Translational andrology and urology最新文献

{"title":"Balancing effectiveness, toxicity, and individualization: enfortumab vedotin in advanced urothelial cancer.","authors":"Nuowei Wang, Karl H Tully","doi":"10.21037/tau-2024-743","DOIUrl":"https://doi.org/10.21037/tau-2024-743","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"503-506"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified Shang Ring circumcision surgical technique under local anesthesia for penile torsion in children.","authors":"Shimeng Zhao, Pengyu Jia, Hongchao Chai, Can Qi, Chaojun Xin, Yun Zhou","doi":"10.21037/tau-2024-698","DOIUrl":"https://doi.org/10.21037/tau-2024-698","url":null,"abstract":"<p><strong>Background: </strong>Penile torsion is a congenital condition characterized by the rotation of the penis along its longitudinal axis. This study aimed to describe a modified Shang Ring circumcision (SRC) surgical technique as a simple and effective approach for correcting penile torsion in children under local anesthesia.</p><p><strong>Methods: </strong>From July 2018 to August 2023, 20 male children with penile torsion underwent the modified SRC technique under local anesthesia, performed by the same surgeon (S.Z.). In our technique, the inner ring of the Shang Ring is placed over the glans penis, while the outer ring is positioned over the outer layer of the foreskin and secured by the first notch of the outer ring. The foreskin is held in place in a semi-locked state between the inner and outer rings. The frenulum is adjusted to achieve mild overcorrection, positioning the urethral opening between the 6 and 7 o'clock positions to correct penile torsion. A good surgical outcome is defined as a postoperative penile torsion angle of less than 30 degrees, while a poor surgical outcome is one with a postoperative penile torsion angle greater than 30 degrees.</p><p><strong>Results: </strong>All cases involved counterclockwise penile torsion, and surgeries, performed under local anesthesia, with an average surgical time of 8.55±1.61 minutes. The preoperative median angle of penile torsion was 45 [45, 60] degrees, with a maximum torsion angle of 60 degrees. The average time for the Shang Ring to fall off was 23.10±6.38 days. Three cases of the Shang Ring did not naturally fall off and were manually removed 30 days post-surgery. After the Shang Ring removal, the median penile torsion angle at follow-up was 10 [0, 10] degrees, with a median correction angle of 42.5 [35, 48.75] degrees. The average follow-up time was 2.06±0.74 years. At the last follow-up, the median penile torsion angle was 10 [0, 10] degrees, with a median correction angle of 42.5 [35, 50] degrees. No significant difference was observed in the postoperative torsion angle between the mild and moderate torsion patients, both after Shang Ring removal and at the last follow-up (P>0.05). All patients had good surgical outcomes.</p><p><strong>Conclusions: </strong>The modified SRC technique is feasible, safe, and effective for correcting mild to moderate penile torsion under local anesthesia, offering a new surgical option for children.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"602-609"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors and nomogram development for survival in renal cell carcinoma patients with multiple primary cancers: a retrospective study.","authors":"Man Tian, Jing Shen, Meng Liu, Xue-Fen Chen, Tie-Jun Wang, Yong-Sheng Sun","doi":"10.21037/tau-24-509","DOIUrl":"https://doi.org/10.21037/tau-24-509","url":null,"abstract":"<p><strong>Background: </strong>Patients with renal cell cancer have an increased risk of developing multiple primary cancers (MPCs) due to improved survival rates. The purpose of this study was to evaluate the clinicopathological features of MPCs and to generate a useful tool for predicting cancer-specific survival (CSS) in these patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on data from renal cell carcinoma (RCC) who were diagnosed with MPCs between 2001 and 2021 from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with RCC meeting the criteria were selected for Kaplan-Meier (KM) survival analysis. The main outcome of this study was CSS, defined as the time from the initial diagnosis to either death due to cancer or the last follow-up. The Cox regression model was used to analyze the CSS factors of MPCs, the results of the multivariate analysis were displayed in a forest map, and the significant variables identified in the multivariate Cox analysis were used to construct the nomogram. Area under the curve (AUC) and calibration plots were used to evaluate the predictive performance of the nomogram.