Translational andrology and urology最新文献

{"title":"Global research trends in the comorbidity of erectile dysfunction and premature ejaculation: a 20-year bibliometric analysis [2005-2025].","authors":"Yuhang Xin, Mengxin Fang, Xinyang Fang, Yanan Chen, Fan Yang","doi":"10.21037/tau-2026-0302","DOIUrl":"10.21037/tau-2026-0302","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) and premature ejaculation (PE) frequently co-occur, presenting a significant clinical challenge in male health. However, existing research remains fragmented, lacking a systematic overview of the field's developmental trajectory, knowledge structure, and future trends. This study aims to systematically map the research landscape of ED/PE comorbidity over the past two decades [2005-2025] using bibliometric methods, revealing its evolutionary pathways, research hotspots, collaborative networks, and emerging frontiers.</p><p><strong>Methods: </strong>Based on the Web of Science Core Collection (WoSCC) database, 1,089 ED/PE comorbidity-related publications were retrieved and analyzed. Tools including VOSviewer, CiteSpace, and Bibliometrix were employed for quantitative analysis and visualization of countries, institutions, authors, journals, keywords, and citation networks.</p><p><strong>Results: </strong>Findings indicate: (I) annual publication volume exhibits exponential growth, with pivotal inflection points occurring in 2008 and 2021. (II) China leads in publication output, whereas Italy and the United States dominate academic influence and international collaboration. (III) Research themes evolved through three phases: epidemiology and disease definition [2005-2013], combination therapies and mechanism exploration [2014-2020], and diversified integrated interventions [2021-2025]. (IV) Cognitive behavioral therapy, pathophysiological mechanisms, and emerging physical therapies represent current frontiers, whereas patient psychological counseling and endocrine regulation remain relatively peripheral.</p><p><strong>Conclusions: </strong>This study presents the first knowledge map of ED/PE comorbidity research, revealing a clear trajectory from isolated disease perspectives toward integrated comorbidity models. Future research should deepen exploration of \"neuro-vascular-psychological\" integrated mechanisms, strengthen high-quality clinical trials, and address current research gaps to advance clinical practice to precision.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"231"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile skin necrosis after complex penile surgery with synthetic grafts: a case report.","authors":"Federica Sordelli, Morgane Genon, Anne-Laure Charvet, Louise Leclercq, Sacha Tomczak, Omid Sedigh, Cyrille Bastide, Jennifer Campagna","doi":"10.21037/tau-2026-1-0173","DOIUrl":"10.21037/tau-2026-1-0173","url":null,"abstract":"<p><strong>Background: </strong>Severe complications following complex penile reconstructive surgery are uncommon but may be devastating, particularly when synthetic grafts are employed. Infection and progressive penile skin necrosis can rapidly compromise erectile structures and functional outcomes. Evidence guiding the optimal management of extensive necrosis after graft-based augmentation procedures remains limited. We report a case of severe penile skin necrosis following complex penile surgery with synthetic graft implantation, highlighting a staged salvage strategy aimed at infection control and preservation of erectile anatomy.</p><p><strong>Case description: </strong>A 36-year-old man presented with progressive penile skin necrosis and infection after undergoing corrective penile surgery at an external centre, including plaque excision, bilateral placement of Gore-Tex^® grafts, suspensory ligament section, circumcision, and vasectomy. Clinical evaluation revealed extensive cutaneous necrosis with partial exposure of synthetic grafts. Urgent surgical exploration was performed, consisting of radical debridement and complete graft removal. The corpora cavernosa were exposed but viable and intentionally left uncovered as part of a staged reconstructive approach. Targeted antibiotic therapy and adjunctive hyperbaric oxygen treatment were initiated. After infection control and wound stabilization, definitive reconstruction was achieved using a split-thickness skin graft combined with a dermal regeneration template (Matriderm^®). The postoperative course was uneventful, with excellent graft take and satisfactory cosmetic results.</p><p><strong>Conclusions: </strong>Extensive penile necrosis following synthetic graft-based surgery requires prompt recognition and aggressive management. Early removal of foreign material, radical debridement, and a staged reconstructive strategy are essential to prevent further tissue loss and preserve erectile structures. Multidisciplinary management and the use of dermal regeneration templates may facilitate reliable coverage and favourable functional recovery in complex salvage scenarios.