Translational andrology and urology最新文献

{"title":"Tracking and analysis of testicular cancer burden in adolescents and young adults globally in Asia and in China: 1990-2021 epidemiological trends.","authors":"Shuhang Zhou, Yue Wu, Haoyue Ren, Xin Wang, Sile Cheng","doi":"10.21037/tau-2025-394","DOIUrl":"10.21037/tau-2025-394","url":null,"abstract":"<p><strong>Background: </strong>Testicular cancer (TC) is the most common malignancy among males aged 15-44 years and is rising in incidence, particularly in Asia and China. Despite improved survival rates, TC imposes a heavy economic and psychological burden. This study aims to analyze the trends in TC incidence, mortality, and the burden of disease across different regions and sociodemographic indices, and to forecast future trends.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease (GBD) study were used to analyze the age-standardized incidence rate (ASIR), age-standardized prevalence rate, mortality, and disability-adjusted life years. Joinpoint regression, decomposition analysis, and Nordpred models were used to assess the trends and forecasts.</p><p><strong>Results: </strong>In 2021, the global ASIR for TC in adolescents and young adults was 0.37 per 100,000, with 5,698 deaths and a decrease in the age-standardized death rates (annual percentage change in the age-specific death rate: -0.28). The incidence and prevalence increased in regions with a medium sociodemographic index (SDI) but decreased in regions with a high SDI. East Asia and Southeast Asia showed notable increases in incidence and prevalence, although mortality decreased.</p><p><strong>Conclusions: </strong>Epidemiological changes and population growth have contributed to the global increase in TC incidence, while advances in early diagnosis and treatment have reduced mortality. Projections suggest a continued rise in TC burden, particularly in China, emphasizing the need for enhanced prevention, early screening, and international collaboration in TC research and healthcare.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2075-2088"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new surgical method of vasoepididymostomy for epididymal obstructive azoospermia to improve the success rate in the rat.","authors":"Quanfa Tian, Jinjie Li, Xiaolong Fan, Liling Yao, Shanshan Xia, Zhihua Wu, Jingxiao Zhang, Yaoqiang Ren, Xiaofan Han, Xiaozhen Wang","doi":"10.21037/tau-2025-91","DOIUrl":"10.21037/tau-2025-91","url":null,"abstract":"<p><strong>Background: </strong>Two-suture longitudinal intussusception vasoepididymostomy (LIVE) surgery has been confirmed by many studies in the treatment of epididymal obstruction; however, the success rate and anastomotic patency rate are not high, which cannot meet the modern human demand for a cure rate for this disease. Based on our preliminary research, we have reason to speculate that the new 2-suture circular intussusception vasoepididymostomy (CIVE) surgery group can greatly improve the anastomosis rate and success rate of treating epididymal obstruction patients. LIVE has become the preferred technique for epididymal and vas deferens anastomosis in North America, Europe, and globally for 22 years. Compared with LIVE, CIVE can greatly improve the anastomosis and success rate of treating epididymal obstruction patients. The aim of this study is to make CIVE the preferred technique for treating epididymal obstruction in North America, Europe, and globally. CIVE ultimately benefits more patients.</p><p><strong>Methods: </strong>Thirty-three male rats (type: Sprague-Dawley, SD) were randomly divided into control (group I) and experimental groups (groups II and III). After 3 weeks of epididymal obstruction, bilateral vasoepididymostomy was performed. In group II, the epididymal tubules (the epididymal tubules, which were cut into circular incisions) were punctured and lifted with a suture under a microscope, the vas deferens was incised obliquely at 45° for CIVE. In group III: LIVE was performed. After 3 months, patency was assessed in a blinded manner.</p><p><strong>Results: </strong>The rates of functional patency (presence of motile sperm in the vas deferens) were 90.9% and 63.6% in groups II and III, respectively (single-tailed test, P=0.042). On retrograde methylene blue vasography of the epididymis, the mechanical patency rate was similar to the functional patency rate. The incidence of sperm granulomas in postoperative groups II and III was 0% and 18.2%, respectively, with a single-tailed test P value of 0.24. Due to insufficient sample size, the sample size can be expanded for further verification in the later stage.