常染色体显性多囊肾病肾移植受者异源体外受精后成功妊娠一例报告

IF 0.8 4区医学 Q4 IMMUNOLOGY

Transplantation proceedings Pub Date : 2025-09-01 DOI:10.1016/j.transproceed.2025.06.013

Luca Apicella , Sarah Hamzeh , Renata Angela Di Pietro , Chiara Crescenzo , Nicoletta Vecchione , Dora Russo , Carmine Secondulfo , Antonio Pisani , Rosa Carrano , Candida Iacuzzo , Giancarlo Bilancio

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引用次数: 0

摘要

背景：慢性肾脏疾病（CKD）常与不孕和不良妊娠结局相关。肾移植提高了生育能力和母婴健康，而辅助生殖技术，包括体外受精（IVF），提供了额外的机会。然而，在文献中没有记录的异源体外受精在肾移植受者中的病例。病例介绍：我们报告了一例患有常染色体显性多囊肾病（ADPKD）的47岁女性患者，她于2018年接受了肾移植手术。2022年，她接受了异源体外受精，以防止ADPKD的传播。第三次胚胎移植成功妊娠，移植物功能稳定，无重大并发症。在怀孕37周时进行剖宫产，生下了一名健康的女婴。产后1年，肾功能保持稳定。讨论与结论：肾移植受者妊娠是高危的，需要谨慎的免疫抑制管理和多学科监测。本病例强调了移植受者异源体外受精的可行性，扩大了遗传性肾病患者的生殖选择。

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Successful Pregnancy Following Heterologous in Vitro Fertilization in a Kidney Transplant Recipient With Autosomal Dominant Polycystic Kidney Disease: A Case Report

Background

Chronic kidney disease (CKD) is often associated with infertility and adverse pregnancy outcomes. Kidney transplantation improves fertility and maternal-fetal health, while assisted reproductive technologies, including in vitro fertilization (IVF), offer additional opportunities. However, there are no documented cases of heterologous IVF in kidney transplant recipients in the literature.

Case Presentation

We report the case of a 47-year-old female with autosomal dominant polycystic kidney disease (ADPKD) who underwent a kidney transplant in 2018. In 2022, she underwent heterologous IVF to prevent the transmission of ADPKD. Pregnancy was achieved after the third embryo transfer, with stable graft function and no major complications. A cesarean section at 37 weeks resulted in the birth of a healthy female newborn. One year postpartum, renal function remained stable.

Discussion and Conclusion

Pregnancy in kidney transplant recipients is high-risk, requiring careful immunosuppressive management and multidisciplinary monitoring. This case highlights the feasibility of heterologous IVF in transplant recipients, expanding reproductive options for patients with hereditary kidney diseases.

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来源期刊

Transplantation proceedings 医学-免疫学

CiteScore

1.70

自引率

0.00%

发文量

502

审稿时长

60 days

期刊介绍： Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication. The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics. Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board. Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.