</p><p><strong>Results: </strong>A total of 2,078 cases of renal cancer with MPCs diagnosed between 2001 and 2021 were included. Age and grade were determined through both univariate and multivariate analyses to be independent prognostic factors affecting CSS. Based on clinical practice, the final nomogram was constructed using the variables: sex, age, grade, summary stage, tumor-node-metastasis (TNM) stage and tumor size to predict CSS at 60, 120, and 180 months. The concordance index (C-index) for the CSS nomogram was 0.670 [95% confidence interval (CI): 0.642-0.698]. The model demonstrated a good predictive performance. To assess the consistency between observed and predicted values, a calibration curve was developed.</p><p><strong>Conclusions: </strong>This study identified risk factors for CSS in patients with clear cell RCC (ccRCC) with MPCs and developed a nomogram to predict CSS in these patients. The model demonstrates strong clinical applicability and can serve as a valuable clinical decision-making tool for physicians and patients.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"685-695"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assisted suspension fixation technique in transperitoneal laparoscopic pyeloplasty for infants and young children with ureteropelvic junction obstruction: a retrospective cohort study.","authors":"Hua Wang, Tian Xia, Chutian Xiao, Houhe Li, Xionglong He, Yuming Qiao, Meinong Zhong, Dejuan Wang, Ke Li","doi":"10.21037/tau-2024-722","DOIUrl":"https://doi.org/10.21037/tau-2024-722","url":null,"abstract":"<p><strong>Background: </strong>Anderson-Hynes pyeloplasty is a classic and highly effective technique for treating congenital ureteropelvic junction obstruction (UPJO). Laparoscopic minimally invasive surgery (MIS) has become the preferred approach for infants and young children. However, a small working area and the complexity of reconstruction procedure pose significant challenges. This study aims to evaluate the efficacy and safety of four-point suspension fixation technique in laparoscopic dismembered pyeloplasty (LDP) for infants and young children with UPJO.</p><p><strong>Methods: </strong>This retrospective cohort enrolled 37 infants and young children diagnosed with UPJO and underwent transperitoneal LDP between 2014 and 2020. The 37 cases were divided into two Groups based on whether suspension fixation was applied during the transperitoneal LDP. Clinical characteristics and follow-up data of these cohorts were retrospectively collected and analyzed. Continuous variables with a normal distribution were expressed as mean ± standard deviation (SD) and analyzed using independent sample <i>t</i>-tests. Non-normally distributed continuous variables were reported as interquartile range (IQR) and analyzed with the Mann-Whitney <i>U</i>-test.</p><p><strong>Results: </strong>In Group A, 21 cases underwent conventional LDP without suspension fixation, while in Group B, 16 cases underwent \"suspension fixation\" LDP. The operative time (237.9±63.0 <i>vs.</i> 186.4±52.3 min, P=0.01), anastomotic suturing completion time (125.2±21.6 <i>vs.</i> 75.9±12.1 min, P<0.001), and postoperative hospital stay duration [6.0 (4.0, 7.5) <i>vs.</i> 4.5 (3.0, 6.5) days, P=0.04] were significantly shorter in Group B than in Group A, and the intraoperative blood loss [15.0 (5.0, 21.0) <i>vs.</i> 7.5 (5.0, 10.8) mL, P=0.04] in Group B was significantly lower than that in Group A. There were no significant differences between the two Groups in preoperative and anteroposterior renal pelvic diameter (APD), postoperative days to drainage tube removal, and postoperative days to removal of double J (D-J) sent. In Group A, one case developed anastomotic stenosis during follow-up, which improved after ureteral balloon dilation. In Group B, one case developed recurrent febrile urinary tract infection (UTI) within two months of D-J stent removal and was ultimately cured with antibiotic treatment during follow-up. The success rates were 95.2% (20/21) in Group A and 93.8% (15/16) in Group B. Other cases who were followed up showed no recurrence of stenosis, urine leakage, or recurrent UTI.</p><p><strong>Conclusions: </strong>The use of assisted suspension fixation in transperitoneal LDP is safe and efficient for infants and young children, helping to reduce operative time, overcome the small laparoscopic operating area, and address the steep learning curve, making it a valuable approach.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"820-830"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of early versus delayed loop diuretic administration in sepsis: a propensity score-matched analysis using the MIMIC-IV database.","authors":"Yingxin Wang, Jiaqian Wu, Tenghao Shao, Xiaoxu Ding, Yukun Tian, Ning Li","doi":"10.21037/tau-24-620","DOIUrl":"https://doi.org/10.21037/tau-24-620","url":null,"abstract":"<p><strong>Background: </strong>Fluid resuscitation is a standard intervention for patients with sepsis, however, the ideal timing for initiating fluid deresuscitation has not been well established. This study examines the prognostic impact of early versus delayed initiation of loop diuretics in patients with sepsis.