into clinical practice. These efforts will improve the clinical applicability and effectiveness of these advanced techniques in epilepsy management, paving the way for more accurate diagnoses and better patient outcomes.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 9","pages":"1617-1633"},"PeriodicalIF":1.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum interleukin-17 level and <i>Mycoplasma pneumoniae</i> pneumonia in children: a systematic review and meta-analysis.","authors":"Nontaphat Leerach, Sutthirat Sitthisak, Thawatchai Kitti, Nattawat Teerawattanapong, Wiriya Mahikul, Supaporn Lamlertthon, Nathorn Chaiyakunapruk, Kannipa Tasanapak","doi":"10.21037/tp-24-218","DOIUrl":"https://doi.org/10.21037/tp-24-218","url":null,"abstract":"<p><strong>Background: </strong><i>Mycoplasma pneumoniae</i> (<i>M</i>. <i>pneumoniae</i>) is a common pathogen of community-acquired pneumonia. Interleukin-17 (IL-17) plays a role in host defense and contributes to disease severity in infection. This present study aims to investigate the association between <i>Mycoplasma pneumoniae</i> pneumonia (MPP) and changes of IL-17 level in the serum of pediatric patients.</p><p><strong>Methods: </strong>The protocol has been registered in PROSPERO (CRD42023489451). A literature search was conducted in PubMed, EMBASE, Scopus, and Web of Science from inception to October 2023. A meta-analysis was performed to pool the mean difference (MD) with 95% confidence intervals (CIs) of IL-17 levels between patients and controls. Publication bias was assessed, and the risk of bias was evaluated using the Newcastle-Ottawa Scale (NOS).</p><p><strong>Results: </strong>Out of 207 records, 10 studies were included in the review and 9 studies were included in the meta-analysis. Of these, 7 studies compared IL-17 in general MPP patients with controls, 6 studies compared severe MPP patients with mild MPP patients. Serum IL-17 levels were significantly elevated in general MPP patients compared with control (MD =33.94 pg/mL, 95% CI: 24.66, 43.22 pg/mL, P=0.01, I²=99.07%; P=0.01). Subgroup analyses showed a difference in serum IL-17 levels treated by macrolide between patients and control (MD =83.96 pg/mL, 95% CI: 76.62, 91.29 pg/mL, P=0.01). In severe and mild MPP, the IL-17 levels were significantly increased (MD =19.08 pg/mL, 95% CI: 11.51, 26.65 pg/mL, P=0.01) and heterogeneity was appeared (I²=99.39%; P=0.01). For the risks of bias, two studies had a \"high risk\" in comparability domain, and the 7 studies were classified as \"low risk\" and \"unclear risk\".</p><p><strong>Conclusions: </strong>Our meta-analysis revealed that serum IL-17 levels are significantly elevated in pediatric with general and severe MPP. IL-17 might be a potential biomarker or therapeutic target for pneumonia caused by <i>M</i>. <i>pneumoniae</i>.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 9","pages":"1588-1599"},"PeriodicalIF":1.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble transferrin receptor is associated with red blood cell transfusion in infant cardiac surgery.","authors":"Peng Gao, Jia Liu, He Wang, Wenting Wang, Yu Jin, Peiyao Zhang, Jinping Liu","doi":"10.21037/tp-24-132","DOIUrl":"https://doi.org/10.21037/tp-24-132","url":null,"abstract":"<p><strong>Background: </strong>Iron deficiency (ID) is linked to an increased need for perioperative red blood cell (RBC) transfusion in cardiac surgery. Traditional markers used to assess ID are often influenced by inflammation, whereas soluble transferrin receptor (sTfR) is less affected by inflammation. Therefore, the purpose of this study is to explore the relationship between sTfR levels and the need for high-volume RBC transfusion in pediatric cardiac surgery patients.</p><p><strong>Methods: </strong>From August 2021 to July 2022, 236 low-weight infants (≤10 kg) who underwent cardiac surgery were included in this study. Preoperative sTfR levels and the volume of RBCs perioperatively transfused were recorded. Receiver operating characteristic (ROC) curve analysis and multivariable logistic model were used to explore the association between sTfR levels and the need for a high-volume of RBC transfusion in this study.</p><p><strong>Results: </strong>In our study, 29 (12.3%) patients received more than 2 units during the perioperative period. sTfR level was the most accurate marker for predicting the need for RBC transfusion [area under the curve (AUC) =0.643; 95% confidence interval (CI): 0.531-0.756]. Moreover, in both the continuous and categorical variable-adjusted models, a high sTfR level was associated with a greater need for RBC transfusion (P=0.006; P<0.001).