Translational pediatrics最新文献

{"title":"Screening for biomarkers of bronchopulmonary dysplasia: a bioinformatics analysis.","authors":"Xiaoqun Zhang, Linzhou Zhu, Huawei Wang, Jinhui Hu, Jie Huo, Shan He, Yueping Shen, Xueping Zhu","doi":"10.21037/tp-2024-595","DOIUrl":"10.21037/tp-2024-595","url":null,"abstract":"<p><strong>Background: </strong>Bronchopulmonary dysplasia (BPD) is a common chronic respiratory disease in preterm infants, and its incidence has gradually increased with advances in medical technology. BPD is associated with multiple complications, significantly impacting the quality of life of affected infants and imposing substantial economic burdens on families and society. Currently, the molecular mechanisms of BPD are not fully understood, and effective treatments are lacking. MicroRNAs (miRNAs), as important gene regulatory molecules, play a critical role in lung development and BPD. This study aims to investigate the potential role of miRNAs in BPD, with a particular focus on miR-9-5p and guanosine triphosphate cyclohydrolase 1 (GCH1).</p><p><strong>Methods: </strong>Differential expression analysis of genes and miRNAs was conducted using the Gene Expression Omnibus (GEO) database. A hyperoxia-induced injury cell model was constructed to examine the expression of miR-9-5p. Target genes of miR-9-5p were predicted using online databases, followed by functional and protein interaction network analyses. In addition, cell culture, real-time quantitative polymerase chain reaction (RT-qPCR), western blotting, reactive oxygen species (ROS) level detection, malondialdehyde (MDA) assay, and Fe²⁺ detection experiments were performed.</p><p><strong>Results: </strong>In the GSE108755 dataset, miR-9-5p was found to be upregulated in the blood of infants with BPD. In the hyperoxia-induced injury cell model, miR-9-5p expression was significantly increased. GCH1 was identified as a target gene through intersection with ferroptosis regulatory gene sets. In the cell model, GCH1 expression was markedly downregulated, while ROS, MDA, and Fe²⁺ levels were significantly elevated.</p><p><strong>Conclusions: </strong>This study provides new insights into the molecular mechanisms of BPD, suggesting that miR-9-5p and GCH1 may serve as potential therapeutic targets for BPD. The findings contribute to a deeper understanding of the molecular basis of BPD, providing theoretical and experimental support for its diagnosis and treatment strategies. Future research will further explore the regulatory relationship between miR-9-5p and GCH1 and their roles in animal models, cell models, and clinical patients.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"658-670"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single cell sequencing technology reveals the correlation between B lymphocytes and vascular inflammatory symptoms of Kawasaki disease.","authors":"Sirui Song, Liqin Chen, Yuanyuan Zhou, Jianhang Huang, Yanbing Xu, Guang Li, Guohui Ding, Tingting Xiao, Min Huang","doi":"10.21037/tp-2025-19","DOIUrl":"10.21037/tp-2025-19","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki disease (KD), an acute vasculitis syndrome affecting children under 5 years, lacks specific biological markers for diagnosis. This study explores immune cell activation in KD patients during early vasculitis symptoms to identify potential diagnostic markers and guide intravenous immunoglobulin (IVIG) therapy timing.</p><p><strong>Methods: </strong>The study included single-cell sequencing (SCS) from 10 patients, comprising seven with KD and three controls, as well as flow cytometry and polymerase chain reaction (PCR) validation from 277 patients. This included 95 children with KD and controls consisting of 12 healthy children and 170 children with febrile illnesses. Children with KD were divided into early vasculitis group and late vasculitis group based on whether the symptoms of vasculitis were less than or more than three days. peripheral blood mononuclear cells (PBMCs) were sequenced using the 10× Genomics platform, and flow cytometry and quantitative PCR (qPCR) verified changes in gene expression and cell proportions.