发布求助
文献互助 智能选刊 最新文献

Toxicon最新文献

筛选
英文 中文
Retrorsine-induced hepatotoxicity is mediated by inhibition of the EGFR/AKT/c-Jun axis and disruption of calcium homeostasis in primary hepatocytes 逆转录酶诱导的肝毒性是通过抑制EGFR/AKT/c-Jun轴和破坏原代肝细胞钙稳态介导的
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-15 Epub Date: 2026-01-13 DOI: 10.1016/j.toxicon.2026.108998
Congcheng Zhang, Qin Zhang, Pan Wang, Hai Yin, Yiling Liu, Shuhang Zhang, Hao Lu
{"title":"Retrorsine-induced hepatotoxicity is mediated by inhibition of the EGFR/AKT/c-Jun axis and disruption of calcium homeostasis in primary hepatocytes","authors":"Congcheng Zhang,&nbsp;Qin Zhang,&nbsp;Pan Wang,&nbsp;Hai Yin,&nbsp;Yiling Liu,&nbsp;Shuhang Zhang,&nbsp;Hao Lu","doi":"10.1016/j.toxicon.2026.108998","DOIUrl":"10.1016/j.toxicon.2026.108998","url":null,"abstract":"<div><div>Pyrrolizidine alkaloids (PAs) occur in approximately 3 %–5 % of flowering plants and are common natural toxins; retrorsine is among the most hepatotoxic. Ingestion of PA-containing products is a major cause of hepatic sinusoidal obstruction syndrome (HSOS). To elucidate the mechanism of retrorsine-induced hepatotoxicity, we combined network toxicology, molecular docking, and functional assays in primary hepatocytes. We identified 136 HSOS-related targets enriched in calcium signaling and PI3K-AKT pathways, including AKT1, JUN, and EGFR. In primary rat hepatocytes, retrorsine significantly decreased p-AKT, p-EGFR, and p-c-Jun levels (<em>p</em> &lt; 0.05). Together, these data suggest that retrorsine inhibits EGFR/AKT/c-Jun axis and triggers intracellular calcium overload, leading to ER stress-associated autophagy and hepatocyte death. These findings reveal a mechanism of retrorsine-induced hepatocyte injury and highlight the EGFR/AKT/c-Jun survival pathway as a potential therapeutic target in PA-induced HSOS.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"272 ","pages":"Article 108998"},"PeriodicalIF":2.4,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145979115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conserved region amino acid mutations in Calcin: Altering the RyR structural-functional relationship 钙蛋白保守区氨基酸突变：改变RyR结构-功能关系。
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2025-12-20 DOI: 10.1016/j.toxicon.2025.108967
Lianbo Wang , Xiaoyu Hua , Xiaofen Ma , Jianguo Wang , Li Xiao , Shumin Wang , Hao Liu , Yangfei Zhao , Héctor H. Valdivia , Liang Xiao , Jinming Wang
{"title":"Conserved region amino acid mutations in Calcin: Altering the RyR structural-functional relationship","authors":"Lianbo Wang ,&nbsp;Xiaoyu Hua ,&nbsp;Xiaofen Ma ,&nbsp;Jianguo Wang ,&nbsp;Li Xiao ,&nbsp;Shumin Wang ,&nbsp;Hao Liu ,&nbsp;Yangfei Zhao ,&nbsp;Héctor H. Valdivia ,&nbsp;Liang Xiao ,&nbsp;Jinming Wang","doi":"10.1016/j.toxicon.2025.108967","DOIUrl":"10.1016/j.toxicon.2025.108967","url":null,"abstract":"<div><div>The scorpion venom-derived peptide Calcin is a high-affinity ligand for Ryanodine Receptors (RyRs), known to modulate calcium release by stabilizing a sub-conductance state. While previous alanine-scanning mutagenesis highlighted the importance of electrostatic interactions, the functional impact of reversing acidic residues to basic ones within its conserved regions remains unexplored. Here, we employed a combined computational and experimental approach to investigate how charge-reversal mutations at two acidic sites (E12 and E29) in OpiCa1, a potent Calcin