Translational andrology and urology最新文献

{"title":"Targeted prostate cancer screening using polygenic risk scores: lessons from the BARCODE1 trial.","authors":"David Hennes, Hyerin Park, Niranjan Sathianathen, David C Chen, Declan G Murphy, Marlon L Perera","doi":"10.21037/tau-2025-320","DOIUrl":"10.21037/tau-2025-320","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2467-2470"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in international medical graduate representation in urology residency and fellowship matches.","authors":"Kamil Malshy, Trevor C Hunt, Zijing Cheng, Ashley Li, Matthew Steidle, Timothy D Campbell, Karen M Doersch, Jean V Joseph, Jathin Bandari","doi":"10.21037/tau-2025-367","DOIUrl":"10.21037/tau-2025-367","url":null,"abstract":"<p><strong>Background: </strong>Diversity enhances quality, innovation, and cultural competence; however, international medical graduates (IMGs) may face disparities in matching into American residency and fellowship programs. This study aimed to examine the influence of medical education [US/Canada (US/CA) <i>vs</i>. IMGs] on match outcomes in urology over time.</p><p><strong>Methods: </strong>We analyzed the American Urological Association residency and subspecialty fellowship match data (2014-2024), examining trends in total match slots and those filled by US/CA <i>vs</i>. IMG applicants across residency and fellowship programs. Secondary analyses assessed residency and fellowship trends separately, compared match rates, and evaluated unmatched applicants. Spearman's correlation assessed trend monotonicity, and chi-squared tests compared match outcomes by applicant group.</p><p><strong>Results: </strong>7,273 applicants [6,061 (83.3%) US/CA; 1,212 (16.7%) IMG] participated in urology matches from 2014-2024, with 4,995 (68.7%) applying to residency and 2,278 (31.3%) to fellowship programs. Total residency and fellowship slots significantly increased from 385 in 2014 to 586 in 2024 (ρ=1.00; P<0.001). Matched US/CA applicants rose significantly from 342 to 499 (ρ=0.99; P<0.001), while matched IMGs showed no significant change (ρ=0.51; P=0.10). US/CA applicants primarily drove the increase in filled slots. Secondary analyses showed US/CA applicants had significantly higher match rates overall [odds ratio (OR) =10.5, 95% confidence interval (CI): 9.1-12.1, P<0.001], in residency (OR =6.7, 95% CI: 5.3-8.5, P<0.001), and fellowship (OR =17.8, 95% CI: 14.4-22.5, P<0.001).</p><p><strong>Conclusions: </strong>Over the past decade, urology residency and fellowship slots have increased, predominantly filled by more US/CA applicants. In contrast, IMG participation and match rates have remained stagnant, with significantly lower outcomes overall and within both matches.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2365-2374"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of mini-percutaneous nephrolithotomy versus flexible ureteroscopic lithotripsy in patients with upper ureteral impacted stones with infection.","authors":"Xi Xie, Guoping Xie, Wei Li, Kazumi Taguchi, Bhaskar Somani, Yuan Yuan, Bo Li","doi":"10.21037/tau-2025-277","DOIUrl":"10.21037/tau-2025-277","url":null,"abstract":"<p><strong>Background: </strong>Urinary stones are a common disease in urology, and stones in ureteral strictures can easily lead to obstruction and subsequent infection. If the upper ureteral impacted stones with infection are not treated promptly, further renal impairment and urinary sepsis can occur. Mini-percutaneous nephrolithotomy (PCNL) and flexible ureteroscopic lithotripsy (fURSL) are common methods for the treatment of upper ureteral impacted stones with infection, but their superiority remains debated. To this end, we designed this study to compare the effects of mini-PCNL versus fURSL in patients with upper ureteral impacted stones with infection.</p><p><strong>Methods: </strong>The data of 182 patients with upper ureteral impacted stones and infection admitted to The First Affiliated Hospital of Chengdu Medical College from January 2021 to December 2024 were retrospectively collected. The patients were divided into an antegrade group (n=88) and a retrograde group (n=94) according to the method they received. The antegrade group was treated with minimally invasive PCNL, and the retrograde group was treated with fURSL. The main outcome measure included inflammatory markers [white blood cell count (WBC), C-reactive protein, interleukin 6, and procalcitonin], and renal function (serum creatinine and urea nitrogen). The other indicators included surgery-related outcomes (operation time and stone-free status) and postoperative complications.</p><p><strong>Results: </strong>Compared with the retrograde group, the one-time stone clearance rate in the antegrade group was significantly higher (96.59% <i>vs.</i> 86.17%; P=0.03). Compared with that in the retrograde group, the operation time in the antegrade group was significantly longer (62.73±4.82 <i>vs.