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"256"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of oral pentoxifylline on semen parameters and reproductive hormones in idiopathic male infertility: a systematic review and meta-analysis.","authors":"Wenguang Zhou, Hao Wang, Dicheng Luo, Youran Dai, Hongyuan Chang, Yongqing Zhao, Dongyue Ma, Anmin Wang, Hui Lv, Jiwei Zhang, Fu Wang","doi":"10.21037/tau-2025-1-999","DOIUrl":"10.21037/tau-2025-1-999","url":null,"abstract":"<p><strong>Background: </strong>Male infertility accounts for nearly half of infertility cases, with abnormal semen quality being a major cause. Pentoxifylline (PTX), a methylxanthine derivative with antioxidant and anti-inflammatory properties, has been proposed to improve semen parameters, but evidence remains inconsistent. This systematic review and meta-analysis aimed to assess the efficacy and safety of oral PTX supplementation compared with placebo in improving semen parameters and reproductive hormone profiles in infertile men.</p><p><strong>Methods: </strong>PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials were searched from inception to July 2025. Randomized controlled trials (RCTs) comparing oral PTX with placebo in infertile men were included. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Primary outcomes included semen parameters (sperm concentration, total motility, morphology, semen volume). Secondary outcomes comprised serum hormones [testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH)]. Data were pooled calculating mean difference (MD) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Five RCTs involving 455 participants were included. PTX dosages ranged from 800 to 1,200 mg/day, with treatment durations of 3 to 6 months. PTX supplementation correlated with increased total sperm motility (MD =10.44, 95% CI: 3.57-17.30) and normal morphology (MD =3.86, 95% CI: 1.01-6.71). Sperm concentration transiently improved at 3 months but did not differ significantly from placebo at 6 months. No significant differences were observed in testosterone (MD =0.22, 95% CI: -0.23 to 0.67) or FSH (MD =-1.51, 95% CI: -4.16 to 1.14) levels, whereas LH decreased marginally (MD =-0.97, 95% CI: -1.45 to -0.49). Reported adverse events were predominantly mild and gastrointestinal.</p><p><strong>Conclusions: </strong>PTX supplementation appears to enhance sperm motility and morphology in infertile men with a favorable safety profile. Its effects on sperm concentration and reproductive hormones are less consistent, and evidence on ultimate clinical effectiveness regarding pregnancy and live birth rates remains unproven. Larger, high-quality trials with reproductive endpoints are needed to clarify its clinical role.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"237"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pharmacological management to regenerative medicine: a bibliometric analysis of global trends and evolutionary patterns in diabetic bladder dysfunction (2000-2024).","authors":"Rui Xu, Junchao Wu, Huitao Wang, Tongxin Yang, Kewei Fang","doi":"10.21037/tau-2026-0296","DOIUrl":"10.21037/tau-2026-0296","url":null,"abstract":"<p><strong>Background: </strong>Diabetic bladder dysfunction (DBD) is a prevalent complication of diabetes that severely impacts quality of life. Conventional treatments have long been confined to managing downstream symptoms with minimal efficacy in advanced stages. This study employs systematic bibliometric analysis to comprehensively map the knowledge foundations, evolving research hotspots, and future translational trajectories in global DBD research spanning 2000 to 2024.</p><p><strong>Methods: </strong>A comprehensive search was conducted on the Web of Science Core Collection (WoSCC) for literature published between January 1, 2000, and August 8, 2024. To maximize the elimination of \"noise\" data typical of automated retrievals, a rigorous two-stage manual full-text screening process was employed, ultimately yielding 264 high-quality core original articles. Bibliometric tools, including CiteSpace and VOSviewer, were utilized to perform visual analyses of country/institution collaboration networks, citation bursts, and keyword timelines.</p><p><strong>Results: </strong>Over the past 25 years, the publication volume in the DBD field has exhibited a fluctuating upward trajectory. The global research landscape has evolved from the absolute dominance of U.S. in the early stages to a multipolar collaborative network that now includes China, Greece, and Germany. Keyword timeline clustering revealed a clear three-phase paradigm shift: the early phase (2000-2010) focused on physiological characterizations and symptomatic management (e.g., 'muscarinic receptors', 'smooth muscle'); the intermediate phase (2010-2018) delved into upstream core pathological mechanisms (e.g., 'oxidative stress', 'hypoxia', 'autonomic neuropathy'); and the recent phase (2019-2024) witnessed the sudden emergence of novel hot clusters such as 'defocused low-energy shock wave' and 'regeneration'.