Translational andrology and urology最新文献

{"title":"Erectile dysfunction in men with human immunodeficiency virus: prevalence and associated factors.","authors":"Suzane Skura, Anna Martha Vaitses Fontanari, Lia Beatriz Henke de Azevedo, Raquel Maiéli Bagatini, Valdir Spada Júnior, Dalila Moter Benvegnú, Paulo Cezar Nunes Fortes, Angelo Brandelli Costa, Guilherme Welter Wendt, Lirane Elize Defante Ferreto","doi":"10.21037/tau-24-234","DOIUrl":"10.21037/tau-24-234","url":null,"abstract":"<p><strong>Background: </strong>Male sexuality plays a crucial role in determining the overall quality of life, and it involves complex interactions between physical systems and psychosocial dimensions. Erectile dysfunction (ED) has a particularly notable impact on men's well-being, especially among those living with human immunodeficiency virus (HIV). This study's aim was to explore the prevalence of ED and its associated factors in men with HIV.</p><p><strong>Methods: </strong>Cross-sectional research was conducted in a specialized care unit in Paraná, involving 120 adult men living with HIV. Data collection occurred from March 2021 to December 2023, and ED was assessed using the 6-item version of International Index of Erectile Function (IIEF-6) questionnaire. Psychological factors were assessed using the Depression, Anxiety and Stress Scales-21 (DASS-21). The primary outcome was ED.</p><p><strong>Results: </strong>The prevalence of ED was 37.5% [95% confidence interval (CI): 28.8% to 46.2%]. A significant association was observed between advanced age and ED. Regarding the type of antiretroviral therapy (ART), the data revealed a significant association with ED, the differences were particularly notable when comparing the therapeutic regimens of nucleoside reverse transcriptase inhibitor (NRTI) + Integrase inhibitor (INI) <i>vs</i>. NRTI + protease inhibitor (PI) and NRTI + NRTI. Furthermore, mental health factors were analyzed, with anxiety demonstrating a significant association with ED [odds ratio (OR) =2.35; 95% CI: 1.02 to 5.43; P=0.046].</p><p><strong>Conclusions: </strong>The findings highlight the urgent need for an integrated approach to clinical management that considers both medical and emotional aspects in men living with HIV. It has also a potential to subside further investigations, particularly those adopting a longitudinal design to capture casual mechanisms of ED in men with HIV.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2396-2407"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct clinical features of urothelial carcinoma with low-expressing human epidermal growth factor receptor 2 status.","authors":"Xiaochen Huang, Shaoqiu Li, Tingting Yang, Dawei Ma, Hongzhou Cai, Xinyu Xu, Yi Zhang","doi":"10.21037/tau-24-354","DOIUrl":"10.21037/tau-24-354","url":null,"abstract":"<p><strong>Background: </strong>Some urothelial carcinoma patients are ineligible for platinum-based chemotherapy, necessitating exploration of other effective therapeutic strategies. Human epidermal growth factor receptor 2 (HER2) protein overexpression, gene amplification or mutations exist in urothelial carcinoma. Our study is to investigate the correlation of three-tier assessment of HER2 expression with clinical pathological characteristics and prognosis of urothelial carcinoma.</p><p><strong>Methods: </strong>HER2 expression in 75 urothelial carcinomas from Jiangsu Cancer Hospital was re-scored by immunohistochemistry and fluorescence in situ hybridization according to HER2 three-tier assessment standards. Its relationship with various pathological parameters of urothelial carcinoma and its correlation with prognosis were analyzed. And validate in The Cancer Genome Atlas (TCGA) cohort.</p><p><strong>Results: </strong>HER2 expression was observed in 82.7% (62/75) of urothelial carcinoma patients, of which HER2-low expression accounted for 61.3% (46/75). HER2 expression was significantly correlated with the tumor-nodes-metastasis (TNM) stage of urothelial carcinoma (P=0.043) and HER2-low was an independent poor prognostic factor for patients with urothelial carcinoma (P=0.04). Follow-up showed that HER2-low patients had the worst prognosis compared with HER2-negative (P=0.02) and HER2 positive (P=0.02) and also had the highest progression rate in TCGA cohort (P=0.02); receiver operator characteristic (ROC) model suggested HER2-low could effectively predict prognosis.</p><p><strong>Conclusions: </strong>HER2 expression is closely related to the TNM stage of urothelial carcinoma; HER2 three-tier assessment can effectively predict clinical prognosis of urothelial carcinoma.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2419-2429"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cancer role of curcumin in prostate cancer cells via regulation of m6A-modified circ0030568-FMR1 signaling pathway.","authors":"Xiaoxiao Sun, Xuan Huang, Li Liu, Weihong Shen, Feifei Zheng, Min Liu, Chengwen Sun","doi":"10.21037/tau-24-276","DOIUrl":"10.21037/tau-24-276","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) is the most prevalent adult malignancies worldwide and studies have shown that circular RNAs (circRNAs) play critical roles in the development and progression of PCa. As the most abundant modification, N6-methyladenosine (m6A) modification functions in regulating circRNAs expression and has been shown to regulate PCa progression. However, the biological relevance of m6A modification of circRNAs in PCa remains unclear. In addition, curcumin is reported to inhibit a variety of cancer cells while the biological functions in PCa have not yet been fully elucidated. Thus, our study aims to investigate whether curcumin can suppress PCa progression through the m6A-modified circRNAs.