Translational andrology and urology最新文献

筛选
英文 中文
Digital spatial profiling reveals the molecular signatures of BK virus infection in renal transplant recipients. 数字空间分析揭示了肾移植受者BK病毒感染的分子特征。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI: 10.21037/tau-2025-451
Long He, Yan Zhang, Kun Dong, Liang Ying, Guosheng Du, Hongliang Wang, Zhangfei Shou, Xuchun Chen, Hongwei Yang
{"title":"Digital spatial profiling reveals the molecular signatures of BK virus infection in renal transplant recipients.","authors":"Long He, Yan Zhang, Kun Dong, Liang Ying, Guosheng Du, Hongliang Wang, Zhangfei Shou, Xuchun Chen, Hongwei Yang","doi":"10.21037/tau-2025-451","DOIUrl":"10.21037/tau-2025-451","url":null,"abstract":"<p><strong>Background: </strong>BK polyomavirus-associated nephropathy (BKVAN) is a major cause of graft dysfunction in kidney transplant recipients, and is often triggered by BK virus reactivation due to immunosuppression. This study used GeoMx digital spatial profiling (DSP) to investigate molecular changes during BK virus infection.</p><p><strong>Methods: </strong>Eight formalin-fixed and paraffin-embedded (FFPE) kidney samples from the following three groups were analyzed: the normal function (n=3), BK polyomavirus viremia (BKV) (n=2), and BKVAN (n=3) groups. Transcriptional changes in epithelial cells, immune cells, and fibroblasts were assessed. Immune microenvironment alterations were analyzed through cellular deconvolution.</p><p><strong>Results: </strong>Distinct molecular signatures were observed across the infection stages and cell types, of which, epithelial cells showed significant dysregulation and unique involvement in ribosomal protein synthesis. The pathway analysis revealed that the pathways associated with viral infection, allogeneic rejection, and immunity (antigen presentation, chemokines, and inflammation) were significantly enriched during BKVAN progression. The key genes associated with BK polyomavirus (BKPyV) infection (<i>RPL4</i>, <i>RPS8</i>, <i>RPL30</i>, <i>CD74</i>, <i>B2M</i>, <i>CD4</i>, <i>HLA-DRA</i>, and <i>HLA-DRA1</i>), progression (<i>HLA-DPA1</i>, <i>LYZ</i>, <i>HLA-DQA2</i>, and <i>IGHM</i>), and BKVAN specificity (<i>PLTP</i>, <i>TNFAIP2</i>, <i>IRF7</i>, and <i>APOC1</i>) were identified. The CD74 major histocompatibility complex (MHC) class II axis may serve as a key immunoregulatory pathway. Cellular deconvolution revealed increased macrophages, dendritic cells (DCs), and CD4<sup>+</sup>/CD8<sup>+</sup> memory T cells, and reduced natural killer (NK) cells and neutrophils in BKVAN.</p><p><strong>Conclusions: </strong>DSP highlighted inter- and intra-patient heterogeneity, offering insights into the molecular mechanisms underlying BKVAN and potential targets for therapeutic intervention.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2089-2105"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Racial differences in hematologic profiles among men with erectile dysfunction: a cross-sectional analysis of NHANES 2001-2004. 勃起功能障碍男性血液学特征的种族差异:2001-2004年NHANES的横断面分析。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI: 10.21037/tau-2025-220
Jinshun An, Boyu Xiang, Jingxuan Peng, Dongjie Li, Yao Liu, Liu Yang
{"title":"Racial differences in hematologic profiles among men with erectile dysfunction: a cross-sectional analysis of NHANES 2001-2004.","authors":"Jinshun An, Boyu Xiang, Jingxuan Peng, Dongjie Li, Yao Liu, Liu Yang","doi":"10.21037/tau-2025-220","DOIUrl":"10.21037/tau-2025-220","url":null,"abstract":"<p><strong>Background: </strong>Racial differences in hematological profiles may play a role in the pathophysiology of erectile dysfunction (ED). However, the available evidence is not comprehensive. This study sought to assess racial disparities in blood cell parameters among patients with ED and to explore their clinical significance.</p><p><strong>Methods: </strong>This investigation utilized cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2004, including a sample of 1,743 ED patients. Linear regression models, adjusted for sociodemographic variables [age, body mass index (BMI), income] and clinical covariates (hypertension, diabetes, smoking status), were used to examine the associations between race and hematological parameters, including hemoglobin (Hb), neutrophils (Neu), white blood cells (Wbc), and platelets (Plt). Additional analyses stratified by age (≤40 <i>vs</i>. >40 years) were conducted to evaluate potential effect modification.