</p><p><strong>Conclusions: </strong>Compared with LIVE, CIVE at a 45° oblique incision of the vas deferens provides a larger anastomotic area and has a higher recanalization rate, which is worthy of further investigation. The aim of this study is to propose a new surgical approach called 'CIVE'. By expanding the anastomotic area to reduce the risk of traditional surgical failure, the ultimate goal is to provide patients with safer and more efficient treatment options.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1874-1881"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between body fat distribution and female stress urinary incontinence: a cross-sectional study with the NHANES 2011-2018.","authors":"Huilin Liu, Beibei Li, Hao Tan, Hang Yang, Mingyang Hu, Qing Li, Jian Cai","doi":"10.21037/tau-2025-166","DOIUrl":"10.21037/tau-2025-166","url":null,"abstract":"<p><strong>Background: </strong>The android to gynoid ratio (A/G ratio) reflects the distribution of abdominal fat relative to gluteofemoral fat and may affect stress urinary incontinence (SUI) by increasing pelvic floor load due to elevated intra-abdominal pressure. However, its direct relationship with SUI remains uncertain. The aim of this study was to explore whether a higher A/G ratio is linked to increased SUI prevalence in American women aged ≥20 years.</p><p><strong>Methods: </strong>This cross-sectional analysis used data from 5,309 women aged ≥20 years in the 2011-2018 National Health and Nutrition Examination Survey (NHANES). The A/G ratio was assessed using dual-energy X-ray absorptiometry (DXA). Weighted multivariable logistic regression was applied to examine the association between the A/G ratio and SUI in women. Subgroup analyses based on smoking status, hypertension, diabetes, hypercholesterolemia, vigorous physical activity, moderate physical activity, vaginal delivery, cesarean section, menopausal status, and body mass index (BMI) were conducted to assess effect modification. Restricted cubic splines (RCS) and receiver operating characteristic (ROC) curve were employed to analyze nonlinear relationships and predictive accuracy, respectively.</p><p><strong>Results: </strong>Among the 5,309 participants, 1,958 reported experiencing SUI. After adjusting for covariates, a higher A/G ratio was independently associated with increased SUI risk [odds ratio (OR) =3.640, 95% confidence interval (CI): 2.150-6.162]. The number of vaginal deliveries, cesarean deliveries, and BMI subgroups may interact with the A/G ratio (P<0.05). In the smoking status subgroup, significant positive associations between the A/G ratio and SUI were observed in both never-smokers (OR =3.611, 95% CI: 1.739-7.497) and current-smokers (OR =4.720, 95% CI: 1.311-16.997), indicating that a higher A/G ratios correlates with increased SUI risk in these two subgroups. In the vigorous activity subgroup, a significant positive association between the A/G ratio and SUI prevalence in the on-vigorous activity group (OR =4.752, 95% CI: 2.386-9.506). RCS analysis showed a linear association between the A/G ratio and SUI (P for nonlinearity =0.25). ROC curve analysis yielded an area under the curve (AUC) of 0.758 for the A/G ratio in predicting SUI.</p><p><strong>Conclusions: </strong>The A/G ratio is a risk factor for SUI in women aged ≥20 years, suggesting its potential utility in clinical risk stratification.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1935-1946"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The RNA helicase DDX17 enhances androgen receptor stability by interacting with the E3 ubiquitin ligase SPOP in prostate cancer.","authors":"Maierhaba Maheremu, Bowen Zheng, Haoran Wen, Qiang Wei, Shidong Lv","doi":"10.21037/tau-2025-167","DOIUrl":"10.21037/tau-2025-167","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) is a common malignancy in men, closely associated with androgen receptor (AR) signaling, and often diagnosed with elevated prostate-specific antigen (PSA). While androgen deprivation therapy (ADT) is effective, resistance develops due to reactivation of AR signaling, driving disease progression. We aimed to explore the role of DDX17 in the progression of PCa through its interaction with SPOP. We hypothesized that DDX17 can stabilize the AR by inhibiting SPOP-mediated ubiquitination, thereby maintaining AR signaling which supports tumor growth and survival.