Transplantation proceedings最新文献

{"title":"Outcomes of Donor/Recipient Size-mismatched Lung Transplantation","authors":"Bong Suk Park ,&nbsp;Dae Joon Kim ,&nbsp;Chang Young Lee ,&nbsp;Byung Jo Park ,&nbsp;Ha Eun Kim ,&nbsp;Young Ho Yang ,&nbsp;Moo Suk Park ,&nbsp;Song Yee Kim ,&nbsp;A La Woo ,&nbsp;Eun Young Kim ,&nbsp;Jin Gu Lee","doi":"10.1016/j.transproceed.2025.04.008","DOIUrl":"10.1016/j.transproceed.2025.04.008","url":null,"abstract":"<div><h3>Background</h3><div>Donor/recipient (D/R) size matching is crucial to achieve proper organ allocation and outcome for lung transplantation (LT). However, studies in this regard have not shown consistent results. We analyzed the results of size-mismatched LT focusing on primary graft dysfunction (PGD) and survival.</div></div><div><h3>Methods</h3><div>A total of 446 patients underwent LT between January 2010 and December 2022. After exclusion, the patients were divided into 3 groups according to the donor/recipient size; D/R ratio &gt;120% was grouped as Over (n = 87), 120%≥D/R ratio≥80% was grouped as Normal (n = 271), 80%&gt;D/R was grouped as Under (n = 19). Early and long-term outcomes were analyzed.</div></div><div><h3>Results</h3><div>Recipient height, weight, and proportion of male were the highest in the Under group, followed by the Normal and Over groups (<em>P</em> &lt; 0.001). The ratio of extracorporeal membrane oxygenation weaning in the operating room was highest in the Under group, followed by the Normal and Over groups (<em>P</em> : 0.04). The proportions of PGD grade 3 within 48 h and 72 h were highest in the Over group, followed by the Normal and Under groups (<em>P :</em> 0.007 and 0.016, respectively). There was no statistical difference in the pulmonary function test results between the groups at 12 months postoperative follow-up. The 5-year survival rate did not differ among the groups (60.9% vs 56.8% vs 54.7%, Under vs Normal vs Over, <em>P :</em> 0.833)</div></div><div><h3>Conclusions</h3><div>Although oversized D/R-matched LT demonstrated late recovery during the early postoperative period, their long-term results were non-inferior in terms of the D/R size ratio.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 868-875"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bariatric Surgery as a Bridge for Renal Transplantation. An Age and BMI-Matched Pair Analysis","authors":"Mohamed H. Zahran ,&nbsp;Talal Khewater ,&nbsp;Mostafa Ayyad ,&nbsp;Ahmed Ali ,&nbsp;Mojahid Ghazi ,&nbsp;Ahmed Serageldeen ,&nbsp;Alaaelden Omar ,&nbsp;Zayed S. Aljohni ,&nbsp;Waad Albalawi ,&nbsp;Konstantinos Fourtounas ,&nbsp;Hussam Adi","doi":"10.1016/j.transproceed.2025.03.003","DOIUrl":"10.1016/j.transproceed.2025.03.003","url":null,"abstract":"<div><h3>Background</h3><div>Morbid obesity is a relative contraindication for renal transplantation (RT) and associated with increased perioperative complications and compromised graft survival. We aimed at evaluating the safety of bariatric surgery (BS) in patients with end-stage renal disease (ESRD) and its efficacy on improving access to RT and to compare RT outcomes to an age- and body mass index (BMI)-matched group.</div></div><div><h3>Methods</h3><div>This is a case-control study including eight patients with ESRD who underwent BS as a bridge before RT (group I). The primary outcome was to assess the safety and efficacy of BS. The secondary outcome was to assess the impact on RT outcomes, surgical complications, and long-term graft survival. The third outcome was to compare them to an age- and BMI-matched control group (group II, 16 patients).</div></div><div><h3>Results</h3><div>In group I, the median (IQR) BMI decreased from 41 (38-45) to 31 (28-33) kg/m² (<em>P</em> = .01) with absolute percent reduction of 24% after BS. Five out of seven patients with diabetes (71%) stopped taking insulin medication (<em>P</em> = .03). All patients with hypertension decreased their medications to a single drug (<em>P</em> = 0.03). Five patients (63%) underwent RT after 25 (5-45) months. All were discharged with functioning grafts with median serum creatinine of 81 (60-90) mmol/L and estimated glomerular filtration rate (eGFR) of 79 (61-91) mL/min/1.73m². One patient (20%) was reoperated for wound infection. After follow-up of 31 (8-62) months, all patients have a functioning graft. No statistically significant differences were identified between both groups in regard to post-operative complications and graft function at discharge and at the last follow-up (<em>P</em> &gt; .05).