</p><p><strong>Results: </strong>The study identified significant racial disparities in hematological parameters. Black patients demonstrated significantly lower levels of Hb, Neu, and Wbc compared to White patients (all P<0.01). These disparities were consistent across various age groups, though they were notably more pronounced in younger individuals (Hb: 14.82 <i>vs</i>. 15.78 in ≤40 years old). While sociodemographic factors partially accounted for disparities in Plt counts, other variations may be attributed to genetic or inflammatory mechanisms.</p><p><strong>Conclusions: </strong>The observed racial differences in hematological profiles among ED patients underscore the necessity for race-specific clinical approaches, particularly emphasizing early screening for anemia and inflammation in younger Black populations.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1947-1958"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A computed tomography-based deep learning model for non-invasively predicting World Health Organization (WHO)/International Society of Urological Pathology (ISUP) pathological grades of clear cell renal cell carcinoma (ccRCC): a multicenter cohort study. 用于无创预测世界卫生组织(WHO)/国际泌尿病理学会(ISUP)透明细胞肾细胞癌(ccRCC)病理分级的基于计算机断层扫描的深度学习模型:一项多中心队列研究。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-25 DOI: 10.21037/tau-2025-222
Ting Huang, Mang Ke, Qing Liu, Mingliang Ying, Meiling Hu, Xiaodan Fu, Yang Hu, Min Xu
{"title":"A computed tomography-based deep learning model for non-invasively predicting World Health Organization (WHO)/International Society of Urological Pathology (ISUP) pathological grades of clear cell renal cell carcinoma (ccRCC): a multicenter cohort study.","authors":"Ting Huang, Mang Ke, Qing Liu, Mingliang Ying, Meiling Hu, Xiaodan Fu, Yang Hu, Min Xu","doi":"10.21037/tau-2025-222","DOIUrl":"10.21037/tau-2025-222","url":null,"abstract":"<p><strong>Background: </strong>Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive subtype of kidney cancer, commonly exhibiting significant morphological heterogeneity in its pathological characteristics. The objective of this study is to develop a deep learning (DL) model for predicting pathological grades of ccRCC based on contrast-enhanced computed tomography (CECT).</p><p><strong>Methods: </strong>Retrospective data were collected from 483 ccRCC patients across three medical centers. Arterial phase and portal venous phase computed tomography (CT) images from the dataset were segmented for renal tumors and kidneys. Three convolutional neural networks (CNNs) were employed to extract features from the regions of interest (ROIs) in the CT images across multiple dimensions including three-dimensional (3D), two-and-a-half-dimensional (2.5D), and two-dimensional (2D). Least absolute shrinkage and selection (LASSO) regression was used for feature selection. The models were evaluated using receiver operating characteristic (ROC) curves and decision curve analysis (DCA).</p><p><strong>Results: </strong>Two types of 2.5D tumor DL models based on ResNet-34 and ShuffleNet_v2 were selected, both had area under the curves (AUCs) greater than 0.72 in the training set as well as in the internal and external test sets. The best model, resulting from the fusion of tumor and kidney models, achieved an AUC of 0.777 (95% confidence interval: 0.704-0.839, P<0.001) in the total test set, showing improved predictive ability compared to the tumor-alone models. DCA demonstrated the clinical utility of the model.</p><p><strong>Conclusions: </strong>The DL model based on CT achieved satisfactory results in predicting the pathological grades of ccRCC.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2018-2028"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural pregnancy following kidney transplantation in an azoospermic male: a case report. 无精子男性肾移植后自然妊娠一例报告。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-25 DOI: 10.21037/tau-2025-319
Ngoc Thai Nguyen, Huu Hoang Quan Nguyen, Teppei Takeshima, Shinnosuke Kuroda, Yasushi Yumura, Widi Atmoko, Huynh Dang Khoa Nguyen
