Transplantation proceedings最新文献

{"title":"Flow Control and Oxygenation of Preservation Solution in Circulatory Determined Death Donors Undergoing Abdominal Normothermic Regional Perfusion","authors":"Marta Velia Antonini ,&nbsp;Alessandro Circelli ,&nbsp;Gaetano La Manna ,&nbsp;Antonio Siniscalchi ,&nbsp;Erika Cordella ,&nbsp;Davide Morri ,&nbsp;Francesco Landi ,&nbsp;Elia Graziani ,&nbsp;Enrico Prosperi ,&nbsp;Guido Fallani ,&nbsp;Chiara Bonatti ,&nbsp;Alberto Stocco ,&nbsp;Giorgia Radi ,&nbsp;Maria Cristina Morelli ,&nbsp;Giuliana Germinario ,&nbsp;Matteo Cescon ,&nbsp;Matteo Ravaioli","doi":"10.1016/j.transproceed.2026.04.004","DOIUrl":"10.1016/j.transproceed.2026.04.004","url":null,"abstract":"<div><div>Normothermic regional perfusion (NRP) is increasingly implemented to optimize the outcome of transplantation from donors undergoing circulatory determination of death. NRP shortens the duration of warm ischemia, allowing splanchnic reperfusion with oxygenated blood. This supports the abdominal organs throughout recovery, allowing for their thorough assessment, avoids the need for rapid recovery, and restores a near physiological environment. However, after NRP, the grafts are exposed to a period of cold ischemia preceding further evaluation and reconditioning through ex situ machine perfusion or direct transplantation. The duration of cold ischemic time may be extremely variable. During cold ischemic time, the liver and the kidneys are indirectly protected by a decrease in metabolic demands induced by deep hypothermia. To optimize protection, the hypothermic state is initiated in situ, immediately after extracorporeal blood flow interruption, via topical cooling with sterile ice and intravascular cooling. The latter is usually induced by the administration of cold preservation solution (CPS) by gravity. We performed an observational study to assess the feasibility, safety, and effectiveness of a controlled strategy of CPS administration and oxygenation employing the NRP circuit and cannulae in controlled circulatory determination of death undergoing abdominal NRP. This approach provided a controlled, fast, and consistent flow, ensuring a prompt induction of hypothermia. Moreover, during CPS administration, the delivery of a fresh gas flow through the membrane lung resulted effective in significantly increasing the oxygen tension in the CPS. The hyperoxygenation of the blood-free perfusate might provide a metabolic substrate to the cells, preconditioning the grafts before cold ischemia.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 632-635"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to <Nutritional Progression of a Child With Hypoplastic Left Heart Syndrome During the Waiting Period for Heart Transplantation: A Case Report><[Transplant Proceedings volume 57 (2025) 1305-1308]>","authors":"Pamela Galesso Lanza ,&nbsp;Estela Azeka","doi":"10.1016/j.transproceed.2026.03.001","DOIUrl":"10.1016/j.transproceed.2026.03.001","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Page 841"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Consequences of Supra-Normal Estimated Glomerular Filtration Rate in Pediatric Solid Organ Transplants: A Single Center Cohort","authors":"Melvin Chan ,&nbsp;Scott R. Auerbach ,&nbsp;Amy G. Feldman ,&nbsp;Margret E. Bock","doi":"10.1016/j.transproceed.2026.03.023","DOIUrl":"10.1016/j.transproceed.2026.03.023","url":null,"abstract":"<div><h3>Purpose</h3><div>In adult recipients of kidney transplants, renal hyperfiltration has been found to be associated with an earlier risk of graft loss. Unfortunately, data is sparse for pediatric recipients of solid organ transplants.</div></div><div><h3>Methods</h3><div>We reviewed all actively followed pediatric liver, heart, and kidney recipients at our center. We determined the estimated glomerular filtration rate (eGFR) during the first 5 years posttransplant and at the last follow-up based on the CKiD-U25 formula using creatinine. Given the lack of renal scintigraphy data, we used a supra-normal eGFR (SNeGFR) as a surrogate for hyperfiltration. SNeGFR was defined as two standard deviations above the mean eGFR for age, CKD as an eGFR of less than 90 mL/min/1.73m², and normal function between CKD and SNeGFR. A contingency table was used to determine the OR of outcomes for those with SNeGFR and normal function and normal function and CKD.