Hua Wang, Tian Xia, Chutian Xiao, Houhe Li, Xionglong He, Yuming Qiao, Meinong Zhong, Dejuan Wang, Ke Li
{"title":"An assisted suspension fixation technique in transperitoneal laparoscopic pyeloplasty for infants and young children with ureteropelvic junction obstruction: a retrospective cohort study.","authors":"Hua Wang, Tian Xia, Chutian Xiao, Houhe Li, Xionglong He, Yuming Qiao, Meinong Zhong, Dejuan Wang, Ke Li","doi":"10.21037/tau-2024-722","DOIUrl":"https://doi.org/10.21037/tau-2024-722","url":null,"abstract":"<p><strong>Background: </strong>Anderson-Hynes pyeloplasty is a classic and highly effective technique for treating congenital ureteropelvic junction obstruction (UPJO). Laparoscopic minimally invasive surgery (MIS) has become the preferred approach for infants and young children. However, a small working area and the complexity of reconstruction procedure pose significant challenges. This study aims to evaluate the efficacy and safety of four-point suspension fixation technique in laparoscopic dismembered pyeloplasty (LDP) for infants and young children with UPJO.</p><p><strong>Methods: </strong>This retrospective cohort enrolled 37 infants and young children diagnosed with UPJO and underwent transperitoneal LDP between 2014 and 2020. The 37 cases were divided into two Groups based on whether suspension fixation was applied during the transperitoneal LDP. Clinical characteristics and follow-up data of these cohorts were retrospectively collected and analyzed. Continuous variables with a normal distribution were expressed as mean ± standard deviation (SD) and analyzed using independent sample <i>t</i>-tests. Non-normally distributed continuous variables were reported as interquartile range (IQR) and analyzed with the Mann-Whitney <i>U</i>-test.</p><p><strong>Results: </strong>In Group A, 21 cases underwent conventional LDP without suspension fixation, while in Group B, 16 cases underwent \"suspension fixation\" LDP. The operative time (237.9±63.0 <i>vs.</i> 186.4±52.3 min, P=0.01), anastomotic suturing completion time (125.2±21.6 <i>vs.</i> 75.9±12.1 min, P<0.001), and postoperative hospital stay duration [6.0 (4.0, 7.5) <i>vs.</i> 4.5 (3.0, 6.5) days, P=0.04] were significantly shorter in Group B than in Group A, and the intraoperative blood loss [15.0 (5.0, 21.0) <i>vs.</i> 7.5 (5.0, 10.8) mL, P=0.04] in Group B was significantly lower than that in Group A. There were no significant differences between the two Groups in preoperative and anteroposterior renal pelvic diameter (APD), postoperative days to drainage tube removal, and postoperative days to removal of double J (D-J) sent. In Group A, one case developed anastomotic stenosis during follow-up, which improved after ureteral balloon dilation. In Group B, one case developed recurrent febrile urinary tract infection (UTI) within two months of D-J stent removal and was ultimately cured with antibiotic treatment during follow-up. The success rates were 95.2% (20/21) in Group A and 93.8% (15/16) in Group B. Other cases who were followed up showed no recurrence of stenosis, urine leakage, or recurrent UTI.</p><p><strong>Conclusions: </strong>The use of assisted suspension fixation in transperitoneal LDP is safe and efficient for infants and young children, helping to reduce operative time, overcome the small laparoscopic operating area, and address the steep learning curve, making it a valuable approach.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"820-830"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yingxin Wang, Jiaqian Wu, Tenghao Shao, Xiaoxu Ding, Yukun Tian, Ning Li
{"title":"Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database.","authors":"Yingxin Wang, Jiaqian Wu, Tenghao Shao, Xiaoxu Ding, Yukun Tian, Ning Li","doi":"10.21037/tau-24-620","DOIUrl":"https://doi.org/10.21037/tau-24-620","url":null,"abstract":"<p><strong>Background: </strong>Fluid resuscitation is a standard intervention for patients with sepsis, however, the ideal timing for initiating fluid deresuscitation has not been well established. This study examines the prognostic impact of early versus delayed initiation of loop diuretics in patients with sepsis.</p><p><strong>Methods: </strong>Data for this analysis were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients diagnosed with sepsis were categorized into two groups based on the timing of loop diuretic administration: an early group (within 48 hours of diagnosis) and a late group (after 96 hours).</p><p><strong>Results: </strong>A total of 8,518 patients with sepsis were included in this study. Of these, 4,485 patients received loop diuretics within the first 48 hours (early group), while the remaining 4,033 patients received loop diuretics after 96 hours (late group). In the early group, 75% of patients required mechanical ventilation, which was significantly lower than the 85.6% in the late group (P<0.001). However, the early group demonstrated a significantly higher 28-day mortality rate compared to the late group (832/4,485 <i>vs.