Translational andrology and urology最新文献

{"title":"Variant histology muscle invasive bladder cancer should not preclude neoadjuvant chemotherapy before cystectomy.","authors":"Sophia Ford, Zachary Adam Hamilton","doi":"10.21037/tau-2025-80","DOIUrl":"10.21037/tau-2025-80","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1187-1189"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waiting in line for a fusion prostate biopsy-what does a patient know, fear and expect.","authors":"Kevin Miszewski, Katarzyna Skrobisz, Laura Miszewska, Philipp Lipowski, Bartłomiej Marczak, Sara Nowak, Marcin Matuszewski","doi":"10.21037/tau-2025-58","DOIUrl":"10.21037/tau-2025-58","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) is among the most prevalent cancers worldwide. Recent advancements in diagnostic techniques, such as multiparametric magnetic resonance imaging (MRI) and fusion prostate biopsies (PB), have significantly improved cancer detection rates; however, patient understanding of these procedures remains underexplored. Effective informed consent is essential for patient-centered care, yet patients often report feeling inadequately informed about medical procedures. Therefore, this study aimed to evaluate the level of knowledge patients acquire during the informed consent process for PB, with a focus on their understanding of the procedure's indications, potential outcomes, and available treatment options.</p><p><strong>Methods: </strong>We conducted a questionnaire-based study involving 177 patients scheduled for PB. The questionnaire included sections on demographic data, knowledge of the biopsy procedure, perceived risks, specific fears, and expectations regarding the biopsy outcomes and post-procedural care.</p><p><strong>Results: </strong>The survey revealed significant gaps in patient knowledge. Notably, 17.5% of respondents were unaware of their prostate-specific antigen (PSA) levels, over half of the participants were uncertain whether a PB could accelerate cancer development, and 61.8% believed that a biopsy always detects cancer if present. Many patients were also unaware of the potential complications and treatment options associated with the procedure.</p><p><strong>Conclusions: </strong>Significant gaps exist in patient understanding of PCa diagnostics and biopsy procedures, despite the informed consent process. Patients often lack awareness of their individual risk of malignancy, potential outcomes of the biopsy, subsequent follow-up procedures, and the advantages and disadvantages of different biopsy techniques. These knowledge deficits may impair their ability to make informed decisions about their care.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1308-1314"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of prostate cancer detection rates and complications between transrectal ultrasound-guided transperineal and transrectal biopsies: a systematic review and meta-analysis.","authors":"Jianhui Du, Shuang Chen, Martha K Terris, Hiroshi Miyamoto, Yanqin Yu, Qiao Ying","doi":"10.21037/tau-2025-150","DOIUrl":"10.21037/tau-2025-150","url":null,"abstract":"<p><strong>Background: </strong>Transrectal ultrasound (TRUS)-guided transperineal (TP) and transrectal (TR) approaches have been used for systematic prostate biopsy. A meta-analysis was conducted to compare the cancer detection rates (CDRs) and associated complications between TP and TR prostate biopsies.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase, Cochrane Library, China Wanfang data, and China National Knowledge Infrastructure (CNKI) were searched for literature on TP and TR biopsies of the prostate from inception to September 2024.</p><p><strong>Results: </strong>A total of 20 studies were included in the meta-analysis of 2,979 and 2,610 patients undergoing TP and TR biopsies, respectively. The pooled analysis indicated no significant difference in the CDR between the TP and TR biopsies [relative risk (RR) =0.98; 95% confidence interval (CI): 0.92-1.04; P=0.46]. Compared to the TR approach, the TP approach was associated with a lower risk of rectal bleeding (RR =0.05; 95% CI: 0.02-0.13; P<0.001), urinary retention (RR =0.70; 95% CI: 0.49-0.99; P=0.046), and fever (RR =0.24, 95% CI: 0.15-0.39; P<0.001). However, the risk of pain after the procedure was higher in the TP group (RR =2.04; 95% CI: 1.47-2.82; P<0.001). No significant difference was found in the risk of hematuria between the two groups (RR =1.05; 95% CI: 0.91-1.22; P=0.52).</p><p><strong>Conclusions: </strong>TP and TR biopsies of the prostate have similar CDRs. Remarkably, compared to TR biopsy, TP biopsy involves a lower risk of rectal bleeding, urinary retention, and fever, but a higher risk of pain.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1418-1428"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of prophylactic use of biologic mesh in ileal conduit: insights from the PUBMIC trial.","authors":"Kenji Zennami","doi":"10.21037/tau-2024-764","DOIUrl":"10.21037/tau-2024-764","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1158-1159"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total periurethral reconstruction with preservation of \"Hood\" structures promotes early recovery of urinary continence in extraperitoneal single-port robot-assisted radical prostatectomy.","authors":"Xuran Ji, Haoxun Zhang, Guoling Zhang, Jiuliang Wang, Zhixing Jiao, Guang Jia, Ao Qi, Yipeng Yu, Yiwen Liu, Chunyang Wang","doi":"10.21037/tau-2025-56","DOIUrl":"10.21037/tau-2025-56","url":null,"abstract":"<p><p>Urinary incontinence is a complex complication of radical prostatectomy (RP), with early urinary continence (UC) recovery influenced