Translational pediatrics最新文献

{"title":"Predicting death and survival without major morbidity for extremely preterm infants using information on hospital admission: a multicenter cohort study.","authors":"Xincheng Cao, Shujuan Li, Xinyue Gu, Huiyao Chen, Chuanzhong Yang, Miao Qian, Xiuying Tian, Falin Xu, Zuming Yang, Yang Wang, Jinzhen Guo, Shoo K Lee, Siyuan Jiang, Yun Cao","doi":"10.21037/tp-2025-33","DOIUrl":"10.21037/tp-2025-33","url":null,"abstract":"<p><strong>Background: </strong>Accurate prediction of outcomes for extremely preterm infants (EPIs) during the early stage is important to assist clinicians and parents in making decisions. This study aimed to develop and validate models for predicting mortality and survival without major morbidity for EPIs using information available on neonatal intensive care units (NICUs) admission.</p><p><strong>Methods: </strong>Two of the largest contemporary cohorts of EPIs born at 24⁺⁰-28⁺⁶ weeks' gestation were included in China. Two predictive models were generated separately to predict mortality and survival without major morbidity at discharge. Potential predictors were identified if they had a well-established association with neonatal outcomes in literatures and could be easily obtained on NICU admission, including gestational age, birth weight, sex, inborn, antenatal steroids, 5-min Apgar score, and invasive ventilation on admission. Logistic regression was employed to develop the models. Model performance was assessed via area under the curve (AUC).</p><p><strong>Results: </strong>Among 2,438 EPIs in the development cohort, the mortality rate was 17.7% (431/2,438) and the rate of survival without major morbidity was 52.5% (1,281/2,438). Among the 5,045 infants in the validation cohort, 9.2% (463/5,045) died, and 59.1% (2,981/5,045) survived without major morbidity. Gestational age, birth weight, invasive ventilation on NICU admission, antenatal steroids use, and 5-min Apgar score were selected as predictors in the mortality model, yielding the AUC of 0.77 [95% confidence interval (CI): 0.75-0.79]. For the survival without major morbidity model, predictors were gestational age, birth weight, invasive ventilation on NICU admission, sex, and 5-min Apgar score, and the AUC was 0.72 (95% CI: 0.70-0.74). The validation cohort resulted in AUCs of 0.76 (95% CI: 0.73-0.78) and 0.70 (95% CI: 0.68-0.71) for the mortality and survival without major morbidity models, respectively.</p><p><strong>Conclusions: </strong>Using commonly available predictors on NICU admission including gestational age, birth weight, invasive ventilation on NICU admission, antenatal steroids use, sex, and 5-min Apgar score, we successfully developed and validated two distinct models with acceptable performance, predicting mortality and survival without major morbidity for EPIs.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"927-938"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in airway resistance and its correlation with disease severity in children with <i>Mycoplasma pneumoniae</i> pneumonia.","authors":"Jiayi Xue, Yinghong Fan, Ronghua Luo, Yaping Duan, Tao Ai, Li Wang","doi":"10.21037/tp-2025-103","DOIUrl":"10.21037/tp-2025-103","url":null,"abstract":"<p><strong>Background: </strong><i>Mycoplasma pneumoniae</i> pneumonia (MPP) can cause lung function damage; however, few studies have examined the correlation between airway resistance and MPP severity. This study aimed to investigate changes in airway resistance related to severe MPP (SMPP) in children and evaluate its role in assessing disease severity.</p><p><strong>Methods: </strong>A total of 96 children with MPP, admitted to Chengdu Women's and Children's Center Hospital from December 2022 to December 2023, were recruited for the study. The children were allocated to the mild MPP (MMPP) group (n=39) and the SMPP group (n=57) based on disease severity. Indices derived from impulse oscillometry (IOS) were compared, and receiver operating characteristic (ROC) curves were generated to assess the predictive value of various indicators for SMPP.</p><p><strong>Results: </strong>The results revealed significant increases in respiratory resistance at 5 Hz (R5), respiratory resistance at 20 Hz (R20), reactance at 5 Hz (X5), and resonant frequency (Fres) in the SMPP group compared to the MMPP group (P<0.05). Compared to the children in the MMPP group, those in the SMPP group had a significantly longer hospital length of stay, and a higher proportion were admitted to the intensive care unit (ICU) and received mechanical ventilation (P<0.05). A positive correlation was found between MPP severity and R5, R20, X5, Fres, and hospital length of stay, of which R5 showed the strongest correlation. The ROC curve analysis indicated that R5 was the most effective predictor of SMPP, with an area under the curve (AUC) indicating good predictive ability [R5 > R20 > hospital length of stay > X5 (0.70)]. R5 had the highest predictive value for SMPP, with a sensitivity of 82.46%, a specificity of 87.18%, a cut-off value of 123.80%, a positive predictive value (PPV) of 90.38%, and a negative predictive value (NPV) of 77.27%.