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The Conundrum of Biventricular Takotsubo Syndrome After Heart Transplantation: A Case Report 心脏移植后双心室Takotsubo综合征的难题:1例报告。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.03.019
Simona Covino , Luigi Marotta , Fiorella Chiara Delle Femine , Diego D'Arienzo , Biagio Liccardo , Francesco Natale , Giovanni Cimmino , Enrica Pezzullo , Irene Mattucci , Adriano Caputo , Claudio Marra , Paolo Golino , Francesco Loffredo , Cristiano Amarelli
{"title":"The Conundrum of Biventricular Takotsubo Syndrome After Heart Transplantation: A Case Report","authors":"Simona Covino ,&nbsp;Luigi Marotta ,&nbsp;Fiorella Chiara Delle Femine ,&nbsp;Diego D'Arienzo ,&nbsp;Biagio Liccardo ,&nbsp;Francesco Natale ,&nbsp;Giovanni Cimmino ,&nbsp;Enrica Pezzullo ,&nbsp;Irene Mattucci ,&nbsp;Adriano Caputo ,&nbsp;Claudio Marra ,&nbsp;Paolo Golino ,&nbsp;Francesco Loffredo ,&nbsp;Cristiano Amarelli","doi":"10.1016/j.transproceed.2025.03.019","DOIUrl":"10.1016/j.transproceed.2025.03.019","url":null,"abstract":"<div><div>Takotsubo syndrome<span> (TTS) is a rare cause of myocardial infarction in heart transplant patients. The heterogeneity of reported cases makes it impossible to identify specific characteristics of patients at risk. The occurrence of biventricular TTS is even less frequent its impact on long-term prognosis is unpredictable. We in here describe a rare case of biventricular TTS occurred in a woman 13 years after heart transplant.</span></div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1246-1249"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donor Transmission of an Intravascular Large B-Cell Lymphoma in Multiorgan Transplantation: A Case Report From a Rare Pitfall in the Predonation Screening for Donor Disease 多器官移植血管内大b细胞淋巴瘤的供体传播:捐献前供体疾病筛查中罕见缺陷的一例报告。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.06.010
Beatriz P. Fernandes , Ana C. Pimenta , Andreia Henriques , Clara Pardinhas , Rita Leal , Maria G. Marques , Lídia Santos , Catarina Romãozinho , Vítor Sousa , Arnaldo Figueiredo , Rui Alves , Luís Rodrigues
{"title":"Donor Transmission of an Intravascular Large B-Cell Lymphoma in Multiorgan Transplantation: A Case Report From a Rare Pitfall in the Predonation Screening for Donor Disease","authors":"Beatriz P. Fernandes ,&nbsp;Ana C. Pimenta ,&nbsp;Andreia Henriques ,&nbsp;Clara Pardinhas ,&nbsp;Rita Leal ,&nbsp;Maria G. Marques ,&nbsp;Lídia Santos ,&nbsp;Catarina Romãozinho ,&nbsp;Vítor Sousa ,&nbsp;Arnaldo Figueiredo ,&nbsp;Rui Alves ,&nbsp;Luís Rodrigues","doi":"10.1016/j.transproceed.2025.06.010","DOIUrl":"10.1016/j.transproceed.2025.06.010","url":null,"abstract":"<div><div>The prevention of donor-transmitted diseases in solid organ transplantation<span> depends on the thorough screening of donors while maintaining a high level of clinical suspicion. The evolution in these practices reduced the incidence of donor-transmitted tumors to minimal and unexpected events. Nevertheless, the recipients of these exceptional transmissions hold significant clinical consequences, challenging decisions, and poor outcomes. The intravascular large B-cell lymphoma (IVLBCL) is an extremely rare and aggressive tumor with almost exclusive intrasmall vessel growth. Its clinical and morphological features make diagnosing potential deceased donors virtually impossible. We report the case of the post-transplant diagnosis of the transmission of this cancer in a multiorgan kidney and liver transplantation<span><span>. Following the IVLBCL diagnosis on a routine preimplantation kidney biopsy, the transplanted </span>kidney grafts were removed, and a conservative management approach was adopted for the liver recipient. Histological examination of the kidney grafts revealed multifocal involvement by an IVLBCL neoplasm. Subsequent liver recipient biopsy showed no evidence of the known IVLBCL. After three years of follow-up, both kidney recipients have undergone a second kidney transplant, and the liver recipient continues to demonstrate no signs of the IVLBCL disease.</span></span></div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1291-1295"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Decline in Renal Allograft Function After Severe COVID-19 in Kidney Transplant Recipients: Evidence From a Four-Year Retrospective Cohort Study 肾移植受者严重COVID-19后同种异体肾功能长期下降:来自四年回顾性队列研究的证据