{"title":"Natural pregnancy following kidney transplantation in an azoospermic male: a case report.","authors":"Ngoc Thai Nguyen, Huu Hoang Quan Nguyen, Teppei Takeshima, Shinnosuke Kuroda, Yasushi Yumura, Widi Atmoko, Huynh Dang Khoa Nguyen","doi":"10.21037/tau-2025-319","DOIUrl":"10.21037/tau-2025-319","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) and its advanced form, end-stage kidney disease (ESKD), disrupt male reproductive capacity, largely due to endocrine disturbances and impaired sperm production. Kidney transplantation (KTx) may reverse these effects by normalizing kidney function and recalibrating the hypothalamic-pituitary-gonadal (HPG) axis. Here, we report the first known case of natural conception in a male with ESKD and non-obstructive azoospermia (NOA) after KTx.</p><p><strong>Case description: </strong>A 32-year-old man experienced reduced sexual desire, mild erectile dysfunction, and infertility for four years. Workup revealed stage 3 CKD from chronic glomerulonephritis and hypertension, later advancing to ESKD, along with NOA confirmed by two semen analyses. Choosing KTx over prompt surgical sperm extraction, he achieved normalized renal function and partial endocrine recovery by 3 months post-transplant. Semen analysis confirmed restored sperm production, leading to a spontaneous pregnancy, which unfortunately ended in a miscarriage at 7 weeks.</p><p><strong>Conclusions: </strong>This case underscores the possibility of fertility restoration in azoospermic men with ESKD after KTx. Despite challenges such as sperm quality issues and immunosuppressive drugs potentially affecting outcomes, KTx appears to enhance sexual function and sperm production, providing a promising fertility option for ESKD patients. Additional reports are essential to elucidate treatment strategies and the long-term impacts of immunosuppressive agents on male reproductive health.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2118-2123"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testicular tumors in men aged 60 years or older undergoing orchiectomy. 60岁及以上男性睾丸肿瘤行睾丸切除术。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI: 10.21037/tau-2025-261
Mohammad Amin Elahi Najafi, Dingani Nkosi, Hiroshi Miyamoto
{"title":"Testicular tumors in men aged 60 years or older undergoing orchiectomy.","authors":"Mohammad Amin Elahi Najafi, Dingani Nkosi, Hiroshi Miyamoto","doi":"10.21037/tau-2025-261","DOIUrl":"10.21037/tau-2025-261","url":null,"abstract":"<p><strong>Background: </strong>Testicular tumors are rare, particularly in aged men. Indeed, germ cell tumors occur mostly in the young population. Importantly, few studies have systematically characterized testicular tumors, other than lymphomas and spermatocytic tumor, diagnosed in the elderly. We herein aim to assess the clinicopathologic features of such tumors, particularly germ cell tumors, and their oncologic outcomes in old men.</p><p><strong>Methods: </strong>We analyzed 46 consecutive patients undergoing orchiectomy for testicular tumors at the age of ≥60 years at the University of Rochester Medical Center, together with 343 control patients aged <60 years.</p><p><strong>Results: </strong>The most common neoplasms identified in the elderly group were diffuse large B-cell lymphoma (n=15, 33%) and pure seminoma (n=15, 33%), followed by mixed germ cell tumor (n=4, 9%) or Leydig cell tumor (n=4, 9%), spermatocytic tumor (n=3, 7%), Sertoli cell tumor (n=2, 4%), and 1 case (2%) of epidermoid cyst, metastatic carcinoma, or plasmacytoma. Seminoma patients had pT1 (n=9) or pT2 (n=5) diseases subsequently treated with prophylactic radiotherapy (n=3) or chemotherapy (n=2), in addition to 1 pT3/cN2 case undergoing chemotherapy with clinically complete response. None of these cases with seminoma had disease recurrence during 10-174 months (median: 82) of follow-up. Mixed germ cell tumors (seminoma component: n=3; embryonal carcinoma: n=3; yolk sac tumor: n=3; choriocarcinoma: n=1; teratoma: n=3) included 3 pT1 and 1 pT2 diseases. Two of these patients with mixed germ cell tumor postoperatively developed lymph node metastasis, underwent lymph node dissection without or with chemotherapy, and were alive without disease after 52 or 157 months, respectively, while the other two, one with prophylactic chemotherapy, had no recurrence 28 and 75 months after orchiectomy. Interestingly, ≥60-year-old patients with mixed germ cell tumor, whose incidence was significantly lower than that in <60-year-old patients, had a significantly higher risk of postoperative recurrence, compared with the younger groups with either mixed germ cell tumor (n=98) or non-seminomatous germ cell tumor (n=31) or only the former in both univariate and multivariable settings.</p><p><strong>Conclusions: </strong>Nineteen (41%) of ≥60-year-old men in our orchiectomy cohort were found to have germ cell tumor. Remarkably, none of these patients appeared to have aggressive disease with or without preventive radiotherapy or chemotherapy or adjuvant treatment, while the age was an independent predictor of recurrence in those with mixed germ cell tumor.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2007-2017"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic effects of a pulsatile GnRH pump on adult male patients with congenital hypogonadotropic hypogonadism (CHH): a retrospective study. 脉冲式GnRH泵治疗成年男性先天性促性腺功能低下(CHH)的疗效:回顾性研究。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI: 10.21037/tau-2025-199