</p><p><strong>Conclusions: </strong>The airway resistance of the children with SMPP was significantly higher than that of the children with MMPP. The primary increase was observed in small airway resistance, which might be accompanied by an increase in large airway resistance, along with a decrease in lung compliance. R5, R20, and X5 were found to be correlated with the severity of MPP, indicating that IOS is a valuable tool for assessing MPP severity.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"939-946"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treatment with decompressive laparotomy for abdominal compartment syndrome induced by asparaginase-associated pancreatitis in a pediatric patient with acute lymphoblastic leukemia: a case report.","authors":"Huiwen Zhang, Weifeng Lu","doi":"10.21037/tp-24-440","DOIUrl":"10.21037/tp-24-440","url":null,"abstract":"<p><strong>Background: </strong>Asparaginase (ASP) has significantly improved the complete remission rate and long-term event-free survival in children with acute lymphoblastic leukemia (ALL). Asparaginase-associated pancreatitis (AAP) is a potentially toxic side effect of ASP, which may even lead to fatal abdominal compartment syndrome (ACS) in extreme cases. Currently, there is no consensus on the indications for decompressive laparotomy (DL), including when to initiate it, what criteria to use for decision-making, or how to perform the procedure. Moreover, available research data remain limited.</p><p><strong>Case description: </strong>We present a case of a 2-year-old boy with ALL who developed ACS, a fatal complication of severe acute pancreatitis (SAP) following treatment with pegaspargase (PEG-ASP). Massive transfusion stabilized his hemodynamics and intraluminal contents were evacuated, yet his symptoms progressed. Consequently, the patient underwent DL and continuous venovenous hemodiafiltration (CVVHDF) with ultrafiltration. Postoperative complications including enteroatmospheric fistulas and abdominal abscesses were gradually corrected by negative-pressure wound therapy (NPWT). The boy was discharged from the intensive care unit (ICU) on the 93rd day after hospital admission. During follow-up, the child's abdominal symptoms gradually improved, and bridging therapy with blinatumomab was administered.</p><p><strong>Conclusions: </strong>In this case, a pediatric ALL patient developed life-threatening complications following PEG-ASP administration, which were ultimately successfully managed through multidisciplinary intervention. When pediatric hematology-oncology patients develop ACS, clinicians should carefully evaluate the oncological context and thoroughly assess the risks of surgical versus conservative management for this potentially fatal condition. Optimal timing of surgical intervention combined with advanced perioperative care is critical for achieving favorable outcomes. We strongly recommend conducting high-quality clinical research to establish evidence-based treatment guidelines.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"1050-1058"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunophenotyping in diagnosing pediatric acute leukemia after setting up the first flow cytometry unit in Mosul City in Iraq: an observational study of the project performed through a contribution from Japan.","authors":"Khalid S Al-Badrani, Lika'a Fasih Y Al-Kzayer, Kenan Hussien Ali, Asmaa M A Khaleel, Nashwan Ahmed Fadhil, Bassam Negem A Alsammak, Yasir S Al-Agele, Abduladheem H Malallah, Dana Ahmed Abdullah, Hiwa Hassan Hamza, Minoru Kamata","doi":"10.21037/tp-2025-24","DOIUrl":"10.21037/tp-2025-24","url":null,"abstract":"<p><strong>Background: </strong>Flow cytometry (FCM) is a powerful tool for classifying acute leukemia (AL) to acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) and further subtyping. Accurate diagnosis of AL improves the outcome. Mosul, a city in Iraq, had no FCM laboratory yet, mainly due to repeated wars in the area. The Japan Chernobyl Foundation (JCF), a Japanese non-profit humanitarian organization, helped establish the first FCM Laboratory in Mosul. We aimed to evaluate the project from a scholarly point of view with a focus on childhood ALL.