</p><p><strong>Results: </strong>KD patients showed higher CD19⁺ B cells, particularly in the late vasculitis group. Pre-treatment CD19⁺ B cells were elevated and normalized post-IVIG treatment. Flow cytometry validation confirmed the increase in CD19⁺ B cells before IVIG treatment, which decreased to normal levels post-treatment, aligning with the SCS results. The study identified a total of 1,680 differentially expressed genes (DEGs) involved in B cell activation and immune responses, with core genes like IFITM1, CD55, FCER1G, and others down-regulated in the late vasculitis group. Time-series analysis revealed genes with high expression in early vasculitis that down-regulated over time, including S100A8, S100A9, and S100A12 which were further validated using qPCR, showing higher expression in the early stage of KD compared to healthy controls.</p><p><strong>Conclusions: </strong>This study highlights the close relationship between the number of immune cells and gene expression changes with the duration of vasculitis in KD, providing new insights into the pathophysiological mechanisms of the disease and potential prognostic indicators for clinical treatment.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"582-596"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of body mass index on clinical outcomes in pediatric patients with mycoplasma pneumoniae pneumonia: a retrospective cohort study.","authors":"Wenjie Xuan, Lingke Liu, Jinjing Lin, Xiaohong Chen, Huanying Yao, Dong Yu","doi":"10.21037/tp-2024-494","DOIUrl":"10.21037/tp-2024-494","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The incidence of mycoplasma pneumoniae pneumonia (MPP) has increased globally, particularly among children and adolescents. Obesity, a major public health challenge, may affect the severity and clinical manifestations of respiratory infections. However, the prognostic role of body mass index (BMI) in MPP remains unclear. This study aimed to investigate the relationship between BMI and clinical outcomes in pediatric patients with MPP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study included 530 children (aged 2-14 years) hospitalized with MPP at Shaoxing People's Hospital between May 2024 and August 2024. Participants were categorized into obesity, overweight, and normal weight groups based on BMI standards. Inclusion criteria required a confirmed diagnosis of MPP according to the National Health Commission's guidelines. Demographic characteristics, clinical factors such as fever, dyspnea, rash, pleural effusion, plastic bronchitis, and laboratory findings were compared among BMI groups. Prognostic outcomes (including duration of fever, length of hospital stay, incidence of plastic bronchitis, and pleural effusion) were assessed, with severe MPP (SMPP) serving as the primary endpoint. The Pearson correlation coefficient was used to evaluate associations between BMI and clinical variables, while binary logistic regression was performed to analyze the relationship between BMI and SMPP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Forty-two patients had obesity (7.9%), 45 were overweight (8.5%), and 443 (83.6%) had normal BMI. There were no significant differences in age, gender, and height distribution among three groups. A longer duration of fever (P=0.01), along with a greater incidence of dyspnea (P=0.006), plastic bronchitis (P=0.007), and SMPP (P=0.008) was observed in the obesity and overweight groups compared to the normal weight group. Laboratory results showed elevated white blood cell count (WBC, P&lt;0.001), neutrophil count (N, P&lt;0.001), and C-reactive protein (CRP, P=0.001) levels in the overweight and obesity groups compared to the normal weight group. Additionally, significant increases in red blood cell count (RBC, P=0.03), and alanine aminotransferase (ALT, P=0.006) levels were observed in the obesity group compared to the normal weight group. Correlation analysis revealed that higher BMI was positively associated with the duration of fever (P=0.03) and levels of WBC (P&lt;0.001), N (P&lt;0.001), CRP (P&lt;0.001), RBC (P=0.009), and ALT (P&lt;0.001). Logistic regression analysis demonstrated that higher BMI was associated with an increased risk of SMPP [odds ratio (OR) =1.143, 95% confidence interval (CI): 1.045-1.250]. This association remained significant after adjusting for age and gender (OR =1.120, 95% CI: 1.020-1.231).