Translational andrology and urology最新文献

{"title":"High intratumoral heterogeneity in clear cell renal cell carcinoma is associated with reduced immune response and survival.","authors":"Qizhou Yang, Yuying Han, Xu Liu, Liting Xue, Zhengguo Ji, Haihong Ye","doi":"10.21037/tau-2024-741","DOIUrl":"10.21037/tau-2024-741","url":null,"abstract":"<p><strong>Background: </strong>Clear cell renal cell carcinoma (ccRCC) exhibits high intratumor heterogeneity (ITH), which drives progression, metastasis, and treatment resistance. Nevertheless, clinically applicable tools for predicting patient prognosis based on ITH remain unavailable, and the association between ITH and immune cell response is a matter of debate. The objective of this study was to establish ITH as a clinically relevant biomarker capable of predicting outcomes and informing treatment strategies in ccRCC.</p><p><strong>Methods: </strong>The Bioconductor R package Maftools was used to analyze somatic variants of ccRCC from The Cancer Genome Atlas (TCGA) and cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) was used to estimate immune cell compositions. A mutant-allele tumor heterogeneity (MATH) algorithm was used to measure ITH, and we explored its correlation with clinical parameters and immune cell response.</p><p><strong>Results: </strong>Our analysis revealed that lower MATH values were significantly associated with increased infiltration of activated dendritic cells (P=0.048) and reduced levels of immunosuppressive regulatory T cells (Tregs; P=0.02), suggesting enhanced antitumor immunity in less heterogeneous tumors. Conversely, high MATH values correlated with worse overall survival and a suppressed immune microenvironment. These findings support the potential of MATH as a stratification biomarker for ccRCC patients, helping identify those who may benefit from immunotherapy or targeted therapies.</p><p><strong>Conclusions: </strong>High MATH value correlates with worse survival and decreased immune response in ccRCC patients.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1190-1203"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice of kidney transplant patients regarding post-transplant complications: a cross-sectional study.","authors":"Jie Shen, Pengfeng Gong, Yangyang Sun, Dong Xue","doi":"10.21037/tau-2024-683","DOIUrl":"10.21037/tau-2024-683","url":null,"abstract":"<p><strong>Background: </strong>The management of complications following kidney transplantation involves self-management, which requires adequate knowledge and favorable attitudes. This study explored the knowledge, attitude, and practice (KAP) of post-transplant complications among kidney transplant patients.</p><p><strong>Methods: </strong>This cross-sectional study included (convenience sampling) kidney transplant patients from our hospital. A self-designed online KAP questionnaire was used for data collection.</p><p><strong>Results: </strong>A total of 499 (89.7%) valid questionnaires were included; 327 were filled out by men and 172 by women, aged 44.41±10.54 years. The mean knowledge, attitude, and practice scores were 6.00±1.99 (possible range, 0-10), 22.29±1.96 (possible range, 6-30), and 29.28±3.78 (possible range, 8-40), respectively. Pearson's correlation analysis revealed a positive correlation between attitude and knowledge (r=0.129, P=0.004), attitude and practice (r=0.334, P<0.001), and practice and attitude (r=0.416, P<0.001). Structural equation modeling showed that post-transplant complications and education were associated with knowledge while drinking alcohol, age, and duration since kidney transplant were negatively associated with knowledge. Knowledge and education were associated with attitude, while post-transplant complications were negatively associated with attitude. Attitude, knowledge, duration since kidney transplant and education were associated with the practice, while age was negatively associated with the practice.</p><p><strong>Conclusions: </strong>Kidney transplant patients showed insufficient knowledge, positive attitude, and proactive practice regarding post-transplant complications. Age, education, drinking alcohol, post-transplant complications, and duration since kidney transplant might affect their KAP. Educational interventions targeting specific KAP items with poor scores should be designed and tested to improve the self-management of patients with kidney transplants.