Transplantation proceedings最新文献

{"title":"Safety and Efficacy of Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation for Salvage Therapy of Myelofibrosis","authors":"Xiaojin Wang ,&nbsp;Andie Fu ,&nbsp;Bin Xu ,&nbsp;Na Wang ,&nbsp;Yang Yang ,&nbsp;Zhenya Hong ,&nbsp;Lifang Huang ,&nbsp;Jinhuan Xu ,&nbsp;Yang Cao ,&nbsp;Fankai Meng ,&nbsp;Donghua Zhang ,&nbsp;Yicheng Zhang","doi":"10.1016/j.transproceed.2026.03.019","DOIUrl":"10.1016/j.transproceed.2026.03.019","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of reduced-intensity conditioning (RIC) allogeneic hematopoietic stem cell transplantation (allo-HSCT) for a salvage therapy of patients with myelofibrosis (MF).</div></div><div><h3>Methods</h3><div>We conducted a retrospective study of 17 MF patients with poor performance status, refractory disease, or progressive disease who underwent RIC-allo-HSCT. Overall survival (OS), progression-free survival (PFS), hematopoietic reconstitution, the cumulative incidence of relapse and improvements in myelofibrosis and splenomegaly were analyzed.</div></div><div><h3>Results</h3><div>All 17 patients received RIC regimens. The neutrophil and platelet engraftment rates were 94.1% and 88.2%, respectively, with median engraftment times of 16 days (range, 11-22 days) and 22 days (range, 10-148 days). The cumulative incidence of grade II-IV acute graft-versus-host disease (aGVHD) within 100 days post-transplant was 41.2%, and that of grade III-IV aGVHD was 17.6%. The overall incidence of chronic GVHD (cGVHD) was 35.3%. The reactivation rates of Epstein-Barr virus (EBV) and cytomegalovirus (CMV) were 47.1% and 29.4%, respectively. Before transplantation, there were 10 patients (58.8%) with MF-3 and splenomegaly. At six months after transplantation, the proportion of MF-3 decreased to 26.7%, MF-0 increased to 40.0%, and the proportion of splenomegaly decreased to 53.3%. As of the follow-up date, the proportion of MF-3 had decreased to 21.4%, MF-0 had increased to 57.1%, and all eight remaining patients with splenomegaly had shown varying degrees of spleen size reduction. The estimated 1-year OS and PFS were 88.2% (95% CI, 60.6%-96.9%) and 81.9% (95% CI, 53.8%-93.8%), and the estimated 3-year OS and PFS were 70.6% (95% CI, 26.0%-91.4%) and 65.5% (95% CI, 25.7%-87.7%), respectively.</div></div><div><h3>Conclusion</h3><div>RIC-allo-HSCT is a feasible and effective alternative for salvage therapy in MF patients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 800-807"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Transplantation Outcome in Patients With Augmented Bladder: A Single-Center Experience","authors":"Rahmi Gokhan Ekin ,&nbsp;Askin Eroglu ,&nbsp;Ebru Sevinc Ok ,&nbsp;Huseyin Toz ,&nbsp;Isik Ozgu","doi":"10.1016/j.transproceed.2026.03.025","DOIUrl":"10.1016/j.transproceed.2026.03.025","url":null,"abstract":"<div><h3>Objective</h3><div>Kidney transplantation (KT) in patients with bladder augmentation (BA) remains controversial due to concerns about infection, surgical complications, and long-term graft survival rate. We retrospectively evaluated patients who underwent KT after BA.</div></div><div><h3>Materials and Methods</h3><div>Between January 2010 and August 2025, data from 15 patients with KT and BA were analyzed. Demographic characteristics, underlying urological diagnoses, type of augmentation, surgical details of transplantation, and post-transplant follow-up were evaluated.</div></div><div><h3>Results</h3><div>Fifteen patients underwent kidney transplantation after bladder augmentation. Median interval from augmentation to kidney transplantation was 176 months. Mean age at KT was 25.07 ± 6.8 years. Living kidney donation rate was 93.3%. The mean follow-up after KT was 98.9±57.4 months. Febrile UTI occurred in 8/15 (53.3%) patients (15 episodes), yet no graft loss was directly infection-mediated. Acute rejection occurred in 3/15 (20.0%). Graft survival rate was 100%, 90.9%, and 72.7% at 1, 5, and 10 years, respectively. Median serum creatinine at last follow-up was 1.58 mg/dL.</div></div><div><h3>Conclusion</h3><div>Kidney transplantation in patients with augmented bladders can achieve satisfactory long-term graft survival.