Translational andrology and urology最新文献

{"title":"L-shaped association between the ratio of serum albumin to globulin and the risk of all-cause mortality among adults with kidney stones: a national cohort study.","authors":"Sian Chen, Yiqiu Cheng, Fei Wang, Jinhai Wu, Xuejin Zhu, Luca Zanoli, Gino Pigatto Filho, Qi Gao, Yanfei Chen","doi":"10.21037/tau-2025-127","DOIUrl":"https://doi.org/10.21037/tau-2025-127","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are a common urological disease with rising global prevalence and are influenced by immune, metabolic, and nutritional factors. The ratio of serum albumin to globulin, a marker of inflammation and nutritional status, has been linked to various inflammatory and chronic conditions, but its role in kidney stone risk and outcomes remains unclear. We aimed to determine the association between ratio of serum albumin to globulin and risk of kidney stones, as well as the impact of ratio of serum albumin to globulin on all-cause mortality in participants with kidney stones.</p><p><strong>Methods: </strong>Multivariable logistic regression was used to explore the association between ratio of serum albumin to globulin and the risk of kidney stones. Multivariate Cox regression and restricted cubic spline (RCS) were performed to clarify the relationship between ratio of serum albumin to globulin and the risk of all-cause mortality.</p><p><strong>Results: </strong>Among 31,091 study participants, 2,955 (9.5%) individuals had kidney stones. Multivariable logistic models demonstrated that each standard deviation (SD) increase in the ratio of serum albumin to globulin (SD =0.30) was associated with a 6% reduction in kidney stone risk. A total of 387 (13.1%) participants with kidney stones died for any reasons during a median follow-up of 6.2 years. The multivariable Cox model showed a significantly lower risk of all-cause mortality in the quartile (Q)2, Q3, and Q4 groups as compared to Q1 [Q2: adjusted hazard ratio (aHR) =0.84, 95% confidence interval (CI): 0.63-1.11; Q3: aHR =0.65, 95% CI: 0.48-0.86; Q4: aHR =0.63, 95% CI: 0.46-0.86; P for trend =0.04].</p><p><strong>Conclusions: </strong>A lower ratio of serum albumin to globulin was associated with an increased risk of kidney stones. Additionally, our study showed that at a cutoff point of 1.5, the association between ratio of serum albumin to globulin and all-cause mortality in participants with kidney stones was nonlinear L-shaped. However, due to the observational nature of the study, our study results should be interpreted with caution.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"751-763"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted benign prostate hyperplasia causally affects prostate cancer: a two-sample Mendelian randomization.","authors":"Haijun Huang, Zhiquan Hu, Zhi Chen, Yucong Zhang, Chunguang Yang","doi":"10.21037/tau-2024-673","DOIUrl":"https://doi.org/10.21037/tau-2024-673","url":null,"abstract":"<p><strong>Background: </strong>Benign prostate hyperplasia (BPH) and prostate cancer (PCa) share several similarities, including androgen dependency and parallel increases in prevalence with age. Although PCa lags by 15-20 years, no causal association has been identified between BPH and PCa. To investigate the potential causal links between BPH and PCa, this study was performed in a two-sample Mendelian randomization (MR) design.</p><p><strong>Methods: </strong>We retrieved single-nucleotide polymorphisms (SNPs) associated with BPH from genome-wide association studies (GWAS), which were obtained from the Integrative Epidemiology Unit database, and conducted a two-sample MR analysis to explore the causal relationship between BPH and PCa. The exposure dataset included 13,118 BPH cases and 72,799 controls, while the outcome dataset comprised 9,132 PCa cases and 173,493 controls, all of European ancestry. Four SNPs were selected as instrumental variables (IVs) after stringent filtering for linkage disequilibrium and potential confounding factors. The causal effect was estimated using the inverse-variance-weighted (IVW) method, supplemented by sensitivity analyses to assess heterogeneity and pleiotropy.