Transplantation proceedings最新文献

{"title":"Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice","authors":"Alireza Rafati ,&nbsp;Reihaneh Ramezani ,&nbsp;Hadi Esmaeili Gouvarchin Ghaleh ,&nbsp;Shabnam Bahrami ,&nbsp;Akbar Ghorbani Alvanegh ,&nbsp;Mahmood Reza Masoudi","doi":"10.1016/j.transproceed.2024.12.020","DOIUrl":"10.1016/j.transproceed.2024.12.020","url":null,"abstract":"<div><h3>Background and Aim</h3><div>Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily involves synovial joints. During the past decade, disease-modifying antirheumatic drugs and biologic agents have been introduced for the treatment of RA. However, they have limitations, including incomplete treatment response, adverse effects requiring drug withdrawal, fall off in efficacy over time, high cost of biologic agents, and refractory cases. Consequently, there is a need to establish safe and effective advanced therapeutic modalities for RA to overcome the shortcomings of current treatments.</div></div><div><h3>Methods</h3><div>MSCs after isolation were exposed to 200 nM calcitriol. Rheumatoid arthritis was induced in BALB/c mice using collagen and Freund's complete adjuvant. One week after immunization, the mice were divided into 3 groups including without treatment, groups treated with untreated and treated MSCs. One week after the last injection, mice sacrificed and samples were taken and the desired evaluations were done.</div></div><div><h3>Results</h3><div>Our results revealed that the respiratory burst capacity, neutrophil phagocytosis, and nitric oxide production in the population of splenocytes were higher in the positive control group compared to the treatment groups. Also, the level of production of IL-4, IL-10 and TGF-β cytokines and INF-γ and IL-17 cytokines showed a significant increase and decrease, respectively, compared to the positive control group.</div></div><div><h3>Conclusion</h3><div>Treatment of MSCs with calcitriol leads to an improvement in regulatory function and inhibitory effects on inflammatory mediators of innate immune cells, particularly splenocytes, in a rheumatoid arthritis model compared to untreated mesenchymal stem cells.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 355-363"},"PeriodicalIF":0.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Study on Myocardial Protective Effect of Xuebijing Injection on Extracorporeal Membrane Oxygenation Perfused Isolated Heart: Based on Autophagy and NLRP3 Inflammatory Pathway","authors":"Shijie Yin ,&nbsp;Chunhua Wang ,&nbsp;Xiao Yue ,&nbsp;Qiangxin Huang ,&nbsp;Wei Wu ,&nbsp;Guanbin Qin ,&nbsp;Lan Luo ,&nbsp;Huabei Wu","doi":"10.1016/j.transproceed.2024.12.022","DOIUrl":"10.1016/j.transproceed.2024.12.022","url":null,"abstract":"<div><h3>Background</h3><div>The purpose of this study was to investigate the myocardial protective effect of Xuebijing (XBJ) injection in isolated donor heart preservation based on autophagy and NLRP3 inflammatory pathway, and to provide clues for improving the quality of donor heart preservation in the clinic.</div></div><div><h3>Methods</h3><div>Fourteen Guangxi Bama miniature pigs were randomly divided into two groups to establish the isolated heart perfusion model of extracorporeal membrane oxygenation (ECMO): (1) normal saline group (NS group): 50 mL normal saline was added to the perfusion solution; and (2) Xuebijing injection group (XBJ group): 10 mL of XBJ was added to the perfusate. Both groups were continuously pumped with 5 mL/h for 8 hours. Hemodynamic changes, inflammatory reaction, and myocardial enzyme levels were observed at five different time points. Western blot and real-time quantitative polymerase chain reaction (RT-qPCR) were used to detect the expression of autophagy markers and the NLRP3 signaling pathway related factors mRNA in myocardial tissue. Hematoxylin and eosin (H&amp;E) staining and transmission electron microscopy were used to observe the pathomorphology and ultrastructure of the myocardium.