</div></div><div><h3>Results</h3><div>A total of 443 actively followed patients were eligible. Forty-four (16%) of the recipients of heart and liver transplants met criteria for SNeGFR. Only one recipient of a kidney transplant met the criteria. In recipients of liver and heart transplants, SNeGFR was correlated with higher risks of developing hypertension than those with normal function (OR 2.22, CI 1.08-4.54). Recipients of liver and heart transplants with CKD not only had a similar risk (OR 2.22, CI 1.22-4.18) but also had a higher risk of having any rejections (OR 1.8, CI 1.06-3.09) than those with normal function.</div></div><div><h3>Conclusions</h3><div>SNeGFR is prevalent in recipients of liver and heart transplants. More studies need to evaluate its association with outcomes.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 695-701"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Statins With Cardiovascular Outcomes Following Kidney Transplantation","authors":"Andres Mata ,&nbsp;Gavin Christy ,&nbsp;Connor Krumm ,&nbsp;Ananta Sriram ,&nbsp;Venkata Peddada ,&nbsp;Eric Stein ,&nbsp;Meghana Gudapati ,&nbsp;Mina M. Benjamin","doi":"10.1016/j.transproceed.2026.03.024","DOIUrl":"10.1016/j.transproceed.2026.03.024","url":null,"abstract":"<div><h3>Background</h3><div>Kidney transplant recipients (KTRs) face high cardiovascular risk, but the benefit of statin therapy for preventing major adverse cardiovascular events (MACE) in this population remains unclear.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, single-center cohort study of adult KTRs between 2015 and 2024. Patients were categorized by statin use at the time of kidney transplantation (statin use [STN] vs no statin use [NoSTN]). We also conducted a separate analysis of patients with no known cardiovascular disease. The primary outcome was a composite of all-cause mortality and MACE. Cox proportional-hazards models were performed, adjusting for confounders identified from logistic regression.</div></div><div><h3>Results</h3><div>A total of 518 patients (202 STN vs 316 NoSTN) were included (mean age 54.3 vs 53.1 years. The STN group had significantly more patients with a history of smoking (73.5% vs 62.1%), whereas in the NoSTN group, diabetes mellitus was more prevalent (40.2% vs 30.7%). Statin use was not associated with a significant difference in MACE (13.8% vs 15.5%, <em>P</em> = .62), all-cause mortality (10% in both), or the composite outcome. Similar findings were observed in the primary prevention subgroup.</div></div><div><h3>Conclusions</h3><div>Statin therapy at the time of kidney transplantation was not associated with a significant reduction in MACE or all-cause mortality in patients with and without known atherosclerotic cardiovascular disease. These results support a review of routine statin use in KTRs and highlight the need for further analysis.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 702-707"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Incisional Hernia Repair After Solid Organ Transplantation","authors":"P. Mihaylov,&nbsp;C. Kubal,&nbsp;J. Fridell,&nbsp;J. Powelson","doi":"10.1016/j.transproceed.2026.03.009","DOIUrl":"10.1016/j.transproceed.2026.03.009","url":null,"abstract":"<div><h3>Objective</h3><div>To describe and evaluate the feasibility of robotic DaVinci incisional hernia repair in the transplant patient population and compare this approach with 2 established surgical hernia repair methods: open and laparoscopic.</div></div><div><h3>Methods</h3><div>We compared 3 surgical techniques for incisional hernia repair. The 66 included patients were divided equally into 3 groups of 22 patients each: robotic DaVinci, fully laparoscopic, and open surgical repair. All patients had undergone a previous abdominal solid organ transplant. All hernia repairs were performed with mesh. Different surgical and patient variables were evaluated among the 3 groups.</div></div><div><h3>Results</h3><div>The major finding was the shortest hospital length of stay in the robotic hernia repair group compared to the other procedural groups. However, operative time and pain score at hospital discharge were higher in the robotic group. There were no significant differences among the groups for all other variables.