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study underscored the critical role of overweight and obesity in exacerbating the severity of MPP in pediatric patients. Higher BMI was associated with an in","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"608-617"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pediatric surgery on anxiety in children and their families and coping strategies: a narrative review.","authors":"Xiaoqian Ma, Zhenkun Zhang, Yiyao Bao, Hangyan Zhao","doi":"10.21037/tp-2025-10","DOIUrl":"10.21037/tp-2025-10","url":null,"abstract":"<p><strong>Background and objective: </strong>During surgical procedures, children often experience significant anxiety, which affects their mental health and may have adverse effects on surgical outcomes and postoperative recovery. Additionally, pediatric emergency surgery, as a high-risk medical intervention, heightens anxiety in both children and their families. Therefore, understanding and addressing anxiety experienced by children and their families during surgery is particularly important. This study aimed to systematically review the relevant literature, analyze the primary factors influencing anxiety in children and their families during surgery, and discuss effective coping strategies to help healthcare providers reduce the anxiety levels of patients and their families, thereby promoting the safety of surgeries and postoperative recovery outcomes.</p><p><strong>Methods: </strong>Recent literature was identified using the PubMed database with combinations of keywords \"pediatric surgery\", \"anxiety\", \"children or families\", and \"coping strategies\", focusing on studies published between 2010 and 2024. Eligible studies were identified through predefined inclusion and exclusion criteria. Data were synthesized using qualitative and quantitative methods to provide an overview of current evidence and identify research gaps.</p><p><strong>Key content and findings: </strong>The review revealed a significant association between a child's age and preoperative anxiety levels. Key risk factors for preoperative anxiety included prior medical experiences, the family environment, and the nature of the surgical procedure. Family members' anxiety levels were positively correlated with those of the children. Notably, children who received preoperative education via virtual reality technology exhibited significantly lower anxiety scores compared to those who received traditional education methods. Additionally, interventions such as parental presence, music therapy, and psychological support were found to be effective in mitigating anxiety.</p><p><strong>Conclusions: </strong>Managing anxiety during children's surgeries requires various approaches, and future research and clinical practice should complement each other to improve surgical experiences and mental health in children. By continuously optimizing the relevant strategies, we can create a safer and more supportive environment for children and their families during surgery.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"718-727"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the predictive value of pH in stratified mortality risk of NEC patients undergoing surgery: a retrospective study based on the PIC database.","authors":"Xue Liu, Wenqiang Sun, Ronghui Yu, Yihui Li, Xueping Zhu","doi":"10.21037/tp-2025-3","DOIUrl":"10.21037/tp-2025-3","url":null,"abstract":"<p><strong>Background: </strong>Neonatal necrotizing enterocolitis (NEC) represents a severe gastrointestinal condition characterized by a high mortality rate, with a paucity of reliable prognostic biomarkers. The presence of an acidic pH, indicative of systemic acidosis and intestinal ischemia, has potential as a predictor of adverse outcomes. However, the relationship between pH levels and inflammatory markers, as well as its applicability across surgical and non-surgical patient subgroups, remains inadequately understood. Utilizing data from pediatric intensive care units, this study investigates the prognostic significance of pH in stratifying mortality risk in NEC and examines its association with variations in neutrophil and leukocyte counts.</p><p><strong>Methods: </strong>Clinical and laboratory data of NEC patients were collected from pediatric critical care datasets. The population was stratified based on whether surgical treatment was performed. Each stratum was further divided into two groups: the mortality group and the discharge group. Intergroup comparisons and multivariate analyses were conducted to evaluate the predictive value of acidic pH levels for outcomes in NEC patients.