Transplantation proceedings最新文献

{"title":"Intraoperative Mean Arterial Pressure in Relation to Delayed Graft Function in Living-Donor Kidney Transplantation","authors":"Chinnarat Pongpruksa ,&nbsp;Nutchanok Khampitak ,&nbsp;Suphamai Bunnapradist ,&nbsp;Victor W. Xia","doi":"10.1016/j.transproceed.2025.12.014","DOIUrl":"10.1016/j.transproceed.2025.12.014","url":null,"abstract":"<div><h3>Background</h3><div>Maintaining optimal kidney graft perfusion is a primary goal of intraoperative kidney transplant care, which is often monitored by mean arterial blood pressure (MAP). Delayed graft function (DGF) is a significant complication that is associated with long-term outcomes. The goal of this study is to study the association of various MAP thresholds and the risk of DGF in adult patients undergoing living-donor kidney transplant.</div></div><div><h3>Methods</h3><div>We collected data from the UCLA data warehouse between 2013 and 2024. We analyzed MAP at various thresholds and associated cumulative minutes during the pre- and postreperfusion periods. DGF, defined by dialysis within 7 days of KT, was the primary outcome.</div></div><div><h3>Results</h3><div>This study comprised 1314 patients. The DGF rate was 5.0%. Forty-two percent experienced at least 1 minute of MAP threshold at ≤60 mm Hg. Those with DGF had longer minutes spent on the MAP thresholds of ≤60 to 85. Adjusted durations of postreperfusion MAP ≤60, 65, 70, 75, 80, and 85 mm Hg associated with the DGF started from 3, 15, 20, 10, 25, and 25 minutes, in that order.</div></div><div><h3>Conclusion</h3><div>We found an association between intraoperative MAP ≤85 mm Hg and DGF. The minimal duration for postreperfusion ≤60 and ≤85 mm Hg associated with DGF was 3 and 25 minutes, respectively.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 45-51"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘Donor-derived bacterial infections in deceased donor liver transplantation: reassessment of risk in the era of marginal grafts’ [Transplantation Proceedings 57(5) (2025) 823–832]","authors":"Caterina Accardo ,&nbsp;Ivan Vella ,&nbsp;Sergio LiPetri ,&nbsp;Duilio Pagano ,&nbsp;Fabrizio di Francesco ,&nbsp;Alessandra Mularoni ,&nbsp;Marco Barbàra ,&nbsp;Marco Canzonieri ,&nbsp;Paolo Grossi ,&nbsp;Salvatore Gruttadauria","doi":"10.1016/j.transproceed.2025.12.015","DOIUrl":"10.1016/j.transproceed.2025.12.015","url":null,"abstract":"","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Page 229"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Analysis of the Correlation Between Intimate Relationships and Caregiver Strain in Spouses of Kidney Transplant Recipients","authors":"Qiaoling Jiang,&nbsp;Fang Xiao,&nbsp;Hao Chen,&nbsp;Ruoyun Tan,&nbsp;Xuejing Wang,&nbsp;Ting Lu","doi":"10.1016/j.transproceed.2025.11.003","DOIUrl":"10.1016/j.transproceed.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>Examine the existing dynamics of intimate relationships between kidney transplant recipients and their spouses, assess its relationship with the hardship of spousal caring, and establish a foundation for the creation of pertinent interventions to mitigate caregiving burdens.</div></div><div><h3>Methods</h3><div>A convenience sampling method was employed to select 76 pairs of recipients and spouses who were consistently monitored postkidney transplantation at a tertiary hospital in Nanjing, Jiangsu Province, China, utilizing a general information questionnaire, the Intimate Bond Measure (IBM), Lock–Wallace Marital Adjustment Test (MAT), Zarit Caregiver Burden Interview (ZBI) and Distress Thermometer (DT) for a cross-sectional study.</div></div><div><h3>Results</h3><div>The IBM scores for kidney transplant recipients and their spouses were (40.86 ± 8.05) and (41.09 ± 7.79), respectively, indicating a moderate level of marital intimacy. The MAT scores for recipients and spouses were (122.38 ± 27.08) and (121.76 ± 22.73), respectively, with 80.26% demonstrating good marital adjustment. The spouses’ total ZBI score was (19.30 ± 10.98), reflecting a mildly burdensome level. The total DT score for spouses was 3.12 ± 2.30, with 26.32% exhibiting psychological disturbances requiring further evaluation and treatment. Correlation analysis indicated a negative relationship between spousal intimacy and spousal care burden (<em>P</em> &lt; .01). Multiple linear regression analysis revealed that four variables—income level of kidney transplant recipients, duration of recipients’ illness, frequency of intimacy behaviors, and degree of spousal psychological distress—were included in the regression equation, collectively accounting for 77.9% of the total variance in spousal care burden (<em>P</em> &lt; .001).