Translational andrology and urology最新文献

{"title":"Knowledge, attitude, and practice of kidney transplant patients regarding post-transplant complications: a cross-sectional study.","authors":"Jie Shen, Pengfeng Gong, Yangyang Sun, Dong Xue","doi":"10.21037/tau-2024-683","DOIUrl":"10.21037/tau-2024-683","url":null,"abstract":"<p><strong>Background: </strong>The management of complications following kidney transplantation involves self-management, which requires adequate knowledge and favorable attitudes. This study explored the knowledge, attitude, and practice (KAP) of post-transplant complications among kidney transplant patients.</p><p><strong>Methods: </strong>This cross-sectional study included (convenience sampling) kidney transplant patients from our hospital. A self-designed online KAP questionnaire was used for data collection.</p><p><strong>Results: </strong>A total of 499 (89.7%) valid questionnaires were included; 327 were filled out by men and 172 by women, aged 44.41±10.54 years. The mean knowledge, attitude, and practice scores were 6.00±1.99 (possible range, 0-10), 22.29±1.96 (possible range, 6-30), and 29.28±3.78 (possible range, 8-40), respectively. Pearson's correlation analysis revealed a positive correlation between attitude and knowledge (r=0.129, P=0.004), attitude and practice (r=0.334, P<0.001), and practice and attitude (r=0.416, P<0.001). Structural equation modeling showed that post-transplant complications and education were associated with knowledge while drinking alcohol, age, and duration since kidney transplant were negatively associated with knowledge. Knowledge and education were associated with attitude, while post-transplant complications were negatively associated with attitude. Attitude, knowledge, duration since kidney transplant and education were associated with the practice, while age was negatively associated with the practice.</p><p><strong>Conclusions: </strong>Kidney transplant patients showed insufficient knowledge, positive attitude, and proactive practice regarding post-transplant complications. Age, education, drinking alcohol, post-transplant complications, and duration since kidney transplant might affect their KAP. Educational interventions targeting specific KAP items with poor scores should be designed and tested to improve the self-management of patients with kidney transplants.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1230-1237"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective study to determine the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy.","authors":"David Sobel, Philip Caffery, Evelyn James, Rebecca Ortiz, Aidan Peat, Chris Tucci, Gyan Pareek","doi":"10.21037/tau-2024-692","DOIUrl":"10.21037/tau-2024-692","url":null,"abstract":"<p><strong>Background: </strong>The American opioid epidemic continues and further efforts are needed to reduce unnecessary opioid prescriptions after urologic surgery. This is a pragmatic feasibility study to evaluate the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy (PCNL) utilizing a nonopioid protocol consisting of preoperative counseling, multimodal analgesics, and detailed postoperative instructions.</p><p><strong>Methods: </strong>A prospective feasibility study (Clinicaltrials.gov: NCT04597619) was conducted at a single institution. All participants underwent single tract stented PCNL. Eligible participants were enrolled prospectively before and after implementation of the nonopioid protocol. Pre-intervention arm participants received opioid prescriptions at the discretion of the provider. Participants in the intervention arm underwent the nonopioid protocol. The primary outcome investigated was discharge following PCNL without a prescription for opioid pain medication. Other outcomes included postoperative pain, symptom questionnaire scores, emergency department (ED) visits for pain, and outpatient telephone calls or requests for prescription refills.</p><p><strong>Results: </strong>Fourteen participants were enrolled in the pre-intervention group. Of these, 10 (71%) were discharged with opioid prescriptions and 4 (29%) were discharged without opioids. Of the 10 discharged with opioids, 2 (14%) presented to the ED for pain concerns and received a new prescription for opioids. Six participants underwent intervention and received the nonopioid protocol. All participants (100%) in the intervention group were discharged without opioids. None (0%) presented to the ED for pain concerns.