</p><p><strong>Methods: </strong>We collected gene expression data and clinical information from PCa patients from The Cancer Genome Atlas and Gene Expression Omnibus databases. Messenger RNA (mRNA) and protein levels were quantified using quantitative real-time polymerase chain reaction (PCR) and western blotting, respectively. Cell viability and invasion capabilities were assessed using cell counting kit-8 (CCK-8) and transwell invasion assays. The interactions between DDX17 and SPOP were examined through coimmunoprecipitation assays.</p><p><strong>Results: </strong>DDX17 exhibited high expression in both PCa tissues and cells. Silencing DDX17 led to reduced proliferation and invasion of PCa cells. Mechanistic investigations revealed that DDX17 directly interacted with SPOP, sustaining AR stability by preventing AR ubiquitination. These findings suggest a role of DDX17 in promoting the progression of PCa by binding and blocking SPOP ubiquitination of AR.</p><p><strong>Conclusions: </strong>This study elucidated a novel mechanism through which the RNA helicase DDX17 can promote PCa progression through its interaction with SPOP, thereby enhancing AR stability by inhibiting AR ubiquitination.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1978-1989"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling SNX10: a key player in bladder cancer progression.","authors":"Fan Yang, Kang Qiu, Jianhua Deng","doi":"10.21037/tau-2025-169","DOIUrl":"10.21037/tau-2025-169","url":null,"abstract":"<p><strong>Background: </strong>Bladder cancer (BC) ranks as the tenth most common cancer globally, posing a substantial public health burden. Its incidence exhibits marked geographic and demographic variations, emphasizing the need for tailored research and therapeutic approaches. Current strategies prioritize inhibiting BC cell proliferation and invasion to improve survival outcomes. In this study, analysis of 408 BC samples revealed sorting nexin 10 (<i>SNX10</i>) as a key differentially expressed gene. While <i>SNX10</i> has been implicated in nutrient metabolism, particularly in lipid and bone metabolism, its mechanistic role in BC progression remains poorly defined.</p><p><strong>Methods: </strong>To investigate <i>SNX10</i>'s function, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)-mediated knockdown was performed in BC cell lines (T24 and UMUC3), followed by phenotypic evaluation. A mouse xenograft model was utilized to assess tumor growth under low <i>SNX10</i> expression. Functional assays, including proliferation, migration, and invasion tests, were conducted alongside quantitative polymerase chain reaction (qPCR) and Western blot analyses. RNA sequencing (RNA-seq) and Western blot were employed to identify downstream targets and pathways regulated by <i>SNX10</i>, with <i>MYBL2</i> emerging as a candidate gene.</p><p><strong>Results: </strong><i>SNX10</i> knockdown significantly suppressed BC cell proliferation, migration, and invasion (P<0.05). <i>In vivo</i>, tumors with reduced <i>SNX10</i> expression exhibited a 40-50% decrease in volume and weight compared to controls (P<0.01). Mechanistic studies linked <i>SNX10</i> to <i>MYBL2</i>, an oncogene that regulates cell cycle progression and transcriptional activity. RNA-seq data demonstrated that silencing <i>SNX10</i> downregulated <i>MYBL2</i> and associated signaling pathways (e.g., PI3K/AKT, MAPK), corroborated by reduced MYBL2 protein levels via Western blot.</p><p><strong>Conclusions: </strong>This study identifies <i>SNX10</i> as a pivotal oncogene in BC, driving tumor progression through <i>MYBL2</i>-dependent pathways. Suppression of <i>SNX10</i> markedly attenuates malignant behaviors and tumor growth, highlighting the therapeutic potential of targeting the <i>SNX10-MYBL2</i> axis. These findings deepen the current understanding of BC pathogenesis and provide a foundation for metabolism-targeted therapies. Further research is warranted on <i>SNX10</i>'s role in the tumor microenvironment (TME) and its clinical translatability.