</p><p><strong>Methods: </strong>An observational study was done after JCF provided the BD FACSCanto II system and all related materials. Anonymous data of the patients, including age, sex, address, initial complete blood count (CBC) with bone marrow aspirate (BMA) results, and coded FCM reports, were prospectively collected from February 2021 to January 2024. In addition to clinical notes on pediatric ALL cases, their treatment, and outcomes with a median follow-up of 26.2 (range, 0-44.3) months.</p><p><strong>Results: </strong>Childhood ALL cases were 76, including (60, 78.9%) B-lineage ALL (B-ALL) and (16, 21.1%) T-lineage ALL (T-ALL) cases. B-ALL cases were classified as pro-B, common-B, pre-B, and mature-B, with frequencies of 11.7%, 76.7%, 10.0%, and 1.6%, respectively. T-ALL included early T-cell precursor (ETP), pro-T, pre-T, cortical-T, and medullary-T, with frequencies of 6.25%, 18.75%, 18.75%, 31.25%, and 25.00%, respectively. Furthermore, 20 pediatric AML cases were identified and sub-typed. Among ALL cases, the male-to-female ratio (M/F) was 1.5. There were 24 (31.6%) cases with white blood cell (WBC) counts of ≥50×10⁹/L and 29 (38.2%) who were aged ≥10 years or ≤12 months. There was a substantial association between high WBC and male sex with the T-ALL subtype. Based on clinical criteria and immunophenotyping of ALL, 47 (61.8%) of patients were identified as a high-risk (HR) group, while 29 (38.2%) were of standard-risk (SR) group. Relapses were reported in 8 (11.6%) patients with ALL, principally in the HR group. The induction mortality rate was 4.2%. Septic death was the leading cause of death (8/17, 47.1%), especially in those younger than 2 years old. The overall survival (OS) in ALL cases was 73.7%. The OS and event-free survival (EFS) for the SR group of ALL were 86.2% and 82.8%, respectively.</p><p><strong>Conclusions: </strong>JCF's role was crucial in providing Mosul City, Iraq, with the first FCM Unit. The project made a breakthrough in AL diagnosis and established one of the important and supposed routine steps represented by ALL immunophenotyping. The HR group represented a significantly large portion of our ALL cases. Although the outcome was satisfactory for the SR group, the survival rate for the HR group was dismal. Further efforts are needed to scale up diagnostic and therapeutic capabilities to improve the outcome of ALL in Mosul City.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"900-914"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain functional connectivity and activity during motor control in children with cerebral palsy: a pilot cross-sectional fNIRS study.","authors":"Xiaoyin Huang, Hongyu Zhou, Jingbo Zhang, Huiying Qiu, Lu He, Jinling Li, Xubo Yang, Fan Wu, Kaishou Xu","doi":"10.21037/tp-2025-11","DOIUrl":"10.21037/tp-2025-11","url":null,"abstract":"<p><strong>Background: </strong>Cerebral palsy (CP) is a neurological disorder caused by non-progressive brain injuries during fetal development or infancy, primarily characterized by impairments in motor control. While motor control challenges in CP have been extensively studied, limited attention has been paid to brain activation patterns and functional connectivity during motor tasks, particularly in pediatric populations. This study aims to compare brain activity and functional connectivity between children with CP and typically developing (TD) children during motor control tasks.</p><p><strong>Methods: </strong>This cross-sectional study employed functional near-infrared spectroscopy (fNIRS) to investigate brain activity and functional connectivity during motor tasks in children with CP. Participants included 6 children with bilateral CP, 6 with hemiplegic CP (HCP), and 5 TD children. Connectivity between critical brain regions, such as the sensory-motor cortex (SMC) and somatosensory association cortex (SAC), was analyzed. Furthermore, the relationship between functional connectivity and motor control performance was examined.</p><p><strong>Results: </strong>Children with bilateral CP (BCP) exhibited significantly reduced functional connectivity between the bilateral SMC and the SAC compared to TD children (P<0.05). However, no significant differences in functional connectivity were observed between children with HCP and either TD children or those with BCP (P>0.05), suggesting neural connectivity patterns in HCP are comparable to those in TD peers. A positive correlation was identified between functional connectivity and motor control, indicating that stronger connectivity is associated with better motor control outcomes.</p><p><strong>Conclusions: </strong>This study provides new insights into the functional connectivity of the brain in children with CP, highlighting differences in connectivity patterns between BCP and TD children. The findings underscore the importance of functional connectivity in motor control and offer potential implications for developing targeted therapeutic strategies. Understanding these connectivity patterns can aid in refining interventions aimed at improving motor function in children with CP.