</p><p><strong>Conclusions: </strong>This feasibility study demonstrates that patients undergoing PCNL via a standardized nonopioid pathway can be safely discharged without opioid prescriptions without impact on outpatient resources. Four participants in the pre-intervention group were discharged without opioids based on provider discretion, suggesting that the standard of care to include an opioid prescription may be changing.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1379-1390"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of core genes in acute kidney injury: evidence from multi-omics human transcriptomic data and <i>in vivo</i> models.","authors":"Pengxiao Sun, Qiting Weng, Jiaxin Zhou, Qingzhou Chen, Rui Zhang, Jing Nie","doi":"10.21037/tau-2024-677","DOIUrl":"10.21037/tau-2024-677","url":null,"abstract":"<p><strong>Background: </strong>Acute kidney injury (AKI) affects up to 23.2% of hospitalized patients, but its complex pathophysiology hinders diagnosis and treatment. Bioinformatics-driven identification of core genes from large-scale omics data offers a promising approach for uncovering diagnostic and therapeutic targets. This study aims to integrate multi-omics data with experimental validation to identify core genes involved in AKI and explore their mechanisms.</p><p><strong>Methods: </strong>We analyzed renal transcriptomic data from 67 AKI patients and 20 controls, integrating differential expression, weighted gene co-expression network analysis (WGCNA), and clinical correlations to identify key genes. A nomogram model was used to assess diagnostic performance, and immune microenvironment characteristics were analyzed using CIBERSORT. AKI was induced in mice by ischemia-reperfusion and cisplatin, with gene expression validated by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR), Western blot, and immunohistochemistry. <i>SUGCT</i> expression and function were further examined in proximal tubules (PT) using human single-nucleus RNA sequencing (snRNA-seq) and spatial transcriptomics.</p><p><strong>Results: </strong>Three core genes, epidermal growth factor (<i>EGF</i>), vascular cell adhesion molecule 1 (<i>VCAM1</i>), and <i>SUGCT</i>, were identified, showing significant associations with AKI phenotypes and clinical renal parameters. Combined, these genes provided a robust diagnostic model for AKI. CIBERSORT associated <i>VCAM1</i> with monocytes, <i>SUGCT</i> with monocytes and M2 macrophages, and <i>EGF</i> with monocytes and T cells. Both mouse models showed downregulation of <i>Sugct</i> and <i>Egf</i>, and upregulation of <i>Vcam1</i>, consistent with human data. Single-nucleus RNA sequencing revealed that <i>SUGCT</i> was highly expressed in healthy PT but downregulated in severely injured PT. Low <i>SUGCT</i> expression correlated with suppressed mitochondrial functions and activated immune responses. Spatial transcriptomics confirmed that regions of high <i>SUGCT</i> expression co-localized with areas of oxidative phosphorylation activity in PT.</p><p><strong>Conclusions: </strong>This study highlights three core genes of AKI, especially <i>SUGCT</i>, which is related to mitochondrial metabolism and immune balance in PT during AKI, offering potential diagnostic and therapeutic targets.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1327-1347"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migrasome-related lncRNAs predict prognosis and immune response of clear cell renal cell carcinoma.","authors":"Rong Chen, Lei Dong, Tianci Wei, Qiang Wang","doi":"10.21037/tau-2024-728","DOIUrl":"10.21037/tau-2024-728","url":null,"abstract":"<p><strong>Background: </strong>Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive renal malignancy. Migrasomes, newly discovered organelles involved in intercellular communication, and long non-coding RNAs (lncRNAs) are emerging regulators of cancer progression. However, the role of migrasome-associated lncRNAs in ccRCC prognosis and immune response remains unclear. This study aimed to investigate the value of migrasome-related lncRNAs and develop a risk model for ccRCC.</p><p><strong>Methods: </strong>By employing data from The Cancer Genome Atlas, we were able to identify prognostically significant migrasome-related lncRNAs through co-expression analysis, Cox regression, and least absolute shrinkage and selection operator (LASSO) regression. Prognostic models were developed and validated using these lncRNAs, and a nomogram combining the risk score with clinical features was constructed. Furthermore, our analyses encompassed gene set enrichment, immune infiltration, mutational burden, and drug sensitivity.