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1912-1924"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic segmentation of clear cell renal cell carcinoma based on deep learning and a preliminary exploration of the tumor microenvironment.","authors":"Hong Tang, Haibin Zhao, Shaoqing Yu, Yang Wang, Jinzhu Su, Xiaodong Wang, Benjamin N Schmeusser, Łukasz Zapała, Guanzhen Yu, Ninghan Feng","doi":"10.21037/tau-2025-400","DOIUrl":"10.21037/tau-2025-400","url":null,"abstract":"<p><strong>Background: </strong>Whole-slide imaging (WSI) is increasingly becoming a standard method for diagnosing clear cell renal cell carcinoma (ccRCC). This advanced imaging technique allows for high-resolution examination of tissue sections, improving diagnosis and management of renal cancers. Immunotherapy has emerged as an effective treatment for tumors; however, the differential characteristics of the tumor microenvironment (TME) significantly influence therapeutic outcomes. Understanding the interactions between cancer cells and the TME is essential for optimizing immunotherapeutic strategies. This study aims to investigate the characteristics of the TME in ccRCC using WSI, with the goal of identifying factors that might influence immunotherapy response and improving therapeutic strategies.</p><p><strong>Methods: </strong>In this study, we proposed a novel method for the automatic segmentation of ccRCC regions based on deep-learning techniques. This method uses advanced convolutional neural networks to effectively distinguish between tumor areas (TAs) and surrounding tissues. Additionally, we employed inverse threshold segmentation to quantitatively analyze the results and spatial distributions of lymphocytes and collagen fibers in immunohistochemical and Masson's trichrome-stained images. This comprehensive approach not only streamlines the diagnostic process but also enhances the precision of histopathological assessments.</p><p><strong>Results: </strong>Our model had a classification accuracy of 96.67% on image patches and a sensitivity of 94.29%, demonstrating its ability to segment TAs both accurately and efficiently. The distribution of cluster of differentiation (CD)3⁺ and CD8⁺ T lymphocytes, and collagen fibers in patients at different tumor-node-metastasis (TNM) stages was analyzed. The results revealed that a high infiltration of CD3⁺ T cells, particularly CD8⁺ cytotoxic T cells, was more prevalent in patients with advanced-stage tumors. Additionally, the proliferation of collagen fibers in tumors was found to be significantly correlated with tumor growth and metastasis.</p><p><strong>Conclusions: </strong>Our results underscore the potential of artificial intelligence (AI) technology to provide novel insights to guide ccRCC immunotherapy. By applying deep learning to tumor segmentation and TME analysis, this methodology offers a promising approach to improve the understanding of tumor biology and therapeutic outcomes. Future research should focus on integrating these findings into clinical practice to optimize patient-specific immunotherapeutic strategies, and thus advance treatment protocols and improve the survival rates of ccRCC patients.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2059-2074"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in erectile dysfunction treatment research: a narrative review.","authors":"Wen-Jie Yao, Jian-Tong Dong, Tian-Pei Jiang, Jin-Na Nie","doi":"10.21037/tau-2025-193","DOIUrl":"10.21037/tau-2025-193","url":null,"abstract":"<p><strong>Background and objective: </strong>Erectile dysfunction (ED) is one of the common diseases in middle-aged and older men, and its etiology mainly includes vascular diseases, neurological diseases, metabolic disorders, and psychological factors. This review takes the physiological mechanisms of penile erection as a starting point and provides an in-depth look at the major current treatments, which include phosphodiesterase type 5 (PDE5) inhibitors, gene therapy techniques, low-intensity extracorporeal shock wave therapy (Li-ESWT), low-intensity pulsed ultrasound therapy (LIPUS), and psychological treatments. The review further provides a critical analysis and summary of the advantages and limitations associated with each treatment approach. Finally, the article discusses the future directions of ED treatment, emphasizing the importance of integrating personalized and precision medicine principles into treatment planning to identify the most appropriate therapeutic strategy for each patient.