</p><p><strong>Results: </strong>The IVW analysis revealed that genetically predicted BPH was causally associated with a 1.02-fold increased risk of PCa [95% confidence interval (CI): 1.0076-1.0286, P<0.001]. Sensitivity analyses, including MR-Egger regression and leave-one-out analysis, confirmed the robustness of these findings, with no significant heterogeneity or pleiotropy detected.</p><p><strong>Conclusions: </strong>This study provides genetic evidence supporting a causal relationship between BPH and an increased risk of PCa. These findings suggest that BPH may contribute to the development of PCa, potentially guiding future clinical practices in screening, diagnosis, and treatment strategies for BPH patients to mitigate PCa risk. Further validation in diverse populations and clinical studies is warranted to confirm these findings.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"661-668"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of presurgical therapy with tislelizumab and axitinib to downsize local lesions in locally advanced and metastatic renal cell carcinoma: a single-institution experience with long-term follow-up.","authors":"Qiang Zhao, Baoan Hong, Yiqiang Liu, Haibin Zhu, Yong Yang, Ning Zhang","doi":"10.21037/tau-24-585","DOIUrl":"https://doi.org/10.21037/tau-24-585","url":null,"abstract":"<p><strong>Background: </strong>Systemic therapy with or without surgery is recommended in advanced renal cell carcinoma (RCC). The potential benefits of tislelizumab and axitinib as presurgical therapy in advanced RCC remain unclear. This study aimed to preliminarily assess the efficacy of short-term presurgical tislelizumab and axitinib in downsizing local lesions and its long-term oncological outcome with or without nephrectomy in advanced RCC.</p><p><strong>Methods: </strong>Data were prospectively collected from patients with advanced RCC who received tislelizumab and axitinib and were scheduled for deferred nephrectomy. Efficacy was evaluated by the remission of all tumor lesions using computed tomography (CT), and oncological outcomes were also reported.</p><p><strong>Results: </strong>Between March 2021 and May 2022, 11 patients were recruited, 10 of whom presented with metastases. Biopsy results confirmed clear-cell RCC in eight patients, and RCC not otherwise specified in three patients. Following a median of three cycles of presurgical treatment, the overall response rate (ORR) and disease control rate (DCR) were 18.2% (2/11) and 100% (11/11), respectively. The median percentage change in the long-axis diameter was -24.0% (range, -8.2% to -39.7%) for all lesions and -12.2% (range, -7.1% to -39.7%) for local lesions. Open nephrectomy was successfully performed in eight patients with high anatomical complexity. After a median follow-up of 23 months (range, 14-34 months), six patients (6/11, 54.5%) experienced disease progression and died, including three patients without nephrectomy (3/3, 100%) and another three with nephrectomy (3/8, 37.5%). Progression-free survival (PFS) and overall survival (OS) were significantly longer in patients who underwent nephrectomy (P=0.002 and P=0.004).</p><p><strong>Conclusions: </strong>Short-term presurgical tislelizumab and axitinib can downsize local lesions and facilitate nephrectomy in advanced RCC with high anatomical complexity, potentially improving long-term oncological outcomes when followed by cytoreductive surgery.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"651-660"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of multivariable biopsy-free nomograms to predict clinically significant prostate cancer in patients with prostate-specific antigen levels ≥20 ng/mL.","authors":"Mingzhe Chen, Shanqi Guo, Junxin Wang, Nan Wang, Simeng Wen, Hongtuan Zhang, Yong Wang, Ranlu Liu, Yong Xu, Xingkang Jiang","doi":"10.21037/tau-24-533","DOIUrl":"https://doi.org/10.21037/tau-24-533","url":null,"abstract":"<p><strong>Background: </strong>Elevated prostate-specific antigen (PSA) levels often lead to prostate biopsies, which can result in overdiagnosis and complications, thereby increasing preoperative anxiety. This study aimed to develop and validate a novel biopsy-free diagnostic nomogram for accurate detection of clinically significant prostate cancer (csPCa) in patients with PSA levels ≥20 ng/mL.