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 690-694"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Anastomosis Techniques in Multiple Arterial Kidney Transplantation: Single or Pants Anastomosis Technique","authors":"Aziz Bulut ,&nbsp;Latif Yilmaz ,&nbsp;Alper Aytekin ,&nbsp;Nurullah Bilen ,&nbsp;Ilyas Baskonus ,&nbsp;Fahrettin Yildiz ,&nbsp;Ozlem Usalan ,&nbsp;Sacid Coban","doi":"10.1016/j.transproceed.2026.03.012","DOIUrl":"10.1016/j.transproceed.2026.03.012","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to compare the outcomes of two arterial anastomosis techniques in kidney transplants with multiple renal arteries: the “pants” technique, which consolidates arteries into a single anastomosis, and the separate anastomosis technique, which connects each artery individually. We evaluated resistive index (RI) and flow rates of renal and interlobar arteries in recipients of both techniques.</div></div><div><h3>Methods</h3><div>At Gaziantep University Organ Transplant Center, we compared outcomes in kidney transplant recipients with multiple arteries who underwent either the pants (26 patients) or separate anastomosis (29 patients) techniques from 2010 to 2021. Data on resistive index and flow rates were obtained from postoperative Doppler examinations and medical records.</div></div><div><h3>Results</h3><div>Among 55 grafts (52 with 2 arteries and 3 with 3 arteries), postoperative Doppler exams showed no significant differences in resistive index between the two techniques. For the pants technique group, the renal artery RI averaged 0.71 on the first and third days and 0.70 on the second day, while the interlobar artery RI was 0.70, 0.68, and 0.72 on days 1, 2, and 3, respectively. In the separate anastomosis group, renal artery RI averaged 0.70 across all days, and interlobar artery RIs were 0.66, 0.65, and 0.68, respectively. No significant differences were found between the groups (<em>P</em> &gt; .05).</div></div><div><h3>Conclusion</h3><div>Both anastomosis techniques yielded comparable outcomes in terms of RI and flow rates. However, the separate anastomosis technique had shorter anastomosis and cold ischemia times, suggesting it may offer logistical advantages without compromising graft function.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 655-659"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmasking a Silent Risk: Impact of Baseline Hypotension on Kidney Allograft Outcomes in Comparison With Normotensive Recipients","authors":"Moatasem Ghoneim ,&nbsp;Ahmed Mohamed Naguib Attiya ,&nbsp;Lionel Rostaing ,&nbsp;Ahmed Yahia Elmowafy","doi":"10.1016/j.transproceed.2026.04.010","DOIUrl":"10.1016/j.transproceed.2026.04.010","url":null,"abstract":"<div><h3>Objectives</h3><div>Chronic hypotension is uncommon among kidney transplant recipients, and may adversely affect graft outcomes.</div></div><div><h3>Patients and Methods</h3><div>Single-center retrospective cohort study including adult recipients who underwent living-donor kidney transplantation, between 2009 and 2024. Of the 1678 recipients screened, 187 met the inclusion criteria. Hypotension was defined as persistent systolic blood pressure (SBP) &lt;100 mm Hg or mean arterial pressure (MAP) &lt;70 mm Hg throughout follow-up; normotensive had SBP ranging from 100 to 130 mm Hg. Early outcomes included primary non-function (PNF), delayed-graft function (DGF), acute rejection, and thrombotic events, whereas late outcomes included graft survival, renal function, proteinuria, and chronic rejection.</div></div><div><h3>Results</h3><div>A total of 187 recipients were included (57 hypotensive and 130 normotensive). Hypotensive recipients experienced significantly higher rates of early adverse outcomes, including DGF, PNF, graft vein thrombosis, and acute cellular rejection. Late outcomes were also inferior, with higher rates of chronic rejection and graft failure, as well as poorer graft function and increased proteinuria. Kaplan–Meier analysis demonstrated significantly reduced graft survival among hypotensive recipients (<em>P</em> = .001). On multivariable analysis, persistent hypotension independently predicted both rejection and graft failure.</div></div><div><h3>Conclusion</h3><div>Baseline hypotension is an underrecognized risk factor in kidney transplantation, associated with an increased risk of early and late graft complications.