</i> 51.84±5.02 min; P<0.001). There were no statistically significant differences in leukocyte, C-reactive protein, or interleukin 6 levels between the two groups before treatment (P>0.05). Compared to the retrograde group 3 days after surgery, the antegrade group had a significantly higher WBC [(10.92±2.88 <i>vs.</i> 8.92±2.62)×10⁹/L; P<0.001], C-reactive protein (12.94±4.72 <i>vs.</i> 10.82±4.82 mg/L; P=0.003), and interleukin 6 level (18.74±9.82 <i>vs.</i> 15.81±9.27 ng/L; P=0.04). There was no statistically significant difference in postoperative complications between the two groups (P>0.05).</p><p><strong>Conclusions: </strong>PCNL can improve stone clearance rate, but the operation time is long and relatively invasive.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2375-2382"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: The correlation between premature ejaculation and a high incidence of erectile dysfunction and its research progress: a narrative review.","authors":"","doi":"10.21037/tau-2025b-02","DOIUrl":"10.21037/tau-2025b-02","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.21037/tau-24-204.].</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2471-2472"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433154/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A female overactive bladder risk model developed by machine learning: based on 2007-2018 NHANES data.","authors":"Bohao Peng, Yu Luo, Chengcheng Wei, Shuai Su, Liangdong Song","doi":"10.21037/tau-2025-282","DOIUrl":"10.21037/tau-2025-282","url":null,"abstract":"<p><strong>Background: </strong>Overactive bladder (OAB) is a urinary system syndrome that has a serious impact on daily life. Currently, the methods for estimating the risk of OAB are relatively limited, mainly relying on the symptoms reported by patients themselves. There is an urgent need to develop new risk models for the OAB diagnosis. This study aims to assess the risk of OAB in the female population by training machine learning (ML) models.</p><p><strong>Methods: </strong>Based on the National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018, a total of 10,807 female participants were included in the model. Support vector machine (SVM), logistic regression fitting, K-nearest neighbor (KNN), random forest (RF) algorithm, gradient boosting, decision tree (DT), extreme gradient boosting (XGBoost) were used to develop OAB risk models. Ten characteristic factors were used in the construction of the models.</p><p><strong>Results: </strong>Among the seven ML algorithms, the RF model demonstrated the best performance with an area under the curve (AUC) value of 0.879. Among the 10 characteristic factors, hypertension was the most important influencing factor, and the impact of diabetes and sleep disorders on OAB risk cannot be ignored.</p><p><strong>Conclusions: </strong>The results show that the female OAB risk model constructed by ML technology in this study has good diagnostic performance and interpretability, which is helpful to improve the diagnosis of OAB in the female population.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2302-2314"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric study of the top 100 most-cited papers in ureteral stricture reconstruction.","authors":"Jingke He, Junkun Li, Shuai Su, Yu Luo, Yunfan Li, Kun Han, Lincen Jiang, Xuanyu Guo, Jindong Zhang, Chengcheng Wei, Delin Wang","doi":"10.21037/tau-2025-72","DOIUrl":"10.21037/tau-2025-72","url":null,"abstract":"<p><strong>Background: </strong>Ureteral stricture is caused by iatrogenic and non-iatrogenic factors. The treatment of ureteral stricture usually involves ureteral reconstruction. This study aimed to identify and analyze the top 100 most cited (T100) papers in ureteral stricture reconstruction, a field lacking prior bibliometric analysis.</p><p><strong>Methods: </strong>Using the Web of Science Core Collection, we retrieved the T100 articles and review articles on ureteral stricture reconstruction and applied bibliometric tools (CiteSpace, VOSviewer, Bibliometrix) to examine citation patterns, authorship, geographic distribution, journal distribution, co-citation networks, and keyword trends.</p><p><strong>Results: </strong>The T100 articles received 4 to 130 citations each, with an average of 25.13. Publications originated from 23 countries, with the USA leading (56 papers, 1,635 total citations) followed by China (17 papers). Temple University (USA, 12 papers) and Peking University (China, 9 papers) were among the most productive institutions. Daniel D. Eun was the top contributing author (12 papers). <i>Urology, Journal of Endourology</i>, and <i>Journal of Urology</i> were the most productive journals. Topic and keywords analysis shows the hot spots of mucosa grafts and robot-assisted surgery.</p><p><strong>Conclusions: </strong>Our study provides a comprehensive overview of influential literature in ureteral stricture reconstruction. Ureteral stricture reconstruction is an emerging research field. Mucosa grafts and robot-assisted surgery are likely to be hot topics in the future.