Toxicon最新文献

{"title":"Ukrainian National Consensus Statement on Botulinum Toxin Therapy for Neuropathic Pain: A Multidisciplinary Initiative in Times of War","authors":"Vadym Biloshytsky , Maryna Biloshytska","doi":"10.1016/j.toxicon.2025.108698","DOIUrl":"10.1016/j.toxicon.2025.108698","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108698"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular Responses to Botulinum Neurotoxin A Formulations: Implications With HSA and Polysorbates on Skin-Derived Cell Types","authors":"Christian Hartmann, Kay Marquardt, Christina Wollenburg, Thomas Hengl","doi":"10.1016/j.toxicon.2025.108764","DOIUrl":"10.1016/j.toxicon.2025.108764","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108764"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Low-Dose Botulinum Neurotoxin Therapy on Balance and Gait Control in Children With Cerebral Palsy","authors":"Soumaya Boudokhane, Houda Migaou, Amr Chaabeni, Amine Kalai, Zohra Ben Salah Frih","doi":"10.1016/j.toxicon.2025.108704","DOIUrl":"10.1016/j.toxicon.2025.108704","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108704"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory Meige Syndrome Successfully Treated With Bilateral Globus Pallidus Internus Deep Brain Stimulation","authors":"Jacquie Deeb , Maha Dannawi , Valentina Simioni , Anjum Misbahuddin , Hu-Liang Low","doi":"10.1016/j.toxicon.2025.108724","DOIUrl":"10.1016/j.toxicon.2025.108724","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108724"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-dose Intestinal Exposure to Botulinum Neurotoxins Increases Susceptibility to Salmonella and Shigella Infection","authors":"Federico Fabris , Paola Brun , Aram Megighian , Giulia Bernabè , Ignazio Castagliuolo , Ilenia Drigo , Luca Bano , Florigio Lista , Maria Lina Bernardini , Eric A. Johnson , Cesare Montecucco , Ornella Rossetto","doi":"10.1016/j.toxicon.2025.108741","DOIUrl":"10.1016/j.toxicon.2025.108741","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108741"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of Masseter Muscle Prominence (MMP) After Treatment With OnabotulinumtoxinA: Results From a Phase 3 Double-Blind, Randomized, Placebo-Controlled Study Period 1 in Japan","authors":"Nobutaka Furuyama , Taro Kono , Akiko Imaizumi , Kiyoko Kato , Akihiro Kume , Mariko Kato , Takeshi Yoshikawa , Mana Hirayama , René Hopfinger , Catherine Foley , Reva McCaskill , Yoko Yajima , Chihaya Morioka , Yupu Wu","doi":"10.1016/j.toxicon.2025.108750","DOIUrl":"10.1016/j.toxicon.2025.108750","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108750"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated network toxicology, molecular docking, molecular dynamics simulation, and experimental verification to elucidate the mechanism of hepatotoxicity and processing detoxification in Fructus Meliae Toosendan","authors":"Shan Ran,&nbsp;Dongshi Gu,&nbsp;Yuhan Zhao,&nbsp;Yujuan Liu,&nbsp;Ning Zhang","doi":"10.1016/j.toxicon.2025.108933","DOIUrl":"10.1016/j.toxicon.2025.108933","url":null,"abstract":"<div><div>Fructus Meliae Toosendan (FMT) has been traditionally used in Chinese medicine, yet its mechanisms of its hepatotoxicity, as well as the detoxification process following processing, are still not fully elucidateed. This study aimed to investigate the hepatotoxic components and targets from FMT and elucidate both its mechanism of hepatotoxicity and the detoxification mechanism induced by processing. We employed a combination of network pharmacology, molecular docking, molecular dynamics simulations and in vitro experiments to explore the potential hepatotoxic targets and mechnisms of FMT. A total of 12 toxicity components and 71 potential hepatotoxicity targets of FMT were identified. Protein-protein interaction (PPI) network analysis identified the top six core potential targets, three of which possess suitable crystal structures for molecular docking. These include meliasenin B-HSD17B4 (ΔG = −7.40 kcal mol⁻¹) and meliasenin B-HMGCR (−7.32 kcal mol⁻¹), melianone-HSD17B4 (−8.19 kcal mol⁻¹) and melianone-SOD2 (−8.51 kcal mol⁻¹). toosendanin-HMGCR (−7.58 kcal mol⁻¹). Additionally, 185 Gene Ontology (GO) terms and 72 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were identified. The three major toxicity ingredients and three core targets mentioned above were subjected to molecular docking analysis using AutoDock Vina. Molecular dynamic simulations confirmed a stable interaction between the meliasenin B, melianone and toosendanin and HSD17B4, HMGCR and SOD2 ligand system. It indicated that melianone, toosendanin and isotoosendanin significantly reduced cell viability in a dose-dependent manner in Human hepatoma cells HepG2 and Human normal liver cell line L02 hepatocytes in vitro experiments. Processing FMT enhances viability in both HepG2 and L02 cells while mitigating its hepatotoxic effects. The hepatotoxicity-reducing effect of processing FMT may involve the PI3K/AKT/FOXO signaling pathway. This study suggests that melianone, toosendanin, isotoosendanin and meliasenin B may be hepatotoxic components of FMT, and the detoxification mechanism of processing FMT may be related to the PI3K/AKT/FOXO signaling pathway, warranting further investigation into their safety profiles in clinical applications.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108933"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145695900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of pertussis toxin in clinical manifestations of pertussis","authors":"Wenjuan Zhao ,&nbsp;Meng Dang ,&nbsp;Shuyue Tang ,&nbsp;Min Hao ,&nbsp;Zengguo Wang","doi":"10.1016/j.toxicon.2025.108972","DOIUrl":"10.1016/j.toxicon.2025.108972","url":null,"abstract":"<div><div>Pertussis is an acute respiratory infectious disease caused by <em>Bordetella pertussis</em> (<em>B. pertussis</em>). In recent years, the resurgence of pertussis has once again drawn widespread attention from the academic community and society at large. The pathogenicity of <em>B. pertussis</em> depends on multiple virulence factors, among which pertussis toxin (PT) is widely recognized as its core virulence factor. PT, with its unique AB₅ structure and ADP-ribosylase activity, broadly disrupts host cell signal transduction. However, the specific role of PT in the complex pathogenic mechanisms of pertussis remains incompletely understood. This review systematically summarizes the molecular structural characteristics and mechanisms of action of PT, with a particular focus on its potential role in the typical and unique clinical manifestations and severe complications of pertussis.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108972"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The impact of experimental variables in twitch tension recording on triphasic action of phospholipase A2 neurotoxins at the neuromuscular junction and acetylcholine release” [Toxicon 266 (2025) 108512]","authors":"Behrooz Fathi Hafshejani ,&nbsp;Alan L. Harvey ,&nbsp;Edward G. Rowan ,&nbsp;Azam Mohammadi","doi":"10.1016/j.toxicon.2025.108621","DOIUrl":"10.1016/j.toxicon.2025.108621","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108621"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum Toxin Type A in the Treatment of Synkinesis: Clinical Case Study","authors":"M.A. Akulov ,&nbsp;V.N. Shimansky ,&nbsp;V.K. Poshataev ,&nbsp;O.R. Orlova ,&nbsp;V.O. Zakharov","doi":"10.1016/j.toxicon.2025.108676","DOIUrl":"10.1016/j.toxicon.2025.108676","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108676"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}