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 645-654"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Haploidentical Transplantation Combined With Umbilical Cord Blood and Mesenchymal Stem Cells Co-Infusion for Aplastic Anemia: A Single-Center Retrospective Study","authors":"Zhengwei Tan ,&nbsp;Yuechao Zhao ,&nbsp;Huijin Hu ,&nbsp;Qinghong Yu ,&nbsp;Yu Zhang ,&nbsp;Bo Wang ,&nbsp;Tonglin Hu ,&nbsp;Dijiong Wu ,&nbsp;Baodong Ye ,&nbsp;Wenbin Liu","doi":"10.1016/j.transproceed.2026.03.017","DOIUrl":"10.1016/j.transproceed.2026.03.017","url":null,"abstract":"<div><div>Haploidentical hematopoietic stem cell transplantation (HID-HSCT) is a critical therapeutic option for severe aplastic anemia (SAA) patients lacking HLA-matched donors. However, its application has been limited by graft failure and graft-versus-host disease (GVHD). The co-infusion of mesenchymal stem cells (MSCs) or umbilical cord blood cells (UCBs) has emerged as a crucial area to enhance transplant outcomes. This single-center retrospective study evaluates the clinical outcomes of HID-HSCT combined with UCBs and MSCs co-infusion in 108 patients. Patients underwent HID-HSCT between January 2018 and January 2025, with 40 receiving co-infusion of UCBs and MSCs. Transplantation outcomes, including neutrophil and platelet engraftment, GVHD incidence, viral reactivation rates, and long-term survival, were compared. Results showed no significant differences in engraftment or GVHD rates between groups. However, the Co-infusion group exhibited a declining trend in grade II-IV aGVHD and significantly improved 5-year overall survival (OS) and graft-versus-host disease-free, relapse-free survival (GRFS). These findings suggest that UCBs and MSCs co-infusion may enhance long-term survival and quality of life in patients undergoing HID-HSCT, offering a promising strategy for clinical haploidentical transplantation. However, the lack of prospective design and standardized protocols limits the conclusions. Future studies should focus on optimizing co-infusion strategies to improve clinical outcomes in haploidentical transplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 808-815"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Attitudes of Health Professionals Towards Organ Donation in Adult Critical Care Units in Paraguay","authors":"Iris Colman ,&nbsp;Marcelo Pederzani ,&nbsp;Federico Fretes ,&nbsp;Silenne Avila ,&nbsp;Belinda Figueredo","doi":"10.1016/j.transproceed.2026.04.003","DOIUrl":"10.1016/j.transproceed.2026.04.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Intensive care unit (ICU) professionals play a pivotal role in the identification and maintenance of potential organ donors, as well as in the accurate certification of brain death.</div></div><div><h3>Objective</h3><div>To describe the knowledge and attitudes toward organ donation among adult ICU professionals in 4 hospitals in Paraguay.</div></div><div><h3>Methods</h3><div>An observational, descriptive, cross-sectional study was conducted using a 25-item electronic questionnaire administered to physicians and nurses working in the adult ICUs of Hospital de Clínicas, Hospital de Trauma Manuel Giagni, Hospital General de San Lorenzo, and the National Institute of Cardiology between October and November 2022. Of the total responses, 288 complete questionnaires (70%) were included in the analysis.</div></div><div><h3>Results</h3><div>The mean age of participants was 36.8 ± 6.7 years, and 64.2% were women. Nurses accounted for 75% of respondents, while 24% were physicians. Brain death was correctly defined by 68% of participants, and 43.4% recognized that its diagnosis is primarily clinical. Although 90.3% reported being aware of the national organ donation law, 53% believed that the decision to donate rests with the family, whereas 45% identified verification of the national refusal registry as the determining factor. Overall, 84% expressed personal willingness to donate organs, and 98% reported interest in receiving further training.</div></div><div><h3>Conclusions</h3><div>ICU professionals demonstrated a broadly favorable attitude toward organ donation. However, relevant gaps persist in the understanding of the clinical diagnosis of brain death and the current legal framework. Targeted continuing education initiatives for ICU staff may enhance donor identification and strengthen organ procurement processes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 621-624"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rifaximin Versus Levofloxacin: A Comparative Analysis of Prophylactic Efficacy in Allogeneic Stem Cell Transplantation","authors":"Yakub Patat ,&nbsp;Gülşah Akyol ,&nbsp;Muzaffer Keklik ,&nbsp;Ali Ünal ,&nbsp;Leylagül Kaynar","doi":"10.1016/j.transproceed.2026.03.015","DOIUrl":"10.1016/j.transproceed.2026.03.015","url":null,"abstract":"<div><div>This study aims to compare the effects of rifaximin and levofloxacin prophylaxis in allogeneic hematopoietic stem cell transplantation (HSCT) on the development of graft-versus-host disease (GVHD), length of hospital stay, engraftment duration, initiation of broad-spectrum antibiotics, incidence of febrile neutropenia, relapse rates, readmission