member, affect its structure, RyR interaction, and functional efficacy. Our results demonstrated that while all mutants (E12R, E12K, E29R, E29K) maintained the native inhibitor cystine knot fold, they exhibited altered surface electrostatic potential. Molecular docking and dynamics simulations revealed distinct binding modes and stabilites with RyR1 and RyR2. Notably, the E29R mutant displayed superior performance in cellular assays, inducing a significantly stronger Ca<sup>2+</sup> release from cardiomyocytes via RyR2 activation compared to wild-type OpiCa1 and other mutants. Our findings identify E29 as a critical residue where a charge-reversal mutation optimally enhances Calcin's activity, primarily by strengthening electrostatic complementarity with the RyR's acidic channel pore. This study provides crucial insights into the structure-function relationship of Calcin and establishes a rational basis for engineering optimized peptide therapeutics targeting RyR-related calcium dysregulation diseases.</div></div>","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108967"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145811280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RelaBoNT-A Treatment of Glabellar Lines and Lateral Canthal Lines of Different Baseline Severity: Subgroup Analyses of Pooled Phase III Study Data RelaBoNT-A治疗不同基线严重程度的眉间线和侧眦线：合并III期研究数据的亚组分析
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108672
Glynis Ablon , Joel Schlessinger , Sachin Shridharani , Z Paul Lorenc , Sherrif F. Ibrahim , Vince Bertucci , Leslie Baumann , Mark S. Nestor , Inna Prygova
{"title":"RelaBoNT-A Treatment of Glabellar Lines and Lateral Canthal Lines of Different Baseline Severity: Subgroup Analyses of Pooled Phase III Study Data","authors":"Glynis Ablon ,&nbsp;Joel Schlessinger ,&nbsp;Sachin Shridharani ,&nbsp;Z Paul Lorenc ,&nbsp;Sherrif F. Ibrahim ,&nbsp;Vince Bertucci ,&nbsp;Leslie Baumann ,&nbsp;Mark S. Nestor ,&nbsp;Inna Prygova","doi":"10.1016/j.toxicon.2025.108672","DOIUrl":"10.1016/j.toxicon.2025.108672","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108672"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodology of the BEOND Phase 3 Clinical Trials for Evaluating AbobotulinumtoxinA for Migraine Prevention BEOND评估肉毒杆菌毒素预防偏头痛的3期临床试验方法学
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108673
Jessica Ailani , Uma Raghunathan , Eve Desplats , Cristina Tassorelli
{"title":"Methodology of the BEOND Phase 3 Clinical Trials for Evaluating AbobotulinumtoxinA for Migraine Prevention","authors":"Jessica Ailani ,&nbsp;Uma Raghunathan ,&nbsp;Eve Desplats ,&nbsp;Cristina Tassorelli","doi":"10.1016/j.toxicon.2025.108673","DOIUrl":"10.1016/j.toxicon.2025.108673","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108673"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of RTP004 Peptide Facilitation of BoNT-A Internalization and SNAP25 Cleavage RTP004肽促进BoNT-A内化和SNAP25裂解的机制
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108688
Andre F. Batista, Dmitri Leonoudakis, Jonathan Giudice, Conor J. Gallagher
{"title":"Mechanisms of RTP004 Peptide Facilitation of BoNT-A Internalization and SNAP25 Cleavage","authors":"Andre F. Batista,&nbsp;Dmitri Leonoudakis,&nbsp;Jonathan Giudice,&nbsp;Conor J. Gallagher","doi":"10.1016/j.toxicon.2025.108688","DOIUrl":"10.1016/j.toxicon.2025.108688","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108688"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Task Complexity Modifies Motor Planning: A Proof-Of-Concept Study 任务复杂性改变运动计划：一项概念验证研究