</div></div><div><h3>Results</h3><div>There was no significant difference in perfusion pressure, heart rate, perfusion flow, and PH value between the two groups. The degree of myocardial tissue injury in the XBJ group was lighter, and the levels of myocardial enzymes, serum inflammatory factors were lower. The mRNA expression levels of beclin-1 and LC3 in the XBJ group were higher than those in the saline group, and the mRNA expression levels of NLRP3, Caspase-1, and ASC were lower.</div></div><div><h3>Conclusions</h3><div>Xuebijing injection can effectively improve the level of autophagy, reduce the activation and release of NLRP3 inflammasome, and slow down the inflammatory response, which has a certain myocardial protection effect.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 416-423"},"PeriodicalIF":0.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Impacting Early Adverse Outcomes in Simultaneous Heart-Kidney Transplantation","authors":"Bernard John DuBray ,&nbsp;Saed Shawar ,&nbsp;Sandip Zalawadiya ,&nbsp;Kelly Schlendorf ,&nbsp;Bonnie Ann Sarrell ,&nbsp;Beatrice P. Concepcion ,&nbsp;Scott A. Rega ,&nbsp;Irene D. Feurer ,&nbsp;David Shaffer ,&nbsp;Rachel C. Forbes","doi":"10.1016/j.transproceed.2024.11.037","DOIUrl":"10.1016/j.transproceed.2024.11.037","url":null,"abstract":"<div><h3>Background</h3><div>Over the last decade, the number of simultaneous heart-kidney transplants (SHKTs) has increased dramatically. There are few reports of renal allograft outcomes in these high acuity patients. The goal of the present study was to identify variables that were related to early adverse outcomes (EAOs), including delayed graft function (DGF), primary non-function (PNF), and renal allograft futility (RAF) after SHKTs.</div></div><div><h3>Methods</h3><div>We performed a single center retrospective review of all adults undergoing SHKTs from October 2011 to August 2021. Multivariable logistic regression models with backward elimination were used to test the relationships between recipient (pre-transplant dialysis, intra-aortic balloon pump, serum lactate, norepinephrine use, and re-do sternotomy) and operative (cold ischemia time [CIT]) variables and the likelihood of DGF, PNF, and RAF.</div></div><div><h3>Results</h3><div>Sixty-eight patients underwent SHKT during the study period. Overall, patient survival was 87%, 83%, and 80% at 6 months, 1 year, and 3 years, respectively. Twenty-four patients (35%) experienced DGF, whereas 4 patients (6%) had PNF, and 12 patients (18%) had RAF (Table 1). Pre-transplant dialysis, serum lactate, and CIT were significantly associated with an increased likelihood of DGF. Norepinephrine (NE) and CIT were associated with increased likelihood of RAF (Table 2).</div></div><div><h3>Conclusions</h3><div>Pre-transplant dialysis is related to an increased likelihood of EAO following SHKT, with CIT and NE contributing to increased likelihood of RAF. Given that SHKT recipients are at risk of remaining on dialysis following SHKT, strategies that allow for expedited kidney transplantation after heart transplantation may mitigate the hemodynamic and ischemic constraints of SHKT that contribute to early adverse outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 390-393"},"PeriodicalIF":0.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Rural Live-Kidney Donation Through Insights From a Decade-Long Analysis at a Single Center in the Northern Great Plains","authors":"Kaleb Dobbs ,&nbsp;Els Reuvekamp ,&nbsp;Benjamin Limburg ,&nbsp;Sujit Vijay Sakpal","doi":"10.1016/j.transproceed.2024.12.018","DOIUrl":"10.1016/j.transproceed.2024.12.018","url":null,"abstract":"<div><h3>Background</h3><div>Data on barriers to live-kidney donation in the rural United States is limited despite its widespread adoption across the country.</div></div><div><h3>Methods</h3><div>A retrospective review of 1776 self-referrals for live-kidney donation between June 1, 2012, and May 31, 2022, was conducted. Multivariate analyses evaluated independent factors which may have potentially influenced donation at different stages in its process.