</i> 679/4,033, P=0.03). Cox regression analysis indicated that the early initiation of diuretics was associated with an increased 28-day mortality rate [hazard ratio (HR) =2.590, 95% confidence interval (CI): 2.325-2.884, P<0.001]. After adjusting for the proportional hazards assumption, the corrected HR was recalculated as exp[3.55-1.20 × ln(t)]. Propensity score matching (PSM) resulted in two well-matched groups of 1,882 patients each. Post-matching analysis revealed that the early group continued to exhibit significantly higher 28-day and in-hospital mortality (P<0.001) along with a significantly higher incidence of stage 3 acute kidney injury (AKI) (8.1% <i>vs.</i> 5.7%, P=0.004).</p><p><strong>Conclusions: </strong>While complete adjustment for all potential confounding factors was not possible, the findings suggest that patients who received loop diuretics within 48 hours had more severe kidney injury and a significantly higher mortality rate compared to those who received later administration (after 96 hours). These findings underscore the need for careful consideration when determining the timing of loop diuretic initiation in clinical practice.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"779-790"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiangen Liu, Yujuan Qi, Tao Zhu, Xiaoyue Ding, Dianshuang Zhou, Conghui Han
{"title":"Butyrate improves testicular spermatogenic dysfunction induced by a high-fat diet.","authors":"Xiangen Liu, Yujuan Qi, Tao Zhu, Xiaoyue Ding, Dianshuang Zhou, Conghui Han","doi":"10.21037/tau-2024-660","DOIUrl":"https://doi.org/10.21037/tau-2024-660","url":null,"abstract":"<p><strong>Background: </strong>Obesity is closely associated with low male fertility and decreased sperm quality. Obesity is accompanied by an ecological imbalance in the gut microbiota, so it is of great significance to intervene in male infertility caused by obesity from the perspective of gut microbiota metabolites. This study aimed to evaluate the efficacy of butyrate in ameliorating obesity-induced spermatogenic dysfunction and to explore the potential molecular mechanisms.</p><p><strong>Methods: </strong>This study explored the role of butyrate in recovering the dysfunctions of spermatogenesis caused by obesity by inducing an obese model of male mice with a high-fat diet (HFD). The effects of HFD and butyrate on testicular function were explored based on metabolomics.</p><p><strong>Results: </strong>The results of the study showed that HFD caused a decrease in sperm count, a decrease in sperm motility, and an increase in sperm malformation rate in mice. After adding butyrate to the HFD, the various sperm indicators of mice were significantly improved. Through the analysis of metabolomics data from mouse testes, this study found that an HFD significantly altered the metabolic status of mice testes, involving multiple metabolic pathways. However, after adding butyrate, some metabolic characteristics tended to be similar to those of normal diet mice, and the steroid biosynthesis and primary bile acid biosynthesis pathways were significantly improved.</p><p><strong>Conclusions: </strong>This study clarified the effect of butyrate on improving sperm quality, providing experimental evidence for the treatment of obesity-induced abnormal spermatogenesis with butyrate.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"627-636"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaifu Wu, Yun Hu, Yuanliang Xie, Shutong Zhang, Xiang Wang
{"title":"Zinner syndrome in adult male: a rare case report.","authors":"Kaifu Wu, Yun Hu, Yuanliang Xie, Shutong Zhang, Xiang Wang","doi":"10.21037/tau-2024-763","DOIUrl":"https://doi.org/10.21037/tau-2024-763","url":null,"abstract":"<p><strong>Background: </strong>Zinner syndrome (ZS) is an extremely rare congenital genitourinary disease. Its typical triad consists of seminal vesicle cysts, ejaculatory duct obstruction, and ipsilateral renal agenesis or hypoplasia. At present, the exact pathogenesis of ZS remains a mystery. It is hypothesized that ZS might be associated with aberrations that occur during the intricate process of embryonic development.</p><p><strong>Case description: </strong>A 40-year-old male presented to the hospital with a chief complaint of experiencing dysuria for 5 consecutive days, accompanied by frequent urination and urgency. Through comprehensive imaging and laboratory examinations, he was diagnosed with ZS. Subsequently, laparoscopic left seminal vesicle cystectomy was successfully carried out. Postoperative pathology revealed the existence of inflammatory infiltration in the wall of the seminal vesicle cyst. The patient recovered smoothly and was discharged without complications. No signs of recurrence were detected during the 6-month follow-up.</p><p><strong>Conclusions: </strong>Ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) examinations are crucial for accurately diagnosing ZS. These imaging techniques offer detailed anatomical information, helping identify features like seminal vesicle cysts and renal anomalies. Acute seminal vesicle cyst infection accompanied by ipsilateral renal agenesis and ureteral developmental malformations is recognized as a clinical manifestation of ZS. Laparoscopic seminal vesicle cystectomy is safe and effective.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"848-854"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qijie Zhang, Xianhua Shao, Yuanchen Lu, Junpeng Deng, Tengyue Zeng, Hongliang Que, Yi Sun, Zhongru Fan, Quan Li, Luwei Xu, Jianjun Xie
