Translational pediatrics最新文献

{"title":"Fetal tachyarrhythmias: current knowledge for clinical practice.","authors":"Maria Elisa Martini Albrecht, Sérgio Faria Makabe, Nathalie Jeanne Bravo-Valenzuela, Edward Araujo Júnior","doi":"10.21037/tp-2025-67","DOIUrl":"10.21037/tp-2025-67","url":null,"abstract":"<p><p>Fetal arrhythmias account for 10-20% of all outpatient consultations in specialized fetal medicine centers. Furthermore, it is evident that tachyarrhythmias account for 8% of all such arrhythmias. Most arrhythmias are benign and easy to manage, but certain tachyarrhythmias require close monitoring due to the risk of decompensation, progression to heart failure with hydrops, and potential fetal death. The aim of this study was to describe the most common fetal tachycardias and their intrauterine management. Using fetal ultrasound/echocardiography, clinicians can assess the heart rate (HR), fetal heart rhythm, and determine rhythm patterns. Differentiating the type of fetal tachyarrhythmia is crucial, as certain antiarrhythmic drugs are more effective for specific arrhythmias. Despite advances in diagnosis and treatment, studies reveal limited numbers of patients, and a wide variety of treatments based on local experience and available resources. The potential of fetal treatment to improve prognosis in both fetal and postnatal life has been well demonstrated. There are several treatment options for fetal tachyarrhythmias, with the most effective medication selected based on the healthcare team's experience and practical treatment considerations. Transplacental therapy is the most widely used route for administering antiarrhythmic drugs in utero. In general, studies have been demonstrated the superior efficacy of flecainide and sotalol in comparison to digoxin in the treatment of fetal supraventricular tachycardia (SVT), with or without fetal edema. Flecainide can be used in combination with digoxin to treat SVT and hydrops in fetuses. For sustained ventricular tachycardia (VT), first-line treatment is maternal intravenous magnesium when fetal HR exceeds 200 bpm. In addition, it is important to keep in mind that frequency control is the treatment option for fetuses in which reversal to sinus rhythm has not been successful and pulmonary immaturity is present.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1624-1636"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of factors influencing mortality in immunocompetent children with severe adenovirus pneumonia undergoing conventional treatments: a retrospective cohort study.","authors":"Tingting Shi, Shuning Wu, Huifeng Fan, Xuehua Xu, Diyuan Yang, Qingshan Chen, Gen Lu","doi":"10.21037/tp-2025-184","DOIUrl":"10.21037/tp-2025-184","url":null,"abstract":"<p><strong>Background: </strong>Severe adenovirus pneumonia (SAP) in immunocompetent children can progress rapidly despite conventional treatment, posing significant clinical challenges. The objective of this study to assess the factors influencing mortality in immunocompetent children with SAP undergoing conventional therapies. Early identification of risk factors for mortality is essential to guide timely intervention and optimize management strategies.</p><p><strong>Methods: </strong>In this study, we conducted a retrospective study of 156 immunocompetent pediatric patients diagnosed with SAP, who were divided into the conventional treatments survivor group and death group, without receiving extracorporeal membrane oxygenation (ECMO). Baseline clinical features, laboratory data, imaging findings, treatments and complications were collected. Patients were followed until discharge or death, with mortality confirmed from medical records.</p><p><strong>Results: </strong>There were 156 children included, with 142 patients in the survivor group and 14 patients in the death group. The mean age was 30.12±28.78 months, with no significant differences in age or sex between the survivor group and the death group (P>0.05). In univariate analysis, significant differences were observed in shortness of breath, tachycardia, low oxygen saturation (SpO₂), partial pressure of oxygen (PO₂), partial pressure of carbon dioxide (PCO₂), and pulmonary consolidation involving two or more lobes and so on (all P<0.05). Respiratory failure, septic shock, and acute respiratory distress syndrome (ARDS) were significantly more common in the death group (P<0.05). In the multivariate analysis, the independent risk factors for death included decreased SpO₂ [odds ratio (OR): 32.336, 95% confidence interval (CI): 2.385-619.473, P=0.02], increased pressure of carbon dioxide in arterial blood (PaCO₂) (OR: 2.187, 95% CI: 1.079-4.434, P=0.03), and pulmonary consolidation affecting two or more lobes (OR: 9.071, 95% CI: 1.123-73.248, P=0.04).