</div></div><div><h3>Results</h3><div>Of the 1776 self-referrals, 398 (22.4%) individuals underwent evaluation and 121 (6.8%) of those became live-kidney donors. Middle-aged people (average age = 43 years), Whites (91.7%), and women (70.2%) were the most likely to donate. One thousand, one hundred, eighteen individuals (63.0%) dropped out after completing the intake form and the primary reasons included lost to follow-up (32.1%) and donor retraction (24.6%). Concerns related to personal health and compatibility were the predominant subjective factors for retraction. Following in-person evaluation, the most common reasons were medical comorbidities (34.9%) and inoperable renal anatomy (26.5%). Of the 1655 people that did not donate, 178 (10.8%) individuals discovered a new diagnosis during their evaluation process.</div></div><div><h3>Conclusions</h3><div>Only a fraction of those who begin the process proceed to donate a kidney, and most withdraw voluntarily before reaching the in-person evaluation phase. Focused approaches aimed at concerns regarding personal health and donor-recipient compatibility in otherwise healthy, motivated candidates in the early phases of donation hold potential for improving retention rates and subsequent donations.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 180-186"},"PeriodicalIF":0.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of Glomerular Filtration Rate Estimating Equations in Kidney Transplant Recipients of Various Races: A Retrospective Cohort Study","authors":"Pooja Budhiraja ,&nbsp;Richard Butterfield ,&nbsp;Musab Hommos ,&nbsp;Raymond L. Heilman ,&nbsp;Wisit Cheungpasitporn ,&nbsp;Salah Alajous ,&nbsp;Hay Me Me ,&nbsp;Harini A. Chakkera ,&nbsp;Rebecca L. Corey ,&nbsp;Bassam G. Abu Jawdeh ,&nbsp;Hassan A. Khamash","doi":"10.1016/j.transproceed.2024.12.026","DOIUrl":"10.1016/j.transproceed.2024.12.026","url":null,"abstract":"<div><h3>Background</h3><div>We assessed the accuracy of different GFR estimating equations in kidney transplant recipients across diverse racial backgrounds, addressing the previously identified validation gap in multiethnic populations predominantly studied in White cohorts.</div></div><div><h3>Methods</h3><div>In this single-center study, eGFR was compared to the measured GFR (mGFR) one year following kidney transplantation.</div></div><div><h3>Results</h3><div>The 1-year eGFR and mGFR data from 1145 participants (54% Whites, 23% Hispanics, 9% Blacks, 7% Native Americans, and 6% Asians) revealed varied correlations across racial groups. For Whites, the combined 2021 CKD-EPI creatinine-cystatin C formulas demonstrated a stronger correlation <em>(r = 0.72, [0.65, 0.78])</em> compared to the 2021 CKD-EPI creatinine and EKFC cystatin C equation. This equation also achieved the highest accuracy <em>(P30: 77.1%).</em> In Black recipients, both the 2009 CKD-EPI (<em>r</em> = 0.56 <em>[0.42, 0.68]</em>) and the 2021 CKD-EPI creatinine (<em>r</em> = 0.56 <em><u>[</u>0.41, 0.68]</em>) exhibited modest correlations. The 2021 CKD-EPI creatinine-cystatin C equation showed improved correlation <u>(</u><em>r = 0.63 (0.43, 0.77)</em>] and an accuracy of <em>62.7% (P30)</em><u>,</u> which was slightly lower than the EKFC cystatin C equation <em>(P30: 64.7%)</em>. However, neither the EKFC (rescaled) cystatin C nor the race-free kidney-specific equations outperformed existing eGFR equations for Black participants In Hispanic patients, combined creatinine-cystatin C equations outperformed creatinine-only equations. Among Native Americans, the combined creatinine-cystatin, EKFC (rescaled) cystatin C, and race-free kidney-specific equations achieved an accuracy rate exceeding 85%. In Asians, the CKD-EPI creatinine-cystatin C equation showed the highest correlation, while the race-free kidney-specific equation had the most accuracy.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that creatinine-cystatin C combined equations outperformed single-marker formulas across all racial groups, with negligible differences between the 2009 CKD EPI and the race-neutral 2021 CKD-EPI version.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 230-240"},"PeriodicalIF":0.