</p><p><strong>Conclusions: </strong>DBD research is undergoing a transition from pharmacological symptom control to regenerative repair targeting the underlying pathologies. Emerging physical-biomodulatory therapies, represented by low-energy shock waves, offer new hope for reversing the decompensation stage of bladder dysfunction. Future research urgently requires large-scale randomized controlled trials to advance the clinical translation of these regenerative medicine strategies.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"246"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and internal validation of a noninvasive predictive model based on iron and fat measurements for pathologic risk stratification in prostate cancer.","authors":"Ziwei Li, Yunshu Zhao, Mengying Zhu, Zhen Tian, Shuting Han, Yonggang Li, Guangzheng Li","doi":"10.21037/tau-2026-0256","DOIUrl":"10.21037/tau-2026-0256","url":null,"abstract":"<p><strong>Background: </strong>Pathological risk stratification of prostate cancer (PCa) guides treatment decisions. Preoperative noninvasive assessment of PCa risk stratification holds promise for reducing unnecessary invasive biopsies. Elevated levels of iron and fat, along with metabolic disorders in PCa significantly correlate with tumor proliferation and aggressiveness, yet its predictive value in risk stratification remains unclear. We aimed to noninvasively measure fat content as well as iron deposition of PCa lesions by multiparametric magnetic resonance imaging (mpMRI) and investigate their effectiveness in predicting PCa risk.</p><p><strong>Methods: </strong>We prospectively collected patients suspected of PCa with preoperative MRI from 2019 to 2022, and ultimately included 109 pathologically confirmed PCa patients. The Gleason score (GS) and International Society of Urological Pathology grade group (ISUP GG) were determined by two uropathologists who evaluated independently and reached a consensus. Patients were stratified based on the ISUP GG, with 42 in the pathological low-risk (PL) group (ISUP GG ≤2; 69.9±6.08 years), 67 in the pathological high-risk (PH) group (ISUP GG ≥3; 71.82±5.86 years). We also collected clinical, pathologic, and imaging data from the patients. Based on the variables screened by Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis, an improved fusion (IF) model was established and visualized with a nomogram plot. The conventional fusion (CF) model was constructed by removing the non-conventional image variables in the IF model. Model performance was evaluated using 10-fold cross-validation, receiver operating characteristic (ROC) analysis, DeLong test, and decision curve analysis (DCA). P<0.05 was considered statistically significant.</p><p><strong>Results: </strong>Significant differences were observed in the prostate-specific antigen (PSA), prostate volume (PV), Prostate Imaging Reporting and Data System (PI-RADS) scores, fat fraction (FF), T2*, and average apparent diffusion coefficient (ADC) values of the lesions between the two groups. These variables were selected to construct the IF model. The CF model was developed by removing FF and T2* values. The IF model demonstrated higher accuracy than the CF model [IF model: sensitivity =0.952, specificity =0.761, area under the curve (AUC) =0.920; CF model: sensitivity =0.762, specificity =0.761, AUC =0.819; DeLong test: P=0.002, <0.05].</p><p><strong>Conclusions: </strong>mpMRI‑derived FF and T2* values were significantly associated with ISUP GG in PCa. Intergrating FF and T2* values with ADC, PI-RADS, PSA and PV may predict pathological risk classification more effectively.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"240"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The modified Whitaker test is a reliable adjunctive rule-out tool for evaluating efficacy after ureteral reimplantation.","authors":"Wenzhi Gao, Bing Wang, Xinfei Li, Xicai Zhang, Linsong Yang, Kunlin Yang, Yaming Gu, Zhihua Li, Yang Yang, Yuke Chen, Caiyong Lai, Huize Huang, Chen Huang, Xuesong Li","doi":"10.21037/tau-2026-0467","DOIUrl":"10.21037/tau-2026-0467","url":null,"abstract":"<p><strong>Background: </strong>Ureteral reimplantation (UR) is the standard treatment for distal ureteral stricture, yet postoperative anastomotic restenosis impairs outcomes, with conventional imaging unable to quantify urinary tract obstruction and dysfunction. This study aimed to explore the clinical value of the modified Whitaker test in ruling out upper urinary tract obstruction and assisting postoperative efficacy evaluation after UR.