</p><p><strong>Conclusions: </strong>RBC transfusion is common for low-weight infants undergoing cardiac surgery. Furthermore, a high preoperative sTfR level is associated with the need for a high-volume perioperative RBC transfusion.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 9","pages":"1529-1539"},"PeriodicalIF":1.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vosoritide therapy in children with achondroplasia under 5 years of age.","authors":"Hiroshi Kitoh","doi":"10.21037/tp-24-186","DOIUrl":"https://doi.org/10.21037/tp-24-186","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 9","pages":"1517-1520"},"PeriodicalIF":1.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain-gut-brain axis, nutrition, and autism spectrum disorders: a review.","authors":"Najlaa Hamed Almohmadi","doi":"10.21037/tp-24-182","DOIUrl":"https://doi.org/10.21037/tp-24-182","url":null,"abstract":"<p><p>Autism is a neurological disorder that affects social skills and behavior. A significant number of children with autism spectrum disorders (ASDs) may not display noticeable symptoms until they reach the age of three or older. Several factors, including genetic and environmental issues, could affect the progression of ASD in children. Dietary behavior or administration may have a crucial role in the development of autism. Epidemiological investigations have demonstrated that environmental influences play a significant role in how changes in diet can affect behavior and physiology. However, exclusion diets have not been thoroughly studied in relation to this effect. Atypical food behaviors, altered nutritional profiles, and being overweight, obese, or underweight are all associated with autism in children. Overweight or underweight was common in children with autism, but it was not necessarily uncommon in children with normal growth. Moreover, deficiencies in certain vitamins (B12, B9, and D), minerals (calcium and iron), fatty acids (omega-3 and -6), energy, and protein have been documented in children with ASD. The deficiency of these nutrients may lead to gastrointestinal (GI) symptoms and change the microbiota in children with ASD. Some nutritional interventions could help individuals with ASD to improve their mental health. Recognizing dietary habits and nutrient requirements can help in planning the best overall treatment for autism. This review discusses GI symptoms and disorders related to nutrition and nutrient-dense diets for ASD.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 9","pages":"1652-1670"},"PeriodicalIF":1.5,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142475708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three patients with new mutations in the <i>EPCAM</i> variant gene for congenital tufting enteropathy and a mutation review in China: a case report.","authors":"Sheng-Nan Wang, Yu-Juan Fu, Xiao-Lan Lu, Shi-Jian Miao, Ping Zhang, Lin Wang, Ying Huang, Yu-Huan Wang","doi":"10.21037/tp-24-97","DOIUrl":"https://doi.org/10.21037/tp-24-97","url":null,"abstract":"<p><strong>Background: </strong>Congenital tufting enteropathy (CTE) is a rare cause of intractable congenital diarrhea in children, always resulting in parenteral nutrition (PN) dependency. We aimed to report novel mutations in Chinese patients and to illustrate the clinical, histopathological, and molecular features of CTE in China.</p><p><strong>Case description: </strong>We report three cases of CTE diagnosed with whole-exome sequencing (WES) and MOC31 [a monoclonal antibody of epithelial cell adhesion molecule (EPCAM)] immunohistochemistry. The main manifestations in the three patients were watery diarrhea and growth retardation. Upper endoscopy in three patients revealed villous atrophy of the duodenal mucosa. Histological examination revealed villus abnormalities and two patients with focal tufting. All of the three patients revealed a complete absence of EPCAM expression through MOC31 immunohistochemistry. Five novel mutations, including c.319delG, c.505_507delGAG, c.491+1G>C, c.60del (p.F20Lfs*17), and c.353G>A, in <i>EPCAM</i> were identified through molecular analysis. In our review, there were 18 different mutations in 11 patients from nine studies, with 12 mutations reported only once. In China, 73% of the patients were compound heterozygotes, and most of the pathogenic variants were in exon 3. All patients presented with congenital diarrhea and needed PN because of growth retardation, even when diarrhea was improved. Of the 11 patients, 3 (27%) died.