</p><p><strong>Results: </strong>A prognostic model incorporating 13 lncRNAs effectively stratified patients into distinct risk categories, with the high-risk cohort demonstrating markedly inferior survival rates. The prognostic accuracy was validated through multiple analyses. Gene enrichment analysis revealed a correlation between these lncRNAs and tumor development and immune pathways. High-risk patients exhibited increased immunosuppressive cell infiltration, oncogenic mutations, and potential for immune escape. Furthermore, they demonstrated a lack of response to immunotherapy and exhibited differential responses to antineoplastic agents when compared to low-risk patients. We propose a prognostic model for ccRCC based on migrasome-related lncRNAs, providing new insights into disease progression and potential individualized treatment strategies.</p><p><strong>Conclusions: </strong>Our study proposes a prognostic model for ccRCC based on migrasome-related lncRNAs, providing new insights into disease progression and potential individualized treatment strategies.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1214-1229"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising incidence and clinical impact of kidney cancer in China and worldwide: a call for targeted prevention, early diagnosis, and equitable treatment.","authors":"Canxuan Li, Xiayu Kuang, Shaopei Zou, Jing Zhang","doi":"10.21037/tau-2024-750","DOIUrl":"10.21037/tau-2024-750","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Kidney cancer is an increasing global public health challenge, with its incidence rising due to aging populations, lifestyle transitions, and advances in diagnostic technologies. However, this growth is unevenly distributed across regions, driven by disparities in healthcare access, socioeconomic conditions, and lifestyle factors. In China, kidney cancer incidence and mortality have escalated significantly, fueled by an aging population, urbanization, and higher prevalence of risk factors such as smoking and hypertension. Rural areas face disproportionately late-stage diagnoses due to healthcare inequities. Globally, notable gender differences persist, as men consistently exhibit higher rates of both incidence and mortality in comparison to women. This study aimed to analyze kidney cancer trends and risk factor contributions in China and globally from 1990 to 2021 to inform targeted public health strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study utilized data from the Global Burden of Disease (GBD) 2021 database to explore trends in kidney cancer between 1990 and 2021. Critical indicators, including age-standardized rates (ASRs) for incidence, prevalence, mortality, and disability-adjusted life years (DALYs), were examined using Joinpoint regression to uncover temporal patterns and demographic distinctions. Data stratification by age, gender, and region was performed, with advanced modeling approaches such as Disease Modeling-Meta-Regression (DisMod-MR) and Cause of Death Ensemble model (CODEm) employed to standardize outcomes and mitigate reporting inconsistencies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;From 1990 to 2021, kidney cancer in China exhibited substantial increases in incidence, prevalence, and mortality rates. The age-standardized incidence rate (ASIR) grew from 1.794 to 3.319 per 100,000, while the prevalence rate rose from 7.191 to 17.754 per 100,000. Mortality rates experienced a moderate rise, with the age-standardized mortality rate (ASMR) increasing from 1.14 to 1.246 per 100,000. Although DALYs rose significantly, the age-standardized DALY rate (ASDR) displayed a marginal decline, dropping from 35.838 to 34.176 per 100,000. In China, contributions of smoking and high body mass index (BMI) to kidney cancer mortality and DALYs increased, while occupational exposure to trichloroethylene remained stable; globally, high BMI rose to become the leading risk factor, surpassing smoking, which declined. On a global scale, incidence and prevalence of kidney cancer steadily climbed, while mortality and DALY rates exhibited slight decreases, attributable to improvements in early diagnosis and treatment strategies. Gender disparities persisted, with men consistently showing higher