</p><p><strong>Methods: </strong>A total of 100 patients (105 renal units) who underwent UR from January 2022 to December 2025, with preoperative nephrostomy tube placement and postoperative modified Whitaker test, were prospectively enrolled. Combined standing and supine position examination, gradient perfusion (5~25 mL/min) pressure measurement combined with imaging development classification was used. Patients were classified into three types based on the pyelovesical pressure difference and ureteral peristalsis. Perioperative and follow-up data were collected to evaluate the curative effect.</p><p><strong>Results: </strong>Among patients undergoing modified Whitaker test after UR, 73 cases (69.52%) were Type I, 24 cases (22.86%) Type II, and 8 cases (7.62%) Type III. The median follow-up time was 12.63 (6.92, 25.80) months. The overall surgical efficacy rate was 92.38% (97/105), and the objective efficacy rate was 98.10% (103/105). In the modified Whitaker test, the median intrapelvic pressure was 20.00 (16.00, 25.50) cmH₂O, the median intravesical pressure was 14.00 (9.50, 20.00) cmH₂O, and the median pressure difference was 5.00 (2.00, 9.00) cmH₂O. The unobstructed results of the modified Whitaker test were consistent with successful overall postoperative efficacy in 85.71% (90/105) of renal units and with successful objective postoperative efficacy in 91.43% (96/105) of renal units. All patients successfully completed the modified Whitaker test without any postoperative discomfort.</p><p><strong>Conclusions: </strong>UR the modified Whitaker test exhibits excellent negative predictive performance and favorable consistency with mid-term postoperative follow-up outcomes. It serves as a reliable adjunctive tool for ruling out upper urinary tract obstruction and guiding nephrostomy tube removal after UR.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"230"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guideline of guidelines: a scoping review on comparison of major clinical guidelines for erectile dysfunction.","authors":"Nicholas Gillman, Eric Chung","doi":"10.21037/tau-2026-1-0168","DOIUrl":"10.21037/tau-2026-1-0168","url":null,"abstract":"<p><strong>Background: </strong>There are numerous published societal guidelines for the management of men with erectile dysfunction (ED), often with specific nuances and some variations in diagnostic and treatment strategies based on relevant locoregional factors such as sociocultural barriers and differences in emphasis between urological organisations versus sexual medicine societies. This \"guideline of guidelines\" narrative format will enable clinicians to identify best clinical practices, standardize the delivery of healthcare and address any inconsistencies so that future research can be undertaken to improve ED care pathways.</p><p><strong>Methods: </strong>The review was conducted as a scoping review with a structured comparison of international clinical practice guidelines for the assessment and management of ED. Guidelines were identified through searches of official websites of major urological organisations and sexual medicine societies and published literature, with further review of references within each guideline. A total of eleven national and international ED guidelines were selected for inclusion in this study.</p><p><strong>Results: </strong>Although first-line pharmacotherapy is well established, recommendations for patient assessment, investigation and further treatment differ across various guidelines. There was a wide consensus in the evaluation of men with ED, especially concerning cardiovascular risk assessment. Divergence was noted in testosterone screening thresholds, adoption of a stepwise management approach and sequencing of intracavernosal injection and vacuum erection device therapy in the treatment algorithm. While there is substantial agreement among the guidelines in assessment and core management principles, meaningful variation exists in testosterone testing thresholds, endocrine evaluation and therapeutic sequencing.</p><p><strong>Conclusions: </strong>Clinicians need to be mindful of existing discrepancies (and similarities) among these major ED guidelines and to adapt specific nuances and tailor critical aspects of these guidelines based on locoregional factors and personalize the care in the ED model specifically to the individual patient.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"254"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cell therapy for erectile dysfunction: a systematic review and meta-analysis.","authors":"Gülsüm Helvacı, Aylin Bilgin, Arthur L Burnett, Sena F Sezen","doi":"10.21037/tau-2026-0348","DOIUrl":"10.21037/tau-2026-0348","url":null,"abstract":"<p><strong>Background: </strong>Erectile dysfunction (ED) is a prevalent sexual dysfunction, and due to the limited efficacy of conventional treatments, stem cell (SC)-based regenerative approaches are being extensively investigated. We aimed to investigate the overall effect of SC therapy (SCT) on ED by consolidating findings from clinical studies and offering a general overview of the intervention content and design of these studies.