</div></div><div><h3>Conclusion</h3><div>The intimacy between spouses in kidney transplant recipients is inversely related to the stress of caregiving experienced by the spouse. Healthcare professionals should underscore the beneficial role of spouses in therapeutic care, implementing strategies to enhance spousal intimacy and alleviate caregiving burdens, thereby improving the quality of spousal care and the survival outcomes of kidney transplant recipients.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 37-44"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Intraoperative Blood Loss in Living Donor Liver Transplantation","authors":"Kaoru Umehara ,&nbsp;Kazuhiro Shirozu ,&nbsp;Ken Yamaura","doi":"10.1016/j.transproceed.2025.11.007","DOIUrl":"10.1016/j.transproceed.2025.11.007","url":null,"abstract":"<div><h3>Background</h3><div>Although several studies have assessed factors associated with intraoperative blood loss (IBL) during liver transplantation, most have been conducted on brain-dead donors, with few studies on living donors that have reported inconsistent findings. This study retrospectively investigated factors associated with IBL in living-donor liver transplantation (LDLT).</div></div><div><h3>Methods</h3><div>This study included 250 patients aged ≥20 years who underwent LDLT at our institution between January 2013 and September 2018. IBL, obtained from anesthetic records, was subjected to log-transformation and analyzed using a general linear regression model. The backward method was used for variable selection and the values were exponentially transformed to describe the results.</div></div><div><h3>Results</h3><div>Multivariable analysis revealed that male sex (vs female, 1.37-fold, 95% confidence interval (CI): 1.14-1.66), body mass index (BMI) (1.05-fold for every 1 kg/m² increase, 95% CI: 1.03-1.08), platelet count (0.98-fold for every 10,000/µL increase, 95% CI: 0.96-0.99), white blood cell (WBC) count (1.04-fold for every 1000/µL increase, 95% CI: 1.002-1.08), serum sodium ion (Na⁺) levels (0.96-fold for every 1 mEq/L increase, 95% CI: 0.94-0.98), serum total protein (TP) (0.88-fold for every 1 g/dL increase, 95% CI: 0.79-0.98), and use of a venous bypass (vs nonuse, 1.96-fold, 95% CI: 1.01-3.73) were significantly associated with IBL.</div></div><div><h3>Conclusions</h3><div>Male sex, high BMI, low platelet count, high WBC count, low Na⁺ levels, low TP levels, and the use of venous bypass can lead to excessive IBL during LDLT. Preoperative assessment of these factors is crucial for perioperative management.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 145-150"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness Study of Bundle Maintenance Strategies in Donor Lung Quality Improvement","authors":"Chao Wang ,&nbsp;Xue Bai ,&nbsp;Jie Lu,&nbsp;Guoqiang Qie,&nbsp;Guangyun Liu,&nbsp;Zijian Tai,&nbsp;Ruiqi Ding,&nbsp;Qianqian Guo,&nbsp;Qi Wang,&nbsp;Congcong Liu,&nbsp;Xiaoxia Sun,&nbsp;Jicheng Zhang","doi":"10.1016/j.transproceed.2025.12.004","DOIUrl":"10.1016/j.transproceed.2025.12.004","url":null,"abstract":"<div><div>To assess the efficacy of a bundle donor lung maintenance strategy in enhancing donor lung quality for transplantation. This retrospective study analyzed 155 potential lung donors admitted to Shandong Provincial Hospital (2022-2024). After excluding 76 cases meeting absolute exclusion criteria, 79 donors received a bundle maintenance protocol, including fluid management, targeted anti-infection therapy, airway care, lung-protective ventilation, and VAP prevention. Outcomes were evaluated by comparing pre- and post-maintenance oxygenation index (PaO₂/FiO₂), lactate levels, infection markers (WBC, PCT, IL-6), and transplantable lung rates. Subgroup analysis compared outcomes between prone and nonprone positioning during maintenance. Post-intervention, oxygenation index increased by 77.25% (<em>P</em> &lt; .01), with lactate reduced by 33.33% (<em>P</em> &lt; .01). Infection markers improved significantly: WBC (-16.42%), PCT (-50%), and IL-6 (-61.30%) (<em>P</em> &lt; .01). Transplantable lung rates rose from 49.37% to 87.34% (χ² = 28.03, <em>P</em> &lt; .01), converting 75% of initially nontransplantable lungs. Prone positioning further amplified benefits: ΔOI improvement (median 214 vs 148, <em>P</em> &lt; .01) and 83.33% oxygenation enhancement (<em>P</em> &lt; .01). The bundle strategy effectively optimizes donor lung quality, increasing transplantable grafts by 37.97% and demonstrating the added value of prone positioning. These findings advocate for standardized protocols to address donor shortages while ensuring transplant success.