periods, and transplant-related mortality. A total of 116 patients aged over 18 who underwent allogeneic HSCT between 2018 and 2022 were included. Exclusion criteria included the use of broad-spectrum antibiotics on the day of transplantation. Of these, 58 patients received rifaximin, and 58 received levofloxacin as prophylaxis. Levofloxacin was associated with a significantly lower incidence of febrile neutropenia in patients with acute myeloid leukemia (AML) compared to rifaximin (<em>P</em> = .017). Among other patient groups, levofloxacin prophylaxis also resulted in a lower fever incidence (<em>P</em> = .031). Levofloxacin demonstrated greater efficacy than rifaximin in reducing the incidence of transition to broad-spectrum antibiotic therapy (<em>P</em> = .008). Among the 116 patients, 54 were readmitted within the first 100 days post-transplantation. Among these, the predominant reason for readmission was infection, followed by graft-versus-host disease (GVHD). The use of levofloxacin prophylaxis was linked to a remarkably lower rate of readmissions (<em>P</em> = .004). In patients with acute lymphoblastic leukemia (ALL), levofloxacin also showed a significant advantage in terms of readmission rates. Moreover, individuals who received levofloxacin for prophylaxis experienced reduced mortality rates (<em>P</em> = .011).</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 816-821"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrative Review of Preparative Regimens Predictive of Mixed Chimerism After HLA-Mismatched Hematopoietic Stem Cell Transplantation: A Starting Point for Combined Solid Organ and Stem Cell Transplantation","authors":"Roberto Crocchiolo ,&nbsp;Ilaria Gandolfini ,&nbsp;Paolo Cravedi ,&nbsp;Giulia Di Maggio ,&nbsp;Elena Borotti ,&nbsp;Giovanni Rombolà ,&nbsp;Lucia Prezioso ,&nbsp;Paola Zanelli ,&nbsp;Umberto Maggiore","doi":"10.1016/j.transproceed.2026.02.002","DOIUrl":"10.1016/j.transproceed.2026.02.002","url":null,"abstract":"<div><div>Transient or permanent mixed hematopoietic chimerism (MC) is associated with immunologic tolerance in combined solid organ and hematopoietic stem cell transplantation. This tolerance allows for the reduction or sometimes even suspension of systemic immunosuppression without graft rejection, with clear benefits regarding the side effects associated with lifelong immunosuppression. However, studies to date have included only living, HLA-matched donors to reduce the risk of graft-versus-host disease (GvHD), whereas the degree of HLA incompatibility between deceased donors and recipients is typically higher. Here we present a narrative review aimed at identifying the conditioning regimens predictive of MC in hematologic patients who have received an HLA-mismatched transplant, to provide some information on immunotolerance for future combined solid organ and stem cell transplantation in an HLA-mismatched setting. Among a total of 90 identified studies, 20 contained some information on MC, with a reported percentage of 2% to 100% of patients; 1186 patients were described in these 20 articles, with a median of 40 (range, 12 to 265) per study. When examining the conditioning regimens associated with MC ≥20% and GvHD &lt;25% (n = 5), it was observed that 4 out of 5 studies contained antithymocyte globulin. The data suggest the importance of T lymphocyte depletion for achieving MC, associated with a low incidence of acute GvHD in hematopoietic stem cell transplantation from HLA-mismatched donors. Although additional work is needed, particularly on the ideal stem cell dose (ie, CD34⁺ and CD3⁺ cells), this information could be translated into the field of solid organ transplantation (SOT) to design a potential combined solid organ–stem cell transplantation protocol aimed at achieving MC for immune tolerance. The present work supports a translational perspective in the setting of SOT, where long-term immune tolerance is a major goal.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 822-826"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147438796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Reliability and Quality of Kidney Transplantation Information on Short-Video Sharing Platforms: A Cross-sectional Analysis","authors":"Yuanyuan Wang,&nbsp;Xiaoqin Chen,&nbsp;Qiling Tan","doi":"10.1016/j.transproceed.2026.03.008","DOIUrl":"10.1016/j.transproceed.2026.03.008","url":null,"abstract":"<div><h3>Background</h3><div>The rise of digital media has increased public use of social platforms for health information. While short-form videos hold potential for disseminating knowledge on kidney transplantation, their variable quality is a major concern. This study aimed to analyze the content and quality of kidney transplantation-related videos on major short video sharing platforms.