Transplantation proceedings最新文献

Advancing Cardiac Care: A Registry of Heart Transplantation in Latin America (1968-2022)

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-10 DOI: 10.1016/j.transproceed.2024.08.036

{"title":"Advancing Cardiac Care: A Registry of Heart Transplantation in Latin America (1968-2022)","authors":"","doi":"10.1016/j.transproceed.2024.08.036","DOIUrl":"10.1016/j.transproceed.2024.08.036","url":null,"abstract":"<div><h3>Introduction</h3><p>Heart transplantation (HTx) has emerged as a pivotal intervention for end-stage heart failure, offering significant improvements in survival and quality of life. This manuscript elucidates the landscape of HTx across Latin America (LATAM) from its advent in 1968 through December 2022, shedding light on its evolution, current practices, and regional disparities.</p></div><div><h3>Methods</h3><p>We distributed a structured questionnaire to the national coordinators or representatives of the Interamerican Council of Heart Failure and Pulmonary Hypertension, collating responses from 20 LATAM nations. This approach facilitated a comprehensive aggregation of regional HTx data.</p></div><div><h3>Results</h3><p>A total of 12,374 HTx were performed in 166 centers across 16 LATAM countries, with Brazil, Argentina, and Colombia accounting for the majority of procedures. Pediatric transplants represented 9% of the total caseload, and combined organ transplants were reported in 62.5% of the participating countries, underscoring the complexity and breadth of transplant services in the region.</p></div><div><h3>Conclusion</h3><p>Despite facing infrastructural and logistical challenges, LATAM has demonstrated a robust capacity to conduct high-complexity transplant procedures. The establishment of a structured, regional HTx registry is imperative to enhance data collection and analysis, which in turn can inform clinical decision-making and policy development, ultimately improving patient outcomes across the continent.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142241403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Frailty, Rational Use of Medications, and Adherence to Immunosuppressive Therapy in Liver Transplant Recipients 评估肝移植受者的虚弱程度、合理用药和坚持免疫抑制疗法的情况。

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-07 DOI: 10.1016/j.transproceed.2024.08.041

{"title":"Assessing Frailty, Rational Use of Medications, and Adherence to Immunosuppressive Therapy in Liver Transplant Recipients","authors":"","doi":"10.1016/j.transproceed.2024.08.041","DOIUrl":"10.1016/j.transproceed.2024.08.041","url":null,"abstract":"<div><h3>Aim</h3><p>The study was conducted to determine the level of frailty, rational medication use, and adherence to immunosuppressive therapy in liver transplant patients and to examine the relationships among them.</p></div><div><h3>Materials and Methods</h3><p>The data of the descriptive cross-sectional study were collected between January 2023 and September 2023. Our study included 200 liver transplant recipients. In addition to demographic and medical characteristics, frailty status, rational drug use, and compliance with immunosuppressive therapy were measured in a 15–20 minute questionnaire administration period.</p></div><div><h3>Results</h3><p>The frailty scores of liver transplant patients were 2.11 ± 1.34, rational drug use scores were 82.88 ± 13.11, and compliance with immunosuppressive therapy scores were 11.12 ± 1.07. The scores for rational drug use and adherence to immunosuppressive therapy were not affected by frailty status, and patients used drugs rationally and adhered to immunosuppressive therapy even when they were frail. It was found that the vulnerability status of the participants was affected by gender and occupational variables, most patients were in the vulnerable group in women and men, and those who did not work were more vulnerable than the other groups.</p></div><div><h3>Conclusion</h3><p>It was found that liver transplant patients were frail, and frailty did not affect the level of rational drug use and compliance with immunosuppressive therapy.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Myeloma and Retroperitoneal Fibrosis: A Rare Association Report and Literature Review 多发性骨髓瘤与腹膜后纤维化：罕见的关联报告和文献综述

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-06 DOI: 10.1016/j.transproceed.2024.08.037

{"title":"Multiple Myeloma and Retroperitoneal Fibrosis: A Rare Association Report and Literature Review","authors":"","doi":"10.1016/j.transproceed.2024.08.037","DOIUrl":"10.1016/j.transproceed.2024.08.037","url":null,"abstract":"<div><p>Multiple myeloma (MM) is a common hematological malignancy. Autologous hematopoietic stem cell transplantation (auto-HSCT) can significantly improve the prognosis of patients with MM, but a variety of complications may occur after transplantation. Retroperitoneal fibrosis (RPF) is a rare cause of obstructive nephropathy. Because there are no specific symptoms at the time of onset and the course of the disease is often insidious, special laboratory and instrumental examination methods are usually needed to confirm the diagnosis. This article describes the clinical case of a 50-year-old female patient diagnosed with multiple myeloma. She developed postoperative acute kidney injury (AKI) more than 20 days after transplantation and was subsequently diagnosed with retroperitoneal fibrosis. After multidisciplinary collaboration, early transurethral vesicoureteral stent placement was performed, the obstruction was relieved, and her renal function returned to normal. Reports of retroperitoneal fibrosis after multiple myeloma transplantation are relatively rare. This case report advances our understanding of these 2 diseases, and the correlation between MM and RPF warrants further exploration.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfusate Exchange Does Not Improve Outcomes in 24-hour Ex Situ Lung Perfusion 灌注液交换不能改善 24 小时原位肺灌注的效果