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.06.012
Suzimar Silveira Rioja, Amanda Orlando Reis, Conrado Lysandro Rodrigues Gomes
{"title":"Long-Term Decline in Renal Allograft Function After Severe COVID-19 in Kidney Transplant Recipients: Evidence From a Four-Year Retrospective Cohort Study","authors":"Suzimar Silveira Rioja,&nbsp;Amanda Orlando Reis,&nbsp;Conrado Lysandro Rodrigues Gomes","doi":"10.1016/j.transproceed.2025.06.012","DOIUrl":"10.1016/j.transproceed.2025.06.012","url":null,"abstract":"<div><h3>Background</h3><div><span>While coronavirus disease (COVID-19) has been extensively studied, long-term follow-up data in </span>kidney transplant<span><span> recipients (KTRs), particularly concerning the impact of severe COVID-19 on graft function, remain limited. This study provides critical evidence of sustained renal injury in KTRs with severe COVID-19, focusing on </span>acute kidney injury<span> (AKI) as a predictor of accelerated graft dysfunction over a 4-year follow-up period.</span></span></div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study<span> of 43 KTRs hospitalized with COVID-19 in Brazil (April 2020 and July 2024). The survivors were followed up for a median of 2.5 years (range: 1.2–4.2 years). Longitudinal graft function was assessed using estimated glomerular filtration rate (eGFR) trajectories modeled with linear mixed-effects analysis.</span></div></div><div><h3>Results</h3><div><span>The in-hospital mortality rate was 37.2%. AKI occurred in 65.1% of patients and was more frequent among nonsurvivors (87.5% vs 51.9%, </span><em>P</em><span> &lt; .05). Of the 13 patients requiring kidney replacement therapy, only 2 survived. Among the 27 survivors, we observed a significant decline in eGFR from 47.99 to 40.57 mL/min/1.73 m² (</span><em>P</em> = .032) in the follow-up period, driven by a steeper annual decline in those with AKI (−6.99 mL/min/1.73 · m² per year vs stable eGFR in non-AKI patients, <em>P</em> = .049). By the final follow-up, AKI survivors had a significantly lower eGFR than non-AKI patients (12.58 vs 47.57 mL/min/1.73 m², <em>P</em> = .003).</div></div><div><h3>Conclusion</h3><div>Severe COVID-19 has a lasting impact on graft function in KTRs, particularly in those with AKI. These findings underscore the importance of long-term nephrological surveillance and individualized post-COVID-19 management strategies for slowing graft dysfunction progression in this high-risk population.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1271-1276"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Living Kidney Donor Perceptions About Organ Donation: Who are They, and How Do They Feel About the Process? 活体肾脏捐赠者对器官捐赠的看法:他们是谁,他们对这个过程的感受如何?
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.05.036
Manuela Almeida , Inês Carvalho Frade , Alexandra Sousa , La Salete Martins , Miguel Silva Ramos , Jorge Malheiro , Isabel Fonseca , Alice Lopes
{"title":"Living Kidney Donor Perceptions About Organ Donation: Who are They, and How Do They Feel About the Process?","authors":"Manuela Almeida ,&nbsp;Inês Carvalho Frade ,&nbsp;Alexandra Sousa ,&nbsp;La Salete Martins ,&nbsp;Miguel Silva Ramos ,&nbsp;Jorge Malheiro ,&nbsp;Isabel Fonseca ,&nbsp;Alice Lopes","doi":"10.1016/j.transproceed.2025.05.036","DOIUrl":"10.1016/j.transproceed.2025.05.036","url":null,"abstract":"<div><h3>Background</h3><div>The panorama of living kidney donors (LKDs) in Portugal has changed over the past decade, including kidney-paired exchange programs, undirected donations, and more complex kidney transplants, which could affect the predisposition to donation. We sought to describe the sociodemographic characteristics of a cohort of LKDs at our center and assess their perceptions of the donation process.</div></div><div><h3>Material and Methods</h3><div>LKDs who donated between January 2018 and December 2019 underwent a predonation psychosocial evaluation and a follow-up evaluation in May 2022, which included questionnaires about perceptions regarding donation. We analyzed the results descriptively.