Translational andrology and urology最新文献

{"title":"Gabapentin as an adjunct to multimodal pain management following scrotal surgery.","authors":"Aurora J Grutman, Taylor P Kohn, Andrew T Gabrielson","doi":"10.21037/tau-2024-704","DOIUrl":"https://doi.org/10.21037/tau-2024-704","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"893-896"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piperlongumine inhibits renal cell carcinoma progression by modulating the DDX11-miR-15b-3p-DLD axis.","authors":"Zhenghao Zhang, Wenfang Xu, Kewen Ye, Shanmei Lv, Jintao Wu, Yadi Zhou","doi":"10.21037/tau-2025-11","DOIUrl":"https://doi.org/10.21037/tau-2025-11","url":null,"abstract":"<p><strong>Background: </strong>Piperlongumine (PL) is a natural alkaloid obtained from the long pepper and can inhibit the progression of various tumors. However, its role in renal cell carcinoma (RCC) remains unclear. Thus, the purpose of this study was to determine whether PL can suppress RCC progression and to clarify the related mechanisms.</p><p><strong>Methods: </strong>Cell Counting Kit-8 (CCK-8) and colony formation assays were applied to characterize the effect of PL in RCC cell proliferation; meanwhile, cellular reactive oxygen species (ROS), Fe²⁺ level, and mitochondrial membrane potential (MMP) assays were used to determine PL's role in mitochondrial homeostasis. Immunofluorescence experiments using MitoTracker red was applied to visualize the morphology of mitochondria. Western blotting and coimmunoprecipitation (Co-IP) and RNA immunoprecipitation (RNA-IP) assays were used to examine PL's regulation of DDX11 expression via miR-15b-3p. In addition, a xenograft mouse model was created to clarify the effect of DDX11 overexpression on RCC progression with or without PL treatment.</p><p><strong>Results: </strong>We found that PL inhibited RCC cell proliferation in a dose-dependent manner by interfering with the mitochondrial homeostasis of RCC cells. In terms of mechanism, RNA sequencing showed that PL decreased the expression of DDX11, inhibited the maturation of miR-15b-3p, and further increased the level of dihydrolipoamide dehydrogenase (DLD) to disrupt the mitochondrial homeostasis of RCC cells. In addition, the vivo xenograft mouse model showed that DDX11 plays a stimulatory role in PL-induced RCC inhibition.</p><p><strong>Conclusions: </strong>Our study demonstrated that DDX11 contributes to PL-induced RCC inhibition by modulating the miR-15b-3p-DLD axis.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"897-912"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraperitoneal laparoscopic versus transperitoneal robot-assisted laparoscopic approaches during radical prostatectomy for low-risk or intermediate-risk prostate cancer.","authors":"Yi Yang, Xiaohong Han, Xingkai Wang, Xinhui Liao, Jieqing Chen, Zhongfu Zhang, Jianting Wu, Jiou Li, Mutong Chen, Hongbing Mei","doi":"10.21037/tau-2024-748","DOIUrl":"https://doi.org/10.21037/tau-2024-748","url":null,"abstract":"<p><strong>Background: </strong>Extraperitoneal laparoscopic radical prostatectomy (E-LRP) and transperitoneal robotic-assisted laparoscopic radical prostatectomy (TRA-LRP) are two types of radical prostatectomy widely used at present, but the comparative study between them is limited. We aimed to compare E-LRP with TRA-LRP in the treatment of low- or intermediate-risk prostate cancer (PCa).</p><p><strong>Methods: </strong>From June 2020 to May 2024, in our department, a total of 80 patients with low- or intermediate-risk PCa, including 45 cases who received E-LRP (E-LRP group) and another 35 cases who received TRA-LRP (TRA-LRP group), were enrolled in our research. All patients were followed up for 6-24 months. Perioperative parameters, erectile function, urinary continence, and biochemical recurrence were compared between the 2 groups.</p><p><strong>Results: </strong>Patients in the TRA-LRP group had longer operative times (165.3 <i>vs.</i> 128.4 min, P<0.05), lesser blood loss (89.6 <i>vs.</i> 139.4 mL, P<0.05), and lower positive surgical margin (PSM) rate (17.1% <i>vs.</i> 37.8%, P<0.05) compared with the E-LRP group. Potent patients who received TRA-LRP showed better potency recovery than those who received E-LRP at 6 months postoperatively (P<0.05). Continence at the first month after TRA-LRP was significantly higher than that after E-LRP (P<0.05). All patients recovered continence at 12 months after operation. None of the patients had biochemical recurrence during the follow-up.</p><p><strong>Conclusions: </strong>Compared with E-LRP, TRA-LRP can reduce the blood loss and PSM rate in low-risk or intermediate-risk PCa, and may help patients regain early continence and potency after operation. It may be superior in reducing intraoperative risk, improving oncological outcomes, and early postoperative rehabilitation.