</p><p><strong>Methods: </strong>A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We systematically reviewed MEDLINE, PubMed, Web of Science and ClinicalTrials.gov from inception to July 26, 2024. The outcomes were analyzed using the Comprehensive Meta-Analysis software version 3.0. The Q statistic and I² statistics were used to evaluate heterogeneity.</p><p><strong>Results: </strong>In this meta-analysis, a total of 11 studies evaluated International Index of Erectile Function (IIEF) levels, with an overall mean effect estimated at 16.872 [95% confidence interval (CI): 13.311-20.432]. The findings demonstrated statistically significant improvements in IIEF (Z=9.288, P<0.001), peak systolic velocity (PSV) (Z=5.384, P<0.001), end-diastolic velocity (EDV) (Z=4.604, P<0.001), erection hardness score (EHS) (Z=4.341, P<0.001), and resistive index (RI) (Z=22.302, P<0.001) levels. The pooled analysis demonstrated a significant improvement in IIEF-5 scores, although heterogeneity was extremely high (I²=92.59%). Furthermore, subgroup analyses revealed significant differences in patient diagnosis (z=3.29, P=0.017), baseline IIEF values (z=-3.64, P=0.003), and the type of SCs applied (z=-2.38, P=0.019).</p><p><strong>Conclusions: </strong>This study suggests that SCT may represent a promising alternative approach for the treatment of ED. However, the current evidence is primarily derived from early-phase studies characterized by small sample sizes, heterogeneous populations, lack of control groups, and short follow-up durations. Therefore, while preliminary findings indicate a potential improvement in erectile function following treatment, the overall level of certainty remains low. Further well-designed, randomized controlled trials with larger sample sizes are required before definitive conclusions can be reached and broader clinical implementation can be recommended.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"243"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rural-urban disparities in high‑risk non-muscle‑invasive bladder cancer: lessons from the Canadian Bladder Cancer Information System.","authors":"Makito Miyake","doi":"10.21037/tau-2026-0412","DOIUrl":"10.21037/tau-2026-0412","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"227"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paravertebral blocks for post-operative analgesia for robotic-assisted partial nephrectomy: a retrospective review.","authors":"Christine Moshe, Jordan S Dutcher, Aditi Verma, Steven Porter, Anna Shapiro, Alexander Hochwald, David D Thiel, Ryan Chadha","doi":"10.21037/tau-2025-1-430","DOIUrl":"10.21037/tau-2025-1-430","url":null,"abstract":"<p><strong>Background: </strong>The interest in opiate-sparing analgesic techniques for post-operative pain management is growing. However, the use of regional analgesic techniques for robotic-assisted surgery is not well established. This study aims to assess the postoperative analgesic efficacy of a paravertebral block (PVB) on post-operative pain scores and opioid consumption in patients undergoing robotic-assisted partial nephrectomies (RAPN).</p><p><strong>Methods: </strong>This study was a retrospective analysis of patients who underwent an elective RAPN by a single surgeon from November 2018 to April 2022. A total of 200 patients (N=81 PVB, N=119 non-PVB) met inclusion criteria for further evaluation. Baseline demographics, analgesic data, and outcomes were collected. Comparisons of outcomes between the PVB and non-PVB groups were made using unadjusted and multivariable regression models appropriate for the nature of the given outcome variable (continuous, ordinal, or count).</p><p><strong>Results: </strong>There were no significant differences between the studied groups regarding age, sex, American Society of Anesthesiology classification, anesthesia type (volatile <i>vs.</i> total intravenous). In comparison to patients without PVB, patients with PVB showed statistically significant lower post-anesthesia care unit (PACU) morphine equivalents (β: -2.43, P=0.006), a higher floor maximum pain score [odds ratio (OR): 2.41, P=0.001], and shorter PACU length of stay (β: -16.95, P=0.002). While these findings were statistically significant, these differences were small.</p><p><strong>Conclusions: </strong>The addition of a PVB did not have a clinically significant impact on the immediate postoperative analgesic experience following RAPN.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"15 7","pages":"241"},"PeriodicalIF":1.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}