Translational andrology and urology最新文献

{"title":"Evaluation of different methods for antibody titre determination in ABO-incompatible kidney transplantation.","authors":"Shanshan Zhou, Qian Liu, Man Fang, Shan Shen, Ran Wang, Yanan Jing, Min Wang","doi":"10.21037/tau-24-617","DOIUrl":"https://doi.org/10.21037/tau-24-617","url":null,"abstract":"<p><strong>Background: </strong>Blood type antibody-mediated rejection is considered the main obstacle to ABO blood type-incompatible kidney transplantation. Choosing an appropriate antibody-level determining method and setting a rational baseline are critical for safely conducting ABO-incompatible kidney allografts. However, due to the differences in antibody detection methods between laboratories, there is no unified baseline to confirm the true titer. Therefore, a generally applicable method must be selected to determine the level of anti-ABO antibodies before surgery, and the actual critical titer level should be set accordingly. This study aims to guide the selection of appropriate antibody titer detection methods for ABO-incompatible kidney transplant recipients by comparing the differences in titer results obtained through various detection methods.</p><p><strong>Methods: </strong>A total of 210 ethylene diamine tetraacetic acid (EDTA)-anticoagulated samples were obtained from patients before or after ABO-I kidney transplantation in our centre. In this study, we tested immunoglobulin M (IgM) and immunoglobulin G (IgG) ABO antibody titres using different detection methods, i.e., a tube test (TT), a microcolumn gel card test (MGT), and a glass bead card test (GBT), to evaluate deviations in antibody levels.</p><p><strong>Results: </strong>According to our results, the IgM titre presented by the TT varied less than one standard dilution from that of the MGT; while the TT resulted in a 2 to 4 titre deviation from that determined by the GBT. For IgG, the titres obtained by the MGT were always one standard dilution higher than those obtained by the TT, and the TT-based and GBT-based titres differed by 2-3 serial dilution steps.</p><p><strong>Conclusions: </strong>It is important that clinical laboratories employ a consistent method of sample testing for a particular patient, and indicate the approach used when reporting results. A further clinical retrospective study revealed that the MGT could effectively monitor titre changes following surgery.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"540-552"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The selection of Y chromosome microdeletion detection methods based on seminal analysis results: a comparison of high-throughput sequencing and fluorescence quantitative polymerase chain reaction (qPCR) applications.","authors":"Bai Dai, Dan Zhao, Ri-Na Sha, Ming Cang","doi":"10.21037/tau-24-593","DOIUrl":"https://doi.org/10.21037/tau-24-593","url":null,"abstract":"<p><strong>Background: </strong>Infertility significantly impacts numerous couples worldwide, and male infertility is a common contributing factor. Y chromosome microdeletions are potential genetic causes of male infertility. However, due to the lack of comparative studies based on semen analysis results, we have difficulty selecting an appropriate method for detecting Y chromosome microdeletions. This study aims to compare the application of high-throughput sequencing and fluorescence quantitative polymerase chain reaction (qPCR) in different types of infertility patients.</p><p><strong>Methods: </strong>This study used high-throughput sequencing [next-generation sequencing (NGS)] and fluorescence qPCR methods to detect Y chromosome microdeletions in two groups: one with azoospermia and another with oligoasthenoteratozoospermia (OAT), characterized by reduced sperm count and motility.</p><p><strong>Results: </strong>The results showed that NGS identified cases of Klinefelter syndrome (congenital bilateral absence of the vas deferens) that were not detected by qPCR in the azoospermia group. In the OAT group, high-throughput sequencing found a b2/b3 deletion of 1.80 Mb, while qPCR did not detect it. Conversely, qPCR identified an AZFd deletion in the OAT group, missed by high-throughput sequencing due to inadequate target region coverage.</p><p><strong>Conclusions: </strong>These research findings are significant for guiding personalized treatment of male infertility patients and provide valuable references for further exploration of the association between Y chromosome microdeletions and male infertility.