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2289-2301"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sympathetic hyperactivity in situational delayed ejaculation (intravaginal anejaculation phenotype): a neurophysiological case-control study.","authors":"Qingqiang Gao, Baibing Yang, Youfeng Han, Yutian Dai, Wen Yu, Dawei Ni","doi":"10.21037/tau-2025-348","DOIUrl":"10.21037/tau-2025-348","url":null,"abstract":"<p><strong>Background: </strong>Situational delayed ejaculation (SD-DE, intravaginal anejaculation phenotype) is a clinically significant disorder marked by preserved masturbatory function but persistent coital anejaculation. This condition substantially impairs quality of life and causes significant distress. The underlying neurophysiology, particularly autonomic mechanisms, remains unclear. This study aimed to investigate sympathetic function in SD-DE using penile sympathetic skin response (PSSR) and assess its clinical correlates.</p><p><strong>Methods: </strong>Sixty-seven SD-DE patients and 65 normal controls (NCs) were enrolled. PSSR latency and amplitude, penile sensory threshold (PST), and clinical characteristics (including psychological evaluations via the Self-Rating Anxiety Scale, SAS) were systematically analyzed to evaluate sympathetic nervous system function.</p><p><strong>Results: </strong>SD-DE patients exhibited significantly shorter PSSR latency compared to NCs (P<0.001), indicating sympathetic hyperactivity. A significant negative correlation was observed between PSSR latency and anxiety scores (P<0.001), suggesting stress-mediated sympathetic overactivation. SD-DE patients also demonstrated higher PST (P=0.03), increased masturbation frequency (>2 times/week: 38.81% <i>vs.</i> 20.00%, P=0.02), and a higher prevalence of atypical masturbation (28.36% <i>vs.</i> 3.08%, P<0.001), reflecting compensatory sensorimotor adaptations.</p><p><strong>Conclusions: </strong>These findings establish sympathetic dysfunction as a core feature of SD-DE [Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) 302.74], with PSSR serving as an objective biomarker. The intravaginal anejaculation phenotype represents a distinct clinical entity within DSM-5 302.74, informing targeted therapeutic strategies. In the future, it is necessary to further verify its pathological circuit mechanism by combining multimodal neuroimaging techniques.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2315-2324"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Internet use and lower urinary tract symptoms suggestive of benign prostatic hyperplasia among older adults: a nationwide longitudinal study.","authors":"Fan Wang, Rui Zhao, Zhaobo Wei, Jian Xu, Xuhan Yao","doi":"10.21037/tau-2025-300","DOIUrl":"10.21037/tau-2025-300","url":null,"abstract":"<p><strong>Background: </strong>With the improvement of the national economic level and the development of information technology, more and more elderly people in China have begun to participate in online entertainment and communication. However, in the digital age, older people's access to the Internet has also brought about many new problems. The aim of this study was to investigate whether Internet access was associated with the onset of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) over 7 years among Chinese older populations.</p><p><strong>Methods: </strong>Measures of health behaviors are self-reported. The logistic regression model was used to analyze the cross-sectional and longitudinal associations between daily Internet use and LUTS/BPH.</p><p><strong>Results: </strong>In the cross-sectional study, Internet exposure was significantly associated with LUTS/BPH in Chinese older adults [odds ratio (OR) =2.61; 95% confidence interval (CI): 1.35-5.02]. During the 7-year follow-up, 422 (10.5%) subjects developed new-onset LUTS/BPH. Participants who used the Internet had a higher risk of new-onset LUTS/BPH (OR =2.71; 95% CI: 1.22-6.02). Subgroup analyses suggest that older adults with high economic levels or comorbidities appear to be more likely to develop LUTS/BPH during long-term Internet use.</p><p><strong>Conclusions: </strong>This study found that older adults who used the Internet had an elevated risk of LUTS/BPH compared to those who did not. The increasing prevalence of Internet use among older adults may prompt thinking about the importance of moderate Internet use.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2235-2244"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value and external validation of biparametric magnetic resonance imaging radiomics in clinically significant prostate cancer.","authors":"Hui Xing, Yibanu Abudureheman, Xueru Ai, Yunling Wang, Jingxu Xu, Chencui Huang, Gulimire Kelimu, Ting Li","doi":"10.21037/tau-2025-209","DOIUrl":"10.21037/tau-2025-209","url":null,"abstract":"<p><strong>Background: </strong>Given the significant economic burden of prostate cancer (PCa), its diagnostic methods need to be improved. The limitations of the subjective Prostate Imaging Reporting and Data System (PI-RADS) underscore the need for generalizable radiomics in clinically significant PCa (csPCa). This study aimed to build a machine-learning model based on biparametric magnetic resonance imaging (bpMRI) to diagnose csPCa.