rates across all metrics compared to women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Over 30 years, kidney cancer burden has risen sharply with regional, demographic, and gender disparities. China needs to reduce urban-rural gaps and impro","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1391-1407"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjustable continence therapy for men (ProACT^TM): systematic review and compendium of adverse events.","authors":"Adrian M Fernandez, Hiren V Patel, Kevin D Li, Ashwin S Balakrishnan, John Buie, Umar Ghaffar, Nizar Hakam, Benjamin N Breyer","doi":"10.21037/tau-24-587","DOIUrl":"10.21037/tau-24-587","url":null,"abstract":"<p><strong>Background: </strong>Adjustable continence therapy for men (ProACT^TM) is an inflatable para-urethral balloon approved for consumer use in the United States by the Food and Drug Administration in 2015. Post-approval adverse events (AEs) have been catalogued in Manufacturer and User Facility Device Experience (MAUDE). To characterize the complication profile of the device, we systematically reviewed all publications and MAUDE narratives outlining AEs related to ProACT^TM.</p><p><strong>Methods: </strong>Thirty-one peer-reviewed publications studying ProACT^TM implantation in humans were identified by search of PubMed and Google Scholar using combination of keywords \"ProACT\", \"balloon\", and \"continence\". Eleven studies were excluded. The MAUDE database was searched for reports of AEs related to the placement of ProACT^TM and narratives of AEs were characterized.</p><p><strong>Results: </strong>Of 1,607 patients treated in published studies, 752 AEs occurred. The most common were mechanical failure (n=224, 30%), device migration/malposition (n=155, 21%), and device erosion (n=120, 16%). Devices were explanted in 24% of patients and revised or reimplanted in 28% of cases. In the MAUDE database, the AEs identified were similar, with most common complications including device erosion (n=32, 49%), surgical site infection (n=15, 19%), and urinary retention (n=9, 11%).</p><p><strong>Conclusions: </strong>Use of the ProACT^TM device is associated with a high rate of AEs. Limitations include the lack of clinical details in the MAUDE database.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1476-1483"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the burden of disease for male infertility globally and in China from 1990 to 2021.","authors":"Zujuan Shan, Shun Chen, Wenju Zhou, Yingwei Yang, Guifu Zhang, Jinquan Zhao","doi":"10.21037/tau-2025-44","DOIUrl":"10.21037/tau-2025-44","url":null,"abstract":"<p><strong>Background: </strong>Infertility affects one in six couples globally, with male infertility contributing to 50% of cases. Despite its high prevalence, male infertility is underexplored in some regions due to cultural and societal factors. Epidemiological data remain sparse and inconsistent. This study uses Global Burden of Disease (GBD) 2021 data to assess the global and Chinese burden of male infertility and project future trends.</p><p><strong>Methods: </strong>Using the GBD 2021 dataset, we analyze global male infertility trends from 1990 to 2021 across different subgroups (age, region, and country), focusing on prevalence, disability-adjusted life years (DALYs), and their corresponding age-standardized rates (ASRs), and compare these trends with China. We examine the correlation between the Socio-Demographic Index (SDI) and the burden of male infertility at national and regional levels. Spearman's rank correlation assesses the relationship between ASRs and SDI. Decomposition analysis identifies drivers of the growing male infertility burden globally, in China, and across SDI regions. The slope index of inequality (SII) and the concentration index (CII) quantify global health inequalities, and the Bayesian-Aperiodic-People-Cohort (BAPC) model predicts future trends in male infertility prevalence and DALYs globally and in China.</p><p><strong>Results: </strong>In 2021, the global prevalence of male infertility surpassed 55 million cases, with over 300,000 DALYs. China accounted for approximately 20% of the global burden, with ASRs significantly exceeding the global average. Globally, male infertility prevalence and DALYs increased steadily from 1990 to 2021, particularly in low and low-middle SDI regions, such as South Asia, Southeast Asia, and Latin America. In contrast, China exhibited a stable trend with a gradual decline after 2008. Population growth was identified as the primary driver of global prevalence increases, while age-related factors played a more significant role in China. South and East Asia reported the highest absolute numbers of prevalence cases and DALYs, contributing to half of the global burden. However, the highest ASRs for prevalence and DALYs were recorded in Eastern Europe and Western Sub-Saharan Africa, reaching 1.5 times the global average.