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Liver Volume Estimation Methods in Living Donor Liver Transplant: CT Volumetry vs MeVis, With Comparison of Open and Laparoscopic Surgery","authors":"Ek Khoon Tan ,&nbsp;Victoria Zheng ,&nbsp;Seok Yin Tuieng ,&nbsp;Albert Su Chong Low ,&nbsp;Steve Tian Sung Chai ,&nbsp;Yi Xuan Phang ,&nbsp;Ye Xin Koh ,&nbsp;Alexander Yaw Fui Chung ,&nbsp;Peng Chung Cheow ,&nbsp;Prema Raj Jeyaraj ,&nbsp;Brian Kim Poh Goh","doi":"10.1016/j.transproceed.2024.12.017","DOIUrl":"10.1016/j.transproceed.2024.12.017","url":null,"abstract":"<div><h3>Background</h3><div>Accurately assessing graft volume is crucial for donor and recipient safety in living donor liver transplantation. This can be performed using manual computed tomography volumetry (CTvol) or semiautomated methods (MeVis). We aimed to compare CTvol and MeVis in estimating the actual graft weight during LDLT, and analyse any differences in weight between laparoscopic and open donor hepatectomy.</div></div><div><h3>Methods</h3><div>A retrospective study of living donors between 2015 and 2022 with complete imaging data was performed. Graft weights were estimated using (1) CT volumetry and (2) semiautomated MeVis software. The primary outcome was graft weight variance ([Predicted weight–Actual weight]/Predicted weight) × 100. The secondary outcome of interest was whether open or laparoscopic surgery affected graft weight variance.</div></div><div><h3>Results</h3><div>Of the 33 donors, 52.6% were right liver without middle hepatic vein grafts. Nineteen donors (57.6%) underwent open hepatectomy. Both CTvol (r = 0.70; <em>P</em> &lt; .001) and MeVis (r = 0.85; <em>P</em> &lt; .001) showed strong correlation with actual graft weight. Weight variance using CTvol was −2.9% vs −15.3% (<em>P</em> = .04) for open vs laparoscopic, while the corresponding using MeVis was −0.9% vs −8.5% (<em>P</em> = .11). Actual graft-to-recipient weight ratio predicted by MeVis was similar between open and laparoscopic approaches (−0.01 vs 0.07; <em>P</em> = .12).</div></div><div><h3>Conclusions</h3><div>Both CT volumetry and MeVis showed strong correlation between predicted and actual graft weights. Laparoscopic hepatectomy showed greater variability in graft weight estimation using CT volumetry, but MeVis was similar across both open and laparoscopic surgery.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 292-297"},"PeriodicalIF":0.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Multiple Kidney Retransplants on Post-Transplant Outcomes in the United States","authors":"Charat Thongprayoon ,&nbsp;Oscar A. Garcia Valencia ,&nbsp;Jing Miao ,&nbsp;Iasmina M. Craici ,&nbsp;Shennen A. Mao ,&nbsp;Michael A. Mao ,&nbsp;Supawit Tangpanithandee ,&nbsp;Justin H. Pham ,&nbsp;Napat Leeaphorn ,&nbsp;Wisit Cheungpasitporn","doi":"10.1016/j.transproceed.2024.12.016","DOIUrl":"10.1016/j.transproceed.2024.12.016","url":null,"abstract":"<div><h3>Background</h3><div>Kidney retransplantation offers a valuable treatment option for patients who experience graft failure after their initial transplant. There is an increasing number of patients undergoing multiple retransplants. However, the impact of multiple kidney retransplants on post-transplant outcomes remains unclear. This study aimed to assess the association between the number of kidney retransplants and post-transplant outcomes in kidney retransplant recipients.</div></div><div><h3>Methods</h3><div>We used the Organ Procurement and Transplantation Network and United Network for Organ Sharing (OPTN/UNOS) database to identify kidney-only retransplant recipients in United States from 2010 through 2019. We categorized kidney retransplant recipients based on their number of kidney retransplant into one and two plus kidney retransplant groups. The association of one vs two plus kidney retransplants with death-censored graft failure and patient death was assessed using Cox proportional hazard analysis, and acute rejection using logistic regression analysis.</div></div><div><h3>Results</h3><div>Of 17,433 kidney retransplant recipients included in this study, 15,821 (91%) and 1612 (9%) had one and two plus kidney retransplants, respectively. Patients with two plus kidney retransplants were younger, predominantly White, had higher panel reactive antibody (PRA), public insurance, and education, but had less history of diabetes mellitus and total HLA mismatch compared with patients with one kidney retransplant. After adjusting for potential confounders, having two plus kidney retransplants was significantly associated with increased risk of death-censored graft failure (hazard ratio [HR] = 1.20, 95% confidence interval [CI] = 1.02-1.42) and allograft rejection (odds ratio [OR] = 1.30, 95% CI = 1.09-1.54), but it was not significantly associated with patient death.