</div></div><div><h3>Conclusions</h3><div>BS is safe and effective in pre-transplant patients with obesity and associated with comparable RT outcomes to those without a history of BS.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 746-751"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Histologic Risk Factors for the Development of Early Allograft Dysfunction in Donation After Circulatory Death Kidney Transplantation","authors":"Jennifer Loza ,&nbsp;Karima Alghannam ,&nbsp;Brian Howard ,&nbsp;Fransia De Leon ,&nbsp;Jeffrey Fine ,&nbsp;Aileen X. Wang ,&nbsp;Kuang-Yu Jen ,&nbsp;Naeem Goussous ,&nbsp;Junichiro Sageshima ,&nbsp;Richard V. Perez ,&nbsp;Peter A. Than","doi":"10.1016/j.transproceed.2025.03.022","DOIUrl":"10.1016/j.transproceed.2025.03.022","url":null,"abstract":"<div><div>Transplantation of kidneys from donors after circulatory death (DCD) may help address the severe shortage of donor organs. However, they remain underutilized due to concerns for increased rates of delayed graft function (DGF) and primary nonfunction (PNF), despite similar long-term patient and allograft outcomes compared to kidneys from donors after brain death (DBD). Kidneys that recover from DGF have good long-term outcomes compared to those resulting in PNF. Considering immediate graft function (IGF), DGF, and PNF as a spectrum of renal allograft injury and recovery, we analyzed donor and recipient characteristics and corresponding time-zero biopsy findings for adult DCD kidney transplants at our center from 2016 to 2021. We compared transplants resulting in DGF with subsequent allograft recovery compared to those progressing to PNF as well as to grafts that functioned immediately. We found 344 patients received DCD kidneys with 153 resulting in DGF with renal recovery by 90-days post-transplant. Excluding surgical complications, 22 patients developed PNF and required ongoing maintenance dialysis after 90-days post-transplant and 169 patients had immediate graft function. Kidney Donor Profile Index ≥85% and donor history of diabetes and hypertension were associated with PNF. Cold and warm ischemia time, donor acute kidney injury, and use of hypothermic machine perfusion were not significantly different between the groups. Formalin-fixed paraffin embedded renal allograft time-zero biopsies demonstrated that increasing severity of donor-derived vascular disease present at the time of transplant were associated with the development of early allograft failure. These findings help define clinical characteristics important in kidney allograft selection.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 764-770"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination and Comparison of the Attitudes of Nursing and Theology Students Toward Organ Donation: Descriptive and Cross-Sectional Study","authors":"Ahmet Göktaş,&nbsp;Şerafettin Okutan,&nbsp;Cihan Önen","doi":"10.1016/j.transproceed.2025.03.011","DOIUrl":"10.1016/j.transproceed.2025.03.011","url":null,"abstract":"<div><div>This study was conducted to determine and compare the attitudes of nursing and Theology students toward organ donation. This descriptive and cross-sectional study was conducted with 350 nursing and Theology students in Türkiye. An Information Form and the Organ Donation Attitudes Scale were used for data collection. Data were analyzed using the SPSS 26.0 software. The mean age of the students participating in the study was 22.59 ± 4.48 years, and 66% were female. 55.7% of the students were Theology students, and 44.3% were nursing students. The mean score for humanity and moral conviction was 92.43 ± 20.72, the mean score for fears of medical neglect was 28.89 ± 9.98, and the mean score for fears of bodily mutilation was 32.13 ± 10.21. It was found that nursing students' positive attitudes (humanity and moral conviction) toward organ donation were significantly higher, and negative attitudes (fears of medical neglect and fears of bodily mutilation) were significantly lower than Theology students (<em>P</em> &lt; .05). The students' attitudes toward humanity and moral conviction regarding organ donation are positive, while their attitudes toward fears of medical neglect and bodily mutilation are negative. Nursing students' attitudes toward both humanity and moral conviction, and fears of medical neglect and bodily mutilation are more positive than the attitudes of Theology students. It is recommended that informative training on organ donation and transplantation processes should be organized in cooperation with nurses and religious leaders.