{"title":"Prone versus lateral retroperitoneoscopic partial nephrectomy for posterior tumors in adults: technique and clinical outcomes.","authors":"Qijie Zhang, Xianhua Shao, Yuanchen Lu, Junpeng Deng, Tengyue Zeng, Hongliang Que, Yi Sun, Zhongru Fan, Quan Li, Luwei Xu, Jianjun Xie","doi":"10.21037/tau-2024-735","DOIUrl":"https://doi.org/10.21037/tau-2024-735","url":null,"abstract":"<p><strong>Background: </strong>Very limited information is available about the prone retroperitoneoscopic partial nephrectomy (RPN) in adults. This study aimed to evaluate the feasibility and clinical outcomes of prone RPN for posterior tumors in comparison with traditional lateral RPN in adults.</p><p><strong>Methods: </strong>The recordings of 101 patients underwent RPN from January 2018 to March 2023 were retrospectively reviewed. Fifty-nine patients underwent surgeries with lateral RPN, and 42 underwent surgeries with prone RPN. Operative time, warm ischemia time, blood loss, renal function, operative complications, and arterial blood gas analysis were recorded and compared between the two groups. Additionally, a dorsal deviation score (DDS) was developed to quantitate the degree to which the tumor was dorsal, which helped to select a suitable operative approach clinically.</p><p><strong>Results: </strong>Patients in prone RPN group had shorter operative time (P<0.001), warm ischemia time (P=0.003), and less blood loss (P=0.03) in comparison with lateral RPN. In arterial blood gas analysis, no significant differences in arterial partial pressure of carbon dioxide (PaCO<sub>2</sub>), arterial partial pressure of oxygen (PaO<sub>2</sub>), and pH were observed between two groups before the operation and 30 min after positioning. For slightly posterior tumors (DDS =1), no significant difference in above parameters was observed. However, shorter operative time (P=0.03, P<0.001, respectively), warm ischemia time (P=0.02, P=0.03, respectively), and less blood loss (P=0.08, P=0.043, respectively) were noticed in prone RPN for moderate or severe posterior (DDS =2 or 3) tumors, especially posterior hilar tumors. Difference in renal function between two groups was insignificant. As for complications, a higher incidence of intraoperative complications appeared in lateral RPN group (11.9%) compared with prone RPN (2.4%), whereas there was no significant difference in postoperative complications.</p><p><strong>Conclusions: </strong>Prone RPN is a feasible operative approach in clinical practice, and is superior to lateral RPN for moderate to severe posterior tumors, especially posterior hilar tumors.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"567-577"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jenna Bates Maffei, Jeffrey J Song, Gal Saffati, Mohit Khera
{"title":"Video discharge instructions increase patient understanding for office-based procedures: a randomized controlled study.","authors":"Jenna Bates Maffei, Jeffrey J Song, Gal Saffati, Mohit Khera","doi":"10.21037/tau-24-501","DOIUrl":"https://doi.org/10.21037/tau-24-501","url":null,"abstract":"<p><strong>Background: </strong>Health literacy significantly influences healthcare outcomes, with poor literacy leading to worse quality of life, increased mortality, and higher readmission rates. Recent efforts to improve post-encounter education include structured teach-back methods, patient preference assessments, and standardized discharge instructions. Studies in emergency departments have shown that incorporating video discharge instructions enhances patient understanding and retention of care information. To address the gap in urology, this study aims to evaluate patient comprehension and satisfaction with video discharge instructions following clinic-based vasectomy procedures.</p><p><strong>Methods: </strong>We performed an Institutional Review Board approved (#H-51614) unblinded randomized controlled study with written consent from each participant. All men undergoing vasectomy from August to September 2022 in our outpatient clinic were included in our study. Patients were randomized to receive either video or written discharge instructions. A standardized questionnaire was administered containing objective comprehension questions regarding the discharge instructions they received. Patients were also queried on their preference of discharge instruction format and subjective Likert-scale of information usefulness and format understandability.</p><p><strong>Results: </strong>Each cohort contained 11 men. There was no difference in age or educational level between the groups (P=0.91, 0.38, respectively). The video cohort exhibited increased comprehension scores (P<0.001). There was no difference between cohorts in ratings of information helpfulness and instruction understandability (P=0.48, 0.06, respectively). Approximately 73% of men in the video group preferred to receive both video and written instructions while 73% patients in the written cohort preferred to receive only written instructions (P<0.001).</p><p><strong>Conclusions: </strong>Use of video discharge instructions significantly improved objective comprehension with similar perceptions of information helpfulness and understandability. Patients who received video discharge instructions were more likely to prefer receiving both written and video instructions than those who received written instructions. Overall, these findings support the utility of video discharge instructions in a urologic setting.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"678-684"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hao-Yang Lu, Rong-Hao Zhang, Xi Wen, Yi Wang, Ke-Qiu Wu, Zhong-Lai Li, Du Geon Moon, Wei-Fan Jiang
