Tobacco Induced Diseases最新文献

{"title":"Usage patterns, knowledge, and attitudes of healthcare providers regarding e-cigarettes: A cross-sectional study in Saudi Arabia.","authors":"Ali M Alasmari, Ahmed A Alzahrani, Keir E J Philip, Ziyad Alshehri, Saeed M Alghamdi, Abdullah S Alsulayyim, Marey A Almaghrabi, Fahad H Alahmadi, Abdulrhman M Hawsawi, Moudi M Alasmari","doi":"10.18332/tid/205871","DOIUrl":"10.18332/tid/205871","url":null,"abstract":"<p><strong>Introduction: </strong>As electronic cigarettes (e-cigarettes) gain global popularity, healthcare providers (HCPs) play a critical role in shaping public health responses. In Saudi Arabia, little is known about HCPs' perspectives on e-cigarettes. Hence, this study aimed to evaluate HCPs' knowledge and attitudes toward e-cigarette use and examine differences based on their personal usage patterns.</p><p><strong>Methods: </strong>This is an observational, cross-sectional study. An online questionnaire was distributed from February to May 2024 among HCPs in Saudi Arabia. The survey, which was previously validated, collected data on sociodemographic, smoking characteristics, and 17 items designed to assess HCPs' knowledge and attitudes about e-cigarette use.</p><p><strong>Results: </strong>A total of 301 HCPs participated in the study. Among the participants, 19.3% were nurses, 18.9% were PharmDs, 13.2% were dentists, 24.3% were respiratory therapists (RTs), and 24.3% were medical doctors (MDs). Approximately 64% of the respondents were male, and the median age was 32 years (IQR: 22-55). E-cigarette users comprised 22.9% of the respondents. The prevalence of e-cigarette use was highest among dentists (20.0%), with lower rates observed among respiratory therapists (11.0%), nurses (8.6%), pharmacists (7.0%), and medical doctors (6.8%). The majority of respondents (68.1%) recognized that e-cigarettes contain nicotine, 64.5% believed that e-cigarettes are addictive, and 48.9% were unsure whether e-cigarettes are FDA-approved products. Additionally, 33.3% of HCPs relied primarily on social media for information about e-cigarettes. HCPs strongly agreed [median score: 5 (IQR: 4-5)] that HCPs should be educated about e-cigarettes. HCPs who used e-cigarettes exhibited significantly more favorable attitudes toward e-cigarettes compared to non-users, based on the total score (p=0.020).</p><p><strong>Conclusions: </strong>HCPs' knowledge and attitudes regarding e-cigarettes vary widely in Saudi Arabia. Specific, targeted, and regularly updated educational initiatives are needed to ensure that healthcare professionals are confident and well informed regarding the use, risks, and guidelines related to e-cigarettes.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12369480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144970372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between maternal smoking during pregnancy and attention-deficit/hyperactivity disorder (ADHD) in children aged 4-15 years: A secondary data analysis from the NHANES dataset.","authors":"Baomei He, Junxiong Peng, Mengqi Wu, Yanbing Deng, Ying Zhang","doi":"10.18332/tid/207094","DOIUrl":"10.18332/tid/207094","url":null,"abstract":"<p><strong>Introduction: </strong>The association between maternal smoking during pregnancy (MSDP) and the risk of attention-deficit hyperactivity disorder (ADHD) in children remains inconclusive. This study aims to investigate the relationship between MSDP and ADHD in children aged 4-15 years, with a particular focus on sex differences.</p><p><strong>Methods: </strong>This secondary analysis used cross-sectional data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES), comprising 5548 US children and adolescents aged 4-15 years. Inclusion criteria comprised complete maternal smoking history during pregnancy and parent-reported ADHD diagnosis data. Multivariable logistic regression models were employed to assess the association between MSDP and ADHD, with further stratified analyses.</p><p><strong>Results: </strong>Multivariable logistic regression analysis identified a significant association between MSDP exposure and elevated odds of ADHD (OR=2.11; 95% CI: 1.48-3.00). Sex-stratified analyses revealed that this association was more pronounced in female children (OR=4.18; 95% CI: 2.17-8.03) than in male children (OR=1.64; 95% CI: 1.13-2.38), the interaction between groups was significant (p for interaction <0.01).</p><p><strong>Conclusions: </strong>MSDP showed a statistically significant association with higher ADHD odds, with more pronounced estimates observed in females compared to males.