</p><p><strong>Conclusions: </strong>These findings emphasize the importance of close monitoring of SpO₂, PaCO₂ levels, and extent of lung consolidation in children with SAP undergoing conventional treatment. Recognizing these risk factors early may prompt consideration of advanced supportive therapies beyond conventional measures to improve survival outcomes.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1530-1540"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of machine learning based on radiomics in the discrimination of intracranial germ cell tumours.","authors":"Zanyong Tong, Hongting Jiang, Yunying Yang, Yu Luo, Fengjiao Gong, Shuang Li, Wenjiao Xiao, Lusheng Li, Yuting Zhang","doi":"10.21037/tp-2025-210","DOIUrl":"10.21037/tp-2025-210","url":null,"abstract":"<p><strong>Background: </strong>Among germ cell tumours, germinomas are extremely sensitive to radiotherapy and chemotherapy. Histological diagnosis is important for clinical treatment decisions. This study aimed to identify germinomas and non-germinomatous germ cell tumours (NGGCTs) using radiomics-based machine learning (ML).</p><p><strong>Methods: </strong>The present retrospective study comprised 141 patients diagnosed with intracranial germ cell tumours (ICGCTs), 71 germinomas, and 70 NGGCTs. Radiomics features were quantitatively extracted from magnetic resonance imaging (MRI) sequences, including T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), T2 Fluid-Attenuated Inversion Recovery (T2-FLAIR), diffusion weighted imaging (DWI) (b=1,000), apparent diffusion coefficient (ADC) images, and contrast-enhanced T1WI. Based on the combination of three feature selection methods and three classification methods, the optimal model was screened out from the internal test set. A combined model of clinical-multi-sequence radiomics was ultimately created by combining with statistically significant clinical features. The performance of the models was evaluated using the area under the curve (AUC), accuracy, sensitivity, specificity, and F1-score.</p><p><strong>Results: </strong>The combination of the least absolute shrinkage and selection operator (LASSO) and logistic regression (LR) yielded the optimal diagnostic performance in the multi-sequence radiomics model, as evidenced by an AUC value of 0.823 in the internal and 0.804 in the external test set. In the combined model, the AUC values of the internal and external tests were 0.838 and 0.809, respectively. The DeLong test revealed no significant difference between multi-sequence radiomics and the combined model, indicating that the inclusion of clinical characteristics did not significantly improve diagnostic accuracy.</p><p><strong>Conclusions: </strong>ML based on radiomics may provide a non-invasive approach for the clinical differentiation of intracranial germinomas and NGGCTs.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1578-1592"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cycloplegic effects of atropine and tropicamide in children with refractive error.","authors":"Linxin Liu, Tingru Chen, Helena Prior Filipe, Jiong He","doi":"10.21037/tp-2025-404","DOIUrl":"10.21037/tp-2025-404","url":null,"abstract":"<p><strong>Background: </strong>Refractive error is the primary cause of vision impairment in children and requires accurate cycloplegic refraction for proper diagnosis and treatment. Various cycloplegic agents are used clinically, but their comparative efficacy remains controversial, particularly across different pediatric age groups and refractive error types. The purpose of this study was to observe the cycloplegic effects of tropicamide and atropine in children of different ages and different refractive errors, and to screen out more suitable drugs for cycloplegia in children with different refractive errors.