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"812-823"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of readout-segmented echo-planar imaging and single-shot echo-planar imaging in the fetal brain.","authors":"Shikang Hu, Yan Zhao, Yishuang Wang, Meining Chen, Tao Lu","doi":"10.21037/tp-2025-77","DOIUrl":"10.21037/tp-2025-77","url":null,"abstract":"<p><strong>Background: </strong>The diagnostic value of diffusion-weighted imaging (DWI) in fetal brain imaging has been established for various brain lesions, yet conventional DWI single-shot echo-planar imaging (SS-EPI) suffers from distortion and artifacts. Readout Segmentation of Long Variable Echo-trains (RESOLVE) is an advanced technology that can produce better image quality than SS-EPI. This study was aimed to evaluate the clinical effectiveness of RESOLVE and SS-EPI in visualizing the fetal brain.</p><p><strong>Methods: </strong>We performed RESOLVE and SS-EPI on 190 fetal brains from December 2019 to December 2021, and two radiologists reviewed the two datasets separately. Qualitative analyses were conducted in susceptibility-related change, image distortion, lesion conspicuity, and overall image quality with a 5-point Likert scale. Inter-reader agreement was measured using a Cohen kappa statistic. The apparent diffusion coefficient (ADC) and signal-to-noise ratio (SNR) of the two sequences in bilateral centrum semiovales were measured and compared.</p><p><strong>Results: </strong>The readers had good agreement with their scores (k>0.6). All the subjective parameters between the two sequences showed statistical significance (all P<0.05). The respective mean (range) scores for SS-EPI and RESOLVE were 4 (3.5, 4) and 4.5 (4, 4.5) for susceptibility-related change, 4.5 (4, 4.5) and 5 (4.5, 5) for image distortion, 4 (3.5, 4.5) and 4.5 (4, 5) for lesion conspicuity, and 4 (3.5, 4) and 4.5 (4, 4.5) for overall image quality. The ADC values in the centrum semiovale did not differ between the two sequences (P=0.64). Last, the SNR was 45.53 for SS-EPI, significantly higher than that of RESOLVE at 35.57 (P<0.001).</p><p><strong>Conclusions: </strong>In terms of distortion, susceptibility-related changes, and lesion conspicuity, RESOLVE was better at visualizing the fetal brain than SS-EPI. However, SS-EPI scored better than RESOLVE in the SNR.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"844-854"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of multiple pregnancies with risk of preterm birth in the United States: a retrospective cohort study.","authors":"Ting Gao, Jiayu Zhou, Lan Yang, Tianwei Wang","doi":"10.21037/tp-2024-518","DOIUrl":"10.21037/tp-2024-518","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The elevated risks of adverse fetal and neonatal outcomes in multiple pregnancies (MPs) are predominantly driven by complications linked to preterm birth (PTB). However, studies on the association between MPs and PTB are limited. Furthermore, the impact of varying degrees of MPs on the likelihood of PTB is unclear, making it challenging to assess the PTB risk degree associated with different types of MPs. This uncertainty can consequently affect prenatal and perinatal management planning and fetal health. In this study, we aimed at examining the association between MPs and the risk of PTB in a large population-based study in the United States (US).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective cohort study examined nationwide birth certificate data from the US National Vital Statistics System (NVSS) between 2016 and 2021. A total of 22,669,736 mothers who had live births and for whom data on the number of fetuses and gestational age at birth were available were included in this study. The exposure was MPs, including the twin, triplet, quadruplet, or more pregnancy. The main outcome was PTB, which is defined as birth before 37 weeks' gestation. The important covariates included maternal age and education, race or ethnicity, marital status, pre-pregnancy body mass index (BMI), smoking during pregnancy, previous history of PTB and cesarean, pre-pregnancy diabetes and hypertension, gestational diabetes and hypertension or pre-eclampsia, eclampsia, infertility treatment, prenatal care, and maternal sexually transmitted infections. The association between MPs and PTB was estimated through logistic regression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;This study enrolled in 22,669,736 mothers {mean [standard deviation (SD)] age, 29.05 (5.8) years; the Hispanic, 5,365,989 (23.7%); the non-Hispanic White, 11,680,688 mothers (51.5%); the