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-06 DOI: 10.1016/j.transproceed.2024.08.027

{"title":"Perfusate Exchange Does Not Improve Outcomes in 24-hour Ex Situ Lung Perfusion","authors":"","doi":"10.1016/j.transproceed.2024.08.027","DOIUrl":"10.1016/j.transproceed.2024.08.027","url":null,"abstract":"<div><h3>Background</h3><p>Reliable 24-hour preservation is required to optimize the rehabilitation potential of Ex Situ Lung Perfusion (ESLP). Other ESLP protocols include fresh perfusate replacement to counteract an accumulation of deleterious by-products. We describe the results of our reliable 24-hour negative pressure ventilation (NPV)-ESLP protocol with satisfactory acute post-transplant outcomes and investigate perfusate exchange (PE) as a modification to enhance prolonged ESLP.</p></div><div><h3>Methods</h3><p>Twelve pig lungs underwent 24 hours of NPV-ESLP using 1.5L of cellular perfusate (500 mL packed red blood cells and 1 L buffered perfusate). The Control (<em>n</em> = 6) had no PE; the PE (<em>n</em> = 6) had 500 mL replaced after 12 hours of NPV-ESLP with 1000 mL fresh perfusate. Three left lungs per group were transplanted.</p></div><div><h3>Results</h3><p>Results are reported as Control vs PE (mean ± SEM). Both groups demonstrated stable and acceptable oxygenation during 24 hours of ESLP with final PF ratios of 527.5 ± 42.19 and 488.4 ± 35.38 (<em>P</em> = .25). Final compliance measurements were 20.52 ± 3.59 and 18.55 ± 2.91 (<em>P</em> = .34). There were no significant differences in pulmonary artery pressure after 24 hours of ESLP (10.02 ± 2.69 vs 14.34 ± 1.64, <em>P</em> = .10), and pulmonary vascular resistance only differed significantly at T12 (417.6 ± 53.06 vs 685.4 ± 81.19, <em>P</em> = .02). Percentage weight gain between groups was similar (24.32 ± 8.4 and 45.33 ± 7.76, <em>P</em> = .07). Post-transplant left lung oxygenation was excellent (327.3 ± 14.62 and 313.3 ± 15.38, <em>P</em> = .28). There was no significant difference in % weight gain of lungs post-transplant (22.20 ± 7.22 vs 14.36 ± 9.96, <em>P</em> = .28).</p></div><div><h3>Conclusion</h3><p>Acceptable lung function was maintained during 24-hour NPV-ESLP and post-transplant regardless of PE.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosis Analysis of Rat Liver Transplantation Under Direct Vision of Single Operator 单人直视下大鼠肝移植的预后分析

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.044

{"title":"Prognosis Analysis of Rat Liver Transplantation Under Direct Vision of Single Operator","authors":"","doi":"10.1016/j.transproceed.2024.08.044","DOIUrl":"10.1016/j.transproceed.2024.08.044","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to investigate the impact of surgical experimental variables on the prognosis of orthotopic liver transplantation (OLT) in rats, with the goal of enhancing the efficacy of modeling techniques.</p></div><div><h3>Methods</h3><p>Using Kamada's “two-cuff method” of rat orthotopic liver transplantation, 76 pairs of SD-Wistar rats were performed orthotopic liver transplantation from March to September 2023. Thirteen experimental factors during the perioperative period and the survival time of recipient rats were collected and recorded. To explore the surgical factors affecting the prognosis of rat liver transplantation and summarize the surgical techniques.</p></div><div><h3>Results</h3><p>The success rate of orthotopic liver transplantation in SD-Wistar rats was 68.4%, with 24 recipients surviving within 3–7 days and 28 recipients surviving more than 1 week. Donor liver perfusion, recipient blood loss, recipient liver blood expulsion, anhepatic phase, suprahepatic inferior vena cava anastomosis time and anesthesia recovery time are related to the survival of recipient rats after liver transplantation. Donor liver perfusion, eliminating blood in recipient liver and intraoperative blood loss of recipient are surgical factors affecting the prognosis of liver transplantation in rats. The survival time of recipient rats with liver perfusion through abdominal aorta, eliminating blood in recipient liver was relatively prolonged after operation.</p></div><div><h3>Conclusion</h3><p>Under the condition of reasonable control of the anhepatic phase, the perfusion method of the donor liver, whether to eliminate blood in recipient liver, and intraoperative blood loss of recipient are important surgical factors affecting the prognosis of liver transplantation in rats.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Transplantation for Budd-Chiari Syndrome From Myeloproliferative Neoplasms - Management and Long-Term Results 骨髓增生性肿瘤引起的巴德-恰里综合征的肝移植--管理和长期效果。