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 177-185"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145936926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Biliary Complications in Pediatric Liver Transplantation: Is There a Role of Anastomosis Type and Epstein–Barr Virus Viremia?","authors":"Cansu Altuntaş ,&nbsp;Alaaddin Aydın ,&nbsp;Ali Koçyiğit ,&nbsp;Eryiğit Eren ,&nbsp;Fatih Ensaroğlu ,&nbsp;Mehmet Tokaç ,&nbsp;Gülden Özek ,&nbsp;Taylan Şahin ,&nbsp;Ayhan Dinçkan","doi":"10.1016/j.transproceed.2025.11.004","DOIUrl":"10.1016/j.transproceed.2025.11.004","url":null,"abstract":"<div><h3>Background</h3><div>Biliary complications remain a common adverse event after pediatric liver transplantation, with distinct etiologies and management approaches based on timing. This study aimed to evaluate the incidence, risk factors, and outcomes of early and late biliary complications in a high-volume living donor pediatric liver transplant center.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 98 pediatric liver transplantations performed between January 2018 and February 2024. Biliary complications were categorized as early (≤90 days) or late (&gt;90 days) post-transplant. Risk factors were assessed using univariate and multivariable logistic regression models. The impact of biliary complications on overall survival was also evaluated.</div></div><div><h3>Results</h3><div>Biliary complications occurred in 34.6% (n = 34) of cases. Early complications (19.4%, n = 19) were predominantly bile leaks, with duct-to-duct anastomosis identified as an independent risk factor (OR: 5.179, 95% CI: 1.511-17.756). Late complications (15.3%, n = 15) were primarily biliary strictures. Older recipient age and EBV viremia emerged as significant independent risk factors for late biliary complications (OR: 1.140 and OR: 60.793, respectively). No significant difference in overall survival was observed between patients with and without biliary complications (<em>P</em> = .158).</div></div><div><h3>Conclusion</h3><div>Duct-to-duct anastomosis remains a safe and reliable option in anatomically suitable pediatric cases when performed by experienced teams, despite a higher risk of early complications. EBV viremia and increased recipient age are significant predictors of late biliary strictures. These findings emphasize the need for vigilant surveillance, individualized transplant timing, and standardized EBV management strategies to reduce long-term biliary morbidity.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 137-144"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145919587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single Center Retrospective Comparison of Post-Transplant Cyclophosphamide and Standard Graft-Versus-Host Disease Prophylaxis in Matched Donor Allogeneic Transplantation","authors":"Haein Kim ,&nbsp;Akil Merchant ,&nbsp;Justin Darrah ,&nbsp;Joshua Sasine ,&nbsp;Hannah Lee ,&nbsp;Robert Vescio ,&nbsp;David Oveisi ,&nbsp;Brittany McGalliard ,&nbsp;Yuliya Linhares ,&nbsp;Ali Rejali ,&nbsp;Patricia Van Strein ,&nbsp;Ellen Klapper ,&nbsp;Behrooz Hekimian ,&nbsp;John Chute ,&nbsp;Ron Paquette ,&nbsp;Noah Merin","doi":"10.1016/j.transproceed.2025.12.008","DOIUrl":"10.1016/j.transproceed.2025.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Post-transplant cyclophosphamide (PTCy) was developed to allow the use of haploidentical donors for allogeneic stem cell transplantation (alloHSCT), then tested with matched donors. Cedars-Sinai Medical Center Blood and Marrow Transplant was an early adopter of PTCy for matched alloHSCT in 2016.</div></div><div><h3>Purpose of the Research</h3><div>We retrospectively analyzed 15-year outcomes of patients who underwent alloHSCT with matched donor stem cells prior to 2016 (n = 252), with the outcomes of patients who were transplanted in the PTCy era, post-2016 (n = 99), to assess the impact of the switch to PTCy, while controlling for other differences between the cohorts.