Translational andrology and urology最新文献

{"title":"Impact of suction ureteral access sheath in ureteroscopy/retrograde intrarenal surgery: a systematic review and meta-analysis.","authors":"Sotaro Kayano, Akihiro Matsukawa, Ekaterina Laukhtina, Yuji Yata, Keiichiro Miyajima, Masaya Murakami, Tatsuya Shimomura, Steffi Kar Kei Yuen, Shahrokh F Shariat, Takahiro Kimura, Takafumi Yanagisawa","doi":"10.21037/tau-2025-138","DOIUrl":"10.21037/tau-2025-138","url":null,"abstract":"<p><strong>Background: </strong>Advances in technology have led to the introduction of the suction ureteral access sheaths (SUASs) in ureteroscopy (URS) and retrograde intrarenal surgery (RIRS), with their clinical benefits becoming widely acknowledged. We aimed to evaluate the efficacy and safety of using SUASs during URS and RIRS.</p><p><strong>Methods: </strong>A systematic search was conducted in April 2024 across the MEDLINE, Scopus, and Web of Science databases. Our focus was on studies investigating the use of SUASs during URS/RIRS for urinary stones. To compare the stone-free rate (SFR) and perioperative outcomes between URS/RIRS procedures with and without SUASs, standard pairwise meta-analyses were conducted. Risk ratios (RRs) and mean differences (MDs) with 95% confidence intervals (CIs) were employed utilizing a random-effects model (PROSPERO: CRD42024538956).</p><p><strong>Results: </strong>Seven studies (n=1,746) were identified. The use of SUASs significantly improved immediate SFR compared to non-SUAS group (RR: 1.23; 95% CI: 1.02 to 1.47; P=0.03), while no significant difference was observed in SFR at one month follow-up. The use of SUASs significantly reduced operation time (MD: -7.98 minutes; 95% CI: -13.46 to -2.50; P=0.004) and overall complication rate (RR: 0.49; 95% CI: 0.34 to 0.71; P<0.001).</p><p><strong>Conclusions: </strong>Our meta-analyses indicate that the use of SUASs during URS/RIRS significantly improves immediate SFR and offers better perioperative outcomes compared to no use of SUASs. To establish SUASs as standard of care, well-designed randomized controlled trials are needed.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1315-1326"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant chemotherapy for muscle-invasive bladder cancer with variant histology and/or divergent differentiation.","authors":"Kojiro Tashiro, Fumihiko Urabe, Takahiro Kimura","doi":"10.21037/tau-2025-13","DOIUrl":"10.21037/tau-2025-13","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1155-1157"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing salvage radiotherapy in prostate cancer: the emerging role of prostate-specific membrane antigen positron emission tomography/computed tomography.","authors":"Elísabet Gonzalez Del Portillo, Fernando López-Campos, Paul Sargos, Felipe Couñago","doi":"10.21037/tau-2025-188","DOIUrl":"10.21037/tau-2025-188","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1182-1186"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsy-free radical prostatectomy for prostate cancer-modern reality or pipe dream?","authors":"Matthew J Roberts, Arya Bahadori, Marlon L Perera","doi":"10.21037/tau-2025-8","DOIUrl":"10.21037/tau-2025-8","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1165-1168"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial considerations among adult men undergoing vasectomy: cost analysis and modeling of outpatient costs associated with vasectomy.","authors":"Samuel Moffet, Tina Lulla, Lambros Stamatakis, Nathan M Shaw","doi":"10.21037/tau-2025-33","DOIUrl":"10.21037/tau-2025-33","url":null,"abstract":"<p><strong>Background: </strong>A noted barrier to men pursuing vasectomy is the out-of-pocket cost associated with the procedure and required follow-up. Published cost ranges vary widely, may be poor proxies for actual patient cost experience and often fail to include the cost associated with pre-procedure visits and post-vasectomy semen analyses (PVSAs). The study aims to identify a realistic total cost for men undergoing vasectomy.</p><p><strong>Methods: </strong>We examine the charges and payments associated with a vasectomy procedure inclusive of any associated pre-procedure office visit, procedure, and follow-up semen analysis. Data on cost for the pre-procedure office visit and procedure were derived from actual charges/payments for 200 consecutive patients seen in a single medical system between 2022 and 2023. Cost of semen analyses were derived from patient-reported and/or published out-of-pocket costs for LabCorp™, local fertility clinic(s), and Fellow^®. Proceeding with the procedure after the initial visit, expected compliance with PVSAs, vasectomy success rates, and regret rate were based on published literature. A Monte-Carlo simulation model was then created with a modelled patient pool of 10,000 patients reflective of the payer mix, compliance, and success rates from the time point of presenting for initial consultation to generate models of total cost. As part of broader independent review board (IRB) approved survey of motivational factors amongst men undergoing vasectomy, a theme of cost emerged as a possible barrier to care. De-identified cost data was then combined with modeling described above.</p><p><strong>Results: </strong>In Model 1 (maximum cost model), the base out-of-pocket cost was $350 plus the cost of PVSA ($139) for an estimated total of $489. The Model 1 average cost was $466. In Model 2 (minimum cost model), the base cost was $276 plus the cost of PVSA ($139) for an estimated total of $415. The Model 2 average cost was $384.42. When incorporating facility fee of $500 with variable insurance coverage, there is a wider range of out-of-pocket cost from $384.42 (full coverage in Model 2) to $1,026 (full facility fee out-of-pocket in Model 1).