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Snakebite epidemiology – findings from a nationally conducted survey in Bangladesh 蛇咬伤流行病学--孟加拉国全国性调查的结果
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107879
{"title":"Snakebite epidemiology – findings from a nationally conducted survey in Bangladesh","authors":"","doi":"10.1016/j.toxicon.2024.107879","DOIUrl":"10.1016/j.toxicon.2024.107879","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial structure, analgesic effects, and TRPA1 modulation of the Kunitz-type sea-anemone peptide HCIQ2C1 Kunitz 型海葵肽 HCIQ2C1 的空间结构、镇痛效果和 TRPA1 调制作用
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107905
{"title":"Spatial structure, analgesic effects, and TRPA1 modulation of the Kunitz-type sea-anemone peptide HCIQ2C1","authors":"","doi":"10.1016/j.toxicon.2024.107905","DOIUrl":"10.1016/j.toxicon.2024.107905","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic manipulation of a sea anemone unravels how venom shapes interspecific interactions and evolutionary tradeoffs 对海葵的遗传操作揭示了毒液如何影响种间相互作用和进化权衡
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107861
{"title":"Genetic manipulation of a sea anemone unravels how venom shapes interspecific interactions and evolutionary tradeoffs","authors":"","doi":"10.1016/j.toxicon.2024.107861","DOIUrl":"10.1016/j.toxicon.2024.107861","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The origins and evolution of snake venom: elucidations from the chromosome-level genome of Tropidolaemus wagleri 蛇毒的起源与进化：从Tropidolaemus wagleri染色体级基因组中获得的启示
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107874
{"title":"The origins and evolution of snake venom: elucidations from the chromosome-level genome of Tropidolaemus wagleri","authors":"","doi":"10.1016/j.toxicon.2024.107874","DOIUrl":"10.1016/j.toxicon.2024.107874","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy 利用毒液诱发消耗性凝血病动物模型在改善动物福利和实验可转化性方面取得进展
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107924
{"title":"Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy","authors":"","doi":"10.1016/j.toxicon.2024.107924","DOIUrl":"10.1016/j.toxicon.2024.107924","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys 番茄红素可减轻玉米赤霉烯酮诱导的小鼠肾脏氧化应激、细胞凋亡和 NLRP3 炎性体激活。
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.108078
{"title":"Lycopene alleviates zearalenone-induced oxidative stress, apoptosis, and NLRP3 inflammasome activation in mice kidneys","authors":"","doi":"10.1016/j.toxicon.2024.108078","DOIUrl":"10.1016/j.toxicon.2024.108078","url":null,"abstract":"<div><p>The aim of this study was to investigate the protective effects of lycopene on renal damage caused by zearalenone (ZEN). Male Kunming mice were treated daily for 4 weeks by intragastric administration with 40 mg/kg ZEN in the presence or absence of lycopene (2.5 or 5 mg/kg). The results showed that lycopene markedly alleviated the damage of renal structure and function in mice induced by ZEN, as indicated by the reduced degree of pathological damage and the decreased levels of urea nitrogen and creatinine. Meanwhile, results of dihydroethidine (DHE) staining and biochemical markers revealed that ZEN exposure notably increased the levels of reactive oxygen species (ROS) and malondialdehyde (MDA), decreased the level of GSH, and reduced the activities of catalase (CAT) and superoxide dismutase (SOD). Administration of lycopene alleviated the increased oxidative stress induced by ZEN. Moreover, ZEN ingestion notably resulted in apoptosis, increased the protein levels of BCL2 associated X protein (Bax) and cleaved caspase-3, and decreased the protein levels of apoptosis regulator Bcl-2 (Bcl-2), which were reversed by lycopene intervention. Results of immunofluorescence demonstrated that lycopene reversed ZEN-induced the upregulation of NOD-like receptor pyrin domain-containing protein 3 (NLRP3), Caspase-1, and interleukin-1 beta (IL-1β) in mice kidneys. Lycopene supplementation could alleviate ZEN-induced renal toxicity by inhibiting oxidative stress, apoptosis, and NLRP3 inflammasome activation.</p></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lacewing venom: Detailed insights into the venom system of a neglected group of venomous insects 草蜻蛉毒液详细了解被忽视的一类毒虫的毒液系统
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107877
{"title":"Lacewing venom: Detailed insights into the venom system of a neglected group of venomous insects","authors":"","doi":"10.1016/j.toxicon.2024.107877","DOIUrl":"10.1016/j.toxicon.2024.107877","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxicity profiling of toxins in snake venoms enabled by nanofractionation analytics and high throughput venomics 利用纳米分馏分析和高通量毒液组学分析蛇毒中毒素的细胞毒性特征
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107950
{"title":"Cytotoxicity profiling of toxins in snake venoms enabled by nanofractionation analytics and high throughput venomics","authors":"","doi":"10.1016/j.toxicon.2024.107950","DOIUrl":"10.1016/j.toxicon.2024.107950","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tick saliva interference with LTβR signaling facilitates the transmission of Lyme disease spirochetes 蜱唾液对 LTβR 信号的干扰促进了莱姆病螺旋体的传播
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107918
{"title":"Tick saliva interference with LTβR signaling facilitates the transmission of Lyme disease spirochetes","authors":"","doi":"10.1016/j.toxicon.2024.107918","DOIUrl":"10.1016/j.toxicon.2024.107918","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new potent peptide blocker, from Poecilotheria subfusca spider, of the human Cav1.2 channel subtype 一种来自 Poecilotheria subfusca 蜘蛛的新型人类 Cav1.2 通道亚型强效多肽阻断剂
IF 2.6 4区 医学
Toxicon Pub Date : 2024-08-23 DOI: 10.1016/j.toxicon.2024.107897
{"title":"A new potent peptide blocker, from Poecilotheria subfusca spider, of the human Cav1.2 channel subtype","authors":"","doi":"10.1016/j.toxicon.2024.107897","DOIUrl":"10.1016/j.toxicon.2024.107897","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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