</p><p><strong>Methods: </strong>We conducted literature searches on academic platforms such as PubMed, Google Scholar, and Web of Science using the terms \"erectile dysfunction\", \"stem cells\", \"low-intensity extracorporeal shock wave\", \"low-intensity pulsed ultrasound\", \"PDE5 inhibitors\", \"gene therapy\", \"penile prosthesis implantation\", and \"psychosexual therapy\" collecting literature published from January 1990 to October 2024.</p><p><strong>Key content and findings: </strong>The incidence of ED is showing a trend of becoming more widespread and affecting younger people. We have identified the main risk factors that cause ED, which include psychological disorders, hypertension, cardiovascular diseases (CVDs), and unhealthy lifestyles. On this basis, this study comprehensively reviews the latest research progress of traditional treatment methods and emerging treatment approaches, and analyzes their respective advantages and limitations.</p><p><strong>Conclusions: </strong>As ED treatment technologies continue to advance, the erectile function of numerous patients has seen significant improvement. Looking at the future development trend, combined treatment is expected to become the mainstream strategy for treating ED, and the treatment methods for this condition will gradually move towards personalization and precision.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2106-2117"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of omental covering technique in robot-assisted lingual mucosa graft ureteroplasty.","authors":"Yuancheng Zhou, Manshun Dong, Shuaishuai Chai, Kangxiang Xu, Ruoyu Li, Chaoqi Liang, Xingyuan Xiao, Bing Li","doi":"10.21037/tau-2025-206","DOIUrl":"10.21037/tau-2025-206","url":null,"abstract":"<p><strong>Background: </strong>Omentum has a wide application value in ureteroplasty, however, some specific situations limit its clinical application. Therefore, we modified the application method of omentum and proposed a new method named omental covering (OC) technique. This study aims to systematically evaluate the safety and efficacy of OC technique in robot-assisted lingual mucosa graft ureteroplasty (RA-LMGU).</p><p><strong>Methods: </strong>We conducted a retrospective analysis of data from 79 patients who underwent RA-LMGU between June 2021 and October 2024 at two hospitals. Patients were divided into two groups according to the method of omental application: the omental wrapping (OW) group and the OC group. Perioperative and follow-up data were collected.</p><p><strong>Results: </strong>A total of 79 patients were included, with 24 in the OW group and 55 in the OC group. The median ureteral stricture length was 4.3 [interquartile range (IQR), 3.7, 6.0] cm in the OW group and 3.0 (IQR, 2.1, 4.0) cm in the OC group (P<0.001). The median operative time was 181 (IQR, 139, 217) min in the OW group and 150 (IQR, 110, 198) min in the OC group (P=0.06). The median postoperative stay was 7 (IQR, 7, 8) days in the OW group and 6 (IQR, 5, 7) days in the OC group (P<0.001). The median follow-up time was 32 (IQR, 26, 39) months in the OW group and 11 (IQR, 4, 16) months in the OC group (P<0.001). It is worth noting that both groups achieved a 100% surgical success rate.</p><p><strong>Conclusions: </strong>These short-term follow-up results demonstrated that the OC technique is also safe and effective in ureteral repair and reconstruction using lingual mucosa graft and it can reduce postoperative stay.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1865-1873"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analgesic efficacy of erector spinae plane block versus quadratus lumborum block in laparoscopic renal cancer surgery: a double-blind randomized trial.","authors":"Meng Zhang, Shuchuan Zhao, Siyuan Song, Huixian Zhou, Mingfang Li, Peng Su, Guangmin Xu","doi":"10.21037/tau-2025-71","DOIUrl":"10.21037/tau-2025-71","url":null,"abstract":"<p><strong>Background: </strong>Ultrasound-guided erector spinae plane block (ESPB) and quadratus lumborum block (QLB) are increasingly used for perioperative analgesia. However, their comparative efficacy, opioid-sparing effects, and impact on recovery outcomes in patients undergoing laparoscopic renal cancer resection remain unclear. This study aimed to directly compare the analgesic effectiveness and recovery benefits of ESPB versus QLB in this surgical population.