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"619-626"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-free RIRS and setting a new standard: redefining safety and efficacy in stone surgery.","authors":"Mahir Akram, Bhaskar Somani","doi":"10.21037/tau-2024-740","DOIUrl":"https://doi.org/10.21037/tau-2024-740","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"485-488"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of prophylactic mesh in the prevention of parastomal hernia after ileal conduit: assessing the current evidence.","authors":"Vikram Lyall, Michael Rezaee, John Seigne","doi":"10.21037/tau-2025-17","DOIUrl":"https://doi.org/10.21037/tau-2025-17","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"499-502"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcomatoid carcinoma of the penis: a case report.","authors":"Qianhao Huang, Yifan Huang, Dongfeng Xiong, Xuan Zhuang, Yuedong Chen","doi":"10.21037/tau-2024-765","DOIUrl":"https://doi.org/10.21037/tau-2024-765","url":null,"abstract":"<p><strong>Background: </strong>Penile cancer is a rare tumour with a global annual incidence of 0.2 to 1 case per 100,000 men. Sarcomatoid carcinoma (SC) of the penis, also known as carcinosarcoma, is a rare form of squamous cell carcinoma (SCC) of the penis, accounting for approximately 1-2% of all penile cancers. We report a case of SC of the penis in a 60-year-old man.</p><p><strong>Case description: </strong>A 60-year-old male patient presented, with a penile glans nodule that had developed over a two-month period. The patient was employed in the agricultural sector and had a history of hypertension, which he asserted was effectively managed through pharmacological intervention. A specialist examination revealed an enlarged, cauliflower-shaped penile head with surface ulceration, approximately the size of 2 cm. He underwent a partial resection and bilateral inguinal and pelvic lymph node dissection. Histopathology demonstrated that the tumour cells were p63-positive, while p16 expression was absent. Vimentin and p53 were positive in the sarcomatous component, and the morphology and immunohistochemistry were consistent with penile SC. After six months, there was no evidence of disease progression.</p><p><strong>Conclusions: </strong>The diagnosis of SC is challenging, and an accurate diagnosis is the first step towards successful treatment, which has a higher probability of success. It presents as a large, aggressive tumour, usually associated with lymph node metastasis and poor prognosis. Our case adds to the literature and reviews the treatment options for this rare disease and the poor prognosis associated with this malignancy.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"855-862"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From obesity to inflammation: emerging frontiers in prostate cancer and metabolic syndrome studies.","authors":"Xi Xu, Jinshan Xu, Hongliang Gao, Zhaoyang Sheng, Yang Xu, Shuxiong Zeng, Guanghua Chen, Zhensheng Zhang","doi":"10.21037/tau-2024-671","DOIUrl":"https://doi.org/10.21037/tau-2024-671","url":null,"abstract":"<p><strong>Background: </strong>According to recent studies, prostate cancer (PCa) is strongly associated with metabolic syndrome (MetS). However, there has not been any bibliometric visual analysis of relevant papers. In order to acquire knowledge about research settings and possible future paths, a thorough bibliometric study of MetS-related PCa research was carried out.</p><p><strong>Methods: </strong>From January 1, 2004 to December 31, 2023, original and review publications about MetS and PCa were retrieved from the Web of Science Core Collection (WOSCC) database. Analysis of co-authorship and co-occurrence was done using VOSviewer. To find the top terms with the greatest citation burst, CiteSpace was used.</p><p><strong>Results: </strong>There were 1,296 publications on PCa and MetS in all. The analysis showed that the number of yearly scientific papers in the sector was on the rise. The three most productive nations were China, Italy, and the USA. Most papers were published in the <i>PLoS One</i>, while most citations were obtained by the <i>European Urology</i>. The most influential author in terms of citations was Professor Smith MR, whereas the most prolific author was Professor Freedland SJ. Keyword analysis revealed that, apart from PCa and MetS, \"obesity\" was the most often used phrase, with \"risk\", \"meta-analysis\", and \"inflammation\" appearing as study subjects. Furthermore, \"components\" and \"sex hormones\" gained more and more attention.</p><p><strong>Conclusions: </strong>The findings provide a thorough understanding of the larger context of this field of study. Future studies need to investigate PCa's metabolic processes and inflammatory mechanism. Furthermore, switching from observational research to meta-analysis offers the possibility of illness prediction and tailored therapies. These results may help researchers navigate the most recent advancements and influence the field's future paths.