Translational pediatrics最新文献

{"title":"Effects of genetic factors and visual behaviors on interventions for myopia prevention and control in children: a systematic review and meta-analysis.","authors":"Sisi Xie, Linzhi He, Xingyu Xie, Xiaoyan Xu","doi":"10.21037/tp-2025-409","DOIUrl":"10.21037/tp-2025-409","url":null,"abstract":"<p><strong>Background: </strong>Childhood myopia has become a global public health problem and is growing rapidly in incidence, especially in East Asia. This study examined the prevention and control of myopia in children by systematically evaluating the interaction between genetic factors and visual behaviors to optimize prevention strategies.</p><p><strong>Methods: </strong>Relevant articles were screened from PubMed and Web of Science. The search period was from January 2000 to January 2024. Inclusion criteria were children aged 6-18 years with clear stratification into intervention groups (receiving specific measures: health education, ≥1 hour daily outdoor activity, optical correction, or 0.01% atropine) and control groups (receiving routine care or no intervention). Both groups were matched for age (±1 year), baseline refractive error (within 0.50 D), and family history of myopia. Including health education, behavior adjustment, outdoor activities, clinically and research-proven interventions for myopia progression delay (including optical interventions such as frame glasses and orthokeratology, and pharmacological interventions such as low-concentration atropine). Outcome indicators included incidence of myopia, change in refractive power (D), and change in axial length (mm). Data were analyzed via RevMan 5.4 (Cochrane) and Stata 16 (StataCorp), and the effects of interventions were assessed using a random-effects model. This article defines the terms randomized controlled trials (RCTs), standardized mean difference (SMD), relative risk (RR), and confidence interval (CI).</p><p><strong>Results: </strong>Twelve high-quality studies that examined the intervention effects of multiple genetic factors and visual behavior were ultimately included, with a total sample of 6,342 cases. The results showed that interventions significantly slowed myopia progression in the genetic high-risk group compared to its control, though the absolute effect remained weaker than in the general population, especially in terms of changes in refractive power (diopters, D) and axial length (millimeters, mm) (SMD =-0.32; 95% CI: -0.5 to -0.13). Among the interventions, health education and outdoor activities were the most effective for myopia prevention and control, with a reduction in the incidence of myopia of approximately 12% (myopia incidence rate =0.88; 95% CI: 0.81-0.96). Adherence to intervention was closely related to the effect of intervention, and the group with higher adherence experienced better control of myopia progression.</p><p><strong>Conclusions: </strong>Genetic factors and visual behavior have significant effects on the prevention and control of myopia in children. The prevention and control of myopia among genetic high-risk population are significantly improved after the application of health education and outdoor activity plan interventions. Improving the compliance of intervention is the key factor to enhancing the effect of childhood intervent","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1602-1615"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Szeto-Schiller 31 eases acute lung injury in neonatal mice with acute respiratory distress syndrome by mediating TXNIP expression and NLRP3 inflammasome activation.","authors":"Meijun Zhu, Lei Song, Yan Wei, Fei Hong, Yan Lu, Juhua Ji, Yongdong Yan","doi":"10.21037/tp-2025-165","DOIUrl":"10.21037/tp-2025-165","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial-targeting anti-oxidant Szeto-Schiller 31 (SS-31) can ease lung injury in several diseases, but whether SS-31 can ameliorate acute lung injury (ALI) in neonatal acute respiratory distress syndrome (ARDS) is unclear. The objective of this study is to explore the efficacy of SS-31 against ALI and the associated molecular mechanisms.</p><p><strong>Methods: </strong>Thioredoxin-interacting protein (TXNIP) was found to be a hub gene for ARDS by bioinformatics analysis. Using the Search Tool for Interactions of Chemicals (STITCH) database, SS-31 was found to work via mediating TXNIP expression. Serum levels of some parameters were analyzed by enzyme-linked immunosorbent assay (ELISA). The effect of SS-31 on oxidative stress (OxS) injury, inflammation, apoptosis, and vascular permeability in lipopolysaccharide (LPS)-induced human lung microvascular epithelial cells (HLMVECs) and ARDS mouse models were investigated to assess the efficiency of SS-31 on ALI by a series of experiments [5-ethynyl-2'-deoxyuridine (EDU), lactate dehydrogenase (LDH), western blot, flow cytometry, histopathological analysis, wet-to-dry weight ratio, and so on].