Varicocele grade does not correlate with the severity of sperm DNA fragmentation levels nor with the amount of improvement in DNA fragmentation following varicocele repair.

IF 1.7 3区 医学 Q4 ANDROLOGY
Translational andrology and urology Pub Date : 2025-07-30 Epub Date: 2025-07-28 DOI:10.21037/tau-2025-154
Parviz K Kavoussi, Romtin Mehrabani-Farsi, Hayden T Henderson, Jason Weiss, Jeissen Pyo, Claire Fason, Arya Farahi, Negar Farzaneh, Sarosh Irani, Shahryar K Kavoussi
{"title":"Varicocele grade does not correlate with the severity of sperm DNA fragmentation levels nor with the amount of improvement in DNA fragmentation following varicocele repair.","authors":"Parviz K Kavoussi, Romtin Mehrabani-Farsi, Hayden T Henderson, Jason Weiss, Jeissen Pyo, Claire Fason, Arya Farahi, Negar Farzaneh, Sarosh Irani, Shahryar K Kavoussi","doi":"10.21037/tau-2025-154","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Varicocele is the most common correctable form of male infertility. Varicoceles have been established to result in worsened semen parameters as well as elevate sperm DNA fragmentation (SDF). There is data indicating that varicocele repair improves semen parameters and SDF, however; there is a paucity of data assessing the correlation of varicocele clinical grade with the severity of SDF and the amount of improvement in SDF with varicocele repair based on grade. The purpose of this study was to assess the difference in baseline sperm DNA fragmentation indices (DFIs) in infertile men with varicoceles based on the clinical grade of the varicocele and the amount of improvement in DFI following varicocele repair.</p><p><strong>Methods: </strong>A retrospective chart review was performed in men who presented for a fertility evaluation and were diagnosed with a clinical varicocele and underwent varicocele repair with preoperative and 3-month postoperative semen analyses with DFI testing.</p><p><strong>Results: </strong>There was no significant difference in the level of SDF based on the grade of varicocele, and there was not a significant correlation between the grade of the varicocele and the amount of improvement in SDF from baseline to 3 months after varicocele repair.</p><p><strong>Conclusions: </strong>When counseling infertile men undergoing varicocele repair for elevated SDF, the grade of varicocele may not impact the amount of improvement expected in SDF following repair, suggesting that varicocele patients may be counseled similarly on expectations for response regardless of varicocele grade.</p>","PeriodicalId":23270,"journal":{"name":"Translational andrology and urology","volume":"14 7","pages":"1904-1911"},"PeriodicalIF":1.7000,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336730/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational andrology and urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21037/tau-2025-154","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/28 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ANDROLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Varicocele is the most common correctable form of male infertility. Varicoceles have been established to result in worsened semen parameters as well as elevate sperm DNA fragmentation (SDF). There is data indicating that varicocele repair improves semen parameters and SDF, however; there is a paucity of data assessing the correlation of varicocele clinical grade with the severity of SDF and the amount of improvement in SDF with varicocele repair based on grade. The purpose of this study was to assess the difference in baseline sperm DNA fragmentation indices (DFIs) in infertile men with varicoceles based on the clinical grade of the varicocele and the amount of improvement in DFI following varicocele repair.

Methods: A retrospective chart review was performed in men who presented for a fertility evaluation and were diagnosed with a clinical varicocele and underwent varicocele repair with preoperative and 3-month postoperative semen analyses with DFI testing.

Results: There was no significant difference in the level of SDF based on the grade of varicocele, and there was not a significant correlation between the grade of the varicocele and the amount of improvement in SDF from baseline to 3 months after varicocele repair.

Conclusions: When counseling infertile men undergoing varicocele repair for elevated SDF, the grade of varicocele may not impact the amount of improvement expected in SDF following repair, suggesting that varicocele patients may be counseled similarly on expectations for response regardless of varicocele grade.

Abstract Image

Abstract Image

Abstract Image

精索静脉曲张等级与精子DNA碎片水平的严重程度无关,也与精索静脉曲张修复后DNA碎片的改善程度无关。
背景:精索静脉曲张是男性不育症最常见的可矫正形式。精索静脉曲张导致精液参数恶化,并提高精子DNA碎片(SDF)。然而,有数据表明精索静脉曲张修复可改善精液参数和SDF;目前缺乏评估精索静脉曲张临床分级与SDF严重程度的相关性以及基于分级的精索静脉曲张修复对SDF改善程度的数据。本研究的目的是根据精索静脉曲张的临床分级和精索静脉曲张修复后DFI的改善程度,评估伴有精索静脉曲张的不育男性基线精子DNA碎片指数(DFI)的差异。方法:对接受生育能力评估并被诊断为临床精索静脉曲张并接受精索静脉曲张修复术的男性进行回顾性图表回顾,术前和术后3个月进行精液分析和DFI测试。结果:基于精索静脉曲张分级的SDF水平无显著差异,精索静脉曲张分级与基线至精索静脉曲张修复后3个月SDF改善量无显著相关性。结论:当对接受精索静脉曲张修复的不育男性进行SDF升高的咨询时,精索静脉曲张的级别可能不会影响修复后SDF预期改善的程度,这表明无论精索静脉曲张级别如何,精索静脉曲张患者都可以接受类似的应答预期咨询。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.10
自引率
5.00%
发文量
80
期刊介绍: ranslational Andrology and Urology (Print ISSN 2223-4683; Online ISSN 2223-4691; Transl Androl Urol; TAU) is an open access, peer-reviewed, bi-monthly journal (quarterly published from Mar.2012 - Dec. 2014). The main focus of the journal is to describe new findings in the field of translational research of Andrology and Urology, provides current and practical information on basic research and clinical investigations of Andrology and Urology. Specific areas of interest include, but not limited to, molecular study, pathology, biology and technical advances related to andrology and urology. Topics cover range from evaluation, prevention, diagnosis, therapy, prognosis, rehabilitation and future challenges to urology and andrology. Contributions pertinent to urology and andrology are also included from related fields such as public health, basic sciences, education, sociology, and nursing.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信