</div></div><div><h3>Conclusion</h3><div>Robotic incisional hernia repair with the DaVinci device is feasible and provides excellent short-term results. Assessment of the hernia defect prior to assigning patients for robotic hernia repair is crucial. Postoperative follow-up for transplant organ dysfunction is mandatory.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 827-832"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Self-Care Behavior in Patients After Heart Transplantation","authors":"Chutima Charoenthanakit ,&nbsp;Wilaiphon Nitusganjananon","doi":"10.1016/j.transproceed.2026.03.014","DOIUrl":"10.1016/j.transproceed.2026.03.014","url":null,"abstract":"<div><h3>Background</h3><div>We aimed to study the quality of life and self-care behavior of patients undergoing heart transplantation.</div></div><div><h3>Methods</h3><div>We conducted a retrospective, descriptive study among recipients of heart transplants at Ramathibodi Hospital between 2017 and 2024. The study included 20 surviving patients, consisting of 17 adult patients and 3 pediatric patients aged 14 to 17 years, and elderly patients were defined as those aged 60 years and older. Patients who were unwilling to participate were excluded. The study utilized a 5-section questionnaire as a data collection instrument: <u>Section1</u> Personal Data; <u>Section2</u> Self-Care Behavior Questionnaire; <u>Section3</u> Thai SF-36 QoL Questionnaire; <u>Section4</u> Thai EQ-5D-5L QoL Questionnaire; and <u>Section5</u> Satisfaction Score Assessment.</div></div><div><h3>Results</h3><div>Most patients were male (71%) and had at least a high school education. Physical self-care behaviors were generally good to very good, with high adherence to medication, infection prevention, and dietary guidelines. Exercise levels were moderate, and emotional well-being was favorable, with low levels of sadness or anxiety. The Thai SF-36 results showed mean scores of 75.03 for the physical component and 80.31 for the mental component. The EQ-5D-5L assessment indicated that most patients reported no problems with self-care (94%), anxiety/depression (90%), pain/discomfort (87%), usual activities (87%), and mobility (81%). The mean health state score from the VAS was 73.71. Satisfaction with QoL significantly improved after transplantation (<em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>Recipients of heart transplants demonstrated improved QoL across physical and mental dimensions and maintained strong self-care behaviors. Continued support from health care teams is essential to sustain long-term outcomes and address remaining limitations in mobility and daily activities.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 774-778"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rabbit Antithymocyte Globulin vs Basiliximab Induction in ABO-Incompatible Kidney Transplantation: A Single-Center Retrospective Cohort Study","authors":"Eunju Jang ,&nbsp;Ki Yoon Moon ,&nbsp;Hyung-Jin Cho ,&nbsp;Sang Seob Yun ,&nbsp;Sun Cheol Park ,&nbsp;Mi-Hyeong Kim ,&nbsp;Jeong-Kye Hwang","doi":"10.1016/j.transproceed.2026.04.007","DOIUrl":"10.1016/j.transproceed.2026.04.007","url":null,"abstract":"<div><h3>Background</h3><div>Rabbit antithymocyte globulin (rATG) is frequently used in immunologically high-risk kidney transplantation (KT), but its comparative effectiveness and safety vs basiliximab in ABO-incompatible (ABOi) KT are not well established. We aimed to compare outcomes of rATG and basiliximab induction in ABOi KT and to evaluate whether ABO compatibility modifies these associations.</div></div><div><h3>Methods</h3><div>We conducted a retrospective single-center cohort study of adult KT recipients at Seoul St. Mary’s Hospital between 2011 and 2020. Patients receiving rATG or basiliximab induction were identified and stratified by ABO compatibility. Primary outcomes were overall patient survival, death-censored graft survival (DCGS), and rejection-free graft survival. Secondary outcomes included serious infection requiring hospitalization and post-transplant malignancy. Time-to-event analyses were performed using Kaplan–Meier methods and Cox proportional hazards models, with an interaction term between induction agent and ABO incompatibility.