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 689-697"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-Analysis and Clinical Guidance of Oxygenated Hypothermic Machine Perfusion for Kidney Transplantation","authors":"Degong Jia ,&nbsp;Shanshan Guo ,&nbsp;Jiefu Luo ,&nbsp;Yuezhou Zhang ,&nbsp;Huiqing Zhang ,&nbsp;Shengwei ,&nbsp;Junyan Liu","doi":"10.1016/j.transproceed.2025.03.006","DOIUrl":"10.1016/j.transproceed.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>It remains unclear whether oxygenated hypothermic machine perfusion (HMPO₂) during kidney preservation is beneficial for prognosis.</div></div><div><h3>Methods</h3><div>A comprehensive search of databases and clinical trial registries was conducted to identify eligible studies on HMPO₂ application during kidney transplantation. A multisubgroup analysis was further conducted to explore the heterogeneity among studies.</div></div><div><h3>Results</h3><div>Compared to the control treatment, HMPO₂ did not significantly alter the incidence of postoperative acute rejection, graft survival, patient mortality, delayed graft function (DGF), functional DGF, primary nonfunction, or estimated glomerular filtration rate, whereas the warm ischemia time appeared to be longer. However, the number of patients with adverse events and the proportion of severe adverse events were reduced in the HMPO₂ group. Subgroup analysis indicated that HMPO₂ performed better in donation after cardiac death (DCD), and continuous HMPO₂ was superior to end-HMPO₂.</div></div><div><h3>Conclusion</h3><div>HMPO₂ application during kidney transplantation reduced the number of patients with adverse events and the proportion of severe adverse events. However, given the issue such as limited number of studies and heterogeneity, rigorous evidence studies are needed to further confirm these findings.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 752-763"},"PeriodicalIF":0.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alirocumab in Adult Patients With Hyperlipidemia After Liver Transplantation: A Short-term Observation","authors":"Tieyan Fan ,&nbsp;Yan Yan ,&nbsp;Jingyue Wang ,&nbsp;Jun Li ,&nbsp;Guangxun Xu ,&nbsp;Qian Lu ,&nbsp;Hong Chen","doi":"10.1016/j.transproceed.2025.04.005","DOIUrl":"10.1016/j.transproceed.2025.04.005","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the clinical efficacy of alirocumab in postoperative hyperlipidemia among liver transplant recipients.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of clinical data from liver transplant recipients with postoperative hyperlipidemia who received alirocumab treatment at our institution.</div></div><div><h3>Results</h3><div>Seventeen cases were observed, with a male-to-female ratio of 12:5. Patient ages ranged from 44 to 65 years, with an average age of 55.47 years. The initiation of alirocumab treatment occurred between 1 and 196 months postliver transplantation, averaging 44.88 months. Treatment duration was a minimum of 3 months. The levels of blood lipids were assessed at 4, 8, and 12 weeks during the treatment regimen. At 8 weeks, a statistically significant reduction in total cholesterol was recorded (<em>P = .012</em>), and this decrease was further pronounced at 12 weeks (<em>P = .004</em>). For LDL cholesterol, significant decreases were evident at 4 weeks (<em>P = .011</em>), 8 weeks (<em>P = .005</em>), and 12 weeks (<em>P = .004</em>). No significant changes were observed in high-density lipoprotein (HDL) cholesterol and triglyceride levels throughout the study period. In addition, all patients maintained stable liver function and immunosuppressant concentrations.</div></div><div><h3>Conclusions</h3><div>Alirocumab demonstrated a significant reduction in total cholesterol and low-density lipoprotein cholesterol levels among liver transplant recipients, with no observed increase in the risk of rejection. This suggests the potential effectiveness of alirocumab as a lipid-lowering therapy in liver transplant recipients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 810-815"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Thyroid Hormones on Brain-Dead Organ Donors: A Systematic Review and Meta-Analysis","authors":"Luís Fernando Ferreira Cavalcante ,&nbsp;Alonzo Armani Prata ,&nbsp;Caio Rezende Lima ,&nbsp;Gabriela Blanco Stutz ,&nbsp;Thalia Melamed ,&nbsp;Paulo Ricardo Gessolo Lins ,&nbsp;Alexandra Régia Dantas Brígido","doi":"10.1016/j.transproceed.2025.03.028","DOIUrl":"10.1016/j.transproceed.2025.03.028","url":null,"abstract":"<div><h3>Introduction</h3><div>The administration of thyroid hormones (TH) in brain-dead donors has been proposed as a strategy to improve organ viability for transplantation, addressing the neuroendocrine insufficiency caused by brain death. While evidence suggests potential benefits, such as hemodynamic stabilization and enhanced organ function, the impact of TH replacement on donor utilization rates and transplant outcomes remains unclear.