{"title":"Video platforms and sexual healthcare in China: assessment of content on premature ejaculation.","authors":"Hao-Yang Lu, Rong-Hao Zhang, Xi Wen, Yi Wang, Ke-Qiu Wu, Zhong-Lai Li, Du Geon Moon, Wei-Fan Jiang","doi":"10.21037/tau-2025-104","DOIUrl":"https://doi.org/10.21037/tau-2025-104","url":null,"abstract":"<p><strong>Background: </strong>Premature ejaculation (PE) is among the most commonly reported types of sexual dysfunction both globally and in China. Despite the growing popularity of online healthcare services and the greater availability of information in mainland China, there is a pressing need to assess the quality and reliability of PE-related content available online and address the potential impact of online misinformation. Thus, in this study, we assessed the quality of information regarding PE videos on the top video websites in China.</p><p><strong>Methods: </strong>The top 10 video platforms in mainland China were searched using PE-related keywords for videos published as of July 2023. All available videos were examined for eligibility and reliability, and two reviewers independently evaluated the videos using Global Quality Score (GQS) scores for quality and DISCERN tools for their content reliability. All data were analyzed with SPSS software (IBM Corp.).</p><p><strong>Results: </strong>Information on sexual medicine content related to PE was found to be available on just seven of the websites examined. From the 1,468 videos initially retrieved, 582 met the inclusion criteria. Of these, 319 videos (54.81%) were deemed reliable, while 263 (45.19%) were classified as unreliable. The agreement between the two urologists reviewing the videos and the intraclass correlation coefficient (ICC) were deemed acceptable. There were significant differences in the quality, reliability, source, presentation format, and themes of the videos.</p><p><strong>Conclusions: </strong>The quality of resources on Chinese video platforms varies widely. Users seeking PE-related information should carefully select the appropriate platforms and opt for higher-quality videos. The existing participation of professional medical personnel was seen as insufficient, and joint efforts are needed to implement content review and the establishment of an evaluation framework.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"729-739"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Basil Razi, Kevin Zhuo, Dane Cole-Clark, Amanda Chung
{"title":"The underappreciated underactive bladder.","authors":"Basil Razi, Kevin Zhuo, Dane Cole-Clark, Amanda Chung","doi":"10.21037/tau-2025-61","DOIUrl":"https://doi.org/10.21037/tau-2025-61","url":null,"abstract":"<p><p>Slow urinary flow is a common lower urinary tract symptom (LUTS) that frequently prompts men to consult their primary care physician. While bladder outlet obstruction (BOO) is well recognised, underactive bladder (UAB) remains underappreciate despite its significant impact on quality of life. This review highlights the pathophysiology, clinical features, and diagnostic challenges and approach to UAB in men. Improving recognition of UAB as a distinct condition separate from other LUTS aetiologies, it can facilitate earlier diagnosis and management. Slow urinary flow is highly prevalent, particularly in an ageing population. UAB is characterised by impaired detrusor muscle activity, leading to slow urinary flow, hesitancy, straining and incomplete bladder emptying. The overlap in symptoms with BOO often leads to misdiagnosis, delaying appropriate intervention. UAB has multiple underlying causes including, neurogenic, myogenic, iatrogenic and idiopathic factors. Diagnosis is further complicated by the limited availability of urodynamic studies, the gold standard for assessing detrusor underactivity. Current management options remain limited with no definitive treatments. Current strategies focus on behavioural modifications, pelvic floor exercises, timed voiding, sacral neuromodulation and intermittent catheterisation. Increased awareness of UAB among primary care physicians and urologists is essential for timely diagnosis and intervention. Recognition of UAB as a distinct clinical entity will lead to a reduction in potential complications and significant improvement in the quality of life of affected men.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"841-847"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}