</div></div><div><h3>Principle Results</h3><div>Overall Survival (OS) was better in the PTCy group (at 1 year, 90% vs 62%, <em>P</em> &lt; .0001), and the difference persisted in OS at 2 years and 3 years. There was no difference in relapse (26% non-PTCy vs 19% PTCy; <em>P</em> = .3560). Non-relapse mortality was lower with PTCy, 7% vs 22% without, <em>P</em> = .0002. Acute GVHD was lower in the PTCy group (16% PTCy vs 33% non-PTCy, <em>P</em> = .0013). Chronic GVHD was similar between the two groups, 35% in the PTCy group and 42% in the non-PTCy group (<em>P</em> = .1235), but the rate of extensive cGVHD was lower, 15% with PTCy vs 29% without; <em>P</em> = .0078. Post-transplant hospital stay was shorter, 23 ± 13.1 days in the non-PTCy group and 18 ± 7.0 days with PTCy, <em>P</em> &lt; .0001.</div></div><div><h3>Conclusions</h3><div>Long-term follow up of patients transplanted using PTCy with matched donors has demonstrated superiority of PTCy compared to tacrolimus methotrexate.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 207-218"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoglobulin Induction Therapy in Kidney Transplant Patients Receiving Organs Donated after Cardiac Death in China: A Real-World Patient-Level Pooled Analysis of the T-DCD and Start-DCD Studies","authors":"Yang Li,&nbsp;Wujun Xue","doi":"10.1016/j.transproceed.2025.11.002","DOIUrl":"10.1016/j.transproceed.2025.11.002","url":null,"abstract":"<div><h3>Background</h3><div>Thymoglobulin is used in kidney transplantation as an induction therapy to prevent acute rejections; however, studies and data to support thymoglobulin induction therapy in Chinese patients undergoing kidney transplant with donation after cardiac death (DCD) kidneys remain unclear. Therefore, we investigated the clinical outcomes of thymoglobulin induction therapy in recipients of DCD kidney transplant in real-world clinical practice.</div></div><div><h3>Methods</h3><div>This pooled analysis from the T-DCD and START-DCD studies was conducted to investigate acute rejection (AR), biopsy-proven AR (BPAR), delayed graft function (DGF), and graft and patient survival at 6 months in patients undergoing DCD kidney transplantation in the pooled population, in subgroups receiving thymoglobulin doses of &lt;4 mg/kg and ≥4 mg/kg, and in subgroups receiving thymoglobulin doses of &lt;1.5 mg/kg, 1.5 mg/kg to 4 mg/kg, and ≥4 mg/kg. Possible risk factors for AR, BPAR, DGF, graft survival, and patient survival were investigated as well.</div></div><div><h3>Results</h3><div>A total of 458 patients were included in this study. The incidence of AR within 6 months was 8% (n = 10) in patients receiving &lt;4 mg/kg of thymoglobulin and 10.5% (n = 35) in those receiving ≥4 mg/kg. The dose-dependent incidence of BPAR was 3.1% in patients receiving a thymoglobulin dose &lt;1.5 mg/kg, 2.3% in those receiving 1.5 to 4 mg/kg, and 1.6% in those receiving ≥4 mg/kg. In these 3 subgroups, a statistically significant reduction in DGF incidence (<em>P</em> = .023) was observed in 21.9%, 15.9%, and 7.2% of patients, respectively. The overall graft survival and patient survival rates at 6 months were 98% and 99.56%, respectively. The possible risk factors for AR were donor or recipient age, those for DGF were baseline creatinine and dosage, and those for graft survival were donor body mass index, warm ischemia time, thymoglobulin dosage, and donor history of cardiopulmonary resuscitation.</div></div><div><h3>Conclusion</h3><div>Based on a pooled analysis of the T-DCD and START-DCD data in Chinese patients, treatment with thymoglobulin as an induction therapy has shown greater dose-dependent protection against DGF within 6 months after kidney transplantation. The higher thymoglobulin dose did not prolong the duration or reduce the incidence of AR and BPAR and showed no significant effect on graft survival or patient survival within 6 months of transplantation.