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1230-1237"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mirabegron efficacy as medical expulsive therapy for distal ureteral stones: a systematic review of the literature, meta-analysis and trial sequential analysis.","authors":"Richard Dobrucki de Lima, Lucas Schenk de Almeida, Breno Cordeiro Porto, Nathalie Cordeiro Hobaica, Carlo Camargo Passerotti, Rodrigo A S Sardenberg, José Pinhata Otoch, José Arnaldo Shiomi da Cruz","doi":"10.21037/tau-2025-112","DOIUrl":"10.21037/tau-2025-112","url":null,"abstract":"<p><strong>Background: </strong>Medical expulsive therapy (MET) is recommended for distal ureteral stones measuring 5 to 10 mm. Mirabegron, a β3-adrenergic agonist, has been proposed as a potential agent to improve stone expulsion rate (SER) and stone expulsion time (SET). This study aims to evaluate the efficacy of mirabegron compared to placebo for MET in distal ureteral stones.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, Embase, and Cochrane Central Register of Controlled Trials from inception until December 2023. Only randomized controlled trials (RCTs) were included in the analysis.</p><p><strong>Results: </strong>Five RCTs including 419 patients were analyzed. No significant differences were observed between mirabegron and placebo for SER [risk ratio (RR): 1.49, 95% confidence interval (CI): 0.91-2.45, P=0.08, I²=53%], SET [mean difference (MD): -1.92, 95% CI: -5.38-1.54, P=0.28, I²=95%], or analgesic use (MD: -1.03, 95% CI: -2.16-0.09, P=0.07, I²=89%). Trial sequential analysis indicated that the current evidence remains insufficient to conclusively determine mirabegron's effect, though the accumulated data are approaching the futility boundary, suggesting that one additional RCT may be sufficient for a definitive conclusion.</p><p><strong>Conclusions: </strong>Mirabegron does not provide a significant benefit as a MET for distal ureteral stones measuring 5 to 10 mm. Further RCTs are necessary to establish its potential role in ureterolithiasis management.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1253-1260"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional survey of experiences and outcomes of using testosterone replacement therapy in UK men.","authors":"Austen El-Osta, Vivian N Liu, David Huang, Jeff Foster, Hans Johnson, Aos Alaa, Benedict Hayhoe","doi":"10.21037/tau-2024-738","DOIUrl":"10.21037/tau-2024-738","url":null,"abstract":"<p><strong>Background: </strong>Prevalence of late-onset testosterone deficiency (TD) ranges between 6-30% depending on diagnostic criteria. Recent data highlights various benefits of testosterone replacement therapy (TRT), including increased libido, mood, bone mineral density, and lean body mass. This study investigated the personal experiences of men with TD around low testosterone and TRT, including barriers to accessing TRT.</p><p><strong>Methods: </strong>Previous or current TRT users were recruited via email from private clinics' emailing lists, professional medical organisations and researchers' professional networks. Participants completed a 52-item structured questionnaire on Qualtrics XM, exploring their perceptions and experiences of TRT on their symptoms and quality of life. Associations between demographics, duration of symptoms and effectiveness were assessed using logistic regressions.</p><p><strong>Results: </strong>Among the 905 men on TD treatment, 86% delayed treatment for at least a year, including 24% who experienced symptoms for over 5 years before seeking care. Older men (aged 51+ years) were 1.61 times more likely to delay treatment. The majority (85%) reported TRT as effective or very effective, with longer-term users 2.6 times more likely to report TRT as very effective compared to recent starters. Primary motivations for seeking TRT included improving personal relationships (79%) and physical appearance (53%). Most (81%) relied on online sources for information; fewer (18%) felt comfortable discussing hormonal health with their peers. Patient expectations during medical consultations focused on diagnosis (77%), treatment options (64%) and learning about potential side effects (51%). The most common side effects were acne (24%), testicular shrinkage (24%) and nipple itchiness/gynaecomastia (19%). TRT users reported notable improvements in overall quality of life (75%), mental wellbeing (71%), self-esteem and self-confidence (69%) and appearance (61%).</p><p><strong>Conclusions: </strong>A significant proportion of men aged over 50 years surveyed reported experiencing prolonged symptoms of TD prior to seeking care. There is a need for greater awareness and education regarding TD symptoms, including streamlining timely and equitable access to effective treatment options.