</p><p><strong>Conclusions: </strong>This study underscores the increasing global burden of male infertility, accompanied by pronounced disparities across regions and socioeconomic groups. While the burden in China shows signs of decline, low and low-middle SDI regions continue to face rising prevalence and DALYs. Official attention, along with a comprehensive approach to managing environmental factors, lifestyle changes, and sexually transmitted diseases (STDs), is essential to address these disparities and mitigate the growing global burden of male infertility.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1363-1378"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fisetin-mediated PPAR-γ upregulation: a novel therapeutic approach for corpus cavernosum smooth-muscle-cell apoptosis and restoration of erectile function after cavernous nerve injury.","authors":"Yijia Fu, Xin Zhang, Runnan Xu, Bodong Lv","doi":"10.21037/tau-2025-63","DOIUrl":"10.21037/tau-2025-63","url":null,"abstract":"<p><strong>Background: </strong>The development of neurogenic erectile dysfunction (NED) is closely associated with apoptosis and fibrosis of corpus cavernosum smooth muscle cells (CCSMCs) following cavernous nerve injury (CNI). This study aimed to examine the preventative effects of fisetin on CCSMC apoptosis and fibrosis, as well as its ameliorative effects on NED, using a rat model of CNI.</p><p><strong>Methods: </strong>Twenty-four male Sprague-Dawley rats were randomly assigned into three groups: a control group (n=8), a model group (CNI; n=8), and a fisetin group [2.5 mg/(kg·day) of fisetin administered via gavage; n=8]. The animal model was established through clamping of the bilateral cavernous nerves. The control and model groups were given an equivalent volume of saline. Erectile function (EF) was evaluated as the ratio of intracavernous pressure to mean arterial pressure (ICP/MAP). Penile tissue samples were collected for Western blotting, Real-time polymerase chain reaction (RT-qPCR), and fluorescence analysis to assess the expression levels of apoptotic proteins, messenger RNA (mRNA), collagen types I (Col-1) and III (Col-3), and peroxisome proliferator-activated receptor gamma (PPAR-γ). Apoptosis in CCSMCs was evaluated using TUNEL staining, while the collagen content in corporal tissue was assessed using Masson staining.</p><p><strong>Results: </strong>Compared to the control group, the model group's ICP:MAP ratio decreased. The model group also exhibited increased levels of apoptotic proteins and their RNA, including caspase 3, caspase 9, and Bax, while those of Bcl-2 were decreased. TUNEL staining indicated the presence of apoptosis in CCSMCs. The expression of the Col-1 and Col-3 proteins was elevated, and Masson staining indicated that the smooth muscle-to-collagen ratio was decreased. Moreover, RT-qPCR and immunofluorescence staining indicated a decrease in PPAR-γ content in corporal tissue. Treatment with fisetin for 4 weeks reversed these changes. <i>In vitro</i> experiments showed that the addition of the PPAR-γ inhibitor T0070907 negated the effects of fisetin in reducing the apoptosis rate and collagen deposition in CCSMCs.</p><p><strong>Conclusions: </strong>Fisetin may exert a protective effect against CNI-induced apoptosis in CCSMCs, ameliorate the fibrosis of the corporal tissue, and enhance EF, primarily through the upregulation of PPAR-γ expression.