Transplantation proceedings最新文献

{"title":"Epstein Barr Virus Quantitative Polymerase Chain Reaction Monitoring in Lung and Bone Marrow Transplant Patients to Predict Post-Transplant Lymphoproliferative Disorder: A Systematic Review","authors":"Chandima Divithotawela ,&nbsp;Shawn Z. Lee ,&nbsp;Michael Schulz ,&nbsp;Daniel C. Chambers","doi":"10.1016/j.transproceed.2025.03.008","DOIUrl":"10.1016/j.transproceed.2025.03.008","url":null,"abstract":"<div><h3>Background</h3><div>Epstein–Barr virus (EBV)-driven post-transplant lymphoproliferative disorder (PTLD) affects up to 10% of lung transplant patients and is associated with high morbidity and mortality. Early identification of patients at risk of PTLD and reduction in immunosuppression may be an effective way to prevent future diseases.</div></div><div><h3>Methods</h3><div>A systematic review was conducted of all bone marrow (BMT/HSCT) and lung transplant studies published in English that assessed quantitative peripheral blood EBV PCR monitoring as a predictive measure of future PTLD occurrence. Studies on pre-emptive therapy before the diagnosis of PTLD were excluded.</div></div><div><h3>Results</h3><div>A thousand of hundred sixty-three studies were screened, and 12 were eligible for the final analysis. The two lung transplant studies reported 60% to 80% sensitivity (SN) and 60% to 86% negative predictive value (NPV), but poor specificity (SP) (30%-75%) and positive predictive value (PPV) (30%-67%). HSCT studies also showed good SN (71.4%-100%) and NPV (94%-100%). However, the SP (range, 50%-96%) and PPV (range, 14%-75%) were poor. The included studies used nonstandardized EBV PCR testing methods, which affected the validity of the results and the applicability of the findings to other transplant programs. Most studies were retrospective and included a small number of cases.</div></div><div><h3>Conclusions</h3><div>In conclusion, this systematic review demonstrated the lack of good-quality evidence and poor SP and PPV of EBV PCR monitoring to predict PTLD development in lung transplantation. The use of PCR-guided preemptive therapy for future PTLD prevention is questionable. Further studies with standardized EBV PCR measurements are required.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 931-939"},"PeriodicalIF":0.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Induction Therapy in Kidney Transplant Recipients: A Propensity Score Matching Analysis in a Multicenter Retrospective Observational Study","authors":"Vural Taner Yılmaz ,&nbsp;Erol Demir ,&nbsp;Hüseyin Koçak ,&nbsp;Ayşe Sinangil ,&nbsp;Rahmi Yılmaz ,&nbsp;Şebnem Karakan ,&nbsp;Rezzan Eren Sadioğlu ,&nbsp;Berna Yelken ,&nbsp;Ebru Ok ,&nbsp;Murathan Uyar ,&nbsp;Arzu Velioğlu ,&nbsp;Ergün Parmaksız ,&nbsp;Elif Arı Bakır ,&nbsp;Ülkem Çakır ,&nbsp;Nurhan Seyahi ,&nbsp;Hamad Dheir ,&nbsp;Aydın Türkmen","doi":"10.1016/j.transproceed.2025.04.003","DOIUrl":"10.1016/j.transproceed.2025.04.003","url":null,"abstract":"<div><h3>Bacground</h3><div>This study aimed to compare the efficacy and safety of induction treatments in kidney transplant recipients.</div></div><div><h3>Methods</h3><div>A total of 2564 kidney transplant recipients from 15 transplant centers were included in the study and were categorized into 3 groups for comparison. Group 1: No induction (n = 222, 8.7%), Group 2: Anti-T lymphocyte globulin (ATLG, n = 1794, 70%) and Group 3: Basiliximab (n = 548, 21.4%). The results were compared across 3 post-transplant periods: the first month, the 1st to 6th month, and the 6th to 12th month.</div></div><div><h3>Results</h3><div>Prior to propensity score matching (PSM), there were no significant differences in graft/patient survival, BKV (polyomavirus) incidence, or rejection rates during the first month among the groups. However, the Anti-T lymphocyte globulin (ATLG) group exhibited higher rates of developing donor-specific antibodies (DSA), cytomegalovirus (CMV) infection, general infections, and delayed graft function (DGF), along with higher rejection rates at 1 month post-transplant. After the PSM analysis, rejection rates (which were higher in the ATLG group compared to the Basiliximab group only in the first month), graft/patient loss, and BKV rates were comparable. Infection, CMV, and DSA rates remained elevated in the ATLG group. Clinical results of groups 1 and 3 were similar.