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"553-566"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L-shaped association between the ratio of serum albumin to globulin and the risk of all-cause mortality among adults with kidney stones: a national cohort study.","authors":"Sian Chen, Yiqiu Cheng, Fei Wang, Jinhai Wu, Xuejin Zhu, Luca Zanoli, Gino Pigatto Filho, Qi Gao, Yanfei Chen","doi":"10.21037/tau-2025-127","DOIUrl":"https://doi.org/10.21037/tau-2025-127","url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are a common urological disease with rising global prevalence and are influenced by immune, metabolic, and nutritional factors. The ratio of serum albumin to globulin, a marker of inflammation and nutritional status, has been linked to various inflammatory and chronic conditions, but its role in kidney stone risk and outcomes remains unclear. We aimed to determine the association between ratio of serum albumin to globulin and risk of kidney stones, as well as the impact of ratio of serum albumin to globulin on all-cause mortality in participants with kidney stones.</p><p><strong>Methods: </strong>Multivariable logistic regression was used to explore the association between ratio of serum albumin to globulin and the risk of kidney stones. Multivariate Cox regression and restricted cubic spline (RCS) were performed to clarify the relationship between ratio of serum albumin to globulin and the risk of all-cause mortality.</p><p><strong>Results: </strong>Among 31,091 study participants, 2,955 (9.5%) individuals had kidney stones. Multivariable logistic models demonstrated that each standard deviation (SD) increase in the ratio of serum albumin to globulin (SD =0.30) was associated with a 6% reduction in kidney stone risk. A total of 387 (13.1%) participants with kidney stones died for any reasons during a median follow-up of 6.2 years. The multivariable Cox model showed a significantly lower risk of all-cause mortality in the quartile (Q)2, Q3, and Q4 groups as compared to Q1 [Q2: adjusted hazard ratio (aHR) =0.84, 95% confidence interval (CI): 0.63-1.11; Q3: aHR =0.65, 95% CI: 0.48-0.86; Q4: aHR =0.63, 95% CI: 0.46-0.86; P for trend =0.04].</p><p><strong>Conclusions: </strong>A lower ratio of serum albumin to globulin was associated with an increased risk of kidney stones. Additionally, our study showed that at a cutoff point of 1.5, the association between ratio of serum albumin to globulin and all-cause mortality in participants with kidney stones was nonlinear L-shaped. However, due to the observational nature of the study, our study results should be interpreted with caution.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"751-763"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of the effects of the COVID-19 pandemic on semen quality based on a nationwide relaxation of COVID-19 restrictions in China at the end of 2022.","authors":"Shengnan Zhang, Tingting Zhang, Jingchao Ren, Ke Feng, Yanqing Xia, Heng Lu, Mingming Liu, Haibin Guo, Guangcai Duan, Guanghui Zhang, Jia Cao","doi":"10.21037/tau-24-562","DOIUrl":"https://doi.org/10.21037/tau-24-562","url":null,"abstract":"<p><strong>Background: </strong>An association between the coronavirus disease 2019 (COVID-19) and a reduction in male semen parameters has been described, but no large-scale population analyses have been conducted. This study aimed to investigate the effects of the COVID-19 pandemic on semen quality. Based on a large-scale ecological comparative study, our study analyzed the impact of the COVID-19 pandemic on semen quality after the national liberalization of restrictions in China at the end of 2022, aiming to explore the impact of the COVID-19 pandemic on semen quality, and provide a basis for the study of the impact of subsequent epidemics on male reproduction as well as clinical diagnosis and treatment.</p><p><strong>Methods: </strong>It is a population-based cross-sectional study. This comparative study was based on the nationwide loosening of COVID-19 curbs in China on December 7, 2022, 1 month after which, an 89% infection rate was reported in Henan Province, China. We compared semen quality and serum hormone levels from January 7, 2023 to April 30, 2023 and January 7, 2022 to April 30, 2022 at the Reproductive Center of Henan Provincial People's Hospital.</p><p><strong>Results: </strong>Our results indicated a significant decrease in semen volume, sperm concentration, total sperm count, progressive sperm motility rate, and non-progressive sperm motility rate following the nationwide relaxation of COVID-19 restrictions. The effects on the semen volume and total sperm count persisted over time. Additionally, an increase in the incidence of sperm neck defects has been reported. Infection also led to hormonal disruptions, including alterations in prolactin (PRL), testosterone (T), sex hormone-binding globulin (SHBG), and the free testosterone index (FTI) along with an increase in osteocalcin and 25-hydroxy vitamin D (25-OH-VD).</p><p><strong>Conclusions: </strong>The present study revealed that mild COVID-19 appears to have a detrimental effect on semen quality.