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1429-1443"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary calcium intake and benign prostatic hyperplasia: a population-based result from NHANES 2003 to 2008.","authors":"Hongyuan Chang, Hao Wang, Anmin Wang, Dongyue Ma, Hui Lv, Di Sun, Ziwei Zhao, Dicheng Luo, Shihao Wang, Jun Guo, Fu Wang","doi":"10.21037/tau-2025-43","DOIUrl":"10.21037/tau-2025-43","url":null,"abstract":"<p><strong>Background: </strong>Benign prostatic hyperplasia (BPH), as a cause of various lower urinary tract symptoms (LUTS), can improve patients' quality of life when effectively controlled. To elaborate on the effect of dietary calcium intake on BPH, we investigated the association between dietary calcium intake and the risk of BPH using data from the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Data from the NHANES conducted from 2003 to 2008 were utilized. BPH was identified through self-reported questionnaires, and dietary calcium intake was calculated based on the mean of two 24-hour dietary recall interviews. Multivariable logistic regression analyses were performed to assess the association, supplemented by restricted cubic spline analysis and subgroup analyses.</p><p><strong>Results: </strong>A total of 590 males aged 40 years and older were included in the study, of whom 138 had BPH. After adjusting for all covariates, a higher dietary calcium intake was associated with an increased risk of BPH [odds ratio (OR), 1.05; 95% confidence interval (CI): 1.01-1.09; P=0.04], and those without hypertension.</p><p><strong>Conclusions: </strong>The study found a positive association between dietary calcium intake and the risk of BPH among U.S. men aged 40 years and older. High calcium intake may be associated with the occurrence of BPH, particularly in older individuals. These findings underscore the importance of monitoring dietary calcium intake as part of BPH prevention strategies.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1273-1282"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical significance of urine-based automated detection of GSTP1 methylation for the diagnosis of suspected prostate cancer patients.","authors":"Ruidong Ji, Liang Zhang, Yaping Xing, Yifei Zhu, Kaifeng Mao, Mingchi Wang, Kenan Xuan, Yu Yang, Richard Lo, Bingfeng Luo, Zhenquan Lu","doi":"10.21037/tau-2024-689","DOIUrl":"10.21037/tau-2024-689","url":null,"abstract":"<p><strong>Background: </strong>Glutathione S-transferase Pi-1 (GSTP1) methylation is detectable in prostate cancer (PCa) tissues, blood, and urine post-prostate massage, with elevated levels in urine samples. But its role in urine samples for PCa diagnosis is still unclear. This study aimed to investigate the clinical significance of urine-based automated detection of GSTP1 methylation technology in the diagnosis of clinical suspected PCa patients.</p><p><strong>Methods: </strong>A retrospective study was performed on 120 patients who underwent prostate biopsy at The University of Hong Kong-Shenzhen Hospital from September 2022 to June 2024. All patients underwent digital rectal examination (DRE) prior to biopsy, with post-DRE urine samples used for GSTP1 methylation testing. Using biopsy pathology as the gold standard, we compared the sensitivity, specificity, and accuracy of urinary GSTP1 methylation with prostate-specific antigen (PSA) for diagnosing PCa. Additionally, we developed a diagnostic prediction model integrating urinary GSTP1 methylation and PSA to assess the combined method's value in enhancing diagnostic efficacy.</p><p><strong>Results: </strong>The sensitivity and specificity of urinary GSTP1 methylation for PCa diagnosis were 81.4% and 83.6%, respectively, with positive predictive value (PPV) of 82.8% and accuracy of 82.5%. In contrast, PSA had sensitivity and specificity of 67.8% and 54.1%, respectively, with PPV of 58.8% and accuracy of 60.8%. Urinary GSTP1 methylation showed no significant difference in sensitivity compared to PSA (P=0.16) but significantly higher specificity (P=0.001). In the PSA gray zone (4.0-10.0 ng/mL), GSTP1 methylation had sensitivity and specificity of 87.5% and 86.2%, respectively, achieving accuracy of 86.7%, demonstrating good diagnostic efficacy. The area under the curve (AUC) for the combined urinary GSTP1 methylation and PSA method was 0.89 [95% confidence interval (CI): 0.84-0.95], P<0.001, significantly superior to PSA alone, notably improving diagnostic efficacy.</p><p><strong>Conclusions: </strong>Automated detection of urinary GSTP1 methylation significantly enhanced PCa diagnostic value, outperforming PSA in sensitivity, specificity, and accuracy. Combining urinary GSTP1 methylation with PSA notably improved accuracy, especially in the PSA gray zone (4.0-10.0 ng/mL), demonstrating excellent efficacy. This non-invasive, easily performed method showed high diagnostic efficacy, indicating strong clinical potential.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1204-1213"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}