</div></div><div><h3>Conclusions</h3><div>This study shown that ATLG provides positive clinical results despite increased infection and DSA formation in patients with high immunological risk, whereas the efficacy and necessity of induction in patients with low-moderate immunological risk is debatable.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 713-722"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Lung Transplant Outcomes: The Critical Role of Pretransplant Gastroenterological Evaluations","authors":"Mahmut Yüksel ,&nbsp;Erdal Yekeler ,&nbsp;Kerem Kenarlı ,&nbsp;Diler Taş Kılıç ,&nbsp;Fatmanur Çelik Başaran ,&nbsp;Yavuz Çağır ,&nbsp;Ahmet Akbay ,&nbsp;Fatma Ebru Akın ,&nbsp;Mevlüt Hamamcı ,&nbsp;Çağdaş Kalkan ,&nbsp;Hasan Tankut Köseoğlu ,&nbsp;Çağdaş Erdoğan","doi":"10.1016/j.transproceed.2025.03.014","DOIUrl":"10.1016/j.transproceed.2025.03.014","url":null,"abstract":"<div><h3>Objective</h3><div>This study evaluates the influence of gastroenterological health on lung transplant candidacy and outcomes, advocating for a standardized pretransplant gastrointestinal assessment protocol.</div></div><div><h3>Methods</h3><div>A retrospective cohort study was conducted at a high-volume tertiary care center from January 2019 to December 2022. Adult patients undergoing comprehensive pre-transplant evaluations, including detailed gastroenterological assessments, were categorized based on their approval status for lung transplantation.</div></div><div><h3>Results</h3><div>Among the candidates evaluated, 19.2% were approved for transplantation. Gastroenterological issues led to the rejection of numerous candidates. Significant rejection factors included advanced liver fibrosis (22.6%), Hepatitis B and C, high-grade dysplasia, intra-mucosal carcinoma, and severe cases of gastroesophageal reflux disease (GERD). These conditions, often associated with severe complications such as portal hypertension and cirrhosis, were pivotal in influencing transplant eligibility and patient outcomes.</div></div><div><h3>Conclusion</h3><div>The findings underscore the critical role of gastroenterological health in the lung transplant evaluation process. Implementing a standardized gastrointestinal assessment protocol could enhance the identification of at-risk patients, reduce post-transplant complications, and improve overall outcomes. This study highlights the need for rigorous pre-transplant evaluations to optimize patient management and transplantation success, promoting the integration of comprehensive gastroenterological assessments into standard care practices for lung transplant candidates.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 859-867"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Infection May Lead to Increased CMV Infection in Renal Transplant Recipients","authors":"Banu Yılmaz ,&nbsp;Sibel Ersan ,&nbsp;Gül Mingsar ,&nbsp;Mehmet Tanrısev ,&nbsp;Hülya Çolak ,&nbsp;Orçun Ural","doi":"10.1016/j.transproceed.2025.03.004","DOIUrl":"10.1016/j.transproceed.2025.03.004","url":null,"abstract":"<div><h3>Background</h3><div>The COVID-19 pandemic has caused significant mortality and morbidity, especially in renal transplant recipients. The mortality and hospitalization rate of COVID-19 infected transplant recipients is much higher than in the healthy population. Although progress has been made in the management of COVID-19 in renal transplant recipients, there are still unexplained clinical differences among patients. We think that cytomegalovirus (CMV) infection may also play a role in this clinical difference in COVID-19 infected transplant recipients. For this purpose, we aimed to screen for the presence of CMV viremia or infection in kidney transplant patient groups who were and were not diagnosed with COVID-19 in the last year.</div></div><div><h3>Method</h3><div>We included 191 consecutive kidney transplant recipients followed in our transplant clinic. The patients were divided into two groups according to whether they had COVID-19 infection or not in the last 1 year. CMV DNA levels were tested in the whole patients’ groups. We compared CMV positivity rates in patients with and without COVID-19.