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1295-1307"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sperm DNA fragmentation with higher miscarriage rates in non-male factor infertility reproductive cycles.","authors":"Hong Yu, Chunyan Shi, Chaowu Zhan, Cheng Wang, Jie Chen","doi":"10.21037/tau-2025-322","DOIUrl":"10.21037/tau-2025-322","url":null,"abstract":"<p><strong>Background: </strong>Although recurrent spontaneous abortion (RSA) is often attributed to maternal or unknown causes, emerging evidence suggests that sperm DNA integrity may also influence pregnancy outcomes. Traditional semen analysis fails to detect subtle chromatin abnormalities, particularly in men without apparent infertility. This study assessed the contribution of the sperm chromatin structure instability in men to RSA in southern Anhui, China, and examined its correlation with RSA.</p><p><strong>Methods: </strong>The experimental group comprised 438 males who visited the Department of Reproductive Medicine at the Second People's Hospital of Wuhu between January 2022 and October 2023 due to RSA in their spouses. The control group included 189 males whose spouses did not experience RSA (non-RSA). The DNA fragmentation index (DFI), standard parameters, and general data related to the sperm were collected and statistically analyzed.</p><p><strong>Results: </strong>The DFI was significantly elevated in the RSA group relative to the non-RSA group (P<0.05). DFI was positively correlated with age and negatively linked to the concentration, total motility, normal morphology, and progressive motility of the sperm (P<0.05). It had no correlation with semen volume, total sperm number, smoking, alcohol consumption, occupation, or sleep duration (P>0.05). Age was negatively associated with the normal forms, while occupation was negatively associated with progressive motility (P<0.05). The routine semen parameters remained consistent across subgroups categorized by sleep duration, alcohol intake, and smoking habits, with no significant differences observed. Additionally, receiver operating characteristic (ROC) curve analysis indicated that age, sperm concentration, progressive motility, total motility, and normal form had moderate predictive value for elevated DFI, with area under the curve (AUC) values ranging from 0.568 to 0.706.</p><p><strong>Conclusions: </strong>The integrity of sperm chromatin structure was correlated with RSA. Age was identified as a contributing factor to elevated sperm DFI, while occupational environment may also influence semen quality. This study emphasizes the importance of considering paternal factors in RSA evaluations and suggests that sperm DNA integrity may serve as a useful biomarker in assessing RSA risk.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1456-1465"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between lifestyle choices, dietary factors, and the risk of adult urolithiasis: insights from a systematic review and meta-analysis.","authors":"Limei Hua, Jingran Cao, Xinhong Zhao, Xiaodong Meng, Jianhong Qiu","doi":"10.21037/tau-2024-768","DOIUrl":"10.21037/tau-2024-768","url":null,"abstract":"<p><strong>Background: </strong>Urinary stone disease (USD) encompasses kidney stones, ureteral stones, bladder stones, and urethral calculi. This study systematically assesses the correlation between dietary factors, lifestyle, and the risk of adult USD, while also exploring relevant clinical intervention measures.</p><p><strong>Methods: </strong>A comprehensive search was conducted across multiple databases, including the Chinese Biomedical Databases (CBM), Wanfang Database, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP Full-text Database, ScienceDirect, EMBASE, and PubMed, to identify correlation and multivariate analyses regarding the risk of adult urolithiasis. Two researchers independently retrieved data and assessed the risk of bias for each included study using the Cochrane Handbook 5.3 standards.</p><p><strong>Results: </strong>Following the Meta-Analyses of Observational Studies in Epidemiology (MOOSE), six studies were included, with a total sample size of 3,500 participants. Among these studies, three reported a correlation between age and the risk of adult urolithiasis (Chi²=0.70, df=2, P=0.70, I²=0%). Four studies examined the relationship between family history of urolithiasis and the risk of developing adult urolithiasis (Chi²=32.66, df=3, P<0.001, I²=91%). Two studies found a connection between increased vinegar intake and the risk of adult urolithiasis (Chi²=0.00, df=1, P=0.95, I²=0%). Two studies reported on the relationship between higher legume consumption and the risk of adult urolithiasis (Chi²=0.00, df=1, P>0.99, I²=0%). Furthermore, three studies indicated a significant relationship between increased daily water intake and the risk of adult urolithiasis (Chi²=21.80, df=2, P<0.001, I²=91%). Funnel plots indicated that most of the included studies exhibited symmetrical distributions, although a small percentage displayed asymmetry, suggesting potential publication bias linked to study heterogeneity and the limited number of included studies.