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.040

引用次数: 0

The Secondary Pulmonary Hypertension Diagnosis is Not Useful in Lung Allocation 继发性肺动脉高压诊断在肺分配中无用。

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.025

{"title":"The Secondary Pulmonary Hypertension Diagnosis is Not Useful in Lung Allocation","authors":"","doi":"10.1016/j.transproceed.2024.08.025","DOIUrl":"10.1016/j.transproceed.2024.08.025","url":null,"abstract":"<div><h3>Background</h3><p>In lung transplant, the United Network for Organ Sharing (UNOS) contains a diagnosis of secondary pulmonary hypertension (SPH). SPH and pulmonary arterial hypertension are treated the same in the allocation scoring system. It is not clear whether utilizing the SPH diagnosis instead of the primary diagnosis is helpful to patients or providers.</p></div><div><h3>Methods</h3><p>Analysis of UNOS data from May 2005 through July 2021, comparing patients listed under the SPH diagnosis with patients listed under COPD and interstitial lung disease (ILD) who met criteria for PH (COPD-PH and ILD-PH, respectively), as well as patients listed under pulmonary arterial hypertension (primary pulmonary hypertension, PPH). Competing-risk analysis examined waitlist and post-transplant outcomes. An exploratory analysis of UNOS spirometry data was performed.</p></div><div><h3>Results</h3><p>Compared to patients listed under the SPH diagnosis, patients with ILD-PH were more likely to undergo transplantation (adjusted HR: 1.34, 95% confidence interval: 1.16-1.54, <em>P</em> < .001), with no significant difference comparing the SPH diagnosis to PPH or to COPD-PH. Waitlist mortality did not vary between groups. Post-transplant survival was lower in patients with PPH (adjusted HR: 1.35, 95% confidence interval: 1.04-1.75, <em>P</em> = .025), with no significant difference comparing the SPH diagnosis to COPD-PH or ILD-PH. Spirometry failed to demonstrate a clear phenotype within the SPH diagnosis.</p></div><div><h3>Conclusion</h3><p>In an adjusted analysis, patients with advanced lung disease and secondary PH were more likely to undergo transplantation when listed for ILD than when listed under the SPH diagnosis. The SPH diagnosis is too clinically heterogeneous to be useful in predictive models and should be considered for removal from UNOS.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life of Hematological Neoplasm Survivors After Hematopoietic Stem Cell Transplantation 造血干细胞移植后血液肿瘤幸存者的生活质量。

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.039

{"title":"Quality of Life of Hematological Neoplasm Survivors After Hematopoietic Stem Cell Transplantation","authors":"","doi":"10.1016/j.transproceed.2024.08.039","DOIUrl":"10.1016/j.transproceed.2024.08.039","url":null,"abstract":"<div><h3>Purpose</h3><p>This study aimed to assess changes in the quality of life (QoL) of patients with hematological neoplasms who underwent hematopoietic stem cell transplantation (HSCT), identify factors influencing these changes, and quantify the associated monetary value.</p></div><div><h3>Methods</h3><p>A total of 122 hematopoietic stem cell transplantation (HSCT) recipients participated in the study completing a recall survey with questions about 3 different stages: (1) pre-HSCT (baseline), (2) 6 months post-transplantation, and (3) between the first and fifth post-transplantation years. The study first estimated the incremental variation in QoL between phases and conducted regression analyses to identify factors linked to QoL changes. Second, it explored the transition probabilities of QoL between phases and their monetary value.</p></div><div><h3>Results</h3><p>Baseline QoL predominantly determined future QoL changes, with disease type, transplantation type, and other sociodemographic factors proving insignificant. Notably, patients with the lowest baseline QoL experienced greater QoL improvement post-HSCT compared to others. Specifically, 90% of patients elevated their QoL quartile within the first post-transplantation year, with over 20% reaching the highest quartile and an average QoL increase of 0.619. The incremental economic benefit for patients with poor baseline QoL, compared to those with high baseline QoL, was 56,880€.</p></div><div><h3>Conclusion</h3><p>This study provides new, useful, and relevant information on the evolution of the QoL of these patients. Our findings support that HSCT significantly enhances QoL for survivors with initially low QoL, while those with high pre-HSCT QoL maintain their levels. Furthermore, other factors were not significant contributors to this relationship. The study introduced a novel method to measure the economic benefit of incremental QoL.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of Deferoxamine With Cyclosporine Synergistically Blunt Renal Cold Ischemia-Reperfusion Injury in Rat Transplantation Model 去铁胺与环孢素联用可协同缓解大鼠移植模型的肾冷缺血再灌注损伤