non-Hispanic Black, 3,269,219 (14.4%) as, and the non-Hispanic Asian 1,418,537 (6.3%)}. Among the mothers, 732,289 (3.2%) were twin pregnancy, 19,573 (0.1%) were triplet pregnancy, and 1,066 (&lt;0.1%) were quadruplet or higher pregnancy. Among the newborns, the PTB accounted for 11.8% (2,683,587 cases), of which 10.2% (2,242,028 cases) were single births, 57.6% (422,097 cases) were twin births, 94.2% (18,446 cases) were triplets, and 95.3% (1,016 cases) were quadruplets or more. After adjustment for all the covariates in this study, the adjusted odds ratio (OR) of PTB was 12.03 [95% confidence interval (CI): 11.97-12.10] for twin, 139.08 (95% CI: 130.43-148.30) for triplet, 161.17 (95% CI: 118.80-218.65) for quadruplet or higher, and 12.51 (95% CI: 12.44-12.58) for any kinds of MPs comparing mothers with these conditions and those without.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study found that MPs were associated with increased risk of PTB, with the risk magnifying as the number of fetuses increases, which may help us to accurately judge the risk degree of PTB in different type of MPs, and provi","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"915-926"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of a solution-focused model discharge readiness coaching intervention on the parents of Chinese pediatric liver transplantation patients: a single-center observational study.","authors":"Ting He, Xiaobo Huang, Zhaoyan Feng, Fang Huang, Fanfan Yang, Chunrong Chen, Jeremie Minani, Qin Wei, Christine Pocha, Lihua Tang","doi":"10.21037/tp-2025-66","DOIUrl":"10.21037/tp-2025-66","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation (LT) is the only effective treatment for pediatric diseases such as cholestatic diseases, genetic metabolic diseases, acute liver failure, and liver malignancies. With the continuous improvement of LT technology, more and more children with end-stage liver disease are receiving this life-saving treatment. Parents of pediatric LT patients often face significant psychological challenges, including anxiety, depression, and a lack of confidence in their ability to provide postoperative care. This study aimed to evaluate the impact of a solution-focused based model discharge readiness coaching intervention on improving the discharge readiness and mental health status of parents of pediatric LT patients.</p><p><strong>Methods: </strong>A convenience sampling method was used to select either the father or the mother of 110 pediatric LT patients hospitalized in the Organ Transplantation Department of The First Affiliated Hospital of Guangxi Medical University as study participants. The study was conducted over 2 years, with 55 parents of children who underwent LT in 2022 serving as the control group and 55 parents of children who underwent LT in 2023 serving as the experimental group. The experimental group received routine education plus tailored, solution-focused counseling sessions lasting approximately 20 to 30 minutes each, conducted every Tuesday and Friday. The control group received standard care. Discharge readiness scores before and after the intervention, as well as the quality scores for the discharge counseling provided, were assessed.</p><p><strong>Results: </strong>The experimental group showed significantly higher discharge readiness scores (total and subscales: personal status, coping ability, anticipatory support) and discharge counseling quality compared to the control group (P<0.05). The effect size for the total discharge readiness score was 0.85, indicating a large effect. The intervention also reduced unplanned readmissions and improved postoperative quality of life. However, due to the limitations of the study design, including the single-center nature and small sample size, the findings should be interpreted with caution.</p><p><strong>Conclusions: </strong>The solution-focused model intervention improved parents' discharge readiness and the quality of discharge counseling, thus improving the patients and caregivers postoperatively quality of life and reducing the unplanned readmission rate of pediatric LT patients. Future studies should address these limitations through multicenter trials with larger sample sizes.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"992-1002"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics of pediatric patients with burn complications and influence between 2016 and 2021: a multi-center retrospective study.","authors":"Xiaohui Liu, Jing Liu, Xinyu Wang, Guoshuang Feng, Xitong Zhao, Kun Chen","doi":"10.21037/tp-2025-20","DOIUrl":"10.21037/tp-2025-20","url":null,"abstract":"<p><strong>Background: </strong>Currently, domestic and international studies on post-burn complications are limited to single diseases, and a single center or on a small scale. Therefore, this large-scale study aimed to describe the epidemiological characteristics of pediatric burns and their complications in China to notify the occurrence of burn complications.