</p><p><strong>Methods: </strong>The cohort of this retrospective analysis included patients with PSA levels ≥20 ng/mL who underwent evaluation including clinical variables, Prostate Imaging-Reporting and Data System (PI-RADS), prostate health index (PHI), and prostate-specific membrane antigen positron emission tomography-computed tomography (PSMA PET/CT). Nomogram performance was evaluated using the concordance index, calibration plot, decision curve analysis, and the area under the receiver operating characteristic curve (AUC).</p><p><strong>Results: </strong>Of 684 patients, 478 and 206 were randomly assigned to the diagnostic and validation cohorts, respectively. Multivariable predictors of csPCa included age, PSA density, PI-RADS, location of suspicious lesion, %PSA variation ratio, and acute urinary retention. The foundational nomogram achieved AUCs of 0.930 and 0.911 for the training and validation sets, respectively. By integrating both PHI and PSMA maximum standardized uptake value (SUVmax), the diagnostic accuracy of the advanced nomogram improved significantly, with AUCs of 0.951 and 0.935 for the training and validation sets, respectively. Limitations included the lack of external validation and potential selection bias.</p><p><strong>Conclusions: </strong>The biopsy-free nomogram presents a promising approach for accurate diagnosis of csPCa in patients with PSA levels ≥20 ng/mL. This non-invasive method can reduce unnecessary biopsies and enhance patient care by identifying those necessitating further evaluation and treatment.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"507-518"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of a continuing international partnership and multiple intensive hands-on workshops on the success rate of bulbar EPA urethroplasty in a low-middle income country: an early experience.","authors":"Valeerat Swatesutipun, Teerayut Tangpaitoon, Do Lenh Hung, Joel Gelman","doi":"10.21037/tau-2024-710","DOIUrl":"https://doi.org/10.21037/tau-2024-710","url":null,"abstract":"<p><strong>Background: </strong>Thailand has one of the 10 highest national rates of traffic accidents, leading to a high incidence of urethral stricture from bulbar straddle and pelvic fracture urethral injuries. Various treatment options are offered including urethroplasty; however, failure rates are high leading to a significant societal burden. Outreach relationships were established between the United States of America (USA), Vietnam, and Thailand by creating an intensive hands-on workshop and mentorship model to improve urethroplasty success. We aim to report the impact of this partnership and hands-on training on bulbar excision and primary anastomosis (EPA) success rates.</p><p><strong>Methods: </strong>The University of California, Irvine Medical Center (UC Irvine), USA, Binh Dan Hospital, Vietnam, and Thammasat University Hospital (TUH), Thailand developed partnerships in urethroplasty training since 2020. Urologists from Thailand seeking expertise in urethroplasty joined intensive hands-on workshops for two 2-week periods. An ongoing mentorship relationship subsequently developed. Important infrastructure similar to that at UC Irvine, a urethroplasty Center of Excellence, was established at TUH to include the purchase of identical urethroplasty and urethral imaging-specific equipment and supplies. Subsequent workshops were attended and hosted at TUH. A database was created to compare success rates before and 12 months after completing the workshops and establishing infrastructure. Cystoscopy 4 months after surgery was performed to assess anatomical success.</p><p><strong>Results: </strong>The study included 29 patients with bulbar urethral stricture who underwent bulbar EPA. There were 19 patients from before the establishment of the partnership that included workshops and infrastructure development. The overall success rate was 57.14%, whereas in comparison, success rates of over 98% were published at Centers of Excellence. After establishing the partnership, bulbar EPA was performed in 10 cases. The success rate increased to 90% (P=0.001) which included anatomical success defined as wide patency on cystoscopy 4 months after surgery and a subsequent absence of recurrent voiding symptoms. The patients who underwent urethroplasty during the workshop and learning period were excluded from this study.