</p><p><strong>Conclusions: </strong>Based on real-world patient data, there is a definable range of out-of-pocket cost for an insured patient including outpatient visit, vasectomy procedure and PVSA of $384-489. The main driver of variability in cost stemmed from facility fee and the insurer contribution toward this cost. This broadens the definable range of out-of-pocket cost to $384-1,026.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1355-1362"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging of paraurethral and paravaginal lesion: relevant diagnoses, key findings and surgical correlation.","authors":"Andrés Labra, Rolando Cocio, Álvaro Saavedra, Giancarlo Schiappacasse, Fernanda Blaskovic","doi":"10.21037/tau-2024-726","DOIUrl":"10.21037/tau-2024-726","url":null,"abstract":"<p><p>Paraurethral and paravaginal lesions are uncommon entities that often present diagnostic challenges due to their anatomical complexity, varied etiologies, and overlapping clinical presentations. Accurate identification and characterization of these lesions are essential for appropriate management and surgical planning. A structured diagnostic approach, based on clinical history, lesion location, and imaging features, is critical to avoid misdiagnosis and unnecessary interventions. Magnetic resonance imaging (MRI) has emerged as the modality of choice due to its excellent soft-tissue contrast, multiplanar capabilities, and non-invasive nature, offering superior delineation of lesion extent and relationship with adjacent pelvic structures. This pictorial review seeks to support radiologists and clinicians by offering a comprehensive yet practical guide to the imaging evaluation of paraurethral and paravaginal lesions. Through high-resolution MRI images and original anatomical illustrations, we aim to reduce the gap between imaging interpretation and clinical decision-making. We summarize the primary MRI indications for evaluating female urethral pathology, provide an overview of common and rare differential diagnoses, and highlight relevant MRI protocol considerations. Additionally, we include correlations with surgical findings when available, to enhance clinical applicability. Rather than providing an exhaustive catalog of entities, our focus is to promote standardized imaging assessment and highlight key anatomical and diagnostic considerations that may facilitate a more confident and informed multidisciplinary approach to these often-overlooked pelvic pathologies.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1484-1502"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic renal cell carcinoma disease response in the era of immune checkpoint inhibitor-based combinations.","authors":"Micah Ostrowski, Georges Gebrael, Benjamin L Maughan","doi":"10.21037/tau-2025-93","DOIUrl":"10.21037/tau-2025-93","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1169-1173"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of modified partial cystectomy in muscle-invasive bladder cancer: balancing tumor control and quality of life.","authors":"Sian Chen, Ran Xu, Yiqiu Cheng, Jinhai Wu, Xuejin Zhu, Osama Mahmoud, Ryan M Antar, Arjun Pon Avudaiappan, Jian Zhang, Bin Wang, Yanfei Chen","doi":"10.21037/tau-2025-243","DOIUrl":"10.21037/tau-2025-243","url":null,"abstract":"<p><strong>Background: </strong>Muscle-invasive bladder cancer (MIBC) is highly aggressive with poor prognosis. Radical cystectomy (RC) with urinary diversion, the standard treatment, impairs patients' quality of life. This study explored modified partial cystectomy (MPC) as a bladder-preserving option, assessing oncological control, perioperative outcomes, and quality of life.</p><p><strong>Methods: </strong>Patients who underwent partial cystectomy for urothelial carcinoma at the Affiliated Cancer Hospital of Guangzhou Medical University between January 2020 and January 2022 were included. Some received standard laparoscopic partial cystectomy (LPC), while others received MPC with laparoscopic pelvic lymph node dissection and open tumor resection. These were compared with a gold standard group undergoing RC and lymph node dissection, evaluating perioperative, functional, and oncological outcomes.</p><p><strong>Results: </strong>Among the 57 patients (16 MPC, 18 LPC, 23 RC), LPC patients were older, RC tumors were more commonly located on the trigone, and tumors in the RC group were larger. Major complications were 21.7% in RC, <i>vs</i>. 5.5% in LPC and 6.2% in MPC (P<0.001). Positive margins occurred in 16.67% of LPC patients, and none occurred in MPC or RC (P=0.03). MPC and LPC had similar quality-of-life scores. After 36 months of follow-up, relapse rates were 34.7% in RC, 33.3% in LPC, and 6.2% in MPC (P=0.19). MPC had significantly longer 3-year recurrence-free survival than LPC (P=0.048) and RC (P=0.034), with comparable overall survival across groups.</p><p><strong>Conclusions: </strong>MPC surpasses LPC in tumor resection, reducing recurrence and enhancing survival. MPC also achieves similar oncological results to RC, making it a promising bladder-preserving alternative for MIBC patients.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1444-1455"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant strategies in locally advanced prostate cancer: progress or premature?","authors":"Tamás Fazekas, Péter Nyirády, Isabel Heidegger","doi":"10.21037/tau-2025-77","DOIUrl":"10.21037/tau-2025-77","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1150-1151"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shifting paradigms in the treatment of small renal masses.","authors":"Kamil Malshy, Nicola Fazaa, Etan Eigner, Matthew Steidle, Ameer Nsair, Melissa Atallah, Thomas Osinski, Phillip M Rappold, Jathin Bandari","doi":"10.21037/tau-2025-213","DOIUrl":"10.21037/tau-2025-213","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 5","pages":"1174-1181"},"PeriodicalIF":1.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}