Hao Jiang, Bo-Jun Li, Da-Chun Jin, Qu-Liang Zhong, Tong Zhu, Yan-Feng Li
{"title":"Therapeutic effects of a pulsatile GnRH pump on adult male patients with congenital hypogonadotropic hypogonadism (CHH): a retrospective study.","authors":"Hao Jiang, Bo-Jun Li, Da-Chun Jin, Qu-Liang Zhong, Tong Zhu, Yan-Feng Li","doi":"10.21037/tau-2025-199","DOIUrl":"10.21037/tau-2025-199","url":null,"abstract":"<p><strong>Background: </strong>Traditional treatments for congenital hypogonadotropic hypogonadism (CHH) primarily focus on human chorionic gonadotropin (hCG) monotherapy, combined gonadotrophin treatment or Testosterone replacement therapy, which has certain limitations in effectiveness. In recent years, pulsatile gonadotropin-releasing hormone (GnRH) pump treatment, capable of mimicking physiological hormone release patterns, has become a more preferred treatment option. However, there is still a scarcity of medium- and long-term studies in this regard. This study aimed to evaluate the medium- and long-term efficacy of pulsatile GnRH on CHH patients by a microinfusion pump, and to assess the varied effects exhibited in subgroups of CHH patients.</p><p><strong>Methods: </strong>We analyzed the clinical data from 54 adult male CHH patients who were treated with pulsatile GnRH pumps. Clinical patient parameters included morphology and size of the external genitalia, sex hormone concentrations, and fertility-evaluated before and at 6, 12, and 24 months of treatment.</p><p><strong>Results: </strong>The mean follow-up time was 15.9 (range, 3-40) months. The mean testicular volume [6.22±1.85 (mean ± standard deviation), 8.90±2.36, 9.73±1.93 mL], serum testosterone level (T) (234±143, 361±117, 381±68 ng/dL), flaccid penile length (4.77±0.68, 5.70±0.69, 6.08±0.52 cm), and stretched penile length (7.87±1.01, 9.44±1.24, 9.63±1.07 cm) of the CHH patients after 0.5, 1, and 2 years of treatment, respectively, were significantly increased compared with the same parameters before treatment (3.19±1.66 mL, 48±47 ng/dL, 3.54±0.92 cm, 5.68±1.27 cm, respectively) (P<0.01). The size of the external genitalia and serum T level of the patients after 1 and 2 years of treatment were further improved when compared with 0.5 year of treatment (P<0.01). Thirty-four of the 45 patients who had over 0.5 year of treatment successfully collected their semen and 27 men produced spermatozoa. CHH patients with normal olfaction, younger patients, and those with initial testicular volumes greater than 4 mL had a faster onset and better outcomes.</p><p><strong>Conclusions: </strong>The use of a GnRH pulsatile pump comprises a strategy with long-term beneficial effects for the treatment of adult male CHH.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"2043-2058"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of the quality and readability level of online content on urinary tract infection treatment in Spanish and English. 西班牙语和英语在线尿路感染治疗内容的质量和可读性评估。
IF 1.7 3区 医学
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI: 10.21037/tau-2025-221
Javier Prieto, Dianelis Gonzalez Pupo, Raeven Grant, Ellie Mehrara, Kymora B Scotland
{"title":"An assessment of the quality and readability level of online content on urinary tract infection treatment in Spanish and English.","authors":"Javier Prieto, Dianelis Gonzalez Pupo, Raeven Grant, Ellie Mehrara, Kymora B Scotland","doi":"10.21037/tau-2025-221","DOIUrl":"10.21037/tau-2025-221","url":null,"abstract":"<p><strong>Background: </strong>The increasing incidence and prevalence of urinary tract infections (UTI) align with the internet's rise to mainstream usage. Today's new digital era has obliged patients to engage in online content relating to their health and well-being, including urological conditions. These recent shifts led this study to assess the quality and readability levels of UTI articles and YouTube videos with the highest online engagement in both English and Spanish.</p><p><strong>Methods: </strong>Google Trends was queried to analyze the popularity trends of the terms \"UTI\" and \"infeccion urinaria\" from November 2018 to November 2023. The DISCERN tool was utilized to assess the quality of the most popular UTI articles and videos in English and Spanish, determined by the content analyzer platform of BuzzSumo. The same materials had their readability levels assessed by two validated readability metrics in each language.