</div></div><div><h3>Conclusions</h3><div>Patients undergoing multiple kidney retransplants face a higher risk of graft failure and rejection compared with those with a single retransplant. These findings underscore the need for tailored management and monitoring strategies to improve outcomes for patients receiving multiple kidney retransplants.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 214-222"},"PeriodicalIF":0.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Membrane Transplantation: Can It Be A Solution For Tissue Defect Repair In Giant Omphaloceles","authors":"Olga Devrim Ayvaz ,&nbsp;Ayşenur Celayir ,&nbsp;Oya Demirci","doi":"10.1016/j.transproceed.2024.12.015","DOIUrl":"10.1016/j.transproceed.2024.12.015","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effect of placental membrane covering of the omphalocele sac on the healing of giant omphaloceles requiring silo repair that could not be treated primarily.</div></div><div><h3>Methods</h3><div><u>This prospective study was performed between October 2021 and October 2023 with the approval of our hospital's ethics committee.</u> All pregnant women diagnosed with prenatal giant omphalocele were informed that their own placenta could be used for omphalocele repair if necessary, and their consent was obtained.</div></div><div><h3>Results</h3><div>Over 24 months, 7 omphaloceles could not be closed primarily, and the placental amniotic membranes were wrapped around the omphalocele sacs and left for secondary healing. All patients underwent cesarean section. The mean gestational age at delivery was 37.6 ± 1.1 weeks (range, 36-39 weeks) according to the last menstruation and 35.3 ± 3.3 weeks (range, 29-39 weeks) according to ultrasound. The mean birth weight was 2814.3 ± 704.9 g (range, 1340-3400 g). Two infants were male (28.5%), and 5 were female (71.5%). The liver and intestines were in the omphalocele sacs. The mean transverse diameter, vertical diameter, and height of omphalocele sac were 15 ± 3.36 cm (range, 11-20 cm), 15.43 ± 3.1 cm (range, 12-19 cm), and 12.33 ± 3.13 cm (range, 8-16 cm), respectively. All the patients had unresectable livers that adhered to the sac. One of the patients had an omphalocele that ruptured during birth, and placental transplantation was performed after rupture repair. After wrapping with the placental membrane, all healed with tight granulation tissue. The mean hospitalization duration was 48.86 ± 26.99 days (range, 21-101 days). The median ventral hernia diameter was 7.07 ± 2.09 cm (range, 5-10 cm). The mean follow-up duration was 10.7 ± 6.8 months (range, 3-23 months). <u>The discharge weight of the infants increased by an average of 789.28</u> ± <u>532.5 g compared with their birth weight, which was statistically significant (</u><em><u>P =</u></em> <u>.028). The average transverse diameter of the omphalocele sac decreased by an average of 7.92</u> ± <u>3.67 cm compared with that at birth, which was statistically significant (</u><em><u>P =</u></em> <u>.018). The vertical diameter measurement of the omphalocele sac decreased by an average of 5.75</u> ± <u>2.18 cm at discharge compared with that at birth, which was statistically significant (</u><em><u>P =</u></em> <u>.046).</u></div></div><div><h3>Conclusions</h3><div>Wrapping the maternal placental membrane around the omphalocele sac is an inexpensive, effective, safe, and successful treatment method for preventing sac rupture during the secondary healing of giant omphaloceles.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 364-370"},"PeriodicalIF":0.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Altered Graft Position During Living Donor Liver Retransplantation and its Outcomes","authors":"Hidekazu Yamamoto ,&nbsp;Kaori Isono ,&nbsp;Masaki Honda ,&nbsp;Yasuhiko Sugawara ,&nbsp;Yukihiro Inomata ,&nbsp;Taizo Hibi","doi":"10.1016/j.transproceed.2024.12.029","DOIUrl":"10.1016/j.transproceed.2024.12.029","url":null,"abstract":"<div><h3>Introduction</h3><div>Liver retransplantation (reLT), which is the only treatment for liver graft failure, remains challenging not only because of its technical nature but also because it is performed in high-risk patients.