</div></div><div><h3>Results</h3><div>There were 83 patients who had COVID-19 and 108 patients who did not. Whereas CMV viremia was detected in 15 transplant recipients with COVID-19 infection, CMV viremia was detected in 4 patients who did not have COVID-19 (<em>P</em> = .001, logistic regression = 4.8, 95% confidence interval [CI] = 1328–17,103; Figure 1).There was no difference in terms of immunosuppressive therapy, steroid use, duration, and type of transplantation. The COVID-19 negative and positive groups were similar in lymphocyte and leukocyte counts (Table 1). In the multivariate analysis, CMV positivity was found to be positively associated with COVID-19 infection but lymphocyte count and estimated glomerular filtration rate (eGFR) were found to be independently and negatively correlated.</div></div><div><h3>Conclusions</h3><div>CMV infection may accompany COVID-19 or may occur in the post-COVID-19 period. It can cause increased morbidity and mortality. Routine screening and early treatment for CMV may reduce mortality in high-risk group.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 910-915"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MELD Score Before and After Plasmapheresis in Recipients of ABO-Incompatible Living Donor Liver Transplantation","authors":"Ja Eun Lee,&nbsp;Sooyeon Lee,&nbsp;Justin Sangwook Ko,&nbsp;Mi Sook Gwak,&nbsp;Gaab Soo Kim","doi":"10.1016/j.transproceed.2025.03.017","DOIUrl":"10.1016/j.transproceed.2025.03.017","url":null,"abstract":"<div><h3>Background</h3><div>In ABO-incompatible living donor liver transplantation (LDLT), many strategies including plasmapheresis have been introduced to overcome the ABO blood group barrier. After plasmapheresis, the MELD score can change because the levels of its three components [international normalized ratio (INR), total bilirubin (Tb), and creatinine (Cr)] may be affected.</div></div><div><h3>Method</h3><div>Present study included 142 recipients of ABO-incompatible LDLT. MELD score was calculated according to the original formula [11.2 ln (INR) + 3.78 ln (Tb) + 9.56 ln (Cr) + 6.43]. We compared the MELD score and the three components of the MELD score before and after plasmapheresis.</div></div><div><h3>Results</h3><div>In the entire cohort, MELD score decreased from 13 to 11 after plasmapheresis. MELD score increased in 41 (28.9%), maintained in 25 (17.6%), and decreased in 76 (53.5%) recipients. The change of INR, Tb, and Cr was mostly in the same direction as the change of MELD score.</div></div><div><h3>Conclusion</h3><div>MELD scores of ABO-incompatible LDLT recipients mostly change after plasmapheresis. Decline in MELD score was most common, followed by rise and maintenance.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 799-802"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Donor/Recipient Size-mismatched Lung Transplantation","authors":"Bong Suk Park ,&nbsp;Dae Joon Kim ,&nbsp;Chang Young Lee ,&nbsp;Byung Jo Park ,&nbsp;Ha Eun Kim ,&nbsp;Young Ho Yang ,&nbsp;Moo Suk Park ,&nbsp;Song Yee Kim ,&nbsp;A La Woo ,&nbsp;Eun Young Kim ,&nbsp;Jin Gu Lee","doi":"10.1016/j.transproceed.2025.04.008","DOIUrl":"10.1016/j.transproceed.2025.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Donor/recipient (D/R) size matching is crucial to achieve proper organ allocation and outcome for lung transplantation (LT). However, studies in this regard have not shown consistent results. We analyzed the results of size-mismatched LT focusing on primary graft dysfunction (PGD) and survival.</div></div><div><h3>Methods</h3><div>A total of 446 patients underwent LT between January 2010 and December 2022. After exclusion, the patients were divided into 3 groups according to the donor/recipient size; D/R ratio &gt;120% was grouped as Over (n = 87), 120%≥D/R ratio≥80% was grouped as Normal (n = 271), 80%&gt;D/R was grouped as Under (n = 19). Early and long-term outcomes were analyzed.</div></div><div><h3>Results</h3><div>Recipient height, weight, and proportion of male were the highest in the Under group, followed by the Normal and Over groups (<em>P</em> &lt; 0.001). The ratio of extracorporeal membrane oxygenation weaning in the operating room was highest in the Under group, followed by the Normal and Over groups (<em>P</em> : 0.04). The proportions of PGD grade 3 within 48 h and 72 h were highest in the Over group, followed by the Normal and Under groups (<em>P :</em> 0.007 and 0.016, respectively). There was no statistical difference in the pulmonary function test results between the groups at 12 months postoperative follow-up. The 5-year survival rate did not differ among the groups (60.9% vs 56.8% vs 54.7%, Under vs Normal vs Over, <em>P :</em> 0.833)</div></div><div><h3>Conclusions</h3><div>Although oversized D/R-matched LT demonstrated late recovery during the early postoperative period, their long-term results were non-inferior in terms of the D/R size ratio.