</p><p><strong>Methods: </strong>Data for this analysis were obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients diagnosed with sepsis were categorized into two groups based on the timing of loop diuretic administration: an early group (within 48 hours of diagnosis) and a late group (after 96 hours).</p><p><strong>Results: </strong>A total of 8,518 patients with sepsis were included in this study. Of these, 4,485 patients received loop diuretics within the first 48 hours (early group), while the remaining 4,033 patients received loop diuretics after 96 hours (late group). In the early group, 75% of patients required mechanical ventilation, which was significantly lower than the 85.6% in the late group (P<0.001). However, the early group demonstrated a significantly higher 28-day mortality rate compared to the late group (832/4,485 <i>vs.</i> 679/4,033, P=0.03). Cox regression analysis indicated that the early initiation of diuretics was associated with an increased 28-day mortality rate [hazard ratio (HR) =2.590, 95% confidence interval (CI): 2.325-2.884, P<0.001]. After adjusting for the proportional hazards assumption, the corrected HR was recalculated as exp[3.55-1.20 × ln(t)]. Propensity score matching (PSM) resulted in two well-matched groups of 1,882 patients each. Post-matching analysis revealed that the early group continued to exhibit significantly higher 28-day and in-hospital mortality (P<0.001) along with a significantly higher incidence of stage 3 acute kidney injury (AKI) (8.1% <i>vs.</i> 5.7%, P=0.004).</p><p><strong>Conclusions: </strong>While complete adjustment for all potential confounding factors was not possible, the findings suggest that patients who received loop diuretics within 48 hours had more severe kidney injury and a significantly higher mortality rate compared to those who received later administration (after 96 hours). These findings underscore the need for careful consideration when determining the timing of loop diuretic initiation in clinical practice.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"779-790"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and future directions of radiation-free retrograde intrarenal surgery.","authors":"Shuzo Hamamoto, Takahiro Yasui","doi":"10.21037/tau-2025-5","DOIUrl":"https://doi.org/10.21037/tau-2025-5","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"496-498"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Butyrate improves testicular spermatogenic dysfunction induced by a high-fat diet.","authors":"Xiangen Liu, Yujuan Qi, Tao Zhu, Xiaoyue Ding, Dianshuang Zhou, Conghui Han","doi":"10.21037/tau-2024-660","DOIUrl":"https://doi.org/10.21037/tau-2024-660","url":null,"abstract":"<p><strong>Background: </strong>Obesity is closely associated with low male fertility and decreased sperm quality. Obesity is accompanied by an ecological imbalance in the gut microbiota, so it is of great significance to intervene in male infertility caused by obesity from the perspective of gut microbiota metabolites. This study aimed to evaluate the efficacy of butyrate in ameliorating obesity-induced spermatogenic dysfunction and to explore the potential molecular mechanisms.</p><p><strong>Methods: </strong>This study explored the role of butyrate in recovering the dysfunctions of spermatogenesis caused by obesity by inducing an obese model of male mice with a high-fat diet (HFD). The effects of HFD and butyrate on testicular function were explored based on metabolomics.</p><p><strong>Results: </strong>The results of the study showed that HFD caused a decrease in sperm count, a decrease in sperm motility, and an increase in sperm malformation rate in mice. After adding butyrate to the HFD, the various sperm indicators of mice were significantly improved. Through the analysis of metabolomics data from mouse testes, this study found that an HFD significantly altered the metabolic status of mice testes, involving multiple metabolic pathways. However, after adding butyrate, some metabolic characteristics tended to be similar to those of normal diet mice, and the steroid biosynthesis and primary bile acid biosynthesis pathways were significantly improved.</p><p><strong>Conclusions: </strong>This study clarified the effect of butyrate on improving sperm quality, providing experimental evidence for the treatment of obesity-induced abnormal spermatogenesis with butyrate.