</p><p><strong>Methods: </strong>This study is a prospective cohort study. In this study, 110 children with refractive error were first dilated with 4 g/L of tropicamide eye drops; after the pupils recovered, they were dilated with 8 g/L of atropine eye ointment, and the results of the two pupil dilation methods were compared.</p><p><strong>Results: </strong>In hyperopic eyes, the cycloplegic refraction obtained using the two methods was the same spherical correction in 8.45%; cylindrical correction differed by >0.25 D in 91.54%, 14.28% were the same, and 85.71% had a difference of ≥0.25 D. Compared with refraction using tropicamide, atropine refraction had a significantly higher mydriatic effect on spherical and cylindrical lenses in all age groups, and the difference was statistically significant (P<0.001). In the myopia group, among the spherical lenses, 13.04% of the eyes were the same, and 86.9% of the eyes had differences; among the cylindrical lenses, 20% of the eyes were the same, and 80% of the eyes had differences. The cycloplegic effect of 4 g/L of tropicamide eye drops on spherical and cylindrical lenses was less than that of 8 g/L of atropine eye ointment. In the mixed astigmatism group, among spherical lenses, 14 eyes had differences, accounting for 100.0% of cases, with the maximum difference being 1.25 D; among cylindrical lenses, 5 eyes had the same results between the two pupil dilation methods, accounting for 35.7% of cases, and 64.3% had a difference of 0.25-0.5 D.</p><p><strong>Conclusions: </strong>In children under 12 years old with mixed astigmatism and hyperopia, cycloplegic refraction using atropine is preferred over tropicamide.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1616-1623"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extract with care: the imperative of rigor, transparency, and reproducibility in meta-analysis.","authors":"Javier Arredondo Montero","doi":"10.21037/tp-2025-337","DOIUrl":"10.21037/tp-2025-337","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1733-1736"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between <i>Mycoplasma pneumoniae</i> pneumonia and interleukin-17: insights and interpretative cautions from a meta-analysis.","authors":"Nontaphat Leerach, Sutthirat Sitthisak, Thawatchai Kitti, Nattawat Teerawattanapong, Wiriya Mahikul, Supaporn Lamlertthon, Nathorn Chaiyakunapruk, Kannipa Tasanapak","doi":"10.21037/tp-2025-377","DOIUrl":"10.21037/tp-2025-377","url":null,"abstract":"","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1737-1740"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and variant spectrum of patients harboring <i>ATAD3A</i> variants.","authors":"Hongfang Mei, Xinyin Zhang, Taixiang Liu, Mingyan Chen, Jiajing Ge, Dingwen Wu, Xiaolu Ma, Liping Shi, Wei Shi, Zheng Chen","doi":"10.21037/tp-2025-60","DOIUrl":"10.21037/tp-2025-60","url":null,"abstract":"<p><strong>Background: </strong><i>ATAD3A</i> deficiency may lead to respiratory chain deficits. This observational study aimed to summarize the clinical features and variant spectrum of patients harboring <i>ATAD3A</i> variants.</p><p><strong>Methods: </strong>We examined patients harboring <i>ATAD3A</i> variants who attended the Children's Hospital of Zhejiang University School of Medicine, further examined similar cases reported in the literature, analyzed the clinical and variation data.</p><p><strong>Results: </strong>Five new patients harboring <i>ATAD3A</i> variants were encountered at Children's Hospital of Zhejiang University School of Medicine. New phenotypes including noncompaction of ventricular myocardium and recurrent asphyxia were observed. Whole-exome sequencing revealed six new variants, including c.1376T>C, c.649G>A, c.1492dup, and three copy number variants. In total, data from 88 patients harboring <i>ATAD3A</i> variants were collected, including those from our center, but only 31.8% were alive at the last follow-up. In total, 54 variants were identified, with deletions being the most common variant type. Moreover, 29 variants were detected in more than one patient, and the top three most common were g.1391996_1460043 duplication, c.1582C>T, and c.229C>G. Among the 88 patients, 38 (43.2%) had a monoallelic variant and 50 (56.8%) had biallelic variants; additionally, 64 (72.7%) had severe variants and 24 (27.3%) had mild variants. In the monoallelic group, hyperlactatemia (50.0% <i>vs.