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.035

{"title":"Combination of Deferoxamine With Cyclosporine Synergistically Blunt Renal Cold Ischemia-Reperfusion Injury in Rat Transplantation Model","authors":"","doi":"10.1016/j.transproceed.2024.08.035","DOIUrl":"10.1016/j.transproceed.2024.08.035","url":null,"abstract":"<div><h3>Objectives</h3><p>Ferroptosis plays a pivotal role in the pathogenesis of renal ischemia-reperfusion injury, where the processes are mediated by free ferrous ions and mitochondrial-released reactive oxygen species. However, the administration of high doses of cyclosporine A (CsA) or deferoxamine (DFO) poses a significant risk of renotoxicity. In contrast, low doses of DFO act as a ferrous iron chelator, and CsA functions as a mitochondrial reactive oxygen species blocker. This study aims to explore the potential protective effects of donor treatment with low-dose CsA, DFO, or their combination against ischemia-reperfusion injury during renal transplantation in a rat model.</p></div><div><h3>Materials and Methods</h3><p>In an ex vivo cold storage (CS) model utilizing renal slices, the impact of incorporating DFO, CsA, and a combination of both into the University of Wisconsin solution was assessed through the measurement of lactate dehydrogenase leakage. Additionally, their potential benefits were investigated in a rat donation after circulatory death (DCD) kidney transplant model, where the extent of damage was evaluated based on graft function, tubular necrosis, and inflammation.</p></div><div><h3>Results</h3><p>The co-administration of DFO and CsA effectively decreased the release of lactate dehydrogenase induced by CS ( <em><u>P</u></em> ≥ <u>.05</u>). In the in vivo model, this combined supplementation demonstrated a mitigating effect on reperfusion injury, evidenced by lower blood urea nitrogen levels and acute tubular necrosis scores compared to the control group <u>(all</u> <em><u>P</u></em> ≤ <u>.05)</u>. Furthermore, the combined treatment significantly reduced apoptotic levels compared to the control group <u>(</u><em><u>P</u></em> ≥ <u>.05)</u>.</p></div><div><h3>Conclusions</h3><p>The combined treatment with DFO and CsA mitigated the cold ischemia-reperfusion injury in the DCD kidney. Hence, this presents a new strategy for the CS of DCD kidney in clinical transplants.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the Radiological Response on Histological Necrosis and on the Survival of Patients Treated With Transarterial Chemoembolization for Hepatocellular Carcinoma Secondary to Cirrhosis on the Liver Transplantation Waiting List 经动脉化疗栓塞治疗肝细胞癌继发性肝硬化患者的放射学反应对组织学坏死和肝移植候诊患者生存期的影响。

IF 0.8 4区医学

Transplantation proceedings Pub Date : 2024-09-05 DOI: 10.1016/j.transproceed.2024.08.033

{"title":"Influence of the Radiological Response on Histological Necrosis and on the Survival of Patients Treated With Transarterial Chemoembolization for Hepatocellular Carcinoma Secondary to Cirrhosis on the Liver Transplantation Waiting List","authors":"","doi":"10.1016/j.transproceed.2024.08.033","DOIUrl":"10.1016/j.transproceed.2024.08.033","url":null,"abstract":"<div><h3>Background and Aims</h3><p>Transarterial chemoembolization is the most common treatment used for HCC patients on liver transplant waiting list. The aims of this study are to evaluate the radio-histological correlation of the post-chemoembolization HCC response and its influence on overall survival (OS) and recurrence-free survival (RFS).</p></div><div><h3>Methods</h3><p>Monocentric, retrospective study, including liver transplant patients with HCC who received chemoembolization from 2007 to 2018. The response of the hypervascular nodules was evaluated according to mRECIST, EASL.</p></div><div><h3>Results</h3><p>A total of 70 patients with 122 hypervascular and 28 hypovascular HCCs were included. A complete radiological response concerned 34.3% patients. Concordance rates of hypervascular nodules (mRECIST, EASL and lipiodol uptake) with tumor necrosis ranged from 49% to 57%, with a specificity of 35% and a positive predictive value of 54%. Bilobar involvement was a predictive factor for incomplete radiological response. Major tumor necrosis was significantly correlated with the decrease in αFP level between the first CEL and liver transplantation. OS and RFS at 5 years were 64% and 60%, respectively, and 69% and 66% at complete radiological response.</p></div><div><h3>Conclusion</h3><p>Radiological response is significantly related to histological tumor necrosis, but with poor prediction. In case of complete radiological response, OS and RFS seem to be improved.</p></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0041134524004688/pdfft?md5=9d6bce54a072962b159958676a16f82c&pid=1-s2.0-S0041134524004688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0