</p><p><strong>Results: </strong>Google Trends found \"UTI\" and \"infeccion urinaria\" were top search terms with average search volume index values of 79 and 81, respectively. For the DISCERN quality ratings, a small number of articles and videos in both languages were considered to be of high-quality content (with minimal shortcomings). Uniformly, the readability levels calculated across the four readability metrics displayed that most UTI online materials are being created above the recommended 6th-grade comprehension level for patients.</p><p><strong>Conclusions: </strong>Despite high demand, online UTI treatment information in English and Spanish falls short in both quality and readability. As such, patients could greatly benefit from insights provided by their healthcare providers concerning reputable and superior online sources of information.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1959-1977"},"PeriodicalIF":1.7,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144837802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urethral stricture excision and primary end-to-end anastomosis: a single-tertiary center long-term experience. 尿道狭窄切除及端到端吻合术:单三级中心的长期经验。
IF 1.9 3区 医学
Translational andrology and urology Pub Date : 2025-06-30 Epub Date: 2025-06-26 DOI: 10.21037/tau-2025-175
Duan Gao, Xiaoyu Li, Wenyuan Leng, Xing Ji, Weimin Hu, Zhenpeng Zhu, Chunru Xu, Jian Lin
{"title":"Urethral stricture excision and primary end-to-end anastomosis: a single-tertiary center long-term experience.","authors":"Duan Gao, Xiaoyu Li, Wenyuan Leng, Xing Ji, Weimin Hu, Zhenpeng Zhu, Chunru Xu, Jian Lin","doi":"10.21037/tau-2025-175","DOIUrl":"10.21037/tau-2025-175","url":null,"abstract":"<p><strong>Background: </strong>Urethral stricture represents a prevalent clinical entity in urological practice, with urethroplasty currently serving as the primary therapeutic approach for complex cases. This study aimed to analyze the efficacy of urethral stricture resection and primary end-to-end anastomosis for treating male urethral strictures and identify potential risk factors for postoperative recurrence.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 37 male patients who underwent this procedure at Peking University First Hospital between February 2018 and September 2024. Clinical data of the patients, including age, preoperative urinary tract infection, etiology of urethral stricture, location of urethral stricture, length of stricture segment, preoperative urethral surgery history, presence of bladder fistula, preoperative and postoperative quality of life (QoL) index, preoperative and postoperative International Prostate Symptom Scores (IPSS) score, postoperative regular dilation, and postoperative complications, were collected and analyzed using statistical methods.</p><p><strong>Results: </strong>The median follow-up time for the patients was 57 [interquartile range (IQR), 39.5-66.5] months, and the stricture length was 20 (IQR, 10-30) mm. The rate of recurrent stricture was 40.54% (15/37), with a median time from surgery to recurrence of 3 (IQR, 1-6) months. The preoperative and postoperative QoL and IPSS scores showed significant differences (P<0.05). Sexual dysfunction and urinary tract infections were the most common postoperative complications. There was no statistically significant difference in efficacy between posterior and anterior urethral strictures.</p><p><strong>Conclusions: </strong>We provided clinical information on stricture resection and end-to-end anastomosis in the treatment of male urethral strictures, providing a baseline reference for relevant research. Individualized assessment and management are crucial for improving surgical success rates and patient QoL.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 6","pages":"1645-1651"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated single-cell genomics, transcriptomics, and pathomics to identify potential biomarkers in muscle-invasive bladder cancer. 整合单细胞基因组学、转录组学和病理学来识别肌肉浸润性膀胱癌的潜在生物标志物。
IF 1.9 3区 医学
Translational andrology and urology Pub Date : 2025-06-30 Epub Date: 2025-06-26 DOI: 10.21037/tau-2025-79
Yifeng He, Fazhong Dai, Zhenwei Wang, Shengming Zhang, Deqin Zeng, Juan Duan, Daiwei Zhou, Zongtai Zheng, Xiaofu Qiu