</p><p><strong>Conclusions: </strong>Identified risk factors for USD include advanced age, a family history of urolithiasis, high intake of animal protein and fat, insufficient daily water consumption, and reduced intake of vinegar and legumes. To validate these correlations, future research should focus on longer intervention durations and improved methodological quality.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1283-1294"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-centered outcomes and preference between darolutamide and enzalutamide: insights from the ODENZA trial.","authors":"Guillaume Lim Fat, Shabbir Alibhai","doi":"10.21037/tau-2024-755","DOIUrl":"10.21037/tau-2024-755","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1160-1164"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study to determine the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy.","authors":"David Sobel, Philip Caffery, Evelyn James, Rebecca Ortiz, Aidan Peat, Chris Tucci, Gyan Pareek","doi":"10.21037/tau-2024-692","DOIUrl":"10.21037/tau-2024-692","url":null,"abstract":"<p><strong>Background: </strong>The American opioid epidemic continues and further efforts are needed to reduce unnecessary opioid prescriptions after urologic surgery. This is a pragmatic feasibility study to evaluate the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy (PCNL) utilizing a nonopioid protocol consisting of preoperative counseling, multimodal analgesics, and detailed postoperative instructions.</p><p><strong>Methods: </strong>A prospective feasibility study (Clinicaltrials.gov: NCT04597619) was conducted at a single institution. All participants underwent single tract stented PCNL. Eligible participants were enrolled prospectively before and after implementation of the nonopioid protocol. Pre-intervention arm participants received opioid prescriptions at the discretion of the provider. Participants in the intervention arm underwent the nonopioid protocol. The primary outcome investigated was discharge following PCNL without a prescription for opioid pain medication. Other outcomes included postoperative pain, symptom questionnaire scores, emergency department (ED) visits for pain, and outpatient telephone calls or requests for prescription refills.</p><p><strong>Results: </strong>Fourteen participants were enrolled in the pre-intervention group. Of these, 10 (71%) were discharged with opioid prescriptions and 4 (29%) were discharged without opioids. Of the 10 discharged with opioids, 2 (14%) presented to the ED for pain concerns and received a new prescription for opioids. Six participants underwent intervention and received the nonopioid protocol. All participants (100%) in the intervention group were discharged without opioids. None (0%) presented to the ED for pain concerns.</p><p><strong>Conclusions: </strong>This feasibility study demonstrates that patients undergoing PCNL via a standardized nonopioid pathway can be safely discharged without opioid prescriptions without impact on outpatient resources. Four participants in the pre-intervention group were discharged without opioids based on provider discretion, suggesting that the standard of care to include an opioid prescription may be changing.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1379-1390"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of core genes in acute kidney injury: evidence from multi-omics human transcriptomic data and <i>in vivo</i> models.","authors":"Pengxiao Sun, Qiting Weng, Jiaxin Zhou, Qingzhou Chen, Rui Zhang, Jing Nie","doi":"10.21037/tau-2024-677","DOIUrl":"10.21037/tau-2024-677","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) affects up to 23.2% of hospitalized patients, but its complex pathophysiology hinders diagnosis and treatment. Bioinformatics-driven identification of core genes from large-scale omics data offers a promising approach for uncovering diagnostic and therapeutic targets. This study aims to integrate multi-omics data with experimental validation to identify core genes involved in AKI and explore their mechanisms.