</div></div><div><h3>Methods</h3><div>Between April 28, 2025 and May 02, 2025, using Chinese search terms for “kidney transplantation,” we collected 263 relevant videos from WeChat, TikTok, and Bilibili. Two independent researchers evaluated video content and quality using the Journal of the American Medical Association (JAMA) benchmark criteria, Global Quality Scale (GQS), modified DISCERN (mDISCERN), and Patient Education Materials Assessment Tool (PEMAT).</div></div><div><h3>Results</h3><div>Healthcare professionals were the primary uploaders (112/263, 42.6%), and disease knowledge constituted the predominant content focus (161/263, 61.2%). Videos sourced from WeChat exhibited higher overall quality than those from TikTok or Bilibili. Videos uploaded by patients garnered significantly more likes and comments (all <em>P</em> &lt; .001). Content featuring personal patient experiences also attracted significantly more likes and comments (all <em>P</em> &lt; .001), whereas disease knowledge content was shared more frequently (<em>P</em> &lt; .001). Patient vlog received significantly more likes and comments, while dialogue formats were shared more often (<em>P</em> &lt; .001). Positive correlations were observed between engagement variables (likes, comments, favorites, shares) and followers (all <em>P</em> &lt; .001), while a negative correlation existed with video duration (all <em>P</em> &lt; .005). Shares and followers positively correlated with video quality (<em>P</em> &lt; .001 and <em>P</em> &lt; .01, respectively).</div></div><div><h3>Conclusion</h3><div>Although numerous kidney transplantation-related videos are available on short video platforms, their quality and reliability vary considerably and require significant improvement.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 660-670"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of Dietary Intervention on Kidney Transplant Recipients With Proteinuria/Chronic Metabolic Acidosis – A Single Cohort Prospective Study","authors":"Wai Pooi Lau ,&nbsp;Kok Peng Ng ,&nbsp;Shubash Shander Ganapathy ,&nbsp;Pei Chien Tah ,&nbsp;Rokiah Ismail ,&nbsp;Soo Kun Lim","doi":"10.1016/j.transproceed.2026.03.020","DOIUrl":"10.1016/j.transproceed.2026.03.020","url":null,"abstract":"<div><h3>Background</h3><div>Proteinuria and chronic metabolic acidosis may negatively impact renal allograft survival. This study aims to evaluate dietary intervention in reducing proteinuria and correcting metabolic acidosis among kidney transplant recipients (KTRs).</div></div><div><h3>Methods</h3><div>This is a prospective dietary intervention study. KTRs who have proteinuria ≥ 0.5g/d or chronic metabolic acidosis with serum bicarbonate ≤ 22 mmol/L for at least two readings in the past 6 months were recruited. All recruited subjects were given one-to-one diet counseling for moderate dietary protein restriction at 0.8 g/kg of ideal body weight (IBW) and high vegetable and fruit intake by a research dietitian. All subjects were encouraged to replace animal protein with plant protein. The duration of the study was 3 months. Changes in proteinuria and serum bicarbonate levels pre- and postintervention were analyzed.</div></div><div><h3>Results</h3><div>A total of 30 KTRs (26 with proteinuria and four with chronic metabolic acidosis) were enrolled and completed the intervention phase. Proteinuria reduced significantly after 1 month of the intervention (<em>z</em> = –2.643, <em>P</em> = .008) in alignment with a significant reduction in dietary protein (<em>z</em> = –2.376, <em>P</em> = .018) and dietary acid load (<em>z</em> = –2.149, <em>P</em> = .032). However, this effect was not sustainable when the dietary protein intake was increased at 3 months. Significant weight reduction was observed after 1 month (<em>z</em> = –3.379, <em>P</em> = .001) and 3 months (z = –3.503, <em>P</em> &lt; .001) after dietary intervention. No statistically significant change in serum bicarbonate was found.</div></div><div><h3>Conclusions</h3><div>Dietary intervention can induce favorable dietary changes, leading to reductions in proteinuria and body weight in KTRs. Hence, dietary counseling should be part of the multiprong approach to managing KTRs.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 671-678"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147701450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}