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polycyclic aromatic hydrocarbons exposure as a potential risk factor for miscarriage among women in the United States: A secondary dataset analysis of NHANES data for the period 2005-2014.","authors":"Xiaoxing Liu, Yanmei Li, Na Chen, Jianshuang Ma, Yujuan Xing, Fengxia Miao","doi":"10.18332/tid/205903","DOIUrl":"10.18332/tid/205903","url":null,"abstract":"<p><strong>Introduction: </strong>Numerous studies have shown that polycyclic aromatic hydrocarbons (PAHs) are endocrine disruptors associated with reproduction, with tobacco smoke identified as a major non-occupational source of PAH exposure. However, there is still a lack of information on the relationship between PAH exposure - particularly from tobacco-related sources - and miscarriage.</p><p><strong>Methods: </strong>The data for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2014. Excluding populations with missing PAH, miscarriage, or baseline information, a total of 2573 individuals were included in this study. Logistic regression, linear regression, restricted cubic spline (RCS) analysis and subgroup analysis were used to analyze the effects of PAHs.</p><p><strong>Results: </strong>Following logistic and linear regression analyses, we found that higher concentrations of 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxypyrene were associated with miscarriage (p<0.05, OR>1). Moreover, after RCS, we found a nonlinear relationship between 1-hydroxynaphthalene and miscarriage (p=0.01). The relationship between 1-hydroxynaphthalene and miscarriage could be described as an 'n-shaped' curve, with a cutoff value (4705 ng/L). At concentrations lower than the cutoff, there was a positive correlation between 1-hydroxynaphthalene and miscarriage. Conversely, at concentrations higher than the cutoff, there was a negative correlation between the two variables. Finally, a subgroup analysis was performed to explore the interaction effect of confounders with the outcome variables, to further demonstrate the robustness of the results.</p><p><strong>Conclusions: </strong>The probability of miscarriage increases with increasing concentration of certain PAHs in the body. Enhancing monitoring of tobacco-related PAHs exposure is highly important for the prevention of miscarriage.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144817470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco exposure and risk of spontaneous abortion, a dose-dependent association: A systematic review and meta-analysis.","authors":"Xuefei Yuan, Fang Zhang, Yan Lv, Baohua Zhao, Hongbin Zhang, Limin Chen, Hongli Yan, Xiaojiao Hao, Zhiyu Dong","doi":"10.18332/tid/207156","DOIUrl":"10.18332/tid/207156","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review and meta-analysis aimed to quantify the dose-dependent association between tobacco exposure (active and passive smoking) and the risk of spontaneous abortion (SA), incorporating subgroup analyses to evaluate the influence of study design.</p><p><strong>Methods: </strong>Following PRISMA guidelines, we conducted a systematic search of PubMed, Embase, and Cochrane Library databases for English-language observational studies published between 1991 and 2023. Studies were included if they reported on the association between active or passive tobacco exposure during pregnancy and SA risk (defined as pregnancy loss before 20 weeks of gestation). Studies involving induced abortion, ectopic pregnancy, or molar pregnancy were excluded. Eligible participants included pregnant women with documented smoking status. Methodological quality was assessed using MMAT, NOS, and GARD. Data were analyzed using fixed-effects or random-effects models, with heterogeneity assessed using I² statistics. Interaction p-values were reported to evaluate heterogeneity between study designs.</p><p><strong>Results: </strong>Fourteen studies (5 cohort, 7 case-control, 2 nested case-control) with a combined sample size of 741698 pregnancies met the inclusion criteria. Active smoking was significantly associated with increased SA risk (OR=1.35; 95% CI: 1.18-1.55; I²=46.8%), with the highest risk observed among individuals consuming ≥20 cigarettes/day (OR=1.45; 95% CI: 1.04-2.03). Secondhand smoke exposure also elevated SA risk (OR=1.32; 95% CI: 1.14-1.55; I²=37.6%). Significant heterogeneity was observed between cohort and case-control studies (interaction p=0.001). No significant interaction was found between active and passive smoking (interaction p=0.842), but a dose-dependent interaction was observed (interaction p=0.049).</p><p><strong>Conclusions: </strong>Tobacco exposure is associated with increased SA risk, particularly at higher levels. Interventions targeting heavy smokers and those exposed to secondhand smoke are needed. Limitations include imprecise smoking exposure measurement and incomplete adjustment for confounders. Future research should focus on biomarker-guided cessation strategies and explore underlying mechanisms.Systematic Review Registration: The protocol was registered in PROSPERO.ID: CRD42023406664.