</div></div><div><h3>Methods</h3><div>We performed a systematic review and meta-analysis of randomized controlled trials (RCT) comparing TH administration with placebo or standard-of-care. Mean differences (MD) and risk ratios (RR) with 95% confidence intervals (CI) were pooled using a random-effects model, and Heterogeneity was assessed using I².</div></div><div><h3>Results</h3><div>Six studies involving a total of 1,197 brain-dead organ donors were included. Of these, 601 received TH, while 597 were given either a placebo or standard-of-care treatment. Overall, the number of transplanted hearts (RR 0.99; 95% CI 0.84-1.17; <em>P =</em> .92), lungs (RR 1.07; 95% CI 0.65-1.75; p 0.80), and livers (RR 1.00; 95% CI 0.78-1.28; <em>P =</em> .99) was similar between groups. Cardiac index showed no significant difference between groups (MD –0.05; 95% CI –0.28 to 0.19; <em>P =</em> .71), and similar trends were observed for other hemodynamic parameters, including heart rate (MD 5.11; 95% CI –1.47 to 11.69; <em>P =</em> .13), pulmonary capillary wedge pressure (MD -0.02; 95% CI –1.54 to 1.50; <em>P =</em> .98), and central venous pressure (MD 0.76; 95% CI –0.63 to 2.14; <em>P =</em> .28), indicating that TH administration did not significantly alter these measures compared to placebo or standard-of-care treatment.</div></div><div><h3>Conclusion</h3><div>Our data suggest that administering TH to brain-dead potential organ donors does not effectively increase the number of organ transplants and has no impact on hemodynamic parameters.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 698-705"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to Remove Tracheal Intubation During ECMO Support in Lung Transplant Patients With Idiopathic Pulmonary Fibrosis","authors":"Jing Tian,&nbsp;Ke Jin,&nbsp;Yan Dong,&nbsp;Hongyang Xu","doi":"10.1016/j.transproceed.2025.03.026","DOIUrl":"10.1016/j.transproceed.2025.03.026","url":null,"abstract":"<div><h3>Background</h3><div>Lung transplantation is the optimal treatment choice, while extracorporeal membrane oxygenation (ECMO) provides cardiopulmonary support during the perioperative period of lung transplantation. Currently, there is no reported research on the ECMO withdrawal and duration of mechanical ventilation (MV) in idiopathic pulmonary fibrosis (IPF) patients undergoing lung transplantation. Therefore, this study aims to evaluate the impact of ECMO duration on prolonged mechanical ventilation (PMV) time in patients, attempting to explore the relationship between the two.</div></div><div><h3>Methods</h3><div>This study included 170 patients with IPF who underwent lung transplantation under ECMO technology. The patients were divided into normal and delayed groups based on the ECMO application time of 72 hours. A multifactor logistic regression analysis was conducted to explore the independent risk factors for PMV time, and restricted cubic spline (RCS) was used to investigate the relationship between ECMO application time and MV time. Receptor operating characteristics (ROC) were further used to find the cut-off value of ECMO application time to predict PMV time.</div></div><div><h3>Results</h3><div>In the normal group, there were 135 cases, of which 79.25% (107 cases) were males and 20.74% (28 cases) were females, whereas in the delayed group, there were 35 cases, of which 57.14% (20 cases) were males and 42.86% (15 cases) were females. In the RCS curves, there was a nonlinear correlation between the duration of ECMO application and the duration of MV, which tended to increase as the duration of ECMO application increased. According to univariate and multivariate logistic analyses, ECMO application time was an influential factor in the occurrence of PMV time, in which the OR of PMV time was 2.02 (95% CI 1.11,1.63, <em>P</em> = .001) when ECMO application time was ≥ 52.01 hours.</div></div><div><h3>Conclusion</h3><div>After lung transplantation, there is a nonlinear relationship between the application time of ECMO and MV time in patients with IPF. The application time of ECMO can predict well the extension of MV in patients during ICU stay. Therefore, clinicians can assess the duration of MV in patients with IPF based on the application time of ECMO, further avoiding complications related to MV.