</i> 95.0%; P=0.02), seizures (22.2% <i>vs.</i> 84.6%; P=0.007), and death (7.7% <i>vs.</i> 96.0%; P<0.001) were more common in patients with severe variants than in those with mild variants. Dysmorphic facies were more common in patients with mild variants in both the monoallelic (90.0% <i>vs.</i> 38.5%; P=0.03) and biallelic (100.0% <i>vs.</i> 38.9%; P=0.02) groups. Monoallelic patients were less likely to have abnormal brain development than biallelic patients, in both the mild (18.2% <i>vs.</i> 100.0%; P=0.001) and severe (18.2% <i>vs.</i> 77.1%; P<0.001) groups. Meanwhile, in patients with severe variants, hypertrophic cardiomyopathy was more common in monoallelic patients than biallelic patients (73.9% <i>vs.</i> 38.1%; P=0.02).</p><p><strong>Conclusions: </strong>Our patients have expanded the variant spectrum and clinical landscape in patients harboring <i>ATAD3A</i> variants. The clinical course of patients harboring <i>ATAD3A</i> variants is related to the variant type. Prenatal genetic consultation is necessary in families with <i>ATAD3A</i> variants.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1402-1413"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the combination of cartoon stickers and fruit juices reduce premedication anxiety in preschool children?-a randomized controlled trial.","authors":"Ting Liu, Dan Wang, Yanting Wang, Yingying Tao, Mazhong Zhang, Zhezhe Peng, Ying Sun","doi":"10.21037/tp-2025-73","DOIUrl":"10.21037/tp-2025-73","url":null,"abstract":"<p><strong>Background: </strong>Perioperative anxiety affects 40-75% of children undergoing surgery, risking complications. Midazolam (0.5 mg/kg) is commonly used but poorly tolerated due to bitterness. This study aimed to determine whether a combination of favorite carton stickers and fruit juices could reduce premedication anxiety in preschool children scheduled for elective surgery.</p><p><strong>Methods: </strong>One hundred and fifty-five healthy children, aged 3-6 years, assigned to elective surgery were randomized to one of four groups: Group A, control group (premedication with traditional midazolam monosaccharide syrup mixtures); Group B, cartoon stickers before traditional premedication; Group C, fruit juices midazolam mixtures premedication and Group D, cartoon stickers and premedication with midazolam fruit juices mixtures. All groups routinely received sedative premedication (oral midazolam, 0.5 mg/kg) before anesthesia induction. The modified Yale Preoperative Anxiety Scale-Short Form (mYPAS-SF) was used to evaluate the anxiety of each child in the following time points: T₀ (baseline anxiety: immediately after arriving in the preoperative holding area), T₁ (3 min after the interventions), T₂ (at the time of midazolam oral administration).</p><p><strong>Results: </strong>There was no significant difference in mYPAS-SF scores among the four groups at T₀ (P=0.17). Children in Group D manifested significantly the lowest mYPAS-SF scores at T₁ compared with the other three groups (<i>vs.</i> Group A, P<0.001, Group B, P=0.02 and Group C, P=0.02) and T₂ (<i>vs.</i> Group A, Group B and Group C, P<0.001). Subjects in Group B showed lower mYPAS-SF scores than those in Group A at T₁ (P=0.043) and T₂ (P=0.01). Patients in Group C showed lower mYPAS-SF scores than those in Group A at T₁ (P<0.001) and T₂ (P<0.001). There was no statistically significant difference in the mYPAS-SF scores of children in Group B and Group C at time T₁ (P=0.13) and T₂ (P=0.15).</p><p><strong>Conclusions: </strong>Cartoon stickers for reducing premedication anxiety were effective, besides, the combination of cartoon stickers and fruit juices was found to be an effective tool to reduce premedication anxiety in preschool children undergoing elective surgery.</p><p><strong>Trial registration: </strong>ChiCTR2200066644 (registered at the Chinese Clinical Trial Registry, www.chictr.org.cn).