</p><p><strong>Results: </strong>SS-31 treatment mitigated LPS-induced OxS, apoptosis, vascular permeability, and inflammatory response in HLMVECs. Consistently, SS-31 treatment ameliorated histopathological changes and oedema in the lungs of neonatal ARDS mice, accompanied by improved alveolar capillary barrier integrity as well as reduced OxS, inflammation, and apoptosis. Serum TXNIP, caspase-1, apoptosis-associated speck-like protein (ASC), and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) levels were overtly higher in newborns with ARDS, and a positive correlation was observed between TXNIP and NLRP3. Interestingly, SS-31 treatment repressed TXNIP and NLRP3 protein levels in ARDS cells and animal models.</p><p><strong>Conclusions: </strong>SS-31 may repress OxS, inflammatory response, apoptosis, and vascular permeability by targeting the TXNIP/NLRP3 pathway in neonatal ARDS, thereby ameliorating ALI.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1563-1577"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial experience of a simplified modified Politano-Leadbetter technique for pneumovesicoscopic ureteral reimplantation in children.","authors":"Haihua Xu, Qingya Meng, Yanran Zhang, Guodong Xu, Jianghua Zhan","doi":"10.21037/tp-2025-200","DOIUrl":"10.21037/tp-2025-200","url":null,"abstract":"<p><strong>Background: </strong>Pneumovesicoscopic ureteral reimplantation (PVUR) has gained popularity due to its minimally invasive characteristics. Most reported PVUR procedures, however, have employed the Cohen technique. The Politano-Leadbetter (PL) technique offers distinct advantages, including the creation of a longer submucosal? Tunnel and preservation of the ureter's natural anatomical course postoperatively. Nevertheless, the technical complexity and steep learning curve associated with the PL technique have restricted its widespread adoption among urologists. In this study, we introduce modified surgical techniques to streamline and standardize the pneumovesicoscopic ureteral reimplantation using the Politano-Leadbetter (PVUR-PL) technique procedure.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study analyzing operative outcomes of PVUR-PL in pediatric patients between November 2021 and May 2024. Patients were stratified into two cohorts: (I) the traditional group (November 2021 to March 2023) receiving standard PVUR-PL; and (II) the modified group (April 2023 to May 2024) undergoing PVUR-PL with technical refinements incorporating anatomical landmarks and optimized surgical maneuvers to simplify procedural steps. Clinical data were retrospectively collected and analyzed.</p><p><strong>Results: </strong>A total of 25 pediatric patients underwent PVUR-PL during the study period, including 10 patients in the traditional group and 15 patients in the modified group. All procedures were successfully completed laparoscopically, with no conversions to open surgery. The modified technique demonstrated significant improvements in operative efficiency. Specifically, the mean operative time for unilateral cases was significantly shorter in the modified group compared to the traditional group (157.73±15.33 <i>vs.</i> 188.90±26.55 min, P<0.01). Similarly, for bilateral cases, the modified group exhibited a significantly reduced mean operative time compared to the traditional group (230.00±27.07 <i>vs.</i> 280.25±16.46 min, P<0.05). In terms of intraoperative complications, peritoneal perforation occurred in 3 patients (30%) within the traditional group, whereas no such complications were encountered in the modified group. Postoperative outcomes also favored the modified technique, demonstrated by significantly lower postoperative pain scores (2.93±1.03 <i>vs.</i> 4.20±1.23, P<0.05) and a shorter duration of hematuria (2.97±0.74 <i>vs.</i> 5.15±1.29 days, P<0.01). Additionally, the modified technique accommodated patients with a smaller minimum bladder capacity (75 <i>vs.</i> 90 mL) and a higher maximum body mass index (26.9 <i>vs.</i> 21.4 kg/m2). All patients completed a 6-month follow-up with favorable recovery outcomes.</p><p><strong>Conclusions: </strong>The modified PVUR-PL technique offers a standardized and easily implementable option for clinicians. By standardizing essential procedural steps and optimizing the use o","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1520-1529"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and genetic analysis of epilepsy caused by <i>CLCN4</i> gene mutation: a case report and literature review.","authors":"Dan-Dan Mao, Si-Xiu Li, Wen-Guang Hu, Hui Chen","doi":"10.21037/tp-2025-157","DOIUrl":"10.21037/tp-2025-157","url":null,"abstract":"<p><strong>Background: </strong>Epilepsy is a prevalent chronic neurological disorder that affects individuals across all age groups. Genetic factors are believed to play a significant role in the etiology of epilepsy; however, epilepsy associated with mutations in the chloride voltage-gated channel 4 (<i>CLCN4</i>) gene is clinically rare.</p><p><strong>Case description: </strong>We report a 2-year and 4-month-old male patient who experienced cluster convulsions due to a heterozygous variant in the <i>CLCN4</i> gene (NM_001830: c.1024G>A, p. Gly342Arg). This patient exhibited focal seizures with impaired consciousness, which responded well to treatment with valproate and lamotrigine, although he presented with mild intellectual disability (ID) and language deficits.