by surgical methods. This study evaluated the efficacy and safety of total periurethral reconstruction preserving \"Hood\" structures on early UC recovery in extraperitoneal single-port robot-assisted laparoscopic RP (sp-RARP). We analyzed perioperative data from 12 extraperitoneal sp-RARP cases employing the novel technique between July 2023 and July 2024. Continence rates and oncologic results at 24 h, 1 week, 4 weeks, and 3 months post-catheter removal were recorded. The technique involves anastomosing the lateral levator ani muscle and median dorsal raphe at the \"Hood\" structures base to the posterior detrusor apron (DA) of the bladder neck (BN) for parachute-style dorsal support before vesicourethral anastomosis (VUA). The anterior DA of BN is anastomosed to the prostate fascia and DA rim above the urethral stump for anterior fixation after VUA. Median and interquartile range (IQR) are used for continuous non-normally distributed variables. The median reconstruction and surgical time were 13.5 (IQR, 11.0-21.5) min and 152 (IQR, 141.25-180) min. No transitions to open surgery or additional auxiliary trocars were necessary. No serious complications occurred during the perioperative period. Continence rates at 24 h, 1 week, 4 weeks, and 3 months post-catheter expulsion were 41.67% (5/12), 66.67% (8/12), 75.00% (9/12), and 91.67% (11/12). The novel technique shows promising early UC recovery following extraperitoneal sp-RARP without increasing complications or compromising oncologic outcomes, suggesting it is a feasible and effective surgical method.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1466-1475"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving outcomes in robot-assisted urologic oncology surgery using a perioperative electronic health program.","authors":"Alae Touzani, Nam-Son Vuong, Alessandro Uleri, Giuseppe Fallara, Alberto Martini, Naoufel Miaadi, Nordine Deffar, Adil Ouzzane, Benjamin Pradère, Jean Rouffilange, Michaël Baboudjian, Jean-Baptiste Beauval, Bernard Malavaud, Guillaume Ploussard","doi":"10.21037/tau-2025-74","DOIUrl":"10.21037/tau-2025-74","url":null,"abstract":"<p><strong>Background: </strong>Robotic surgery has demonstrated its ability to improve perioperative outcomes thanks to a minimally invasive approach. In addition, the implementation of a perioperative optimized pathway, including eHealth programs, may provide a synergistic effect and help facilitate recovery and reduce complications. The purpose of this study is to evaluate the impact of the BETTY COACHING program on the 90-day complication rate following robot-assisted oncologic urologic surgery.</p><p><strong>Methods: </strong>We conducted a study to evaluate the impact of the BETTY COACHING program, an app-based, multi-level perioperative digital pathway, on the 90-day complication rate following robot-assisted onco-urologic surgery. Patients were divided into two groups: one benefiting from our coaching program and the other receiving standard care without digital support. Data were analyzed from a prospectively maintained, multicenter registry. Secondary endpoints included hospital stay, readmission, number of days out of hospital, prolonged care at discharge, unplanned visits, and patient satisfaction.</p><p><strong>Results: </strong>A total of 196 consecutive patients undergoing radical prostatectomy, partial nephrectomy, or radical cystectomy were included in the analysis, with 98 patients in each group. Patients who followed our coaching program experienced significantly fewer post-operative complications [26.5% <i>vs.</i> 9.2%; odds ratios (OR) 0.28; P=0.002] compared to those in the standard care group. The digital program was also associated with a significant reduction in unplanned visits (OR 0.08; P=0.003), readmission rates (OR 0.23; P=0.02), and prolonged care after discharge (OR 0.21; P=0.004). Additionally, patients in the coaching program group had a higher number of days out of the hospital within 90 days post-surgery (89.1 <i>vs.</i> 87.5 days; P=0.002) and reported greater satisfaction (9.1 <i>vs.</i> 7.7/10; P=0.02).</p><p><strong>Conclusions: </strong>The addition of a digital optimized perioperative program improves 90-day outcomes after robot-assisted onco-urologic surgical procedures in terms of complications, readmission, prolonged care, and patient experience.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1348-1354"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let food be thy healer, and movement thy shield, before the scalpel entering the field-praise for a pre-prostatectomy diet and exercise program.","authors":"Victoria E Gonzalez, Helen Y Hougen","doi":"10.21037/tau-2024-771","DOIUrl":"10.21037/tau-2024-771","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1152-1154"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel anoikis-related genes for the diagnosis of non-obstructive azoospermia.","authors":"Xiaolian Xu, Jinlong Xie, Wenchang Cheng","doi":"10.21037/tau-2024-745","DOIUrl":"https://doi.org/10.21037/tau-2024-745","url":null,"abstract":"<p><strong>Background: </strong>Non-obstructive azoospermia (NOA) is a prevalent cause of male infertility, featured by the absence of sperm in the ejaculate due to impaired spermatogenesis. The involvement of anoikis in the pathogenesis of NOA remains inadequately understood. This research aims to identify anoikis-related genes as potential biomarkers for NOA diagnosis.