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 28-36"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality Estimation in Renal Disease (MERD Score): A Model Predicting Waitlist Mortality in Kidney Transplant Candidates","authors":"Aisha Albu Mustaf ,&nbsp;Jose Ramirez ,&nbsp;Ashley Montgomery ,&nbsp;Gwendolyn Henry ,&nbsp;Abbas Rana","doi":"10.1016/j.transproceed.2025.11.010","DOIUrl":"10.1016/j.transproceed.2025.11.010","url":null,"abstract":"<div><h3>Background</h3><div>Predicting waitlist mortality is important for prioritizing organ allocation and selecting candidates for extended criteria donors. Currently, there is no widely adopted and reliable index for predicting early mortality among kidney transplant candidates. In this study, we aim to develop an index score utilizing variables from the OPTN database to predict mortality among adult kidney transplant candidates within 3 years of being on the waitlist.</div></div><div><h3>Methods</h3><div>This study utilized data from 147,307 adult kidney transplant candidates listed in the OPTN database from 2018 to 2023. The cohort was randomly divided into training and validation groups. Sixteen variables were analyzed using univariate logistic regression, with significant factors incorporated into a multivariable analysis to develop the MERD (Mortality Estimation in Renal Disease) score. Predictive performance was assessed through ROC analysis in both cohorts.</div></div><div><h3>Results</h3><div><u>T</u>en variables, age, ABO blood type, ethnicity, dialysis duration, presence of peripheral vascular disease, albumin level, functional status, Previous kidney malignancy, primary etiologies of kidney disease, and insurance type were identified as significant predictors and used to formulate the MERD score. The AUC was 0.6657 in the training cohort and 0.6580 in the validation cohort.</div></div><div><h3>Conclusion</h3><div>The MERD score provides proof of concept for short-term mortality prediction for kidney transplant waitlist candidates. Further prospective validation and model refinement are warranted.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 83-93"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Patient Symptoms After Kidney Transplantation","authors":"Catherine P. King ,&nbsp;Amelia R. Cossart ,&nbsp;Nicole M. Isbel ,&nbsp;Scott B. Campbell ,&nbsp;Meng-Wong Taing ,&nbsp;Diana Leary ,&nbsp;Vincent Houlihan ,&nbsp;Christine E. Staatz","doi":"10.1016/j.transproceed.2025.11.005","DOIUrl":"10.1016/j.transproceed.2025.11.005","url":null,"abstract":"<div><h3>Background</h3><div>Immunosuppressant usage in kidney transplant recipients is commonly associated with toxicity which can manifest in a variety of adverse effects. This study aimed to compare the nature and frequency of patient-reported symptoms before and after kidney transplantation.</div></div><div><h3>Methods</h3><div>A single-center study was conducted involving adult kidney transplant recipients at 3 to 11 weeks post-transplantation. Patients completed a questionnaire pertaining to the prevalence of symptoms experienced a few months before and since transplantation. A paired Student’s t-test and Wilcoxon signed-rank tests were used to identify changes in the number and frequency of symptoms, respectively, with a <em>p</em>-value &lt;.05 considered statistically significant.</div></div><div><h3>Results</h3><div>Eighty patients completed this non-interventional study. While a similar number of symptoms (mean ± standard deviation) were experienced before and after transplantation (9.9 ± 4.8 and 9.0 ± 4.7, respectively; <em>p</em> = .098) there was a shift in the frequency of symptoms. Since transplantation, there was an improvement (reduced frequency) in itch (<em>p</em> ≤ .001), tiredness/fatigue (<em>p</em> = .045), nausea (<em>p</em> ≤ .001), headache/migraine (<em>p</em> ≤ .001), fidgetiness/restlessness (<em>p</em> = .018) and mind going blank (<em>p</em> = .022). However, hand tremor (<em>p</em> ≤.001), tremor elsewhere (<em>p</em> ≤.001), waking at night (<em>p</em> ≤.001), and dysesthesia (thermodysregulation and paresthesia) (<em>p</em> = .008) worsened (increased frequency), as reported by 75%, 26%, 45%, and 38% of patients, respectively.</div></div><div><h3>Conclusion</h3><div>Many patients experience tremor and dysesthesia as new symptoms or report them more frequently early after transplantation. Further research into understanding and managing these toxicities over this period is warranted.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"58 1","pages":"Pages 58-65"},"PeriodicalIF":0.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}