</p><p><strong>Conclusions: </strong>CTE is rare and fatal, and lacks characteristic changes during endoscopy. Patients with CTE require early diagnosis via histological examination and genetic detection to improve survival.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 8","pages":"1486-1495"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric surgery in adolescents-a vital treatment option.","authors":"Gitanjali Srivastava","doi":"10.21037/tp-24-160","DOIUrl":"https://doi.org/10.21037/tp-24-160","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 8","pages":"1287-1289"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of spirituality in the well-being of families with children with congenital heart disease: scoping review.","authors":"Sophia Livas de Morais Almeida, Luana Izabela Azevedo de Carvalho, Edward Araujo Júnior, Jonas Byk, Luciane Alves da Rocha Amorim","doi":"10.21037/tp-24-134","DOIUrl":"10.21037/tp-24-134","url":null,"abstract":"<p><strong>Background: </strong>Congenital heart disease (CHD) is the leading cause of death from malformations in infants and has a significant psychological impact on families. This scoping review explored the role of spirituality in supporting families of children with CHD. It also sought to identify gaps in the existing literature and suggest directions for future research.</p><p><strong>Methods: </strong>A synthesis review was conducted following the framework of Arksey and O'Malley, incorporating the principles of the Joanna Briggs Institute. We systematically searched four databases-Medline, Embase, Lilacs, and Scielo-selecting studies based on inclusion criteria focused on spirituality in families of children with CHD. Articles without full text, book chapters, lectures, conference abstracts, review articles, and editorials were excluded. We analyzed the year of publication, study location, objectives, methodology, participants of the study, and main results.</p><p><strong>Results: </strong>A total of 17 studies were included in the review, most of which were conducted in the past 10 years. The studies were conducted in various regions of the world, including Japan, the USA, China, Iran, Sweden, and Brazil, and they examined different religious traditions, including Christianity, Islam, Buddhism, and non-denominational spiritual practices. Twelve qualitative studies, three descriptive studies, one cross-sectional study, and one case report were included. The articles were categorized based on several themes: the influence of spirituality on mental and emotional well-being, cultural and religious diversity, integration of spirituality into health care, and its assistance in decision-making.</p><p><strong>Conclusions: </strong>Spirituality plays a crucial role in addressing the emotional and psychological challenges of CHD. There is a need for structured models of spiritual counseling and more research in diverse cultural and socioeconomic contexts. Identifying these gaps can help guide future studies to enhance our understanding and improve the support provided to these families, thereby promoting more holistic and patient-centered healthcare.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 8","pages":"1457-1468"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective study of resting energy expenditure in children hospitalized with different nutritional status.","authors":"Wen-Li Yang, Lu-Lu Xia, Dong-Dan Li, Wen-Li Zhao, Jie Yan","doi":"10.21037/tp-24-168","DOIUrl":"https://doi.org/10.21037/tp-24-168","url":null,"abstract":"<p><strong>Background: </strong>Resting energy expenditure (REE) refers to the energy consumption of the body in a resting state without skeletal muscle activity. This study aimed to examine the REE among children hospitalized with varying nutritional status.</p><p><strong>Methods: </strong>This was a retrospective study. We enrolled 109 pediatric cases that underwent indirect calorimetry (IC) and divided into four groups: mild malnutrition group (15 cases), moderate malnutrition group (30 cases), severe malnutrition group (32 cases), and obesity group (32 cases). We compared and analyzed the measured REE (mREE) using IC with the predicted REE (pREE) using five energy equations. The paired t-test was used to compare the results of two samples. Pearson analysis was used to assess the correlation between two values. The agreement analysis was performed using the Bland-Altman method.