</div></div><div><h3>Results</h3><div>Forty-four LKDs were included, aged 47.3 ± 10.3 years. Most were female (68.2%). A total of 52.4% only attended primary school; 52.3% were genetically related to the recipients, and 40.9% were spouses. In 86.4% of the LKDs, the decision to donate was easy; in 13.6%, it was a little difficult, with some doubts. All donors said that the information provided was adequate. Most LDs (79.5%) stated that the relationship with the recipient did not change, and most (88.6%) believed that the recipient’s health state improved significantly. Only one LD would not donate again, and 77.3% would strongly encourage others to do it.</div></div><div><h3>Conclusions</h3><div>The perceptions about donation in our cohort were very positive, and most donors would encourage others to donate. All felt well-informed about the process, and the regret rate was very low. Although these results must be studied in larger cohorts, sharing previous donors' experiences can add value to the dissemination of LKD programs.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1251-1257"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tacrolimus Toxicity Induced by Nirmatrelvir/Ritonavir in a Renal Transplant Recipient Managed With Phenytoin: A Case Report and Literature Review 苯妥英治疗肾移植受者尼马特利韦/利托那韦致他克莫司毒性:1例报告及文献复习。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.06.019
Ching-Yu Wang , Cheng-Hsu Chen , Shang-Feng Tsai
{"title":"Tacrolimus Toxicity Induced by Nirmatrelvir/Ritonavir in a Renal Transplant Recipient Managed With Phenytoin: A Case Report and Literature Review","authors":"Ching-Yu Wang ,&nbsp;Cheng-Hsu Chen ,&nbsp;Shang-Feng Tsai","doi":"10.1016/j.transproceed.2025.06.019","DOIUrl":"10.1016/j.transproceed.2025.06.019","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic has led to widespread use of nirmatrelvir/ritonavir in high-risk populations. Ritonavir, a strong CYP3A4 inhibitor, can significantly increase tacrolimus levels, causing toxicity in transplant recipients. This report presents a case of nirmatrelvir/ritonavir -induced tacrolimus toxicity in a kidney transplant patient, successfully managed with phenytoin, a CYP3A4 inducer.</div></div><div><h3>Case report</h3><div>A 63-year-old male kidney transplant recipient experienced malaise and hand tremors after nirmatrelvir/ritonavir treatment for mild COVID-19. Lab tests revealed ac1ute kidney injury and supratherapeutic tacrolimus levels (&gt;60 ng/mL). Tacrolimus was discontinued, and hydration was initiated. Persistent toxicity required phenytoin, leading to rapid improvement. A renal biopsy showed no toxicity, and the patient was discharged without complications.</div></div><div><h3>Discussion</h3><div>Among 51 reported cases of nirmatrelvir/ritonavir -induced tacrolimus toxicity, 13 used CYP3A4 inducers. This case highlights phenytoin's efficacy in reducing toxicity and protecting renal function. Timely initiation with a loading dose is crucial for optimal outcomes.</div></div><div><h3>Conclusion</h3><div>Early recognition and prompt management with hydration and CYP3A4 inducers, such as phenytoin, are essential in mitigating nirmatrelvir/ritonavir -associated tacrolimus toxicity.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1329-1333"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Chylopericardium after Heart Transplantation due to Lymphatic Malformation in a Patient With Noonan Syndrome 病例报告:努南综合征患者因淋巴畸形心脏移植后出现乳糜心包。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.08.008
Tatiana Costa Diamantino Vaz, Camila Esteves Paredes, Vera Demarchi Aiello, Santiago Raul Arrieta, Adailson Wagner da Silva Siqueira, Luiz Fernando Caneo, Marcelo Biscegli Jatene, Estela Azeka
{"title":"Case Report: Chylopericardium after Heart Transplantation due to Lymphatic Malformation in a Patient With Noonan Syndrome","authors":"Tatiana Costa Diamantino Vaz,&nbsp;Camila Esteves Paredes,&nbsp;Vera Demarchi Aiello,&nbsp;Santiago Raul Arrieta,&nbsp;Adailson Wagner da Silva Siqueira,&nbsp;Luiz Fernando Caneo,&nbsp;Marcelo Biscegli Jatene,&nbsp;Estela Azeka","doi":"10.1016/j.transproceed.2025.08.008","DOIUrl":"10.1016/j.transproceed.2025.08.008","url":null,"abstract":"<div><div>Chylopericardium is a rare condition, typically associated with the postoperative period following cardiac surgery, lymphatic system obstruction, or congenital malformations. We report the case of a school-aged child with Noonan syndrome who developed treatment-resistant chylopericardium after undergoing heart transplantation. Further investigation revealed an anomalous lymphatic system.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1303-1304"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic Profile of Living Kidney Donors: A One-Year Analysis 活体肾供者的代谢特征:一年分析
