SriGita Krishna Madiraju , Kunal Yadav , Natalie Mainland , Advait Deshmukh , Snehi Shah , Stephen Hong , Puneet Sindhwani
{"title":"狭窄与结石:体外输尿管镜术抢救结石负担大的供肾一例报告。","authors":"SriGita Krishna Madiraju , Kunal Yadav , Natalie Mainland , Advait Deshmukh , Snehi Shah , Stephen Hong , Puneet Sindhwani","doi":"10.1016/j.transproceed.2025.06.018","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>The waiting list for kidney transplants far exceeds the pool of available donors. A significant population in the United States is living with end-stage renal disease (ESRD) yet many procured donor kidneys are not utilized. Significant renal stone disease has often been a relative contraindication to transplantation and a reason to discard these “high-risk” kidneys due to the possibility of post-transplant complications and suboptimal graft function. Salvaging these kidneys presents a chance to increase the availability of transplantable kidneys and assist with the critical shortage of organs.</div></div><div><h3>Methods</h3><div>We present a case of successful transplantation of a donor kidney with substantial stone burden that underwent ex vivo ureteroscopy with stone extraction and treatment of a ureteral stricture during pre-transplant preparation. Utilizing standard ureteroscopy instruments, we successfully cleared the donor kidney of its renal stone burden.</div></div><div><h3>Results</h3><div>At the 2- and 12-month marks, the recipient had no radiographic signs of ureteral obstruction or stone recurrence with excellent graft function.</div></div><div><h3>Conclusions</h3><div>Salvage of a donor kidney with concomitant heavy stone burden and ureteral stricture has not been reported before in the literature. This case report demonstrates that pre-transplant stone extraction with ex vivo ureteroscopy is an effective strategy for salvaging a kidney that would otherwise be discarded.</div></div>","PeriodicalId":23246,"journal":{"name":"Transplantation proceedings","volume":"57 7","pages":"Pages 1334-1337"},"PeriodicalIF":0.8000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Strictures and Stones: Ex Vivo Ureteroscopy to Salvage Donor Kidney with Extensive Stone Burden: A Case Report\",\"authors\":\"SriGita Krishna Madiraju , Kunal Yadav , Natalie Mainland , Advait Deshmukh , Snehi Shah , Stephen Hong , Puneet Sindhwani\",\"doi\":\"10.1016/j.transproceed.2025.06.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>The waiting list for kidney transplants far exceeds the pool of available donors. A significant population in the United States is living with end-stage renal disease (ESRD) yet many procured donor kidneys are not utilized. Significant renal stone disease has often been a relative contraindication to transplantation and a reason to discard these “high-risk” kidneys due to the possibility of post-transplant complications and suboptimal graft function. Salvaging these kidneys presents a chance to increase the availability of transplantable kidneys and assist with the critical shortage of organs.</div></div><div><h3>Methods</h3><div>We present a case of successful transplantation of a donor kidney with substantial stone burden that underwent ex vivo ureteroscopy with stone extraction and treatment of a ureteral stricture during pre-transplant preparation. Utilizing standard ureteroscopy instruments, we successfully cleared the donor kidney of its renal stone burden.</div></div><div><h3>Results</h3><div>At the 2- and 12-month marks, the recipient had no radiographic signs of ureteral obstruction or stone recurrence with excellent graft function.</div></div><div><h3>Conclusions</h3><div>Salvage of a donor kidney with concomitant heavy stone burden and ureteral stricture has not been reported before in the literature. This case report demonstrates that pre-transplant stone extraction with ex vivo ureteroscopy is an effective strategy for salvaging a kidney that would otherwise be discarded.</div></div>\",\"PeriodicalId\":23246,\"journal\":{\"name\":\"Transplantation proceedings\",\"volume\":\"57 7\",\"pages\":\"Pages 1334-1337\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Transplantation proceedings\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0041134525003690\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation proceedings","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0041134525003690","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Strictures and Stones: Ex Vivo Ureteroscopy to Salvage Donor Kidney with Extensive Stone Burden: A Case Report
Background
The waiting list for kidney transplants far exceeds the pool of available donors. A significant population in the United States is living with end-stage renal disease (ESRD) yet many procured donor kidneys are not utilized. Significant renal stone disease has often been a relative contraindication to transplantation and a reason to discard these “high-risk” kidneys due to the possibility of post-transplant complications and suboptimal graft function. Salvaging these kidneys presents a chance to increase the availability of transplantable kidneys and assist with the critical shortage of organs.
Methods
We present a case of successful transplantation of a donor kidney with substantial stone burden that underwent ex vivo ureteroscopy with stone extraction and treatment of a ureteral stricture during pre-transplant preparation. Utilizing standard ureteroscopy instruments, we successfully cleared the donor kidney of its renal stone burden.
Results
At the 2- and 12-month marks, the recipient had no radiographic signs of ureteral obstruction or stone recurrence with excellent graft function.
Conclusions
Salvage of a donor kidney with concomitant heavy stone burden and ureteral stricture has not been reported before in the literature. This case report demonstrates that pre-transplant stone extraction with ex vivo ureteroscopy is an effective strategy for salvaging a kidney that would otherwise be discarded.
期刊介绍:
Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication.
The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics.
Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board.
Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.