活体肾供者的代谢特征：一年分析

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-09-01 DOI:10.1016/j.transproceed.2025.07.013

Ana Cunha , Maria Rita Dias , Henrique Borges , Joana Pereira Dias , Bárbara Beirão , Beatriz Gil Braga , José Silvano , Catarina Ribeiro , Manuela Almeida , Jorge Malheiro , Sofia Pedroso , La Salete Martins

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引用次数: 0

摘要

肾脏捐献对肾功能的影响已被充分证明，但其代谢后果却很少被探索。为了向捐赠者提供准确的信息并确保适当的随访，本研究评估了肾脏捐赠在12个月内的潜在代谢影响。方法：对26名活体肾脏供者进行纵向研究，在捐献前（T0）、捐献后6 （6M）和12 （12M）个月对参与者进行评估。关键参数包括身体质量指数（BMI）、肾功能、糖化血红蛋白（HbA1c）、血脂、营养和激素指标、贫血和高血压。将T0与6M和12M进行比较。结果：该队列以女性为主(n = 20；76.9%)，中位年龄52.19±8.16岁。BMI、血脂和营养指标（如白蛋白）没有明显变化。骨代谢指标（如甲状旁腺激素、钙、磷）稳定。HbA1c水平在6M时略有上升(T0: 5.54±0.37 g/dL；6M: 5.57±0.13 g/dL；P = 0.010)，但与临床无关。TSH水平轻度升高(T0: 1.67±0.83 mUI/L；6M: 2.29±1.25 mUI/L；P = 0.011；12M: 2.14±1.01 mUI/L；P = .021)。血红蛋白在12M时升高(T0: 12.84±1.73 g/dL；12M: 13.29±1.19 g/dL；P = .013)。高血压发病率略有上升(T0: 8 [30.77%]；12m: 9 [34.62%]；P < 0.001)。肾功能（估计肾小球滤过率）下降(T0: 110.10±12.33 mL/min/1.73 m²；6m: 68.71±10.84；12m: 71.21±11.61；P < 0.001)，与捐献后适应一致。结论：肾脏捐献在代谢上是安全的。体重指数、血脂和营养指标保持稳定。HbA1c、TSH和高血压的轻微升高没有临床意义。血红蛋白升高可能反映代偿性红细胞生成。高血压的增加值得进一步研究潜在的长期心血管风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Metabolic Profile of Living Kidney Donors: A One-Year Analysis

Introduction

Kidney donation’s effects on renal function are well-documented, but its metabolic consequences are less explored. To provide accurate information to donors and ensure appropriate follow-up, this study evaluates the potential metabolic impact of kidney donation over 12 months.

Methods

A longitudinal study of 26 living kidney donors assessed participants at predonation (T0), 6 (6M), and 12 (12M) months postdonation. Key parameters included body mass index (BMI), renal function, HbA1c, lipid profile, nutritional and hormonal markers, anemia, and hypertension. Comparisons were made between T0 and both 6M and 12M.

Results

The cohort was predominantly female (n = 20; 76.9%), median age 52.19 ± 8.16 years. BMI, lipid profile, and nutritional markers (eg, albumin) showed no significant changes. Bone metabolism markers (eg, parathyroid hormone, calcium, phosphorus) were stable. HbA1c levels rose slightly at 6M (T0: 5.54 ± 0.37 g/dL; 6M: 5.57 ± 0.13 g/dL; P = .010), though not clinically relevant. TSH levels increased modestly (T0: 1.67 ± 0.83 mUI/L; 6M: 2.29 ± 1.25 mUI/L; P = .011; 12M: 2.14 ± 1.01 mUI/L; P = .021). Hemoglobin increased at 12M (T0: 12.84 ± 1.73 g/dL; 12M: 13.29 ± 1.19 g/dL; P = .013). Hypertension incidence rose slightly (T0: 8 [30.77%]; 12M: 9 [34.62%]; P < .001). Renal function (estimated glomerular filtration rate) decreased (T0: 110.10 ± 12.33 mL/min/1.73 m²; 6M: 68.71 ± 10.84; 12M: 71.21 ± 11.61; P < .001), consistent with postdonation adaptation.

Conclusion

Kidney donation appears metabolically safe. BMI, lipids, and nutritional markers remained stable. Minor increases in HbA1c, TSH, and hypertension were not clinically significant. Hemoglobin elevation may reflect compensatory erythropoiesis. Hypertension increase warrants further study for potential long-term cardiovascular risks.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.