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1111-1118"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current perspectives of urine-based tests for screening and post-treatment monitoring of urothelial carcinoma of the bladder.","authors":"Makito Miyake","doi":"10.21037/tau-2025-27","DOIUrl":"https://doi.org/10.21037/tau-2025-27","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"872-876"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of tryptophan metabolism-related risk model and molecular subtypes for predicting postoperative biochemical recurrence in prostate cancer.","authors":"Yuan Shao, Xiaolei Zhang, Yinchi Zhang, Zihao Liu, Zhen Yang, Yang Liu, Hua Huang, Zeyuan Wang, Zhinan Fu, Yong Wang","doi":"10.21037/tau-2025-39","DOIUrl":"https://doi.org/10.21037/tau-2025-39","url":null,"abstract":"<p><strong>Background: </strong>Biochemical recurrence (BCR) following radical prostatectomy (RP) remains a major challenge in prostate cancer (PCa) management. Tryptophan metabolism plays a pivotal role in tumor progression and immune modulation. This study aimed to develop and validate a tryptophan metabolism-related risk model and molecular subtypes to predict BCR in PCa patients after RP.</p><p><strong>Methods: </strong>The Cancer Genome Atlas-Prostate Adenocarcinoma (TCGA-PRAD) dataset, including 421 PCa patients, was analyzed to identify key tryptophan metabolism-related genes (TMRGs) using differential expression, univariate Cox, and the least absolute shrinkage and selection operator (LASSO) regression analyses. The tryptophan metabolism-related risk model was constructed through multivariate Cox regression, and tryptophan metabolism-related molecular subtypes were established using consensus clustering. External validation was conducted using an independent dataset, while immunohistochemistry (IHC) and single-cell sequencing further confirmed TMRG expression patterns and their roles in the tumor microenvironment (TME).</p><p><strong>Results: </strong>The tryptophan metabolism-related risk model and molecular subtypes effectively stratified PCa patients into low- and high-risk groups or two molecular subtypes. High-risk PCa patients (n=211) and those in Cluster 1 (n=261) exhibited significantly poorer biochemical recurrence-free survival (BRFS) and distinct clinicopathological features, immune infiltration profiles, and TME characteristics. External validation confirmed the robustness of the tryptophan metabolism-related risk model and molecular subtypes. IHC and single-cell sequencing highlighted the expression patterns of TMRGs and their regulatory roles in the TME.</p><p><strong>Conclusions: </strong>This study established and validated tryptophan metabolism-related risk scores and molecular subtypes as reliable predictors of BCR in PCa patients after RP. These findings provide a foundation for personalized follow-up and treatment strategies, contributing to improved clinical outcomes in PCa management.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1082-1110"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic mesh placement is not sufficient: what should we do to prevent parastomal hernia associated with ileal conduit?","authors":"Toshiaki Tanaka","doi":"10.21037/tau-2024-686","DOIUrl":"https://doi.org/10.21037/tau-2024-686","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"877-879"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adenosquamous cell carcinoma of the penis: a case report and literature review.","authors":"Qianhao Huang, Dongfeng Xiong, Yifan Huang, Xuan Zhuang, Yuedong Chen","doi":"10.21037/tau-24-616","DOIUrl":"https://doi.org/10.21037/tau-24-616","url":null,"abstract":"<p><strong>Background: </strong>Penile cancer is a relatively uncommon malignancy. It is most commonly a squamous cell carcinoma (SCC), but other non-squamous malignancies, including basal cell carcinoma, melanoma, sarcoma, metastatic carcinoma and adenosquamous cell carcinoma, have also been documented. Primary adenosquamous carcinoma of the penis (ASC) is an uncommon variant of SCC, accounting for approximately 1-2% of all SCC cases.</p><p><strong>Case description: </strong>A 77-year-old male presented to The First Affiliated Hospital of Xiamen University with an enlarged penile head, persistent pain, urinary tract infection, and dilute urine, which had progressively worsened over the past month. Specialist examination showed normal penile development without malformation, but the foreskin was long and could not be turned up and was circumcised. The patient underwent surgical intervention, followed by regular reviews and subsequent follow-ups. A review of the literature reveals that only 13 cases have been documented since 1986, and there is a paucity of relevant literature available for review and update.