{"title":"成人肾结石患者血清白蛋白与球蛋白的比值与全因死亡风险之间的l型相关性：一项国家队列研究。","authors":"Sian Chen, Yiqiu Cheng, Fei Wang, Jinhai Wu, Xuejin Zhu, Luca Zanoli, Gino Pigatto Filho, Qi Gao, Yanfei Chen","doi":"10.21037/tau-2025-127","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Kidney stones are a common urological disease with rising global prevalence and are influenced by immune, metabolic, and nutritional factors. The ratio of serum albumin to globulin, a marker of inflammation and nutritional status, has been linked to various inflammatory and chronic conditions, but its role in kidney stone risk and outcomes remains unclear. We aimed to determine the association between ratio of serum albumin to globulin and risk of kidney stones, as well as the impact of ratio of serum albumin to globulin on all-cause mortality in participants with kidney stones.</p><p><strong>Methods: </strong>Multivariable logistic regression was used to explore the association between ratio of serum albumin to globulin and the risk of kidney stones. Multivariate Cox regression and restricted cubic spline (RCS) were performed to clarify the relationship between ratio of serum albumin to globulin and the risk of all-cause mortality.</p><p><strong>Results: </strong>Among 31,091 study participants, 2,955 (9.5%) individuals had kidney stones. Multivariable logistic models demonstrated that each standard deviation (SD) increase in the ratio of serum albumin to globulin (SD =0.30) was associated with a 6% reduction in kidney stone risk. A total of 387 (13.1%) participants with kidney stones died for any reasons during a median follow-up of 6.2 years. The multivariable Cox model showed a significantly lower risk of all-cause mortality in the quartile (Q)2, Q3, and Q4 groups as compared to Q1 [Q2: adjusted hazard ratio (aHR) =0.84, 95% confidence interval (CI): 0.63-1.11; Q3: aHR =0.65, 95% CI: 0.48-0.86; Q4: aHR =0.63, 95% CI: 0.46-0.86; P for trend =0.04].</p><p><strong>Conclusions: </strong>A lower ratio of serum albumin to globulin was associated with an increased risk of kidney stones. Additionally, our study showed that at a cutoff point of 1.5, the association between ratio of serum albumin to globulin and all-cause mortality in participants with kidney stones was nonlinear L-shaped. However, due to the observational nature of the study, our study results should be interpreted with caution.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"751-763"},"PeriodicalIF":1.7000,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986477/pdf/","citationCount":"0","resultStr":"{\"title\":\"L-shaped association between the ratio of serum albumin to globulin and the risk of all-cause mortality among adults with kidney stones: a national cohort study.\",\"authors\":\"Sian Chen, Yiqiu Cheng, Fei Wang, Jinhai Wu, Xuejin Zhu, Luca Zanoli, Gino Pigatto Filho, Qi Gao, Yanfei Chen\",\"doi\":\"10.21037/tau-2025-127\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Kidney stones are a common urological disease with rising global prevalence and are influenced by immune, metabolic, and nutritional factors. The ratio of serum albumin to globulin, a marker of inflammation and nutritional status, has been linked to various inflammatory and chronic conditions, but its role in kidney stone risk and outcomes remains unclear. We aimed to determine the association between ratio of serum albumin to globulin and risk of kidney stones, as well as the impact of ratio of serum albumin to globulin on all-cause mortality in participants with kidney stones.</p><p><strong>Methods: </strong>Multivariable logistic regression was used to explore the association between ratio of serum albumin to globulin and the risk of kidney stones. Multivariate Cox regression and restricted cubic spline (RCS) were performed to clarify the relationship between ratio of serum albumin to globulin and the risk of all-cause mortality.</p><p><strong>Results: </strong>Among 31,091 study participants, 2,955 (9.5%) individuals had kidney stones. Multivariable logistic models demonstrated that each standard deviation (SD) increase in the ratio of serum albumin to globulin (SD =0.30) was associated with a 6% reduction in kidney stone risk. A total of 387 (13.1%) participants with kidney stones died for any reasons during a median follow-up of 6.2 years. The multivariable Cox model showed a significantly lower risk of all-cause mortality in the quartile (Q)2, Q3, and Q4 groups as compared to Q1 [Q2: adjusted hazard ratio (aHR) =0.84, 95% confidence interval (CI): 0.63-1.11; Q3: aHR =0.65, 95% CI: 0.48-0.86; Q4: aHR =0.63, 95% CI: 0.46-0.86; P for trend =0.04].