</p><p><strong>Methods: </strong>In this randomized, double-blind trial, 54 patients scheduled for laparoscopic nephrectomy were allocated to receive either ESPB or QLB with 25 mL of 0.4% ropivacaine under ultrasound guidance. Postoperative analgesia was managed using morphine-based patient-controlled analgesia. The primary outcome was cumulative morphine consumption within 6 hours postoperatively. Secondary outcomes included pain scores, morphine pump activations, the 15-item Quality of Recovery scale (QoR-15) scores, and length of hospital stay.</p><p><strong>Results: </strong>Patients receiving ESPB had significantly lower morphine consumption during the first 6 hours postoperatively compared to those receiving QLB (4.11±4.05 <i>vs.</i> 6.63±4.61 mg, P<0.05). ESPB was also associated with lower early pain scores, fewer morphine pump activations, higher QoR-15 scores at 24 and 48 hours, and shorter hospitalization (P<0.05 for all). No block-related complications were observed in either group.</p><p><strong>Conclusions: </strong>Compared with QLB, ESPB may provide more effective early postoperative analgesia and enhanced recovery in patients undergoing laparoscopic renal cancer surgery. These findings suggest that ESPB may be a valuable option for perioperative pain management in laparoscopic nephrectomy; however, as an exploratory study with limited sample size, further validation in larger populations is necessary.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR2300074743.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2029-2042"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term testosterone pellet insertion in women with low libido shows no evidence of erythrocytosis and a minimal side effect profile.","authors":"Beatriz S Hernandez, Gal Saffati, Katherine A Lowrey, Amit Reddy, Bridget S Park, Jeffrey J Song, Gabrielle Lyon, Mohit Khera","doi":"10.21037/tau-2025-51","DOIUrl":"10.21037/tau-2025-51","url":null,"abstract":"<p><strong>Background: </strong>Testosterone therapy for low libido in women has become increasingly prevalent in recent years. While numerous testosterone formulations exist and have been studied in women, there has been little data assessing the safety and efficacy of subcutaneous testosterone pellet use in this population. The primary objective of this study is to understand the biochemical effects and side effect profile of female patients who underwent testosterone pellet insertion in a clinical practice.</p><p><strong>Methods: </strong>A retrospective chart review of female patients who underwent testosterone pellet insertion from 2009 to 2022 was undertaken. Women taking 75 and 100 mg testosterone pellets were identified and analyzed for biochemical and clinical data. Analysis of variance was performed to determine statistical significance of laboratory values over duration of testosterone pellet insertion.</p><p><strong>Results: </strong>A total of 220 pellet insertions were performed across the two cohorts. The administration of 75 mg testosterone pellets did not result in a significant change in trough testosterone levels (P=0.51) compared to baseline throughout the treatment period, nor did it significantly affect hematocrit levels (P=0.96) or systolic blood pressure (SBP) (P=0.87). Two patients (10.5%) reported genitourinary side effects during the study period. In the cohort receiving 100 mg testosterone pellets, a significant increase in testosterone levels was observed over the study period (P=0.01), with no significant changes in hematocrit (P=0.78) or SBP (P=0.70). Two patients in this group were initiated on new antihypertensive medications during the course of treatment. No adverse effects were reported.</p><p><strong>Conclusions: </strong>Testosterone pellets of 100 mg result in a statistically significant increase in testosterone levels. Neither the 75 nor 100 mg doses led to a significant increase in erythrocytosis or SBP. Additionally, both dosages are associated with minimal side effects. These findings suggest that regulated testosterone pellet administration offers a safe biochemical profile for women with low libido.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1842-1848"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}