</p><p><strong>Results: </strong>A total of 124 NEC neonates were included, with a median age at admission of 9 days and a median weight of 2.34 kg. In both the non-surgical and surgical subgroups, neonates in the mortality group exhibited acidic pH levels. Multivariate regression analysis in the surgical group identified acidic pH as a risk factor for adverse outcomes. Among all NEC neonates, stratification based on pH levels revealed the highest mortality rate in the acidic pH group. A generalized linear regression model using pH as the dependent variable demonstrated that, in addition to conventional factors such as lactate and potassium (K+), increases in neutrophils and white blood cells (WBCs) also contributed to pH variations.</p><p><strong>Conclusions: </strong>Acidic pH is closely associated with adverse outcomes in NEC neonates. Inflammation-related increases in WBC and neutrophils may reflect changes in pH levels in these patients.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"646-657"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower blood pressure targets in childhood chronic kidney disease.","authors":"Manish D Sinha, Phil Chowienczyk","doi":"10.21037/tp-2025-9","DOIUrl":"10.21037/tp-2025-9","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"773-775"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of human adenovirus load and viral genotype diversity with respiratory disease severity in children: a systematic review and meta-analysis.","authors":"Ruizhong Zhang, Taichiro Goto, Xiaowei Zhang","doi":"10.21037/tp-2024-627","DOIUrl":"10.21037/tp-2024-627","url":null,"abstract":"<p><strong>Background: </strong>Human adenoviruses (HAdVs) are one of the most prevalent viruses in pediatric outpatients worldwide. The correlation between different genotypes of HAdVs and disease severity requires further investigation. The aim of this meta-analysis was to determine the association among HAdV load, viral genotypic diversity, and respiratory disease severity in children.</p><p><strong>Methods: </strong>We conducted subject-term searches in English language databases, including Web of Science, PubMed, American Medical Association (AMA), Cochrane Library, and European Society for Clinical Nutrition and Metabolism (ESPEN), in addition to a Chinese language database, China National Knowledge Infrastructure (CNKI). We assessed the quality of the literature and performed a meta-analysis using RevMan 5.3 and STATA version 15.1. The study indicators were HAdV load, viral type, and disease severity. We assessed effect sizes using odds ratio (OR), standard error, and diagnostic efficacy indicators. We also performed heterogeneity tests, sensitivity analyses, and publication and bias assessments.</p><p><strong>Results: </strong>We retrieved 12 papers on HAdV load, genotyping, and severity of respiratory disease in children. Four papers on viral load indicated that a high viral load was associated with an increased risk of severe pneumonia [combined OR =2.02; 95% confidence interval (CI): 1.64-2.47]. Six papers on B3 subtype viruses reported a combined sensitivity of 0.42 and specificity of 0.99. Eight publications on B7 subtype viruses reported a combined sensitivity of 0.71 and specificity of 0.97. The combined OR increased with sample size, but the association was not significant for the B3 subtype and was more significant for the B7 subtype. For severe pneumonia, the combined sensitivity of quantitative polymerase chain reaction (qPCR) was 0.20 for B3 (95% CI: 0.13-0.28) and 0.48 for B7 (95% CI: 0.43-0.53), while the combined specificity for B3 was 0.96 (95% CI: 0.95-0.97) and 0.92 for B7 (95% CI: 0.85-0.98), which were higher than those of other polymerase chain reaction (PCR) methods.</p><p><strong>Conclusions: </strong>In children, we found a significant association among HAdV load, the B3 and B7 subtypes, and respiratory disease severity. qPCR showed high sensitivity and specificity for detecting the B3 and B7 virus subtypes, suggesting its suitability for clinical use. This study provides important insights into the role of HAdVs in childhood respiratory infections and may guide clinical diagnosis and therapeutic strategies.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"671-682"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital patellar dislocation with genu valgum and Klinefelter syndrome: a case report.","authors":"Tengyao Li, Jiewei Weng, Tianyou Li","doi":"10.21037/tp-2024-594","DOIUrl":"10.21037/tp-2024-594","url":null,"abstract":"<p><strong>Background: </strong>Congenital patellar dislocation (CPD) is a complex disease lacking consensus on the treatment. While genu valgum is a risk factor for patellar dislocation in general, it is less common in the congenital cases. In this report, a retrospective analysis of a child with bilateral CPD and genu valgum is presented, detailing the clinical characteristics, diagnostic approach, surgical intervention, and outcomes.