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 876-884"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echinococcal Liver Infections: Comparing Transplant Strategies for Granulosus and Alveolaris","authors":"Yazici Sinan Efe ,&nbsp;Atasever Ahmet ,&nbsp;Turan Ebru ,&nbsp;Sahin Tolga ,&nbsp;Yuzer Yildiray","doi":"10.1016/j.transproceed.2025.04.006","DOIUrl":"10.1016/j.transproceed.2025.04.006","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate liver transplantation strategies for patients with <em>Echinococcus granulosus</em> (EG) and <em>Echinococcus alveolaris</em> (EA), comparing surgical approaches, complications, and outcomes in both groups.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 11 patients who underwent liver transplantation for EG or EA at our center between 2006 and 2024. Patient data included demographics, surgical details, preoperative and postoperative management, and follow-up outcomes.</div></div><div><h3>Results</h3><div>All EG patients presented with cirrhosis, primarily due to treatment-related complications, while EA patients exhibited diffuse parenchymal and hilar involvement. Transplantation in EG cases was performed to address complications, whereas EA cases required transplantation due to the disease’s malignant behavior and advanced liver involvement. All patients underwent living donor liver transplantation, with inferior vena cava (IVC) plasty performed in 2 EA patients. No recurrence was observed in either group during follow-up. Mortality was reported in 2 EG patients: 1 due to early postoperative complications and another from leukemia 2 years post-transplant. EA patients achieved excellent outcomes, with no mortality or recurrence observed during a mean follow-up period of 10 years.</div></div><div><h3>Conclusions</h3><div>Liver transplantation is a safe and effective treatment for EG and EA, requiring distinct strategies tailored to each disease. EG transplants are typically performed to manage complications, whereas EA transplants necessitate advanced surgical techniques, including minimal liver manipulation and IVC plasty. These findings emphasize the critical role of specialized centers and tailored strategies in managing complex echinococcal liver infections.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 916-921"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Web-Based Education on Symptoms and Adherence To Immunosuppressive Medications In Liver Transplant Patients","authors":"Nihal Dolanbay ,&nbsp;Meral Ozkan","doi":"10.1016/j.transproceed.2025.03.005","DOIUrl":"10.1016/j.transproceed.2025.03.005","url":null,"abstract":"<div><h3>Aim</h3><div>Liver transplant patients experience several symptoms associated with immunosuppressive medications and have problems in medication adherence. This study aims to examine the effect of web-based education on symptoms and adherence to immunosuppressive medications in liver transplant patients.</div></div><div><h3>Materials and Methods</h3><div>This is a randomized controlled trial study. The population of the study consisted of patients who had liver transplantation in a university hospital at least 2 months and at most 2 years before the interview (N = 116). The sample of the study consisted of a total of 90 liver transplant patients who were determined by a power analysis. The data were collected between January and July 2021 using a patient information form, the Modified Transplant Symptom Occurrence and Symptom Distress Scale-59 Items (MTSOSD-59), and the Immunosuppressive Medication Adherence Scale (IMAS).</div></div><div><h3>Results</h3><div>Liver transplant patients in the experimental group were given a web-based education for 1 month. After the education, a significant decrease was observed in their symptom’s occurrence and discomfort with symptoms scores and a significant increase in their immunosuppressive medication adherence scores, compared to that of those in the control group (<em>P &lt;</em> .05).</div></div><div><h3>Conclusion</h3><div>As a result, the web-based education reduced the symptoms and discomfort associated with immunosuppressive medications in liver transplant patients and increased their immunosuppressive medication adherence.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 5","pages":"Pages 803-809"},"PeriodicalIF":0.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}