</p><p><strong>Conclusions: </strong>Developing and continuing international partnerships with a mentorship model and multiple intensive hands-on workshops, including established appropriate hospital infrastructure could improve the success rate of bulbar urethroplasty in countries seeking to develop a urethroplasty Center of Excellence.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"610-618"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost benefit micro-analysis of performing urine cultures as a mean to reduce post-flexible cystoscopy urosepsis: a comparative study between two centres.","authors":"Adib Rahman, Matthew Qiu, Kapilan Ravichandran, Devang Desai","doi":"10.21037/tau-24-417","DOIUrl":"https://doi.org/10.21037/tau-24-417","url":null,"abstract":"<p><strong>Background: </strong>In Australia, flexible cystoscopy is a key diagnostic tool in urology, employed to manage various conditions. However, it carries risks like urinary tract infections and urosepsis, which lead to significant healthcare expenses. This study evaluates the cost-effectiveness of pre-procedure urine cultures to prevent post-cystoscopy urosepsis.</p><p><strong>Methods: </strong>A retrospective analysis of data from regional Toowoomba Base Hospital and metropolitan Gold Coast University Hospital was conducted to assess the efficacy of urine cultures in reducing urosepsis following flexible cystoscopy. The study reviewed patient records, analysing both the incidence of post-procedure urosepsis and the associated economic impact.</p><p><strong>Results: </strong>The incidence of post-procedure urosepsis was found to be exceptionally low at 0.03%. Comparative analysis showed no significant reduction in urosepsis rates with the use of pre-procedure urine cultures (P=0.93). The financial analysis highlighted that the regional centre, which conducted urine cultures, incurred costs $ 26.14 per patient greater compared to the metropolitan centre that did not perform these cultures.</p><p><strong>Conclusions: </strong>The study indicates that the low incidence of urosepsis does not justify the routine use of pre-operative urine cultures, given the substantial costs involved. These findings support current guidelines that do not recommend routine pre-procedure cultures for cystoscopy due to lack of evidence of benefit.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"707-714"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historic progression of prostatectomy techniques and associated outcomes.","authors":"Lauren Folgosa Cooley, Neal D Shore","doi":"10.21037/tau-2025-3","DOIUrl":"https://doi.org/10.21037/tau-2025-3","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"493-495"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of 4N-enhanced recovery after surgery in retroperitoneal laparoscopic resection of adrenal tumors.","authors":"Bingfeng Luo, Sucai Liao, Yuan Yuan, Yifei Zhu, Yaping Xing, Wei Liang, Xiang Yi, Ruidong Ji, Mingchi Wang, Xinliang Cai, Ruxi Tang, Yu Yang, Weide Zhong, Richard Lo, Zhenquan Lu","doi":"10.21037/tau-24-608","DOIUrl":"https://doi.org/10.21037/tau-24-608","url":null,"abstract":"<p><strong>Background: </strong>Enhanced recovery after surgery (ERAS) has been widely applied in various surgical fields to improve postoperative recovery and reduce complications. However, its application in retroperitoneal laparoscopic resection of adrenal tumors remains limited. This study aimed to evaluate the effect and value of the 4N-ERAS protocol, which includes no Foley catheter, no drainage, no antibiotics, and \"no pain\" management for the postoperative recovery of patients undergoing retroperitoneal laparoscopic adrenal tumors resection.</p><p><strong>Methods: </strong>We retrospectively analyzed data from 85 patients with adrenal tumors who were treated in the Urology Department of The University of Hong Kong-Shenzhen Hospital from January 2019 to December 2023. Of them, 42 patients were treated with the 4N-ERAS protocol (4N-ERAS group) and 43 patients received traditional treatment (control group). We compared clinical characteristics, such as sex, age, mean body mass index (BMI), preoperative diagnosis, tumor size, tumor location, and postoperative outcomes, including time to first flatus, time to first ambulation, time to Foley catheter removal, time to retroperitoneal drainage tube removal, postoperative pain score [Numeric Rating Scale (NRS)], length of hospital stay, total hospitalization costs, and postoperative complications between the two groups.