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.07.013
Ana Cunha , Maria Rita Dias , Henrique Borges , Joana Pereira Dias , Bárbara Beirão , Beatriz Gil Braga , José Silvano , Catarina Ribeiro , Manuela Almeida , Jorge Malheiro , Sofia Pedroso , La Salete Martins
{"title":"Metabolic Profile of Living Kidney Donors: A One-Year Analysis","authors":"Ana Cunha ,&nbsp;Maria Rita Dias ,&nbsp;Henrique Borges ,&nbsp;Joana Pereira Dias ,&nbsp;Bárbara Beirão ,&nbsp;Beatriz Gil Braga ,&nbsp;José Silvano ,&nbsp;Catarina Ribeiro ,&nbsp;Manuela Almeida ,&nbsp;Jorge Malheiro ,&nbsp;Sofia Pedroso ,&nbsp;La Salete Martins","doi":"10.1016/j.transproceed.2025.07.013","DOIUrl":"10.1016/j.transproceed.2025.07.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Kidney donation’s effects on renal function are well-documented, but its metabolic consequences are less explored. To provide accurate information to donors and ensure appropriate follow-up, this study evaluates the potential metabolic impact of kidney donation over 12 months.</div></div><div><h3>Methods</h3><div>A longitudinal study of 26 living kidney donors assessed participants at predonation (T0), 6 (6M), and 12 (12M) months postdonation. Key parameters included body mass index (BMI), renal function, HbA1c, lipid profile, nutritional and hormonal markers, anemia, and hypertension. Comparisons were made between T0 and both 6M and 12M.</div></div><div><h3>Results</h3><div>The cohort was predominantly female (<em>n</em> = 20; 76.9%), median age 52.19 ± 8.16 years. BMI, lipid profile, and nutritional markers (eg, albumin) showed no significant changes. Bone metabolism markers (eg, parathyroid hormone, calcium, phosphorus) were stable. HbA1c levels rose slightly at 6M (T0: 5.54 ± 0.37 g/dL; 6M: 5.57 ± 0.13 g/dL; <em>P</em> = .010), though not clinically relevant. TSH levels increased modestly (T0: 1.67 ± 0.83 mUI/L; 6M: 2.29 ± 1.25 mUI/L; <em>P</em> = .011; 12M: 2.14 ± 1.01 mUI/L; <em>P</em> = .021). Hemoglobin increased at 12M (T0: 12.84 ± 1.73 g/dL; 12M: 13.29 ± 1.19 g/dL; <em>P</em> = .013). Hypertension incidence rose slightly (T0: 8 [30.77%]; 12M: 9 [34.62%]; <em>P</em> &lt; .001). Renal function (estimated glomerular filtration rate) decreased (T0: 110.10 ± 12.33 mL/min/1.73 m²; 6M: 68.71 ± 10.84; 12M: 71.21 ± 11.61; <em>P</em> &lt; .001), consistent with postdonation adaptation.</div></div><div><h3>Conclusion</h3><div>Kidney donation appears metabolically safe. BMI, lipids, and nutritional markers remained stable. Minor increases in HbA1c, TSH, and hypertension were not clinically significant. Hemoglobin elevation may reflect compensatory erythropoiesis. Hypertension increase warrants further study for potential long-term cardiovascular risks.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1261-1264"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status 1A ABO Incompatible Liver Transplant With Eculizumab as a Rescue Treatment for a Patient With Primary Non-Function: Case Report 状态1A ABO不相容肝移植用Eculizumab作为原发性无功能患者的抢救治疗:病例报告
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.07.016
Katsunori Miyake, Luke G. Atia, Maria Jimena Alaniz, Pierpaolo Di Cocco, Jorge A. Almario Alvalez, Stephen Bartlett, Ivo Tzvetanov, Enrico Benedetti, Mario Spaggiari
{"title":"Status 1A ABO Incompatible Liver Transplant With Eculizumab as a Rescue Treatment for a Patient With Primary Non-Function: Case Report","authors":"Katsunori Miyake,&nbsp;Luke G. Atia,&nbsp;Maria Jimena Alaniz,&nbsp;Pierpaolo Di Cocco,&nbsp;Jorge A. Almario Alvalez,&nbsp;Stephen Bartlett,&nbsp;Ivo Tzvetanov,&nbsp;Enrico Benedetti,&nbsp;Mario Spaggiari","doi":"10.1016/j.transproceed.2025.07.016","DOIUrl":"10.1016/j.transproceed.2025.07.016","url":null,"abstract":"<div><div>Primary graft non-function (PNF) after liver transplant (LT) due to graft necrosis necessitates urgent graftectomy and Status 1A liver re-transplant. To find a suitable donor promptly, ABO blood type incompatibility (ABOi) is a crucial immunological barrier. We present the case of a 68-year-old man with nonalcoholic steatohepatitis cirrhosis (model of end stage liver disease score = 23) who underwent an initial LT. Unfortunately, the transplant was complicated by portal vein thrombosis and hemodynamic instability, resulting in primary graft non-function. An