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 868-875"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric Surgery as a Bridge for Renal Transplantation. An Age and BMI-Matched Pair Analysis","authors":"Mohamed H. Zahran ,&nbsp;Talal Khewater ,&nbsp;Mostafa Ayyad ,&nbsp;Ahmed Ali ,&nbsp;Mojahid Ghazi ,&nbsp;Ahmed Serageldeen ,&nbsp;Alaaelden Omar ,&nbsp;Zayed S. Aljohni ,&nbsp;Waad Albalawi ,&nbsp;Konstantinos Fourtounas ,&nbsp;Hussam Adi","doi":"10.1016/j.transproceed.2025.03.003","DOIUrl":"10.1016/j.transproceed.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Morbid obesity is a relative contraindication for renal transplantation (RT) and associated with increased perioperative complications and compromised graft survival. We aimed at evaluating the safety of bariatric surgery (BS) in patients with end-stage renal disease (ESRD) and its efficacy on improving access to RT and to compare RT outcomes to an age- and body mass index (BMI)-matched group.</div></div><div><h3>Methods</h3><div>This is a case-control study including eight patients with ESRD who underwent BS as a bridge before RT (group I). The primary outcome was to assess the safety and efficacy of BS. The secondary outcome was to assess the impact on RT outcomes, surgical complications, and long-term graft survival. The third outcome was to compare them to an age- and BMI-matched control group (group II, 16 patients).</div></div><div><h3>Results</h3><div>In group I, the median (IQR) BMI decreased from 41 (38-45) to 31 (28-33) kg/m² (<em>P</em> = .01) with absolute percent reduction of 24% after BS. Five out of seven patients with diabetes (71%) stopped taking insulin medication (<em>P</em> = .03). All patients with hypertension decreased their medications to a single drug (<em>P</em> = 0.03). Five patients (63%) underwent RT after 25 (5-45) months. All were discharged with functioning grafts with median serum creatinine of 81 (60-90) mmol/L and estimated glomerular filtration rate (eGFR) of 79 (61-91) mL/min/1.73m². One patient (20%) was reoperated for wound infection. After follow-up of 31 (8-62) months, all patients have a functioning graft. No statistically significant differences were identified between both groups in regard to post-operative complications and graft function at discharge and at the last follow-up (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>BS is safe and effective in pre-transplant patients with obesity and associated with comparable RT outcomes to those without a history of BS.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 746-751"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Histologic Risk Factors for the Development of Early Allograft Dysfunction in Donation After Circulatory Death Kidney Transplantation","authors":"Jennifer Loza ,&nbsp;Karima Alghannam ,&nbsp;Brian Howard ,&nbsp;Fransia De Leon ,&nbsp;Jeffrey Fine ,&nbsp;Aileen X. Wang ,&nbsp;Kuang-Yu Jen ,&nbsp;Naeem Goussous ,&nbsp;Junichiro Sageshima ,&nbsp;Richard V. Perez ,&nbsp;Peter A. Than","doi":"10.1016/j.transproceed.2025.03.022","DOIUrl":"10.1016/j.transproceed.2025.03.022","url":null,"abstract":"<div><div>Transplantation of kidneys from donors after circulatory death (DCD) may help address the severe shortage of donor organs. However, they remain underutilized due to concerns for increased rates of delayed graft function (DGF) and primary nonfunction (PNF), despite similar long-term patient and allograft outcomes compared to kidneys from donors after brain death (DBD). Kidneys that recover from DGF have good long-term outcomes compared to those resulting in PNF. Considering immediate graft function (IGF), DGF, and PNF as a spectrum of renal allograft injury and recovery, we analyzed donor and recipient characteristics and corresponding time-zero biopsy findings for adult DCD kidney transplants at our center from 2016 to 2021. We compared transplants resulting in DGF with subsequent allograft recovery compared to those progressing to PNF as well as to grafts that functioned immediately. We found 344 patients received DCD kidneys with 153 resulting in DGF with renal recovery by 90-days post-transplant. Excluding surgical complications, 22 patients developed PNF and required ongoing maintenance dialysis after 90-days post-transplant and 169 patients had immediate graft function. Kidney Donor Profile Index ≥85% and donor history of diabetes and hypertension were associated with PNF. Cold and warm ischemia time, donor acute kidney injury, and use of hypothermic machine perfusion were not significantly different between the groups. Formalin-fixed paraffin embedded renal allograft time-zero biopsies demonstrated that increasing severity of donor-derived vascular disease present at the time of transplant were associated with the development of early allograft failure. These findings help define clinical characteristics important in kidney allograft selection.