</p><p><strong>Methods: </strong>Prognostic model development: This study retrospectively included the data of 445 patients from two centers, of whom 206 had csPCa and 239 had clinically non-significant PCa (ncsPCa). The training set comprised 120 csPCa patients and 141 ncsPCa patients. The test set comprised 52 csPCa patients and 61 ncsPCa patients. The external validation comprised 34 csPCa patients and 37 ncsPCa patients.</p><p><strong>Results: </strong>Features were extracted from T2-weighted imaging (T2WI) sequences and apparent diffusion coefficient (ADC) maps based on bpMRI radiomics. From 3662 radiomics features, 10 stable radiomics features were selected for model construction based on intraclass correlation coefficients (ICCs). Three diagnostic models for csPCa were constructed. The area under the curve (AUC) values for the PI-RADS-scoring model, which was based on visual assessments by radiologists, were 0.8271, 0.7905, and 0.8331 in the training, test, and external validation sets, respectively; while those for the clinical scoring model were 0.9236, 0.8846, and 0.8378, respectively; and those for the radiomics model were 0.9790, 0.9584, and 0.9523, respectively. There were significant differences between the radiomics model and the PI-RADS-scoring model (P<i><</i>0.001) in both the training and test sets. The P value for the radiomics model and clinical scoring model in the training set was <0.001, while that in the validation set was 0.056. Overall, the AUC values for the three models indicated that the diagnostic performance of the bpMRI radiomics model, which was based on T2WI sequences and ADC images, for csPCa was better than that of both the PI-RADS-scoring and clinical scoring models.</p><p><strong>Conclusions: </strong>The radiomics model can reliably detect and classify csPCa, and is a very powerful non-invasive auxiliary tool that could be used as an alternative method for diagnosing csPCa in personalized medicine.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2269-2278"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of drug-coated balloon dilation in patients with radiation-related urethral stenosis.","authors":"Joel Masopeh, Audra Garrigan, Kevin Heinsimer, Lucas Wiegand","doi":"10.21037/tau-24-461","DOIUrl":"10.21037/tau-24-461","url":null,"abstract":"<p><strong>Background: </strong>The Optilume^® drug-coated balloon is a urethral dilation balloon with a paclitaxel coating that combines mechanical dilation for immediate symptomatic relief with local drug delivery to maintain urethral patency. The ROBUST III trial concludes that Optilume is safe and superior to standard direct vision internal urethrotomy/dilation for the treatment of recurrent anterior urethral strictures <3 cm in length. However, there have been limited studies to show efficacy in the treatment of urethral stricture in the setting of post-radiation patients. This study aimed to clarify the safety and early efficacy of Optilume balloon dilation for urethral strictures in post-radiation patients.</p><p><strong>Methods: </strong>All patients undergoing Optilume balloon dilation with at least 3 months of follow-up were evaluated over 27 months in a retrospective multi-institutional setting. Thirty patients who received pelvic radiation and subsequently developed symptomatic urethral strictures were selected from a total of 246 patients identified with symptomatic urethral strictures. Success was defined as the absence of recurrence of original presenting symptoms, no need for intermittent self-dilation, and no requirement for surgical intervention within the follow-up period for their urethral stricture.</p><p><strong>Results: </strong>Successful Optilume balloon dilations without recurrence of symptoms were achieved in 24/30 (80%) patients. Failures with recurrence of strictures occurred in 20% (6/30) of cases. At a median follow-up of 353 (range: 91-818) days, 80% (24/30) of radiated patients had successful Optilume balloon dilation. Our data showed that 83% (5/6) of patients who experienced recurrence did so after 12 months. Among radiated patients without baseline incontinence, new stress incontinence developed postoperatively in 20% (3/15), while one patient had improved stress incontinence.</p><p><strong>Conclusions: </strong>Optilume balloon dilation is a safe mechanism of treatment for urethral stricture disease in radiated patients. Early follow-up data of the treatment of urethral strictures in radiated patients suggests similar efficacy. However, long-term follow-up data is needed.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 8","pages":"2129-2134"},"PeriodicalIF":1.7,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}