emergent explant was performed, and the patient was an-hepatic for 16 hours with a portocaval shunt for status 1A LT. The first available donor was an ABOi 34-year-old man, and re-transplantation was performed with a single dose of Eculizumab administered 2 hours before reperfusion as part of a desensitization protocol. The ABO blood type antibody titer of the recipient before receiving Eculizumab was 1:128. Notably, plasmapheresis and immunoglobulin therapy were not required, simplifying management for this hemodynamically unstable patient. The patient was discharged without any sign of rejection or complication related to the re-transplantation. This case report underscores the significance of Eculizumab as an alternative desensitization strategy for ABOi LT hemodynamically unstable patients listed as Status 1A.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1352-1355"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological Outcomes in a Cohort of Portuguese Living Kidney Donors 葡萄牙活体肾供者队列的心理结果。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.05.006
Manuela Almeida , Inês Carvalho Frade , Alexandra Sousa , La Salete Martins , Miguel Silva Ramos , Jorge Malheiro , Isabel Fonseca , Alice Lopes
{"title":"Psychological Outcomes in a Cohort of Portuguese Living Kidney Donors","authors":"Manuela Almeida ,&nbsp;Inês Carvalho Frade ,&nbsp;Alexandra Sousa ,&nbsp;La Salete Martins ,&nbsp;Miguel Silva Ramos ,&nbsp;Jorge Malheiro ,&nbsp;Isabel Fonseca ,&nbsp;Alice Lopes","doi":"10.1016/j.transproceed.2025.05.006","DOIUrl":"10.1016/j.transproceed.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>The psychosocial aspects of living kidney donation remain a challenge nowadays. We sought to evaluate the psychological outcomes of donation in a cohort of living kidney donors (LKDs).</div></div><div><h3>Material and methods</h3><div><span>LKDs who underwent nephrectomy<span> from January 2018 to December 2019 completed a predonation psychosocial assessment followed by a postdonation evaluation using 36-Item Short Form (SF-36) and Hospital Anxiety and Depression Scale forms in May 2022. Mean scores were compared before and after the donation using the paired </span></span><em>t</em>-test. Peason’s correlation tested the relationship between anxiety and depression scores and relevant variables.</div></div><div><h3>Results</h3><div>Forty-four LKDs were included. Most were female (68.2%), aged 47.3 ± 10.3 years, 52.3% were genetically related, and 63.6% were compatible and donated directly to their recipients. Overall, we observed a statistically significant reduction postdonation in various components of SF-36: physical functioning (<em>P</em> = .037), bodily pain (<em>P</em> = .003), vitality (<em>P</em> = .023), social functioning (<em>P</em> = .023), and mental health (<em>P</em> = .006). Only LKDs who experienced stressful life events (<em>n</em> = 19), showed significant reductions in some SF-36 domains: physical functioning (<em>P</em> = .012), physical role (<em>P</em> = .028), bodily pain (<em>P</em> = .006), and mental health (<em>P</em> = .009). Depression scores increased significantly postdonation (<em>P</em><span> = .029) but lacked clinical significance. Additionally, there was a positive and significant correlation between predonation depression scores and postdonation anxiety levels postdonation.</span></div></div><div><h3>Conclusions</h3><div>Living donation is usually a safe procedure regarding psychosocial aspects. Nonetheless, some LKDs, particularly those with medical complications or stressful live events, may face adverse emotional impacts, Therefore, transplant professionals must screen, assess, and provide psychosocial support before and after donation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1284-1290"},"PeriodicalIF":0.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Psychosocial Evaluation of the Patient Candidate for Liver Transplantation at ASST Papa Giovanni XXIII in Bergamo With the Stanford Integrated Psychosocial Assessment for Transplants 贝加莫市Papa Giovanni XXIII医院肝移植候选者的社会心理评估与斯坦福移植综合社会心理评估。
IF 0.8 4区 医学
Transplantation proceedings Pub Date : 2025-09-01 DOI: 10.1016/j.transproceed.2025.05.002
Alessandra Merisio , Aida Niang , Luisa Pasulo , Filippo Leonardi , Domenico Pinelli , Stefano Fagiuoli , Maria Simonetta Spada
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