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaping is associated with increased length of stay among cardiac inpatients.","authors":"Javad Heshmati, Kerri-Anne Mullen, Kathryn L Walker, Hassan Mir","doi":"10.18332/tid/207800","DOIUrl":"10.18332/tid/207800","url":null,"abstract":"<p><strong>Introduction: </strong>The rapid increase in e-cigarette use, especially among youth, raises significant health concerns. Understanding their impact on high-risk populations, such as those with cardiovascular disease, is crucial for improving patient outcomes and reducing healthcare utilization. The aim of this study is to assess the impact of e-cigarette use on hospital length of stay (LOS) in patients with cardiovascular disease.</p><p><strong>Methods: </strong>This cross-sectional survey was conducted at the University of Ottawa Heart Institute (November 2019-May 2020) among consecutive cardiology inpatients. Eligible participants were those admitted to the cardiac unit, fluent in French or English, and without cognitive or hearing impairments. The primary outcome is length of hospital stay. Data analysis included descriptive statistics and adjusted linear regression to explore e-cigarette use and hospital stay length, with significance set at p<0.05.</p><p><strong>Results: </strong>Of 1616 cardiac patients, 1089 (73.0%) completed the survey. E-cigarette ever users were 10.4% (4.9% former, 5.5% current). Mean LOS was 11.03 days, longer for ever-users (13.1 days) than never-users (10.8 days). Ever users had a significantly longer LOS by 2.45 days (p=0.040), and current users by 3.24 days (p=0.039).</p><p><strong>Conclusions: </strong>E-cigarette use is associated with longer hospital stays among cardiac patients, even after adjusting for confounders. This underscores the potential harmful effects of vaping on cardiac recovery. Further research is needed to explore these associations and their implications for healthcare utilization.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence synthesis of effective e-cigarette prevention messages for adolescents and young adults: A scoping review.","authors":"Yu Chen, Haoyi Liu, Shiyu Liu, Jing Xu, Xinyao Yu, Yujiang Cai, Si Chen, Ying Wang","doi":"10.18332/tid/208097","DOIUrl":"10.18332/tid/208097","url":null,"abstract":"<p><strong>Introduction: </strong>This scoping review aims to examine existing evidence regarding information design for youth e-cigarette prevention, identify research gaps, and provide recommendations for future research and practice.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted from the inception of databases to April 2024 across six databases: Web of Science Core Collection (including MEDLINE), PubMed, Embase, Scopus, PsycINFO, and CNKI. Peer-reviewed articles related to information design for youth e-cigarette prevention were included based on eligibility criteria. Two reviewers independently screened articles, extracted data, and synthesized results following PRISMA-ScR guidelines.</p><p><strong>Results: </strong>Thirty studies met the inclusion criteria. Most studies were conducted in the United States (n=28) and employed quantitative methods (n=20). Gain-loss framing was the most commonly used theoretical framework. Three core themes in youth e-cigarette prevention information design were identified: emphasizing usage risks, optimizing presentation methods, and segmenting target audiences. Primary outcome measures included perceived message effectiveness (PME) and e-cigarette-related knowledge, beliefs, attitudes, and behavioral intentions.</p><p><strong>Conclusions: </strong>Preliminary evidence provides guidance for youth e-cigarette prevention information design. Future research should evaluate message effectiveness across diverse populations, explore message customization strategies, assess behavioral outcomes, and strengthen theoretical foundations and applications.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering gene-smoking interactions in age-related macular degeneration through cross-biobank genomic integration.","authors":"Ju Guo, Yuhan Jiang, Xinran Xu, Jianhua Wang, Xueming Yao, Xiaohong Wang, Hongxi Yang, Mulin J Li, Hua Yan","doi":"10.18332/tid/205419","DOIUrl":"10.18332/tid/205419","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to identify genetic loci associated with age-related macular degeneration (AMD) and assess the interaction between genetic susceptibility and smoking history.</p><p><strong>Methods: </strong>A meta-analysis of discovery genome-wide association studies (GWASs), involving a total of 42542 AMD patients and 920322 controls from four large-scale European cohorts, was conducted using METAL, a software tool commonly used for meta-analysis of GWAS. A polygenic risk score (PRS) was derived from the meta-analysis results for 331281 UK Biobank participants. Cox proportional hazards models evaluated interactions between genetic predisposition and smoking history at both PRS and variant levels. Logistic regression models examined plasma complement protein profiles across AMD PRS and smoking status groups.