</div></div><div><h3>Methods</h3><div>Nineteen patients who underwent reLT (second LT, <em>n</em> = 18; third LT, <em>n</em> = 1) between 1999 and 2021 were divided into two groups according to the graft laterality between prior transplantation and reLT (ipsilateral group, <em>n</em> = 9; contralateral group, <em>n</em> = 10). The aim of this study was to evaluate the short- and the long-term outcomes of patients who underwent living donor reLT and compared graft survival between ipsilateral and contralateral grafts.</div></div><div><h3>Results</h3><div>For hepatic vein reconstruction, the previous anastomotic orifice of the recipient was used in 8 (88.9%) patients in the ipsilateral group, while a new orifice on inferior vena cava of the recipient was created in 8 (80%) patients in the contralateral group. The conduit for the portal vein and hepatic artery were employed in 2 and 2 patients in the ipsilateral group and in 5 and 0 patients in the contralateral group, respectively. The overall incidence of hepatic artery and portal vein complications was 11.1% and 11.1% in the ipsilateral group, and 30% and 11.1% in the contralateral group, respectively. The 1-, 5-year graft survival rates were 70.8%, 66.7% in the ipsilateral group, and 70%, 70% in the contralateral group, respectively.</div></div><div><h3>Conclusions</h3><div>There was no difference between ipsilateral and contralateral grafts in reLT in terms of surgical complications and graft survival.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 284-291"},"PeriodicalIF":0.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-Onset Seizures After Orthotopic Liver Transplantation: A Single-Center Retrospective Study","authors":"Federica Avorio ,&nbsp;Giovanna Russelli ,&nbsp;Rossella Alduino ,&nbsp;Antonio Arcadipane ,&nbsp;Salvatore Gruttadauria ,&nbsp;Vincenzina Lo Re","doi":"10.1016/j.transproceed.2024.12.021","DOIUrl":"10.1016/j.transproceed.2024.12.021","url":null,"abstract":"<div><h3>Background</h3><div>After encephalopathy, epileptic seizures (ES) are the second most common neurologic complication after orthotopic liver transplantation (OLT) and may announce a disabling/fatal neurologic disease.</div></div><div><h3>Methods</h3><div>In this retrospective study, we collected clinical information from patients who underwent OLT at our institution and analyzed outcomes and potential risk factors for developing ES after OLT.</div></div><div><h3>Results</h3><div>Fourteen of our 376 patients (3.72%) who underwent OLT had ES. After excluding 2 patients with already known epilepsy, among the other 12 patients, 2 were diagnosed with nonanoxic cerebral edema, 2 with anoxic damage, 1 with intracranial hemorrhage, 1 with metabolic derangement, and 4 with neurotoxicity; 2 did not receive a diagnosis of certainty. 9 of 12 patients had structural abnormalities on neuroimaging exams. Patients with ES had lower body mass index, higher rate of pretransplant portal thrombosis, and lower pre-transplant plasma concentration of albumin than patients without ES. Multiple post-transplantation systemic complications, postoperative infections, and graft rejection were correlated with a significantly higher risk of ES. Compared with patients without seizures, patients with ES had longer in-hospital and intensive care unit (ICU) length of stay, higher probability of ICU readmission, in-hospital death, and need for rehabilitation. Just 3 of the 12 patients with ES had a good prognosis, while the other 9 had at least mild neurologic sequelae, 5 of whom died because of the underlying neurologic disease.</div></div><div><h3>Conclusions</h3><div>ES after OLT may announce detrimental neurologic disease. When an underlying neurologic disease is excluded, prognosis in terms of seizure recurrence and long-term antiseizure medication need is warranted.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 2","pages":"Pages 324-331"},"PeriodicalIF":0.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}