</p><p><strong>Conclusions: </strong>A review of the existing literature identified only 60 cases, demonstrating a wide phenotypic spectrum. ID of varying degrees is observed in the majority of patients. Seizures typically commence in infancy and early childhood and manifest as multiple types, with focal seizures and generalized tonic-clonic seizures being the most common. Notably, missense variants may lead to a more severe phenotype compared to frameshift variants, and the p. Pro369Leu variant may represent a potential hotspot within the <i>CLCN4</i> gene. Nearly half of the patients exhibit refractory seizures despite treatment with multiple medications, while valproate, levetiracetam, and lamotrigine are considered viable therapeutic options.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1717-1725"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed diagnosis of isolated congenital H-type tracheoesophageal fistula: a case report of surgical repair supported by TachoSil^® as an adjunct in chronically inflamed tissues.","authors":"Ugo Maria Pierucci, Irene Paraboschi, Costantino Zamana, Carlotta Paola Maria Canonica, Gerson Isaac Capelo Guazco, Antonio Mario Bulfamante, Francesca Izzo, Salvatore Zirpoli, Anna Camporesi, Gloria Pelizzo","doi":"10.21037/tp-2025-72","DOIUrl":"10.21037/tp-2025-72","url":null,"abstract":"<p><strong>Background: </strong>H-type tracheoesophageal fistulas (TEFs) are rare congenital malformations characterized by an abnormal connection between the trachea and esophagus in the absence of esophageal atresia. These lesions may remain undiagnosed for years due to subtle and non-specific symptoms, often resulting in chronic pulmonary complications. Delayed diagnosis can contribute to the development of long-standing inflammation and fibrosis, which significantly complicates surgical intervention.</p><p><strong>Case description: </strong>We present the case of a 14-year-old girl with a previously undiagnosed H-type TEF who was treated for recurrent lower respiratory tract infections since early childhood. Her condition acutely worsened with severe respiratory distress requiring hospitalization. Comprehensive imaging, including contrast-enhanced esophagography and chest computed tomography (CT), identified the presence of a congenital H-type TEF with associated chronic peritracheal and paraesophageal inflammatory changes. Surgical repair was performed via a cervical approach. Intraoperatively, significant fibrotic tissue surrounding the fistulous tract posed challenges to dissection and closure. To reinforce the primary suture line and reduce the risk of postoperative complications, a fibrinogen-thrombin-coated hemostatic patch (TachoSil^®) was applied. The patient recovered uneventfully and demonstrated no evidence of recurrence or airway compromise at 12-month follow-up.</p><p><strong>Conclusions: </strong>This case highlights the importance of heightened clinical suspicion in children with persistent respiratory symptoms. In delayed TEF diagnoses, chronic inflammation should be anticipated. Adjunctive use of hemostatic sealants may enhance surgical safety and improve outcomes in complex cases.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1668-1674"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Fournier gangrene: comprehensive insights into diagnosis, management, and outcomes-a narrative review.","authors":"Khalid A Alzahrani","doi":"10.21037/tp-2025-112","DOIUrl":"10.21037/tp-2025-112","url":null,"abstract":"<p><strong>Background and objective: </strong>Fournier gangrene (FG) is an uncommon, severe condition characterized by the onset of severe tissue infection in the perineal area, with significant implications for the pediatric population. The current review has been drafted to shed light on the various aspects of pediatric FG, including its etiology, risk factors, clinical presentation, diagnostic approach, management strategies, and outcomes.</p><p><strong>Methods: </strong>A comprehensive review of pediatric FG was conducted on the existing data on its strategies, clinical features, complications, treatments, and outcomes. A detailed literature search was done on databases using PubMed, Scopus, and Web of Science with keywords such as \"Fournier gangrene\", \"Pediatric Fournier gangrene\", \"Fournier gangrene in children\", and \"necrotizing soft tissue infections (NSTI)\". Due to the limited pediatric data, adult FG data were used to explain the diagnostic scoring system, treatment strategies.</p><p><strong>Key content and findings: </strong>The review highlights the prevalence of FG in pediatric populations and reinforces the requirement for early diagnosis with prompt medical intervention to manage pediatric FG. The etiology and pathophysiology of pediatric FG are also discussed, along with the underlying causes and specific risk factors such as existing congenital abnormalities of the genitourinary and gastrointestinal systems. The management of pediatric FG requires the implementation of a multidisciplinary approach, which should begin with immediate clinical intervention, proper surgical procedures, implementation of pharmacological therapies, and antibiotic regimens to avoid potential complications. Preventive strategies should focus on public health education, hygiene, and vaccination to boost immunity and prevent pediatric FG. The current review suggests future directions to ameliorate clinical practices and achieve favourable outcomes in managing pediatric FG.