</p><p><strong>Methods: </strong>By conducting m6A methylation immunoprecipitation combined with quantitative real-time polymerase chain reaction (MeRIP-qPCR) assay, cell counting kit-8 (CCK-8) assay and wound healing assay, increased m6A modification on circ0030568 was detected and upregulated circ0030568 was also observed in different PCa cells lines, which promotes proliferation and migration of PCa cells.</p><p><strong>Results: </strong>More importantly, the results confirmed that curcumin could suppress the proliferation and migration of PCa cells lines by inhibiting METTL3-modified circ0030568. Mechanistically, m6A reader YTHDF2 elevated the stability of circ0030568 via m6A modification and curcumin could suppress PCa progression by inhibiting YTHDF2 mediated circ0030568 stability.</p><p><strong>Conclusions: </strong>Taken together, circ0030568 may act as a promising biomarker and an attractive target for PCa treatment and curcumin's inhibition of m6A-modified circ0030568 may be a potential mechanism of its anti-PCa.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2358-2375"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Single-nucleotide polymorphisms of matrix metalloproteinase genes are associated with graft fibrosis after kidney transplantation.","authors":"","doi":"10.21037/tau-2024-02","DOIUrl":"10.21037/tau-2024-02","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/tau-22-506.].</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2658-2660"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring radiotherapy combined with a radiosensitizer for Bacillus Calmette-Guérin-unresponsive non-muscle-invasive bladder cancer with carcinoma in situ.","authors":"Ho Kyung Seo, Eui Hyun Jung, Geehyun Song","doi":"10.21037/tau-24-480","DOIUrl":"10.21037/tau-24-480","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2354-2357"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erectile dysfunction associated with prostate cancer treatment and therapeutic advances: a narrative review.","authors":"Xin Zhang, Jiangxiao Pan, Runnan Xu, Yijia Fu, Bodong Lv","doi":"10.21037/tau-24-514","DOIUrl":"10.21037/tau-24-514","url":null,"abstract":"<p><strong>Background and objective: </strong>The treatment of prostate cancer (PCa) often comes with the risk of erectile dysfunction (ED). As therapeutic technologies continue to advance, the incidence of ED and its treatment methods are also evolving. This paper aimed to provide a comprehensive analysis of the latest developments in PCa treatment, with a particular focus on its relationship with ED, and to review current innovative strategies for ED treatment.</p><p><strong>Methods: </strong>This study conducted a literature search in databases including PubMed, Excerpta Medica, Web of Science, Scopus, and the Cochrane Library, using keywords including \"prostate cancer\", \"active surveillance\", \"radiation therapy\", \"cryotherapy\", \"radical prostatectomy\", \"immunotherapy\", \"chemotherapy\", \"androgen deprivation therapy\", \"erectile dysfunction\", and \"therapeutic advances\", to collect English-language literature published from 1966 to June 2024.</p><p><strong>Key content and findings: </strong>Active surveillance (AS) strategies have significantly reduced the incidence of ED. Technological advancements such as radiation therapy (RT), precise delineation techniques, and improvements in cryotherapy equipment are all dedicated to reducing the risk of ED. Intraoperative nerve monitoring combined with robot-assisted radical prostatectomy (RP) plays a key role in protecting the cavernous nerves and improving postoperative erectile function (EF) recovery. The impact of immunotherapy and chemotherapy on the risk of ED still needs to be clarified with additional clinical data. Androgen deprivation therapy (ADT) is often carried out as part of a combined treatment or through novel administration modalities to reduce its side effects. Given the limitations of traditional ED treatment methods, emerging treatments such as physical energy therapy, stem cell and platelet-rich plasma (PRP) therapy, gene and targeted therapies, tissue engineering and nerve transplantation, and traditional Chinese medicine (TCM) represent novel solutions for ED treatment.</p><p><strong>Conclusions: </strong>With the innovation of PCa treatment technologies, the incidence of ED has declined, and emerging ED treatment methods have benefited the recovery of sexual function in patients with PCa. These advances may form the basis from which further innovations in PCa treatment strategies can be developed.