</p><p><strong>Methods: </strong>We analyzed renal transcriptomic data from 67 AKI patients and 20 controls, integrating differential expression, weighted gene co-expression network analysis (WGCNA), and clinical correlations to identify key genes. A nomogram model was used to assess diagnostic performance, and immune microenvironment characteristics were analyzed using CIBERSORT. AKI was induced in mice by ischemia-reperfusion and cisplatin, with gene expression validated by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, and immunohistochemistry. <i>SUGCT</i> expression and function were further examined in proximal tubules (PT) using human single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics.</p><p><strong>Results: </strong>Three core genes, epidermal growth factor (<i>EGF</i>), vascular cell adhesion molecule 1 (<i>VCAM1</i>), and <i>SUGCT</i>, were identified, showing significant associations with AKI phenotypes and clinical renal parameters. Combined, these genes provided a robust diagnostic model for AKI. CIBERSORT associated <i>VCAM1</i> with monocytes, <i>SUGCT</i> with monocytes and M2 macrophages, and <i>EGF</i> with monocytes and T cells. Both mouse models showed downregulation of <i>Sugct</i> and <i>Egf</i>, and upregulation of <i>Vcam1</i>, consistent with human data. Single-nucleus RNA sequencing revealed that <i>SUGCT</i> was highly expressed in healthy PT but downregulated in severely injured PT. Low <i>SUGCT</i> expression correlated with suppressed mitochondrial functions and activated immune responses. Spatial transcriptomics confirmed that regions of high <i>SUGCT</i> expression co-localized with areas of oxidative phosphorylation activity in PT.</p><p><strong>Conclusions: </strong>This study highlights three core genes of AKI, especially <i>SUGCT</i>, which is related to mitochondrial metabolism and immune balance in PT during AKI, offering potential diagnostic and therapeutic targets.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1327-1347"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrasome-related lncRNAs predict prognosis and immune response of clear cell renal cell carcinoma.","authors":"Rong Chen, Lei Dong, Tianci Wei, Qiang Wang","doi":"10.21037/tau-2024-728","DOIUrl":"10.21037/tau-2024-728","url":null,"abstract":"<p><strong>Background: </strong>Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive renal malignancy. Migrasomes, newly discovered organelles involved in intercellular communication, and long non-coding RNAs (lncRNAs) are emerging regulators of cancer progression. However, the role of migrasome-associated lncRNAs in ccRCC prognosis and immune response remains unclear. This study aimed to investigate the value of migrasome-related lncRNAs and develop a risk model for ccRCC.</p><p><strong>Methods: </strong>By employing data from The Cancer Genome Atlas, we were able to identify prognostically significant migrasome-related lncRNAs through co-expression analysis, Cox regression, and least absolute shrinkage and selection operator (LASSO) regression. Prognostic models were developed and validated using these lncRNAs, and a nomogram combining the risk score with clinical features was constructed. Furthermore, our analyses encompassed gene set enrichment, immune infiltration, mutational burden, and drug sensitivity.</p><p><strong>Results: </strong>A prognostic model incorporating 13 lncRNAs effectively stratified patients into distinct risk categories, with the high-risk cohort demonstrating markedly inferior survival rates. The prognostic accuracy was validated through multiple analyses. Gene enrichment analysis revealed a correlation between these lncRNAs and tumor development and immune pathways. High-risk patients exhibited increased immunosuppressive cell infiltration, oncogenic mutations, and potential for immune escape. Furthermore, they demonstrated a lack of response to immunotherapy and exhibited differential responses to antineoplastic agents when compared to low-risk patients. We propose a prognostic model for ccRCC based on migrasome-related lncRNAs, providing new insights into disease progression and potential individualized treatment strategies.</p><p><strong>Conclusions: </strong>Our study proposes a prognostic model for ccRCC based on migrasome-related lncRNAs, providing new insights into disease progression and potential individualized treatment strategies.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1214-1229"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}