</p><p><strong>Conclusions: </strong>FG, despite its rare occurrence in the pediatric population, poses a humongous challenge to the healthcare community owing to its rapid onset, complex diagnosis, and high morbidity and mortality rates. Early diagnosis, combined with prompt medical and surgical intervention, with a coordinated multidisciplinary approach, is essential in the management of FG in children. The review provides a glimpse of the shortcomings of the healthcare system and emphasizes the need to improve treatment protocols while also evaluating the long-term impacts of the disease.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1652-1667"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of disulfidoptosis-related genes reveals molecular heterogeneity and key regulators in retinoblastoma progression.","authors":"Xiwen Zhang, Li Liu, Yanchen Chen, Yumiao Cheng, Xinru Li, Tianli Pei, Fengmei Zhang","doi":"10.21037/tp-2024-596","DOIUrl":"10.21037/tp-2024-596","url":null,"abstract":"<p><strong>Background: </strong>Disulfidoptosis, a newly recognised form of cell death, has been studied in many cancers but not in retinoblastoma. Therefore, this study aimed to investigate the role of disulfidoptosis-related genes (DRGs) in retinoblastoma.</p><p><strong>Methods: </strong>Three retinoblastoma datasets (GSE208143, GSE97508, and GSE24673) were obtained from the Gene Expression Omnibus database. Differentially expressed DRGs (DE-DRGs) in retinoblastoma were identified, and key genes were screened using machine learning algorithms. Consensus cluster analysis was applied to identify the disulfidoptosis-based molecular subtypes. The pathways and immune characteristics of the subtypes were examined via gene set variation analysis, single-sample gene set enrichment analysis, and ESTIMATE. The expression of key genes was validated in retinoblastoma cells, and their roles were explored through functional experiments.</p><p><strong>Results: </strong>Compared with controls, the disulfidoptosis score was significantly lower (P<0.05) in retinoblastoma, and eight DE-DRGs were identified, suggesting the potential involvement disulfidoptosis in retinoblastoma. Consensus clustering revealed two molecular subtypes (C1 and C2). The C2 subtype exhibited multiple activated oncogenic pathways associated with tumourigenesis, lower infiltration levels of immune cells, lower immune and stromal scores, and reduced immune checkpoint expression. Least absolute shrinkage and selection operator and support vector machine-recursive feature elimination algorithms identified two key down-regulated genes-EPAS1 and SLC7A11-in retinoblastoma. The expression of EPAS1 and SLC7A11 was significantly correlated with oxidative phosphorylation and immune cell infiltration levels. EPAS1 overexpression significantly inhibited the viability, migration, and invasion of retinoblastoma cells and induced their apoptosis (P<0.05). Furthermore, EPAS1 overexpression significantly increased the relative nicotinamide adenine dinucleotide phosphate (NADP)+/reduced NADP (NADPH) ratio in retinoblastoma cells (P<0.05).</p><p><strong>Conclusions: </strong>This study highlights the involvement of DRGs in retinoblastoma progression and molecular subtype heterogeneity. EPAS1 and SLC7A11 may serve as key targets for the diagnosis and treatment of retinoblastoma.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1454-1470"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of perinatal sterile gloves on neonatal mortality: a post hoc analysis of a randomised clinical trial in Zambia.","authors":"Mingling Cui, Xinglin Chen, Xuejie Zhang, Yanyan Zhang, Yan Huang, Jiajuan Lin, Zuming Yang, Lirong Shen, Yuelan Ma","doi":"10.21037/tp-2025-88","DOIUrl":"10.21037/tp-2025-88","url":null,"abstract":"<p><strong>Background: </strong>Sterile gloves, an inexpensive method of hand hygiene, are attributed both protective and useless characteristics concerning neonatal mortality. This study aimed to perform a post hoc secondary analysis of a cluster-randomised controlled trial (cRCT) to examine the association between intrapartum sterile gloves and neonatal mortality.</p><p><strong>Methods: </strong>Data from the Zambia Chlorhexidine Application Trial, a cRCT of 4% chlorhexidine umbilical cord care in Zambia from 2011-2013, were analyzed. A randomised controlled trial (RCT) (NCT01241318) provided pregnant women with clean delivery kits containing sterile gloves. Neonatal mortality was compared between the glove use and nonuse groups. Group differences were evaluated and multivariable logistic regression analyses were performed.