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2625-2643"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a new Peyronie's disease self-assessment screening app.","authors":"Gregory A Broderick, Jesse N Mills, Lisa Bathish, Christopher Davis, Mohit Khera","doi":"10.21037/tau-24-273","DOIUrl":"10.21037/tau-24-273","url":null,"abstract":"<p><p>Peyronie's disease (PD) is an underdiagnosed and undertreated fibroproliferative disorder associated with the formation of plaques that results in penile curvature and discourages some men from seeking medical consultation. The PD self-assessment app, a digital application (app), was developed to increase PD awareness, provide men with a self-screening and educational tool for PD, and help eliminate barriers to seeking consultation with a physician. Prior to deployment, 4 board-certified urologists provided qualitative reviews on the app's usability and utility as a screening tool. The PD self-assessment app features a questionnaire that addresses penile curvature, challenges with penetration, partner distress, and the impact on sexual experiences. The app uses the phone's camera lens to perform a live scan employing a mathematical algorithm to determine the degree of curvature of an erect penis. Results include a three-dimensional (3D) penile simulation and a two-dimensional (2D) penile outline, allowing the user to mark plaque locations and determine the maximum curvature without requiring personal photographs. The user can choose to email their answers to the questionnaire and the representative penile simulation results to their physician. The app also includes external links directing users to an educational website focused on PD and to help with finding a treating physician. The app was designed with privacy and security features including optional password protection, encryption of sensitive data, in-app storage of all screening results, and the erasing of all data when the app is uninstalled. Patients will be empowered to self-assess their PD and locate a PD-experienced physician privately and securely. The app is not designed for diagnosing, treating, curing, or preventing any medical conditions, or diseases, nor does it substitute for a medical consultation. For security, scanning technology, rather than personal photography, is adjunctive to the diagnosis process. The app is designed to be flexible and expandable for future updates. It aims to assist men and their partners in learning about PD, tracking penile deformity, and enabling communication with a health care provider (HCP).</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2617-2624"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexamethasone: a cheap and convenient way to alleviate subsequent stenosis after thermal injury on ureter.","authors":"Weiping Xia, Fang Huang, Qingtian Song, Yunbo He, Bingsheng Li","doi":"10.21037/tau-24-343","DOIUrl":"10.21037/tau-24-343","url":null,"abstract":"<p><strong>Background: </strong>Ureteral thermal injury (UTI) occurs when the ureter is exposed to high temperatures during surgical procedures, leading to tissue damage and ureteral stricture. Dexamethasone (DEX) has been widely used to treat a variety of diseases for its anti-inflammatory and immunosuppressant effects. However, its role in treating UTI remains unclear. The aim of this study was to determine the efficacy of treatment in mice with UTI.</p><p><strong>Methods: </strong>Thirty C57BL/6J mice were randomly divided into three groups (n=10 per group): (I) control group, (II) UTI group, (III) UTI + DEX group. UTI mouse models were constructed using a fast-pack pro-obturation pack handpiece instrument, and the therapeutic effect of DEX (2.5 mg/kg) on UTI was investigated via intraperitoneal injection for two weeks. Pathological changes in the ureter, renal function, extracellular matrix protein deposition, and inflammatory markers in the kidneys were evaluated in mouse models.</p><p><strong>Results: </strong>Ureteral histopathological changes were more severe in the UTI group than in the control group; however, DEX treatment alleviated these changes to a certain extent. Mice in the UTI group exhibited elevated renal function. Although DEX alleviated renal function deterioration, the difference was not statistically significant. Moreover, in comparison to the control group, kidney samples from the mice in the UTI group revealed increased messenger RNA (mRNA) levels of inflammation markers, indicating a progressive inflammation response, while DEX significantly reversed interleukin-1β (IL-1β) expression at the protein level. Additionally, fibrosis-related markers were markedly increased in the kidneys of UTI mice. These findings were significantly reversed by DEX treatment, revealing its anti-inflammatory and anti-fibrotic activities.</p><p><strong>Conclusions: </strong>DEX reduces the severity of renal fibrosis and inflammation after UTI and exerts a significant renal protective effect.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2498-2509"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor characteristics, treatments, and oncological outcomes of prostate cancer in men aged ≤60 years: real-world data from a single urological center over a 10-year period.","authors":"Wei Liu, Shan-Qi Guo, Xiong Xiao, Yong Wang, Ran-Lu Liu, Nan Wang, Yong Xu, Xing-Kang Jiang","doi":"10.21037/tau-24-410","DOIUrl":"10.21037/tau-24-410","url":null,"abstract":"<p><strong>Background: </strong>Prostate cancer (PCa) has emerged as one of the most common malignancies among men globally. However, its pathogenesis, clinical features, and treatment responses in younger patients (aged 60 years or below) remain underexplored. This study aims to evaluate the distinctive clinical features, treatment strategies, and oncological outcomes of PCa in men aged 60 years or younger over a 10-year period at a single urological center.