</p><p><strong>Conclusions: </strong>This paper aims to present a case of ASC in an elderly male with a chief complaint of 'pain' and to provide a comprehensive overview of the aetiology, epidemiology, clinical presentation, histopathology, diagnosis and treatment options of ASC. In short, the treatment plan and outcome of this case offer a valuable reference point for the selection and optimisation of treatment modalities for this disease.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1138-1146"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choosing the path: insights into transperineal <i>vs.</i> transrectal prostate biopsy.","authors":"Mandy Hsu, Stephen Sekoulopoulos, Jay D Raman","doi":"10.21037/tau-2024-754","DOIUrl":"https://doi.org/10.21037/tau-2024-754","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"883-887"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of a 9-RBPs-related gene signature associated with prognosis and immune infiltration in bladder cancer based on bioinformatics analysis and machine learning.","authors":"Yan Chen, Zhijie Yan, Lusi Li, Yixing Liang, Xueyan Wei, Yinian Zhao, Ying Cao, Huaxiu Zhang, Liping Tang","doi":"10.21037/tau-2024-688","DOIUrl":"https://doi.org/10.21037/tau-2024-688","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Bladder cancer (BLCA) is the most common type of malignancy affecting the urinary tract, characterized by high recurrence rates, propensity for progression, metastatic potential, and multidrug resistance, all of which ultimately contribute to an unfavorable prognosis. RNA-binding proteins (RBPs) play a critical role in cancer development and have been associated with the progression and prognosis of the disease. However, comprehensive investigations into the biological functions and molecular mechanisms of RBPs in BLCA remain limited. The study aims to explore the relationship between RBPs and prognosis in BLCA, and to develop and validate an RBPs-based prognostic signature, providing new insights for the diagnosis and treatment of BLCA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Clinical data and RBPs expression profiles of BLCA patients were sourced from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A systematic bioinformatics analysis was conducted to identify differentially expressed RBPs and assess their prognostic significance. The optimal predictive model was selected by integrating multiple machine learning algorithms, enabling the identification of hub genes associated with BLCA prognosis and developing an RBP-related gene signature. To evaluate the prognostic signature's efficacy, survival curves and receiver operating characteristic (ROC) curves were generated. A nomogram was constructed and validated to predict the survival of BLCA patients at 1, 3, and 5 years. Furthermore, analyses of immune infiltration and gene set enrichment analysis (GSEA) were conducted to explore the roles of RBPs in immune cell interactions and elucidate underlying biological pathways.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A prognostic signature was effectively developed using nine RBPs (OAS1, MTG1, DUS4L, IGF2BP3, NOL12, PABPC1L, ZC3HAV1L, TRMT2A and TRMU), represented as risk score, through the integration of 13 combinatorial machine learning algorithms. Kaplan-Meier analysis revealed that the high-risk group exhibited a significantly poorer overall survival (OS) probability compared to the low-risk group. The areas under the ROC curves for the risk score model at 1, 3, and 5 years were 0.661, 0.655, and 0.676, respectively. The nomogram, which integrated clinical characteristics and risk scores, demonstrated robust prognostic accuracy. Furthermore, single-sample gene set enrichment analysis (ssGSEA) demonstrated significant correlations between both the risk score model and hub RBPs with the immune status of BLCA patients. GSEA indicated that major signaling pathways enriched in the high-risk group included extracellular matrix (ECM) components and interaction, as well as cytokine and receptor interaction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This study successfully identified and developed a prognostic signature based on nine RBPs, accompanied by a nomogram for predicting survival probability in BLCA patients. Our finding","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"1066-1081"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive outcomes in prostate cancer treatment: insights from the ODENZA trial and future considerations.","authors":"Bryan J Neth, Jeffrey S Wefel, Kevin T Nead","doi":"10.21037/tau-2024-747","DOIUrl":"https://doi.org/10.21037/tau-2024-747","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 4","pages":"864-867"},"PeriodicalIF":1.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144080655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}