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 764-770"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination and Comparison of the Attitudes of Nursing and Theology Students Toward Organ Donation: Descriptive and Cross-Sectional Study","authors":"Ahmet Göktaş,&nbsp;Şerafettin Okutan,&nbsp;Cihan Önen","doi":"10.1016/j.transproceed.2025.03.011","DOIUrl":"10.1016/j.transproceed.2025.03.011","url":null,"abstract":"<div><div>This study was conducted to determine and compare the attitudes of nursing and Theology students toward organ donation. This descriptive and cross-sectional study was conducted with 350 nursing and Theology students in Türkiye. An Information Form and the Organ Donation Attitudes Scale were used for data collection. Data were analyzed using the SPSS 26.0 software. The mean age of the students participating in the study was 22.59 ± 4.48 years, and 66% were female. 55.7% of the students were Theology students, and 44.3% were nursing students. The mean score for humanity and moral conviction was 92.43 ± 20.72, the mean score for fears of medical neglect was 28.89 ± 9.98, and the mean score for fears of bodily mutilation was 32.13 ± 10.21. It was found that nursing students' positive attitudes (humanity and moral conviction) toward organ donation were significantly higher, and negative attitudes (fears of medical neglect and fears of bodily mutilation) were significantly lower than Theology students (<em>P</em> &lt; .05). The students' attitudes toward humanity and moral conviction regarding organ donation are positive, while their attitudes toward fears of medical neglect and bodily mutilation are negative. Nursing students' attitudes toward both humanity and moral conviction, and fears of medical neglect and bodily mutilation are more positive than the attitudes of Theology students. It is recommended that informative training on organ donation and transplantation processes should be organized in cooperation with nurses and religious leaders.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 689-697"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis and Clinical Guidance of Oxygenated Hypothermic Machine Perfusion for Kidney Transplantation","authors":"Degong Jia ,&nbsp;Shanshan Guo ,&nbsp;Jiefu Luo ,&nbsp;Yuezhou Zhang ,&nbsp;Huiqing Zhang ,&nbsp;Shengwei ,&nbsp;Junyan Liu","doi":"10.1016/j.transproceed.2025.03.006","DOIUrl":"10.1016/j.transproceed.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>It remains unclear whether oxygenated hypothermic machine perfusion (HMPO₂) during kidney preservation is beneficial for prognosis.</div></div><div><h3>Methods</h3><div>A comprehensive search of databases and clinical trial registries was conducted to identify eligible studies on HMPO₂ application during kidney transplantation. A multisubgroup analysis was further conducted to explore the heterogeneity among studies.</div></div><div><h3>Results</h3><div>Compared to the control treatment, HMPO₂ did not significantly alter the incidence of postoperative acute rejection, graft survival, patient mortality, delayed graft function (DGF), functional DGF, primary nonfunction, or estimated glomerular filtration rate, whereas the warm ischemia time appeared to be longer. However, the number of patients with adverse events and the proportion of severe adverse events were reduced in the HMPO₂ group. Subgroup analysis indicated that HMPO₂ performed better in donation after cardiac death (DCD), and continuous HMPO₂ was superior to end-HMPO₂.</div></div><div><h3>Conclusion</h3><div>HMPO₂ application during kidney transplantation reduced the number of patients with adverse events and the proportion of severe adverse events. However, given the issue such as limited number of studies and heterogeneity, rigorous evidence studies are needed to further confirm these findings.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 752-763"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}