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"715-728"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically predicted benign prostate hyperplasia causally affects prostate cancer: a two-sample Mendelian randomization.","authors":"Haijun Huang, Zhiquan Hu, Zhi Chen, Yucong Zhang, Chunguang Yang","doi":"10.21037/tau-2024-673","DOIUrl":"https://doi.org/10.21037/tau-2024-673","url":null,"abstract":"<p><strong>Background: </strong>Benign prostate hyperplasia (BPH) and prostate cancer (PCa) share several similarities, including androgen dependency and parallel increases in prevalence with age. Although PCa lags by 15-20 years, no causal association has been identified between BPH and PCa. To investigate the potential causal links between BPH and PCa, this study was performed in a two-sample Mendelian randomization (MR) design.</p><p><strong>Methods: </strong>We retrieved single-nucleotide polymorphisms (SNPs) associated with BPH from genome-wide association studies (GWAS), which were obtained from the Integrative Epidemiology Unit database, and conducted a two-sample MR analysis to explore the causal relationship between BPH and PCa. The exposure dataset included 13,118 BPH cases and 72,799 controls, while the outcome dataset comprised 9,132 PCa cases and 173,493 controls, all of European ancestry. Four SNPs were selected as instrumental variables (IVs) after stringent filtering for linkage disequilibrium and potential confounding factors. The causal effect was estimated using the inverse-variance-weighted (IVW) method, supplemented by sensitivity analyses to assess heterogeneity and pleiotropy.</p><p><strong>Results: </strong>The IVW analysis revealed that genetically predicted BPH was causally associated with a 1.02-fold increased risk of PCa [95% confidence interval (CI): 1.0076-1.0286, P<0.001]. Sensitivity analyses, including MR-Egger regression and leave-one-out analysis, confirmed the robustness of these findings, with no significant heterogeneity or pleiotropy detected.</p><p><strong>Conclusions: </strong>This study provides genetic evidence supporting a causal relationship between BPH and an increased risk of PCa. These findings suggest that BPH may contribute to the development of PCa, potentially guiding future clinical practices in screening, diagnosis, and treatment strategies for BPH patients to mitigate PCa risk. Further validation in diverse populations and clinical studies is warranted to confirm these findings.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"661-668"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of presurgical therapy with tislelizumab and axitinib to downsize local lesions in locally advanced and metastatic renal cell carcinoma: a single-institution experience with long-term follow-up.","authors":"Qiang Zhao, Baoan Hong, Yiqiang Liu, Haibin Zhu, Yong Yang, Ning Zhang","doi":"10.21037/tau-24-585","DOIUrl":"https://doi.org/10.21037/tau-24-585","url":null,"abstract":"<p><strong>Background: </strong>Systemic therapy with or without surgery is recommended in advanced renal cell carcinoma (RCC). The potential benefits of tislelizumab and axitinib as presurgical therapy in advanced RCC remain unclear. This study aimed to preliminarily assess the efficacy of short-term presurgical tislelizumab and axitinib in downsizing local lesions and its long-term oncological outcome with or without nephrectomy in advanced RCC.</p><p><strong>Methods: </strong>Data were prospectively collected from patients with advanced RCC who received tislelizumab and axitinib and were scheduled for deferred nephrectomy. Efficacy was evaluated by the remission of all tumor lesions using computed tomography (CT), and oncological outcomes were also reported.</p><p><strong>Results: </strong>Between March 2021 and May 2022, 11 patients were recruited, 10 of whom presented with metastases. Biopsy results confirmed clear-cell RCC in eight patients, and RCC not otherwise specified in three patients. Following a median of three cycles of presurgical treatment, the overall response rate (ORR) and disease control rate (DCR) were 18.2% (2/11) and 100% (11/11), respectively. The median percentage change in the long-axis diameter was -24.0% (range, -8.2% to -39.7%) for all lesions and -12.2% (range, -7.1% to -39.7%) for local lesions. Open nephrectomy was successfully performed in eight patients with high anatomical complexity. After a median follow-up of 23 months (range, 14-34 months), six patients (6/11, 54.5%) experienced disease progression and died, including three patients without nephrectomy (3/3, 100%) and another three with nephrectomy (3/8, 37.5%). Progression-free survival (PFS) and overall survival (OS) were significantly longer in patients who underwent nephrectomy (P=0.002 and P=0.004).</p><p><strong>Conclusions: </strong>Short-term presurgical tislelizumab and axitinib can downsize local lesions and facilitate nephrectomy in advanced RCC with high anatomical complexity, potentially improving long-term oncological outcomes when followed by cytoreductive surgery.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"651-660"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}