</p><p><strong>Results: </strong>There was no significant difference in mREE between the mild, moderate, and severe malnutrition groups, but each differed significantly from the obesity group. All populations exhibited significant correlation between the mREEs and all five energy equations, and the equation with the highest predictive accuracy was the Schofield equation, which achieved an accuracy of 47.7%. In subgroup analysis, there was no significant difference between mREE and pREE for each of the five equations in the mild, moderate malnutrition groups. Only the prediction result of the Liu equation was not significantly different from the mREE in the severe malnutrition group. The prediction accuracy of the Liu equation was relatively the highest (34.4%). However, in the obese group, there were significant differences in pREE and mREE between the Liu equation and Mifflin equation. Under different nutritional statuses, the results of the Bland-Altman analysis suggested that deviation values between REEs predicted by each equation and mREE were greater than ±10%.</p><p><strong>Conclusions: </strong>There were differences in REE among children with different nutritional status. The results obtained from the five predictive energy equations deviated from the IC results. When REE cannot be measured by IC, it is essential to choose an appropriate predictive energy equation based on the nutritional status of the individual.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 8","pages":"1359-1367"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a prediction model for rebound hyperbilirubinemia: a Chinese neonatal cohort study.","authors":"Huiyi Li, Xihua Huang, Zhenyu Liang, Haijian Liang, Si He, Li Tang","doi":"10.21037/tp-24-21","DOIUrl":"https://doi.org/10.21037/tp-24-21","url":null,"abstract":"<p><strong>Background: </strong>Rebound hyperbilirubinemia (HBB) is still present in as high as 10% of newborn babies. However, the applicability of established prediction models for rebound HBB to Chinese newborns is unclear. This study aimed to establish a model to predict HBB rebound after phototherapy among Chinese neonates.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 1,035 HBB infants receiving phototherapy. Rebound HBB was defined as total serum bilirubin (TSB) returning to or above the American Academy of Pediatrics (AAP) phototherapy threshold within 72 hours after the end of phototherapy. The predictive effects of previously published two- and three-variable scores were verified. Neonates were randomly assigned in a 6:4 ratio to the training (n=621) group and the testing (n=414) group. All variables in the training set were used to select predictors by least absolute shrinkage and selection operator (LASSO) regression analysis. The internal validation of the prediction model was performed using the testing set. The model's predictive performance was evaluated by area under the curve (AUC), accuracy, sensitivity, and specificity, each with 95% confidence intervals (CIs). Receiver operating characteristic (ROC) and calibration curves were constructed to evaluate the discrimination ability and fitting effect of the prediction model, respectively.</p><p><strong>Results: </strong>Rebound HBB was observed in 210 patients (20.3%). The AUC for the two- and three-variable scores were 0.498 (95% CI: 0.455-0.540) and 0.498 (95% CI: 0.457-0.540), respectively. Predictive factors for the risk of rebound HBB included formula feeding (>3 times/day), standard phototherapy irradiation time, TSB levels and age at termination of phototherapy, neonatal weight, and differences between TSB levels at the phototherapy termination and phototherapy threshold. The prediction model's AUC was 0.935 (95% CI: 0.911-0.958), the sensitivity was 0.880 (95% CI: 0.809-0.950), the specificity was 0.831 (95% CI: 0.790-0.871), and the accuracy was 0.841 (95% CI: 0.805-0.876).</p><p><strong>Conclusions: </strong>The established model performed well in predicting rebound risk among Chinese infants with HBB, which may be beneficial in treating and managing HBB in infants.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"13 8","pages":"1302-1311"},"PeriodicalIF":1.5,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11384426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142296382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}