</p><p><strong>Methods: </strong>Based on the Gene Expression Omnibus (GEO) database and Limma R package, we identified differentially expressed genes of NOA and downloaded anoikis-related genes based on the GeneCards database. Subsequently, anoikis-related hub genes were screened by machine learning (ML), and validated using external validation sets. A nomogram constructed from these genes demonstrated high predictive accuracy, while boxplots and complex heatmaps illustrated the differential expression patterns observed in NOA samples. Additionally, immune infiltration analysis was performed using the CIBERSORT algorithm to evaluate the distribution of immune cells in both NOA and control groups. The validation of candidate genes was conducted through receiver operating characteristic (ROC) curve analysis, with the area under the curve (AUC) indicating predictive accuracy.</p><p><strong>Results: </strong>Ultimately, we screened three hub genes: <i>GLO1</i>, <i>BAP1</i>, and <i>PLK1</i>. GLO1 was found to be up-regulated, while both BAP1 and PLK1 were down-regulated. Immune cell infiltration analysis elicited significant differences in 16 immune cell types between NOA patients and normal controls, with Tregs and macrophages notably up-regulated in NOA. ROC analysis indicated that all the three hub genes exhibited excellent diagnostic efficacy. Specifically, ROC curve analysis confirmed the diagnostic potential of GLO1, BAP1, and PLK1, yielding AUC values of 0.981, 0.980, and 0.981 in internal datasets, and 0.750, 0.875, and 1.000 in external datasets.</p><p><strong>Conclusions: </strong>By ML analysis, this research identified three anoikis-related genes that may be diagnostic biomarkers for NOA, offering views into the underlying molecular mechanisms and therapeutic targets.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"940-952"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The disease burden of kidney cancer in Asian countries and regions from 1990 to 2021: a study based on the Global Burden of Disease database.","authors":"Juan Chen, Tie Chong, Anxia Li, Yuanyang Yan, Lijun Wei","doi":"10.21037/tau-2024-652","DOIUrl":"https://doi.org/10.21037/tau-2024-652","url":null,"abstract":"<p><strong>Background: </strong>There are huge differences in the disease burden of kidney cancer (KC) between countries and regions in Asia. Therefore, we conducted this study to investigate the KC burden and attributable risk factors in Asia.</p><p><strong>Methods: </strong>We obtained data on the incidence, prevalence, mortality, disability adjusted life years, sociodemographic index (SDI), and attributable risk factors of KC in Asian countries and regions from 1990 to 2021 in the Global Burden of Disease database. Joinpoint regression was used to analyze the overall trend of the change in KC burden in Asia. The health inequalities of KC in Asia were evaluated. The correlation between SDI and KC burden was assessed. Autoregressive integrated moving average was used to predict the KC burden in the next 15 years. The age-period-cohort model evaluated the relative risk (RR) of the KC burden in different dimensions. In addition, frontier analyses were performed in this study. Finally, comprehensive analyses of the attributable risk factors of KC were performed.</p><p><strong>Results: </strong>The KC burden in Asia showed a significant upward trend from 1990 to 2021. The KC burden was mainly concentrated in relatively wealthy countries and regions (high SDI). In the next 15 years, the KC burden would rise further. The RR of KC generally increased with age and period, and decreased with birth cohorts. The most concerning risk factor for KC was high body mass index (HBMI), and the KC burden attributed to HBMI also indicated a significant upward trend and was positively correlated with SDI.</p><p><strong>Conclusions: </strong>The KC burden in Asian countries and regions is still rising. Therefore, targeted medical interventions are needed to improve early diagnosis and treatment of KC.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1049-1065"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile cancer awareness and knowledge among adult patients in an ambulatory urology clinic.","authors":"Nick A Kamkari, Vadim Osadchiy, Erika L Wood, Kristen C Williams, Eduardo Piqueiras, Nicholas M Donin","doi":"10.21037/tau-2025-41","DOIUrl":"https://doi.org/10.21037/tau-2025-41","url":null,"abstract":"<p><p>Penile cancer (PeCa) is a rare urologic malignancy in the United States, and public awareness remains low. In this brief report, we design and execute a survey to evaluate knowledge and awareness of PeCa focusing on general PeCa knowledge, treatment options, and willingness to recommend a preventative intervention. Study participants were recruited with a study flyer from the waiting room of two Los Angeles community-based urology clinics. All patients were English-speaking and over 18 years old. Study recruitment took place from October 2021 to June 2022 and 83 participants were included. The majority of respondents were men (90%) and white (87%), with a mean age 63 years. Ninety-eight percent of respondents reported either knowing \"nothing\" or \"a little\" about PeCa; 69% of respondents did not know a person could get cancer on the penis. Knowledge of risk factors for PeCa was particularly poor, with respect to phimosis (5% correctly identified this as a risk factor), balanitis (28%), and human papilloma virus (HPV) (44%). The majority of respondents, however, reported that they would recommend administration of an HPV vaccine for the prevention of PeCa (89%) once informed of HPV as a risk factor. Our findings underscore the lack of knowledge and awareness of PeCa, which may contribute to future delays in care.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1129-1137"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}