</p><p><strong>Methods: </strong>This study included 11,092 pediatric burn medical records of Futang Research Center of Pediatric Development (FRCPD) database between January 1, 2016, and December 31, 2021. General and hospitalization information for patients with the first diagnosis of \"T20-T32\" [according to the 10th revision of the International Classification of Diseases, burns and corrosions of external body surface, specified by site (T20-T25), burns and corrosions confined to eye and internal organs (T26-T28), burns and corrosions of multiple and unspecified body regions (T29-T32)] was extracted.</p><p><strong>Results: </strong>This retrospective, large-scale, and multi-center study included pediatric burn cases in the FRCPD database. The prevalence of respiratory infections was 5.5%, shock was 2.8%, hypoproteinemia was 1.3%. In terms of age, children <1 year' incidence of respiratory infections and anemia was 6.9% and 3.2% (P<0.001). The rates of myocardial damage and esophageal stenosis in children aged 15-18 years were 18.8%. For burn causes, respiratory infection caused by hydrothermal scald was 3.7%, flame was 14.7% and chemical was 26.6%. Myocardial damage caused by electric was 8.5%. For burns in the trunk, the proportion causing shock and hypoproteinemia were 24.4% and 10.5%, respectively.</p><p><strong>Conclusions: </strong>Boys, 1-3 years, and children whose hospitals in urban areas were susceptible to burns from hydrothermal scalds. Children aged 4-7 years were susceptible to shock due to flame burns involving limbs or multiple parts. In terms of age, children <1 year had the highest incidence of respiratory infections and anemia among all age groups. The rates of myocardial damage and esophageal stenosis in children aged 15-18 years were highest in different age groups. From burn causes, myocardial damage was the most common complications caused by electric. From burn area, the most common areas for shock and hypoproteinemia were the trunk.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"947-959"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of <i>NEFL</i> gene polymorphisms with neuroblastoma risk in Chinese children from Jiangsu Province.","authors":"Xiaofeng Chang, Jinhong Zhu, Chunlei Zhou, Wei Yang, Mengzhen Zhang, Jiaming Chang, Jiabin Liu, Jing He, Huanmin Wang","doi":"10.21037/tp-2024-611","DOIUrl":"10.21037/tp-2024-611","url":null,"abstract":"<p><strong>Background: </strong>Neuroblastoma is the predominant extracranial solid tumor occurring in children, and genetic factors like genetic polymorphism play a crucial role in its etiology. In this study, we investigated the associations between three <i>NEFL</i> polymorphisms (rs11994014 G>A, rs2979704 T>C, and rs1059111 A>T) and neuroblastoma susceptibility in a cohort of 402 neuroblastoma patients and 473 controls from Jiangsu Province.</p><p><strong>Methods: </strong>Genotyping was determined using the TaqMan method. Genotype distributions between cases and controls were assessed via both univariate and multivariate logistic regression models to assess the associations between <i>NEFL</i> polymorphisms and neuroblastoma risk. Stratified analyses were performed based on age, sex, clinical stage, and site of origin to explore potential effect modifications and subgroup-specific associations.</p><p><strong>Results: </strong>In the overall analysis, no significant associations were found between any of the three <i>NEFL</i> polymorphisms and neuroblastoma risk. When subjects were grouped on the basis of the number of risk genotypes, no significant alteration in susceptibility was observed in children carrying three risk genotypes compared with controls carrying fewer risk genotypes. Stratified analyses based on age, sex, clinical stage, and site of origin also revealed no significant results.</p><p><strong>Conclusions: </strong>Our findings suggest that <i>NEFL</i> polymorphisms do not significantly modify neuroblastoma susceptibility in this population, suggesting that the previously reported neuroblastoma susceptibility loci in <i>NEFL</i> in Caucasians may not be consistent across different populations. Further research, including larger, more diverse cohorts, is necessary to clarify the potential role of <i>NEFL</i> and other genetic factors in neuroblastoma etiology.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 5","pages":"984-991"},"PeriodicalIF":1.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12163770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}