</div></div><div><h3>Results</h3><div>Among 1546 KT recipients, 285 underwent ABOi KT, including 69 receiving rATG and 216 basiliximab. In unstratified analyses, overall patient survival, rejection-free graft survival, and infection-related hospitalization did not differ significantly between induction strategies. Cytomegalovirus viremia was more frequent in the rATG group. In adjusted models, a significant interaction between induction strategy and ABO compatibility was observed for DCGS (<em>P</em> = .031), whereas no significant interactions were observed for rejection-free graft survival or overall patient survival.</div></div><div><h3>Conclusion</h3><div>In ABOi KT, rATG induction was associated with improved DCGS compared with basiliximab, while patient survival and serious infectious complications were similar. The association between induction strategy and graft survival varied by ABO compatibility, supporting a risk-adapted approach to induction therapy.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 730-738"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Death and Cold Storage Induce Renal Inflammation and Injury in an Experimental Model","authors":"Naiane do Nascimento Gonçalves ,&nbsp;Gabriele Preti ,&nbsp;Ludimila Leite Marzochi ,&nbsp;Marcus Alexandre Mendes Luz ,&nbsp;Gloria Elisa Florido Mendes ,&nbsp;Cristiano Jesus Correia ,&nbsp;Mario Abbud-Filho ,&nbsp;Heloisa Cristina Caldas","doi":"10.1016/j.transproceed.2026.03.004","DOIUrl":"10.1016/j.transproceed.2026.03.004","url":null,"abstract":"<div><h3>Background</h3><div>Brain death (BD) and cold storage (CS) are key determinants of donor kidney quality and transplant outcomes. Although both processes are known to induce inflammation, the temporal hierarchy and molecular specificity of inflammatory activation during organ preservation remain poorly defined. This study investigated the inflammatory and histopathological evolution of donor kidneys following BD and during CS using an experimental rat model.</div></div><div><h3>Methods</h3><div>Rats were assigned to sham, BD, or BD followed by 12 or 24 hours of CS. In BD animals, contralateral kidneys were stored for different durations, allowing paired analysis across preservation times. Hemodynamic parameters, serum creatinine, inflammatory gene expression, and histopathological injury were evaluated.</div></div><div><h3>Results</h3><div>BD induced hemodynamic instability and early renal dysfunction, reflected by increased serum creatinine levels and upregulation of inflammatory mediators. During CS, expression of <em>Toll-like receptor 4, CASP1</em>, interleukin<em>-1β</em>, and <em>tumor necrosis factor-α</em> remained elevated, while interleukin-6 increased progressively, particularly between BD and 12 hours of CS. In contrast, <em>NLRP3</em> expression did not significantly increase during preservation. Histopathological analysis demonstrated progressive renal injury with increasing CS duration, including tubular and glomerular damage and features of acute tubular necrosis.</div></div><div><h3>Conclusions</h3><div>BD-induced inflammation persists throughout CS, supporting the concept that organ preservation represents an active injury phase rather than a passive metabolic pause. Distinct temporal inflammatory signatures during preservation highlight molecular pathways that may be targeted to mitigate preservation-associated injury.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 833-840"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147618423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anita Law: Effect of Its Implementation on Tissue and Organ Donation and Transplant in Paraguay","authors":"Marcelo Pederzani ,&nbsp;Federico Fretes ,&nbsp;Agustín Saldivar ,&nbsp;Iris Colman ,&nbsp;Belinda Figueredo","doi":"10.1016/j.transproceed.2026.03.006","DOIUrl":"10.1016/j.transproceed.2026.03.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Organ shortages are the main limitation for transplantation worldwide. Paraguay’s Anita Law (Law 6216/2019) introduced presumed consent to increase organ and tissue donation. This study assesses its impact on donor identification and transplantation outcomes.