</p><p><strong>Results: </strong>We identified two novel risk loci, OCA2 melanosomal transmembrane protein (OCA2) and nitric oxide associated 1 (NOA1). Incorporating the PRS significantly enhanced AMD risk prediction in 331281 UK Biobank participants, with the area under the curve (AUC) increasing from 0.74 to 0.76 (p=2×10^-16). During a mean follow-up of 13.6 years, Cox models revealed significant additive (relative excess risk due to interaction, RERI=0.13; 95% CI: 0.06-0.19; attributable proportion, AP=0.08; 95% CI: 0.04-0.13; synergy index, SI=1.33; 95% CI: 1.13-1.56) and multiplicative interactions (hazard ratio, HR=1.08; 95% CI: 1.03-1.14, p=2.65×10^-3) between PRS and smoking history. Variant-level interactions were prominent at complement factor H (CFH) and complement factor I (CFI) loci. Individuals who have ever smoked and high PRS exhibited dysregulated plasma proteins in the alternative, classical and lectin complement pathways.</p><p><strong>Conclusions: </strong>This study revealed the genetic architecture of AMD and highlighted the synergistic effects of smoking and genetic risk, emphasizing the potential need to integrate genetic assessments into prevention strategies.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco smoking as an endocrine disrupting chemical: An assessment through biological monitoring.","authors":"Ho-Sun Lee, Hyun-Kyung Na, Seong-Sil Chang, Soo-Young Kim, Chang Seong Kim, Min Ju Kim, Mihi Yang","doi":"10.18332/tid/205064","DOIUrl":"10.18332/tid/205064","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco smoke is a mixture of endocrine disrupting chemicals (EDCs), which may accelerate biological ageing.</p><p><strong>Methods: </strong>Within this cross-sectional study we recruited adult and adolescent subjects (2013-2014) and performed biological monitoring to clarify health end points of tobacco smoking between adolescents and adults (n=620) with exposure biomarkers, i.e. CO, urinary cotinine, t,t-muconic acid (TTMA), malondialdehyde (MDA), and obtained information of behavioral factors and tobacco addiction status in South Korea. We also analyzed the 96 SNPs for metabolism, addiction, and expression differences and compared mtDNA abnormalities in buccal and blood cells.</p><p><strong>Results: </strong>There was an association between tobacco smoking and oxidative stress with urinary cotinine and MDA levels. Youth smokers showed lower frequency in some of mtDNA alteration, SNPs for consistent bases between buccal and blood cells, than youth non-smokers or adult smokers. Among the SNPs, the polymorphisms on SULT1A1, DRD2, and ADH1B were related to multiple of the above exposure biomarkers. Interestingly, urinary MDA or TTMA in youth were similar to those in adults (MDA, 2.7 ± 1.5 vs 2.4 ± 1.3 μM; TTMA, 74.1 ± 129.9 vs 98.8 ± 126.1 μg/L), although urinary cotinine levels were approximately four-fold lower in youth than adults (0.1 ± 0.4 vs 0.6 ± 0.9 mg/L; p<0.0001). Urinary MDA, an oxidative stress biomarker, were negatively associated with the growth rate among the adolescents.</p><p><strong>Conclusions: </strong>The present biological monitoring study assessed the impact of combustible cigarette smoking with various exposure, susceptibility and response biomarkers to clarify how tobacco smoking differently affects adolescents and adults in South Korea.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global trends and cross-country inequalities in laryngeal cancer: A systematic analysis of the 2021 Global Burden of Disease study represented by China.","authors":"Zhizhen He, Yifan Hu, Xiuping Yang, Baoai Han, Shuang Li, Shuo Huang, Xiong Chen","doi":"10.18332/tid/205796","DOIUrl":"10.18332/tid/205796","url":null,"abstract":"<p><strong>Introduction: </strong>Laryngeal cancer is one of the most common malignant tumors in the upper respiratory tract, accounting for approximately 4.5% of all malignant tumors. Smoking, drinking alcohol and occupational exposure are its main risk factors. Based on the Global Burden of Disease (GBD) database from 1990 to 2021, this study conducted a comparative analysis of laryngeal cancer-related data in China and around the world.</p><p><strong>Methods: </strong>This is a secondary dataset analysis based on the Global Burden of Disease Study 2021. Chinese and global laryngeal cancer data for the period from 1990 to 2021 were extracted from the GBD database, and the Joinpoint regression model was used to analyze age-standardized incidence, prevalence, mortality, and DALYs. The inequality slope index (SII) and concentration index were calculated to assess health inequalities and risk factor attribution analysis was performed. Finally, a Bayesian hierarchical modeling method was used to predict the laryngeal cancer burden from 2022 to 2050.