</p><p><strong>Results: </strong>There were no significant differences in terms of clinical characteristics between the two groups. Compared to the control group, the 4N-ERAS group exhibited shorter times for first flatus, first ambulation, Foley catheter removal, retroperitoneal drainage tube removal, lower postoperative pain scores (NRS), and shorter hospital stays (P<0.05). Furthermore, compared to the control group, the total hospitalization cost was significantly lower in the 4N-ERAS group (P<0.05). There were no significant differences in terms of postoperative complications between the two groups (P=0.19).</p><p><strong>Conclusions: </strong>The 4N-ERAS protocol for retroperitoneal laparoscopic resection of adrenal tumors may expedite postoperative recovery, reduce pain, and lower overall hospital costs. This preliminary study demonstrated the safety and feasibility of the 4N-ERAS protocol for retroperitoneal laparoscopic resection of adrenal tumors, warranting future multicenter prospective, randomized, controlled trials in this field.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"696-706"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and prognosis of small cell carcinoma of the bladder: a single center retrospective analysis.","authors":"Zhaoyang Sheng, Maoyu Wang, Yang Xu, Jinshan Xu, Chen Zhang, Hui Zhang, Jinpeng Zhu, Shuxiong Zeng, Chuanliang Xu, Zhensheng Zhang","doi":"10.21037/tau-2024-645","DOIUrl":"https://doi.org/10.21037/tau-2024-645","url":null,"abstract":"<p><strong>Background: </strong>Small cell carcinoma of the bladder (SCCB) is a rare and aggressive subtype, usually diagnosed at advanced stages. Due to its rarity, the clinical features, prognostic factors, and treatment strategies are not well defined, and data on long-term outcomes are limited. This study aims to analyze the clinical characteristics, treatment options, and prognostic factors of SCCB to enhance clinical understanding and guide practice.</p><p><strong>Methods: </strong>A retrospective analysis of 41 SCCB cases treated at Changhai Hospital between 2006 and 2023 was conducted. Clinical, pathological, and treatment data were collected. The median follow-up duration was calculated as 41.0 months [95% confidence interval (CI): 31.3-50.7] using the reverse Kaplan-Meier method. Overall survival (OS) rates were estimated using the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to identify prognostic factors.</p><p><strong>Results: </strong>The median age was 71 years (range, 41-89 years). Pure SCCB accounted for 56.1% of cases, and 48.78% of tumors were located on the lateral bladder wall. Tumors ≥4 cm were found in 56.10% of cases. According to the tumor-node-metastasis (TNM) classification, 63.41% of patients underwent radical cystectomy, and 34.14% had lymph node or distant metastasis. None of the patients received neoadjuvant chemotherapy (NACT), while 41.03% underwent adjuvant chemotherapy post-surgery. The median OS was 30 months, with 1- and 3-year OS rates of 74.8% and 41.4%, respectively. Univariate analysis showed that T stage (P=0.002), lymph node metastasis (P<0.001), and distant metastasis (P<0.001) were associated with poor prognosis. Multivariate analysis confirmed T stage (P=0.04) and distant metastasis (P<0.001) as independent prognostic factors.</p><p><strong>Conclusions: </strong>SCCB is often diagnosed at a late stage with gross hematuria as the most common symptom, Neoadjuvant therapy and immunotherapy can extend OS. T stage and distant metastasis are critical prognostic factors. Early diagnosis and intervention are crucial for improving outcomes.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"529-539"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of perioperative and oncological outcomes between two different surgical procedures for the treatment of prostate cancer.","authors":"Takuya Koie, Keita Nakane, Koji Iinuma","doi":"10.21037/tau-2024-739","DOIUrl":"https://doi.org/10.21037/tau-2024-739","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"481-484"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}