</p><p><strong>Results: </strong>Sterile gloves were used in 96.9% of the 37,003 newborns, which varied significantly by place of delivery. The 28-day mortality rates for hospital, health center and nonfacility deliveries were 2.7%, 1.1% and 1.3%, respectively (P<0.001). After adjusting for confounders, logistic regression revealed that the use of sterile gloves was associated with a lower risk of neonatal mortality [odds ratio (OR) =0.10; 95% confidence interval (CI): 0.07-0.15]. The use of perinatal sterile gloves was associated with a reduced risk of immediate neonatal death (<24 hours) (OR =0.47; 95% CI: 0.24-0.91) and early neonatal death (1-6 days) (OR =0.26; 95% CI: 0.16-0.39).</p><p><strong>Conclusions: </strong>The use of perinatal sterile gloves may significantly improve neonatal outcomes in low- and middle-income countries (LMICs). The provision of sterile gloves to promote newborn health may be feasible in LMICs.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1422-1431"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, and national burden of neonatal infectious diseases from 1990 to 2021.","authors":"Mengting Ni, Jingqian Zhou, Minfei Hu, Wei Zhou, Tianming Yuan","doi":"10.21037/tp-2025-57","DOIUrl":"10.21037/tp-2025-57","url":null,"abstract":"<p><strong>Background: </strong>Neonatal infectious diseases are very common during the neonatal period, and severe neonatal infections such as sepsis, meningitis, pneumonia can be life-threatening. Despite significant advances in neonatal medicine, neonatal sepsis is still the third leading cause of neonatal mortality and accounts for nearly half of all deaths in children under five globally. However, comprehensive data on the incidence, disability-adjusted life years (DALYs), and trends of these diseases remain scarce. This study leverages the Global Burden of Disease (GBD) database to evaluate the global, regional, and national burdens of neonatal infectious diseases.</p><p><strong>Methods: </strong>We extracted data from the GBD database, covering neonatal sepsis and other infectious diseases from 1990 to 2021, focusing on incidence and DALYs. We calculated the estimated annual percentage change (EAPC) to assess trends in incidence and DALYs and employed joinpoint regression to determine the annual percentage change (APC) and average APC (AAPC). The data were stratified by sex, age, socio-demographic index (SDI), region, and country.</p><p><strong>Results: </strong>From 1990 to 2021, a global decline in both the incidence and DALYs rates of neonatal infectious diseases was observed [AAPC -0.71 (incidence), -0.70 (DALYs)]. Males and 0-6 days neonates had higher risk in neonatal infectious diseases. The majority of the disease burden was concentrated in countries with lower SDI values, and Africa had higher disease burden with lower SDI values.</p><p><strong>Conclusions: </strong>The worldwide burden of neonatal infectious diseases has decreased over the past decades and is inversely related to SDI values. Continued efforts are needed to address these disparities and further reduce the impact of these diseases.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1498-1510"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue, anxiety and depression in parents of children with retinoblastoma: a cohort study.","authors":"Na Du, Xuyang Wen, Shijie Chen, Ting Zhao, Yanjuan Xu, Lin Wang, Changjuan Zeng","doi":"10.21037/tp-2025-145","DOIUrl":"10.21037/tp-2025-145","url":null,"abstract":"<p><strong>Background: </strong>Retinoblastoma (RB) is the most common primary ocular malignancy in childhood, possibly causing vision loss and even a threat to life. Parents, as the primary caregivers of children with RB, are prone to negative emotions such as fatigue, anxiety, and depression. This study aimed to investigate the longitudinal fluctuations in fatigue, anxiety, and depression in parents of children with RB and the factors influencing them.</p><p><strong>Methods: </strong>Parents of children with RB who met the inclusion and exclusion criteria were surveyed using the General Demographic Information Questionnaire, the Fatigue Severity Scale (FSS), the Generalized Anxiety Disorder-7 (GAD-7) and the Patient Health Questionnaire-2 (PHQ-2). A follow-up questionnaire survey was conducted at the 18^th month.</p><p><strong>Results: </strong>Fatigue, anxiety, and depression among parents of children with RB exhibited fluctuations over time. Independent factors influencing fatigue included the child's sex and parents' self-reported health. The independent factors influencing anxiety included parents' self-reported health and family income. The independent factors influencing depression included parents' self-reported health and family income, with differences being statistically significant (P<0.05).</p><p><strong>Conclusions: </strong>Parents of children with RB experience severe fatigue, anxiety and depression, which are fluctuated and influenced by multiple factors. Clinical staff should pay attention to early screening and early detection of high-risk groups and formulate reasonable interventions to prevent and reduce these conditions.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1432-1442"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}