</div></div><div><h3>Methods</h3><div>A retrospective, cross-sectional, descriptive, and observational study with an analytical component was performed. The study included all cases of brain death reported to the National Institute of Transplantation (INAT) before (2016–2018) and after (2019–2023) the law, excluding 2020–2021 due to COVID-19. Donor notifications, organ and tissue donations, and transplant rates were analyzed. Categorical and continuous variables were compared using chi-square/Fisher exact tests and t-tests, respectively.</div></div><div><h3>Results</h3><div>Of 550 patients (178 pre-law; 372 post-law), 63% were male, median age 35 years. Notifications increased significantly after the law (178 vs. 372; P ≤ .0001). Effective organ donation rose from 36 to 54 (P = .9), and tissue donation from 13 to 33 (P ≤ .03). Kidneys and corneas remained the most procured organs and tissues. Family refusal (46% vs. 41%) and medical contraindications (∼30%) were the main barriers. Notifications from hospitals outside the capital increased from 3.9% to 10.7% (P = .15). Unused donors accounted for 2% post-law.</div></div><div><h3>Conclusions</h3><div>The Anita Law enhanced donor notifications and tissue donation but did not significantly increase effective organ donation. Persistent family refusal and medical contraindications remains limiting factors. Implementation of intra-hospital transplant coordinators is essential to optimize donor detection, increase organ utilization, and reduce waiting lists, providing a strategic foundation for strengthening Paraguay’s transplant system.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 627-631"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147617329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Risk Factors for Early Human Cytomegalovirus Reactivation Following Liver Transplantation","authors":"Yanyue Zhang ,&nbsp;Genyong Gui ,&nbsp;Xiaopeng Yu ,&nbsp;Jun Fan ,&nbsp;Xiaoping Pan","doi":"10.1016/j.transproceed.2026.03.007","DOIUrl":"10.1016/j.transproceed.2026.03.007","url":null,"abstract":"<div><h3>Background</h3><div>Human cytomegalovirus (HCMV) is the most common opportunistic infection following liver transplantation (LT). This study aimed to identify risk factors for HCMV reactivation early post-transplantation.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed data from 150 LT recipients aged ≥14 years who received preemptive therapy in China from July 2017 to December 2018. We performed univariate and multivariate analyses to identify risk factors for HCMV reactivation within the first 90 days post-transplantation.</div></div><div><h3>Results</h3><div>HCMV reactivation occurred in 32 patients (21.33%) within the first 90 days post-LT. Intensive care unit length of stay (odds ratio [OR], 1.055; 95% confidence interval [CI], 1.007-1.104; <em>P</em> = .023), fungal infections (OR, 3.093; 95% CI, 1.092-8.764; <em>P</em> = .034), and non-hepatitis B virus (HBV)-related liver disease (OR, 5.576; 95% CI, 2.137-14.552; <em>P</em> = .000) were significant risk factors for HCMV reactivation within the first 90 days post-LT. The cumulative incidence of HCMV reactivation was significantly higher in patients with non-HBV-related liver diseases (<em>P</em> = .0007) than in those with HBV-related liver diseases. In the former, HCMV reactivation early after transplantation was associated with the pretransplantation hepatitis B surface antibody (HBsAb) serological status (<em>P</em> = .006). Higher HBsAb titers were significantly associated with reduced HCMV reactivation risk (<em>P</em> = .011).</div></div><div><h3>Conclusions</h3><div>This study suggested that HCMV is a common opportunistic infection early after LT. Reducing intensive care unit lengths of stay and preventing fungal infections may reduce the risk of HCMV reactivation early after transplantation. Pretransplantation HBsAb titers might be a useful predictor in patients with non-HBV-related liver diseases.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 4","pages":"Pages 739-747"},"PeriodicalIF":0.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}