</p><p><strong>Conclusions: </strong>A lower ratio of serum albumin to globulin was associated with an increased risk of kidney stones. Additionally, our study showed that at a cutoff point of 1.5, the association between ratio of serum albumin to globulin and all-cause mortality in participants with kidney stones was nonlinear L-shaped. However, due to the observational nature of the study, our study results should be interpreted with caution.</p>\",\"PeriodicalId\":23270,\"journal\":{\"name\":\"Translational andrology and urology\",\"volume\":\"14 3\",\"pages\":\"751-763\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-03-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986477/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational andrology and urology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.21037/tau-2025-127\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"ANDROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational andrology and urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tau-2025-127","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/26 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ANDROLOGY","Score":null,"Total":0}
L-shaped association between the ratio of serum albumin to globulin and the risk of all-cause mortality among adults with kidney stones: a national cohort study.
Background: Kidney stones are a common urological disease with rising global prevalence and are influenced by immune, metabolic, and nutritional factors. The ratio of serum albumin to globulin, a marker of inflammation and nutritional status, has been linked to various inflammatory and chronic conditions, but its role in kidney stone risk and outcomes remains unclear. We aimed to determine the association between ratio of serum albumin to globulin and risk of kidney stones, as well as the impact of ratio of serum albumin to globulin on all-cause mortality in participants with kidney stones.
Methods: Multivariable logistic regression was used to explore the association between ratio of serum albumin to globulin and the risk of kidney stones. Multivariate Cox regression and restricted cubic spline (RCS) were performed to clarify the relationship between ratio of serum albumin to globulin and the risk of all-cause mortality.
Results: Among 31,091 study participants, 2,955 (9.5%) individuals had kidney stones. Multivariable logistic models demonstrated that each standard deviation (SD) increase in the ratio of serum albumin to globulin (SD =0.30) was associated with a 6% reduction in kidney stone risk. A total of 387 (13.1%) participants with kidney stones died for any reasons during a median follow-up of 6.2 years. The multivariable Cox model showed a significantly lower risk of all-cause mortality in the quartile (Q)2, Q3, and Q4 groups as compared to Q1 [Q2: adjusted hazard ratio (aHR) =0.84, 95% confidence interval (CI): 0.63-1.11; Q3: aHR =0.65, 95% CI: 0.48-0.86; Q4: aHR =0.63, 95% CI: 0.46-0.86; P for trend =0.04].
Conclusions: A lower ratio of serum albumin to globulin was associated with an increased risk of kidney stones. Additionally, our study showed that at a cutoff point of 1.5, the association between ratio of serum albumin to globulin and all-cause mortality in participants with kidney stones was nonlinear L-shaped. However, due to the observational nature of the study, our study results should be interpreted with caution.
期刊介绍：
ranslational Andrology and Urology (Print ISSN 2223-4683; Online ISSN 2223-4691; Transl Androl Urol; TAU) is an open access, peer-reviewed, bi-monthly journal (quarterly published from Mar.2012 - Dec. 2014). The main focus of the journal is to describe new findings in the field of translational research of Andrology and Urology, provides current and practical information on basic research and clinical investigations of Andrology and Urology. Specific areas of interest include, but not limited to, molecular study, pathology, biology and technical advances related to andrology and urology. Topics cover range from evaluation, prevention, diagnosis, therapy, prognosis, rehabilitation and future challenges to urology and andrology. Contributions pertinent to urology and andrology are also included from related fields such as public health, basic sciences, education, sociology, and nursing.
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