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"627-636"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal approach for MRI-targeted prostate biopsy in detecting clinically significant prostate cancer: transperineal or transrectal?","authors":"Hiroshi Kiuchi, Fumie Yoshioka, Yushi Miyata, Tetsuji Soda, Kenichiro Sekii","doi":"10.21037/tau-2024-757","DOIUrl":"https://doi.org/10.21037/tau-2024-757","url":null,"abstract":"","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"489-492"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinner syndrome in adult male: a rare case report.","authors":"Kaifu Wu, Yun Hu, Yuanliang Xie, Shutong Zhang, Xiang Wang","doi":"10.21037/tau-2024-763","DOIUrl":"https://doi.org/10.21037/tau-2024-763","url":null,"abstract":"<p><strong>Background: </strong>Zinner syndrome (ZS) is an extremely rare congenital genitourinary disease. Its typical triad consists of seminal vesicle cysts, ejaculatory duct obstruction, and ipsilateral renal agenesis or hypoplasia. At present, the exact pathogenesis of ZS remains a mystery. It is hypothesized that ZS might be associated with aberrations that occur during the intricate process of embryonic development.</p><p><strong>Case description: </strong>A 40-year-old male presented to the hospital with a chief complaint of experiencing dysuria for 5 consecutive days, accompanied by frequent urination and urgency. Through comprehensive imaging and laboratory examinations, he was diagnosed with ZS. Subsequently, laparoscopic left seminal vesicle cystectomy was successfully carried out. Postoperative pathology revealed the existence of inflammatory infiltration in the wall of the seminal vesicle cyst. The patient recovered smoothly and was discharged without complications. No signs of recurrence were detected during the 6-month follow-up.</p><p><strong>Conclusions: </strong>Ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI) examinations are crucial for accurately diagnosing ZS. These imaging techniques offer detailed anatomical information, helping identify features like seminal vesicle cysts and renal anomalies. Acute seminal vesicle cyst infection accompanied by ipsilateral renal agenesis and ureteral developmental malformations is recognized as a clinical manifestation of ZS. Laparoscopic seminal vesicle cystectomy is safe and effective.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"848-854"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prone versus lateral retroperitoneoscopic partial nephrectomy for posterior tumors in adults: technique and clinical outcomes.","authors":"Qijie Zhang, Xianhua Shao, Yuanchen Lu, Junpeng Deng, Tengyue Zeng, Hongliang Que, Yi Sun, Zhongru Fan, Quan Li, Luwei Xu, Jianjun Xie","doi":"10.21037/tau-2024-735","DOIUrl":"https://doi.org/10.21037/tau-2024-735","url":null,"abstract":"<p><strong>Background: </strong>Very limited information is available about the prone retroperitoneoscopic partial nephrectomy (RPN) in adults. This study aimed to evaluate the feasibility and clinical outcomes of prone RPN for posterior tumors in comparison with traditional lateral RPN in adults.</p><p><strong>Methods: </strong>The recordings of 101 patients underwent RPN from January 2018 to March 2023 were retrospectively reviewed. Fifty-nine patients underwent surgeries with lateral RPN, and 42 underwent surgeries with prone RPN. Operative time, warm ischemia time, blood loss, renal function, operative complications, and arterial blood gas analysis were recorded and compared between the two groups. Additionally, a dorsal deviation score (DDS) was developed to quantitate the degree to which the tumor was dorsal, which helped to select a suitable operative approach clinically.</p><p><strong>Results: </strong>Patients in prone RPN group had shorter operative time (P<0.001), warm ischemia time (P=0.003), and less blood loss (P=0.03) in comparison with lateral RPN. In arterial blood gas analysis, no significant differences in arterial partial pressure of carbon dioxide (PaCO₂), arterial partial pressure of oxygen (PaO₂), and pH were observed between two groups before the operation and 30 min after positioning. For slightly posterior tumors (DDS =1), no significant difference in above parameters was observed. However, shorter operative time (P=0.03, P<0.001, respectively), warm ischemia time (P=0.02, P=0.03, respectively), and less blood loss (P=0.08, P=0.043, respectively) were noticed in prone RPN for moderate or severe posterior (DDS =2 or 3) tumors, especially posterior hilar tumors. Difference in renal function between two groups was insignificant. As for complications, a higher incidence of intraoperative complications appeared in lateral RPN group (11.9%) compared with prone RPN (2.4%), whereas there was no significant difference in postoperative complications.</p><p><strong>Conclusions: </strong>Prone RPN is a feasible operative approach in clinical practice, and is superior to lateral RPN for moderate to severe posterior tumors, especially posterior hilar tumors.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 3","pages":"567-577"},"PeriodicalIF":1.9,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}