</p><p><strong>Case description: </strong>A 3-year-old boy presented with an abnormal gait and Klinefelter syndrome. Comprehensive preoperative imaging evaluations were made to assess osseous and soft tissue morphology, revealing bilateral CPD and genu valgum which localized to proximal tibia and knee joint. Surgical correction involved open reduction of both patellar dislocations with lateral retinacular release, medial retinacular reefing, temporary proximal tibial epiphysiodesis by eight-plate, and iliotibial band lengthening. Intraoperative patellar stability was satisfactory. At the 3-year follow-up, the patient showed normal patella tracking and favorable knee function.</p><p><strong>Conclusions: </strong>CPD is a rare and complex pediatric disorder lacking a universally accepted treatment strategy. To date, there have been no reported cases of CPD presenting both genu valgum and Klinefelter syndrome. The immature skeletal system in children necessitates careful consideration of surgical techniques and early diagnosis to optimize growth, correct deformity, and ensure mobility. For the case, as the patellar dislocation and genu valgum can influence each other, a single-stage operation addressing both simultaneously was performed, resulting in a favorable outcome.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"748-753"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future directions for the molecular therapy of rhabdomyosarcoma: how do we detect and investigate new, appropriate target mutations and populations?","authors":"Kenji Nakano","doi":"10.21037/tp-2024-605","DOIUrl":"10.21037/tp-2024-605","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"769-772"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the combined application of multiple critical illness scoring systems in neonatal respiratory distress syndrome.","authors":"Liqin Yan, Jiayang Mao, Qin Li, Tingting Yu, Lianghua Lu","doi":"10.21037/tp-2024-563","DOIUrl":"10.21037/tp-2024-563","url":null,"abstract":"<p><strong>Background: </strong>As a severe complication in premature birth, neonatal respiratory distress syndrome (NRDS) significantly threatens the health and life of the neonate. Therefore, the early identification of the severity and mortality risk of NRDS is considered crucial. This study aimed to compare the predictive roles of the neonatal critical illness score (NCIS), the Score for Neonatal Acute Physiology-II (SNAP-II), and the Score for Neonatal Acute Physiology with Perinatal Extension-II (SNAPPE-II) in predicting comorbidities and mortality in NRDS infants.</p><p><strong>Methods: </strong>A total of 192 infants diagnosed with NRDS at the neonatal intensive care unit (NICU) of the Children's Hospital of Soochow University between January 2019 and August 2020 were included. Based on discharge outcomes, they were divided into the survival and mortality groups, as well as the complication group and non-complication group. The individual or combination of the NCIS, SNAP-II, and SNAPPE-II scoring systems were applied to evaluate the survival and comorbidities in all infants. Receiver operating characteristic (ROC) curves were generated to compare the area under the curve (AUC) values.</p><p><strong>Results: </strong>All the three scoring systems exhibited good efficacy in predicting mortality among NRDS infants, with NCIS showing superior performance compared to SNAPPE-II, which was more effective than SNAP-II (P<0.001). The predictive efficacy of the three scoring systems was enhanced when combined in pairs or collectively, with the combination of NCIS and SNAPPE-II exhibiting the highest predictive performance (P<0.001). The three scoring systems were significantly effective in predicting the risk of comorbidities in NRDS (P<0.001).</p><p><strong>Conclusions: </strong>The NCIS, SNAP-II, and SNAPPE-II scoring systems demonstrate good predictive value for assessing the condition and prognosis of NRDS infants. The combination of NCIS with SNAP-II and SNAPPE-II exhibits high predictive efficacy for estimating mortality in NRDS.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 4","pages":"597-607"},"PeriodicalIF":1.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}