</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1414-1421"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological and clinical characteristics of pediatric patients with extremely severe burns: a retrospective study of 101 cases.","authors":"Xitong Zhao, Jing Liu, Xiaohui Liu, Zhaohan Zhuang, Yanni Wang, Yining Wang, Hongyan Qi, Xin Ni, Kun Chen","doi":"10.21037/tp-2025-156","DOIUrl":"10.21037/tp-2025-156","url":null,"abstract":"<p><strong>Background: </strong>Burn injuries represent a critical global public health issue, significantly threatening human life and well-being, particularly among children. This study aims to systematically summarize the epidemiological and clinical characteristics of pediatric patients with extremely severe burns in northern China.</p><p><strong>Methods: </strong>This study retrospectively collected clinical data from 101 pediatric patients with extremely severe burns treated at Beijing Children's Hospital between 2013 and 2023. The data collected included gender, age, cause of injury, location of the incident, length of stay (LOS), total burn surface area (TBSA) and mortality.</p><p><strong>Results: </strong>A total of 101 pediatric patients with extremely severe burns (51.49% male) were included in this study, representing 5.7% of all burn-related hospitalizations at our hospital over an 11-year period. The annual number of admissions for extremely severe burns exhibited an overall declining trend. The highest proportion of cases occurred in children aged 1 to 3 years (61.4%). Two causes of injury were identified, with scalds constituting the majority (81.2%). Notably, flame burns (18.8%) were associated with a high wound infection rate (89.5%), and wound infection emerged as a significant factor influencing the LOS. More than half of the patients presented with extensive burns to the head and neck regions. Additionally, there were 8 fatalities among the 101 patients.</p><p><strong>Conclusions: </strong>In Northern China, scalding is the predominant cause of extremely severe burns in children. Children aged 1 to 3 years should be the primary target group for prevention efforts. It is essential to enhance safety education at both family and society levels.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1387-1401"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Chinese family caregiver vigilance in preventing hospitalized children falls from the attention network theory perspective: a qualitative study.","authors":"Xiuhong Li, Xiaoqin Tian, Peimin Huang, Qin Liao, Yangfei Feng, Jinghua Wang, Shuli Luo, Zhitian Xiao","doi":"10.21037/tp-2025-96","DOIUrl":"10.21037/tp-2025-96","url":null,"abstract":"<p><strong>Background: </strong>Falls among hospitalized children frequently occur when they are accompanied by family caregivers, posing a significant safety concern. This study aims to utilize the attention network theory (ANT) to understand how Chinese family caregivers allocate their attention and maintain vigilance in preventing falls among hospitalized children, providing evidence for reducing the incidence of such events.</p><p><strong>Methods: </strong>A qualitative research approach was adopted, incorporating purposive sampling and field notes for data collection. Semi-structured interviews were conducted using a self-designed outline. The interview focused on how family caregivers identify and respond to environmental and behavioral risk factors that may lead to falls. The collected data were systematically analyzed using Dedoose software to identify key themes and patterns.</p><p><strong>Results: </strong>A total of 17 interviewees were included in this study. The family caregivers comprised 7 mothers, 6 fathers, 3 grandmothers, and 1 nanny. Four themes were extracted: low alertness; orienting deviation; insufficient information reception and inadequate execution.</p><p><strong>Conclusions: </strong>Family caregivers have a low level of vigilance in preventing falls among hospitalized children, and they do not pay sufficient attention to the prevention of such incidents, with attention bias existing. Medical staff should change the attention allocation of family caregivers through multiple educational ways to reduce the occurrence of falls.</p>","PeriodicalId":23294,"journal":{"name":"Translational pediatrics","volume":"14 7","pages":"1443-1453"},"PeriodicalIF":1.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}