{"title":"Integrated single-cell genomics, transcriptomics, and pathomics to identify potential biomarkers in muscle-invasive bladder cancer.","authors":"Yifeng He, Fazhong Dai, Zhenwei Wang, Shengming Zhang, Deqin Zeng, Juan Duan, Daiwei Zhou, Zongtai Zheng, Xiaofu Qiu","doi":"10.21037/tau-2025-79","DOIUrl":"10.21037/tau-2025-79","url":null,"abstract":"<p><strong>Background: </strong>The integration of multi-omics approaches provides a powerful strategy for understanding cancer. By combining these methods, researchers gain insights into tumor diversity, gene activity, and the tumor microenvironment, which are essential for advancing cancer biology, improving early detection, refining prognostic tools, and developing targeted treatments. This study aims to explore key biomarkers in muscle-invasive bladder cancer (MIBC) and to develop a predictive model for better understanding disease progression and therapeutic responses.</p><p><strong>Methods: </strong>Single-cell analysis of MIBC samples from public datasets identified basal-related genes. Using Cox analysis of The Cancer Genome Atlas (TCGA)-bladder urothelial carcinoma (BLCA) clinical data and the expression matrix, and combining it with weighted gene co-expression network analysis (WGCNA) of another MIBC dataset, a disintegrin and metalloprotease protein 17 (<i>ADAM17</i>) was identified as a key target gene. We collected BLCA patient samples from TCGA, Shanghai Tenth People's Hospital (STPH), and Guangdong Second Provincial General Hospital (GD2H) to develop the pathomics model for predicting <i>ADAM17</i> expression. Single-cell validation of <i>ADAM17</i> expression was performed using GD2H MIBC samples.</p><p><strong>Results: </strong><i>ADAM17</i> was highly expressed in MIBC and associated with poor prognosis. Its expression correlated with clinical features such as non-papillary subtype, advanced pathological stage, and higher tissue grade. <i>ADAM17</i> overexpression was linked to immune reprogramming and drug resistance. The pathomics model effectively predicted <i>ADAM17</i> expression in BLCA samples. Single-cell analysis of GD2H MIBC samples confirmed <i>ADAM17</i> overexpression in epithelial cells and identified key pathways in cell communication, matrix remodeling, tumor invasion, and immune regulation.</p><p><strong>Conclusions: </strong>Multi-omics approaches effectively identify biomarkers for MIBC, with <i>ADAM17</i> emerging as a key biomarker. Further research is needed to clarify its role in MIBC progression.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 6","pages":"1610-1630"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Penile calciphylaxis: surgical management in the setting of Fournier's gangrene-a case report and literature review. 阴茎钙化治疗:富尼耶坏疽的外科治疗一例报告并文献复习。
IF 1.9 3区 医学
Translational andrology and urology Pub Date : 2025-06-30 Epub Date: 2025-06-26 DOI: 10.21037/tau-2025-75
Anh Nguyen, Jacob Veliky, Payal Shah, Rebecca Anderson, Amjad Alwaal
{"title":"Penile calciphylaxis: surgical management in the setting of Fournier's gangrene-a case report and literature review.","authors":"Anh Nguyen, Jacob Veliky, Payal Shah, Rebecca Anderson, Amjad Alwaal","doi":"10.21037/tau-2025-75","DOIUrl":"10.21037/tau-2025-75","url":null,"abstract":"<p><strong>Background: </strong>Penile calciphylaxis is a rare and severe manifestation of calciphylaxis. It refers to calcification of the small subcutaneous vessel network in the otherwise highly vascularized penis. Given how rare the condition is, there are no clear guidelines for treatment yet. The role of biopsy or surgery remains controversial due to concerns about exacerbating the condition in the context of poor wound healing. We had a rare case of penile calciphylaxis with superimposed infection. Through our case as well as through review of additional reports, we aim to further the discussion of treatment for penile calciphylaxis and provide an example of successful surgical resection.</p><p><strong>Case description: </strong>We report a case of penile calciphylaxis complicated by Fournier's gangrene following a partial penectomy. He presented with penile drainage and a foul odor three months after undergoing a partial penectomy at another institution for the treatment of penile calciphylaxis. The patient underwent total penectomy with penoscrotal urethrostomy and was treated with antibiotics. At follow-up, the patient demonstrated good wound healing and recovery.</p><p><strong>Conclusions: </strong>A review of 19 operative case reports on penile calciphylaxis highlights varied management strategies for this highly morbid condition. Current evidence suggests that treatment should be tailored to disease severity. In severe cases with infection, aggressive surgical intervention may be necessary to achieve source control and improve outcomes.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 6","pages":"1832-1838"},"PeriodicalIF":1.9,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信