</p><p><strong>Results: </strong>From 1990 to 2021, the ASPR in China increased from 7.83 per 100000 people to 9.86, while the ASIR in the world decreased from 15.27 per 100000 people to 12.56, showing an opposite trend. The global inequality index (SII) shows a downward trend but is still greater than 0 (SII was 3.70 in 2021), and the concentration index has changed from -0.23 to -0.13, indicating that health problems related to laryngeal cancer are concentrated in poor countries, but the inequality between poor and rich countries is narrowing. Among women in high-income countries, the attributed deaths caused by tobacco and alcohol consumption are 58.5% and 9.8%, respectively, which are much higher than the global average of 30.9% and 3%. The attributable proportions of DALYs caused by tobacco and alcohol consumption were 61.5% and 10.7%, respectively, which were much higher than the global average proportions of 29% and 3.1%. It is estimated that by 2050, the global incidence rate of laryngeal cancer will decrease to 2.020 per 100000 people, the mortality rate will decrease to 1.028 per 100000 people, the cancer incidence rate among Chinese men will be 0.453 per 100000 people, and the ASMR will decrease to 0.173 per 100000 people.</p><p><strong>Conclusions: </strong>The global burden of laryngeal cancer decreased overall from 1990 to 2021, but the incidence and prevalence in China are complex and may be influenced by urbanization and lifestyle changes. The incidence of laryngeal cancer in Chinese women continues to rise, which is worthy of attention. Low-income countries face greater challenges, where digital health technologies can help with early screening and treatment.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of tobacco use and related factors among adolescents in South Africa: Insight from the Global Youth Tobacco Survey.","authors":"Mukhethwa Londani, Constance Sewani-Rusike, Olalekan Ayo-Yusuf, Olanrewaju Oladimeji","doi":"10.18332/tid/207126","DOIUrl":"10.18332/tid/207126","url":null,"abstract":"<p><strong>Introduction: </strong>Adolescent multiple tobacco use is a major public health issue, both in South Africa and globally. This study sought to use latent class analysis to identify patterns of tobacco products use (combustible cigarettes, chewing tobacco, snuff) and combustible non-cigarette tobacco products smoking (such as cigars, little cigars, pipes) and related factors among adolescents in South Africa.</p><p><strong>Methods: </strong>Data from the Global Youth Tobacco Survey (2011) were used. A nationally representative cross-sectional school-based survey was conducted among secondary school students using a stratified two-stage cluster sampling. The sample comprised 10822 students in grades 8 to 11 in South Africa (approximately aged 13-18 years). Latent class analysis was used to identify patterns of tobacco use and examined how sociodemographic and tobacco-related characteristics are associated with such patterns. Subsequently, the multinomial logistic regression analysis was used to assess the relationship between covariates and tobacco-related variables with the probability of belonging to a specific latent class.</p><p><strong>Results: </strong>The latent class analysis identified three classes: Class 1 (8.8%) was characterized by high probabilities of multiple tobacco product use; Class 2 (3.4%) had high probabilities of combustible non-cigarette tobacco products smoking; and Class 3 (83.9%) showed a minimal likelihood of current use across all four products. Compared to non-users, adolescents exposed to peer smoking had significantly higher odds of multiple product use (AOR=4.07; 95% CI: 2.93-5.66) and combustible tobacco use (AOR=6.29; 95% CI: 4.15-9.53). Parental smoking was also associated with increased odds of both multiple (AOR=2.33; 95% CI: 1.81-3.00) and combustible (AOR=1.91; 95% CI: 1.31-2.79) tobacco use. Females had lower odds than males of using multiple (AOR=0.65; 95% CI: 0.49-0.87) and combustible products (AOR=0.51; 95% CI: 0.36-0.71). Older adolescents (aged ≥18 years) were more likely to be multiple users (AOR=4.18; 95% CI: 1.59-10.98). Support for smoke-free policies was associated with reduced odds of tobacco use, while knowledge of smoking harms was associated with combustible tobacco use (AOR=1.60; 95% CI: 1.07-2.39).</p><p><strong>Conclusions: </strong>Multiple tobacco use and combustible non-cigarette tobacco products smoking is common among South African adolescents. Understanding different patterns of multiple tobacco use and combustible non-cigarette tobacco products smoking can help to inform prevention and cessation programs for adolescents. Given the risk adolescents face, tobacco cessation interventions tailored to their tobacco product of choice are urgently needed.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}