</p><p><strong>Methods: </strong>We retrospectively analyzed data from The Second Hospital of Tianjin Medical University, spanning January 2010 to June 2020. The study included patients aged ≤60 years who underwent prostate biopsies. We examined clinical characteristics, pathological findings, treatment approaches, and survival outcomes using <i>t</i>-tests and chi-square tests. Adjusted linear regression models evaluated the relationships between treatment modalities and outcomes, while Kaplan-Meier survival analysis and Cox regression assessed progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS).</p><p><strong>Results: </strong>Of the 5,686 patients who underwent prostate biopsy, 643 (11.3%) were ≤60 years old. Among these, 42.8% (275/643) were diagnosed with PCa, with 59.6% presenting at advanced stages. Compared to those with negative pathology, patients with PCa were older and more likely to have hypertension, alcohol consumption, and metabolic syndrome. Most patients (69.8%) received definitive local therapy, while 22.2% opted for palliative care and 8.0% were loss to follow-up. The median follow-up period for the entire cohort was 28.0 months and the median PFS was 77.0 months. For patients receiving definitive local therapy, the median CSS and OS were not reached, while those undergoing palliative therapy had median CSS and OS of 52.0 and 59.0 months, respectively. Multivariable analysis identified prostate-specific antigen >20 ng/mL, International Society of Urological Pathology >3, bone metastasis, and localized treatment as independent factors affecting PFS. Propensity score matching showed that definitive therapy led to superior PFS compared to palliative therapy for patients with localized PCa and a life expectancy of over 5 years.</p><p><strong>Conclusions: </strong>Our findings highlight the influence of incidence, diagnostic characteristics, and treatment methods in younger men with PCa, emphasizing the need to identify specific risk factors and treatment response patterns. Further large-scale, multi-center research is necessary to improve diagnosis and outcomes for PCa patients in this age group.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2408-2418"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the hidden link: neuroticism as a risk factor for upper urinary tract calculi-insights from Mendelian randomization analysis.","authors":"Shang Gao, Renli Tian","doi":"10.21037/tau-24-379","DOIUrl":"10.21037/tau-24-379","url":null,"abstract":"<p><strong>Background: </strong>Upper urinary tract calculi (UUTC) are major risk factors for renal insufficiency and nephrectomy with psychological distress, notably depression and anxiety, being common among affected patients. Depression and anxiety are associated with heightened neuroticism. Individuals with neuroticism frequently exhibit a range of urological disorders. Given the limited research on UUTC and neuroticism, this study aims to explore this relationship using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>We assessed the effects of neuroticism and associated psychological traits on UUTC using a two-sample MR approach, primarily employing the inverse variance weighted (IVW) method, with additional analysis via MR-Egger and weighted median methods. To ensure robustness, we conducted sensitivity analyses using Cochran's Q test, MR-Egger intercept, and MR-pleiotropy residual sum and outlier (PRESSO). At the same time, we selected the neuroticism score for verification queue of the exposure. Furthermore, to explore the independent effects of neuroticism traits on UUTC, we performed multivariable MR analyses on phenotypes with no pleiotropy, IVW P values below 0.05, and consistent directions across all three MR methods.</p><p><strong>Results: </strong>Our MR analysis revealed a significant causal impact of neuroticism on UUTC using the IVW [odds ratio (OR) =1.15, 95% confidence interval (CI): 1.02 to 1.29, P=0.03) and weighted median (OR =1.22, 95% CI: 1.03 to 1.44, P=0.02) methods. Verification queue similarly confirmed that the neuroticism score was a risk factor for UUTC (IVW, OR =1.11, 95% CI: 1.03 to 1.19, P=0.007). Sensitivity analyses indicated no heterogeneity or pleiotropy. Additionally, IVW analyses identified experiencing mood swings (OR =1.41, P=0.047), feeling lonely (OR =6.03, P<0.001), and feeling worry (OR =1.58, P=0.03) as significantly associated with UUTC. Multivariate MR analysis showed that experiencing mood swings is a stand-alone risk factor for UUTC (OR =1.75, P=0.03).</p><p><strong>Conclusions: </strong>Our MR analysis has pinpointed neuroticism as a risk factor for UUTC, with experiencing mood swings identified as an independent risk factor for UUTC, offering new insights into the brain-kidney connection. The exact pathways driving this relationship require further study. These results highlight the necessity of vigilant urinary stone surveillance in individuals exhibiting neurotic traits.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"13 11","pages":"2430-2438"},"PeriodicalIF":1.9,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}