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108683
Ian J. Baguley , Hannah LH. Barden , Helen Redmond
{"title":"Task Complexity Modifies Motor Planning: A Proof-Of-Concept Study","authors":"Ian J. Baguley ,&nbsp;Hannah LH. Barden ,&nbsp;Helen Redmond","doi":"10.1016/j.toxicon.2025.108683","DOIUrl":"10.1016/j.toxicon.2025.108683","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108683"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use Of Botulinum Toxin in Patients With Dysphagia and Posterior Sialorrhea in Acute Ischemic Stroke 肉毒毒素在急性缺血性脑卒中患者吞咽困难及后涎液中的应用
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108759
Vadim Gusev , Olga Lvova , Tatyana Balueva
{"title":"Use Of Botulinum Toxin in Patients With Dysphagia and Posterior Sialorrhea in Acute Ischemic Stroke","authors":"Vadim Gusev ,&nbsp;Olga Lvova ,&nbsp;Tatyana Balueva","doi":"10.1016/j.toxicon.2025.108759","DOIUrl":"10.1016/j.toxicon.2025.108759","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108759"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telehealth Follow-Up for Chronic Migraine Treated With OnabotulinumtoxinA: Patient-Reported Satisfaction 肉毒杆菌毒素治疗慢性偏头痛的远程健康随访：患者报告的满意度
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108763
Kelly Harper , Shuang Wu , Sheffield Sharp , Jacqueline Meystedt , Kian Pazira , David Charles
{"title":"Telehealth Follow-Up for Chronic Migraine Treated With OnabotulinumtoxinA: Patient-Reported Satisfaction","authors":"Kelly Harper ,&nbsp;Shuang Wu ,&nbsp;Sheffield Sharp ,&nbsp;Jacqueline Meystedt ,&nbsp;Kian Pazira ,&nbsp;David Charles","doi":"10.1016/j.toxicon.2025.108763","DOIUrl":"10.1016/j.toxicon.2025.108763","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108763"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Usefulness of Instrumented Gait Analysis in Monitoring the Quality of Gait Before and After Foot and Ankle Surgery for Spasticity 仪器步态分析在监测足部和踝关节痉挛手术前后步态质量中的作用
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108701
Ève Boissonnault , Stacey M. Wray , Nicole Rinas , Justin C. Lewicke , Lalith Satkunam
{"title":"The Usefulness of Instrumented Gait Analysis in Monitoring the Quality of Gait Before and After Foot and Ankle Surgery for Spasticity","authors":"Ève Boissonnault ,&nbsp;Stacey M. Wray ,&nbsp;Nicole Rinas ,&nbsp;Justin C. Lewicke ,&nbsp;Lalith Satkunam","doi":"10.1016/j.toxicon.2025.108701","DOIUrl":"10.1016/j.toxicon.2025.108701","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108701"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Real-World Implications of Botulinum Neurotoxin A (BoNT-A) Immunoresistance for Consumer and Practitioners: Insights From the ASCEND Panel 探索肉毒杆菌神经毒素A （BoNT-A）免疫耐药性对消费者和从业者的现实意义：来自ASCEND小组的见解
IF 2.4 4区 医学
Toxicon Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.toxicon.2025.108716
Niamh Corduff , Je Young Park
{"title":"Exploring Real-World Implications of Botulinum Neurotoxin A (BoNT-A) Immunoresistance for Consumer and Practitioners: Insights From the ASCEND Panel","authors":"Niamh Corduff ,&nbsp;Je Young Park","doi":"10.1016/j.toxicon.2025.108716","DOIUrl":"10.1016/j.toxicon.2025.108716","url":null,"abstract":"","PeriodicalId":23289,"journal":{"name":"Toxicon","volume":"271 ","pages":"Article 108716"},"PeriodicalIF":2.4,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书