Tobacco Induced Diseases最新文献

{"title":"Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin.","authors":"Cancan Zhou, Ruiqi Cao, Qiqi Wang, Jiantao Mo, Weikun Qian, Zhengyuan Feng, Shengzhan Zhang, Xin Chen, Jie Hao, Qingyong Ma, Zheng Wu, Zheng Wang","doi":"10.18332/tid/203455","DOIUrl":"https://doi.org/10.18332/tid/203455","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking is a key risk factor for pancreatic cancer (PC). Nicotine-derived nitrosamine ketone (NNK), a major tobacco smoke constituent, has been shown to promote cancer growth, but its specific role in PC progression remains unclear. While long non-coding RNA LINC00857 (lnc RNA) is implicated in cancer progression, its regulation by NNK is unknown. This study aims to investigate whether NNK can drive PC growth and elucidate the underlying mechanisms.</p><p><strong>Methods: </strong>Employing an experimental methodology, this investigation treated human pancreatic cancer cell lines (CFPAC-1 and Panc-1) with NNK and utilized various assays (CCK-8, colony formation, and EdU cell proliferation) to assess the effects on cell proliferation. The interplay between LINC00857 expression profiles, PC, and smoking was systematically investigated through cross-database bioinformatic interrogation encompassing public resources and institutional biobank data. Experiments were performed to knock down LINC00857 in PC cells using siRNA technology. We used Western blotting and quantitative real-time PCR (qRT-PCR) to assess β-catenin expression and elucidate the mechanism by which the tobacco carcinogen NNK promotes PC formation.</p><p><strong>Results: </strong>Some evidence that NNK enhanced the proliferative capacity of PC cells was found. Bioinformatic analysis of public databases, combined with data from our center's database, revealed that LINC00857 was up-regulated in PC and correlated with smoking. Moreover, we discovered that knockdown of LINC00857 inhibited PC cell proliferation, with β-catenin identified as a potential downstream molecule. Importantly, after LINC00857 knockdown, we observed suppression of NNK-induced β-catenin upregulation at both protein and transcriptional levels.</p><p><strong>Conclusions: </strong>NNK potentially induces PC progression through the LINC00857/β-catenin axis. These findings provide new perspectives on the mechanisms of PC progression and highlight the clinical relevance of smoking cessation for preventing PC.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal smoking around birth as a risk factor for offspring chronic obstructive pulmonary disease: Evidence from Mendelian randomization.","authors":"Qiliang Jian, Huyan Huo, Fangxiang Mu, Fang Wang","doi":"10.18332/tid/203186","DOIUrl":"https://doi.org/10.18332/tid/203186","url":null,"abstract":"<p><strong>Introduction: </strong>Previous observational studies suggested that exposure of the fetus to maternal smoking during pregnancy may increase the likelihood of chronic obstructive pulmonary disease (COPD). Hence, following the STROBE-MR guidelines, we carried out a two-sample MR analysis to explore the association between maternal smoking around birth and offspring COPD.</p><p><strong>Methods: </strong>We used independent single nucleotide polymorphisms (SNPs) related to maternal smoking around birth, obtained from genome-wide association study summary data, as instrumental variables (IVs). The dataset included 121634 controls and 276098 cases. The selected outcome was chronic obstructive pulmonary disease (COPD) in offspring, with 454945 controls and 13530 cases. We performed analyses using inverse variance weighting (IVW), weighted median, and MR-Egger regression methods. Multivariate MR included maternal illnesses (high blood pressure and heart disease) as covariates to address potential mediators. Sensitivity analysis was conducted using leave-one-out analysis, Cochran's Q test, and MR-Egger intercept test.</p><p><strong>Results: </strong>In the univariate MR analysis, it was found that maternal smoking around birth significantly increased the likelihood of offspring COPD (IVW, OR=35.13; 95% CI: 10.18-121.20; p<0.001). Furthermore, after adjusting the variates for maternal illnesses, the relationship between maternal smoking around birth and offspring COPD remained statistically significant (adjusted odds ratio, AOR= 62.11; 95% CI: 16.60-232.46; p<0.001).</p><p><strong>Conclusions: </strong>The study provides MR evidence of a potential association between maternal smoking around birth and increased COPD risk in offspring.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping indicators of tobacco and related product use: Unveiling challenges and variations in the Eurobarometer surveys over three decades.","authors":"Ayaka Teshima, Cristina Martínez, Filippos T Filippidis, Anthony A Laverty, Constantine I Vardavas, Ariadna Feliu, Armando Peruga, Esteve Fernandez","doi":"10.18332/tid/202651","DOIUrl":"https://doi.org/10.18332/tid/202651","url":null,"abstract":"<p><strong>Introduction: </strong>The European Commission's Special Eurobarometer surveys on tobacco are widely used as comparable and representative data across the European Union for monitoring consumption patterns. Despite their broad use, certain challenges persist, including inconsistencies in survey timelines and variations in the collected information across waves. This study aims to identify available tobacco and related product indicators, and assess their temporal comparability, to support researchers to better understand the potential uses of these data and their alignment with other sources.</p><p><strong>Methods: </strong>We explored questionnaires and reports in these surveys on tobacco from the Eurobarometer official website since its inception (1992, 2002, 2005, 2006, 2008, 2009, 2012, 2014, 2017, 2020 and 2023 waves). We extracted and compared questions and responses on use of tobacco and related products, as well as on sociodemographic variables. Finally, we compared all indicators, including frequency and wording, and further mapped the consistency of the indicators and type of product used across the different waves.</p><p><strong>Results: </strong>Current, daily, former and never use of conventional cigarettes has been consistently assessed across all waves, enabling temporal comparisons. From 2009, the surveys have expanded to include e-cigarette use; since 2012, the surveys include various combusted products such as cigars, pipes, cigarillos, and waterpipes, and from 2020, heated tobacco products. By contrast, detailed data on product-specific use intensity and initiation remain limited. While indicators for secondhand smoke exposure and smoking cessation were present in multiple waves, their comparability is hindered by variations in question-wording and responses.</p><p><strong>Conclusions: </strong>Some challenges exist in using Eurobarometer surveys for temporal estimation of tobacco-related burden. Nonetheless, these surveys remain a valuable and unique tool for monitoring tobacco and related product use across the European Union. To further enhance their utility, periodic re-evaluation by tobacco control experts is recommended to ensure that the surveys maintain comparability with past data while capturing effectively emerging products and trends.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO FCTC: How we got here and where we are going.","authors":"Laurent Huber, Megan Arendt-Manning","doi":"10.18332/tid/203569","DOIUrl":"https://doi.org/10.18332/tid/203569","url":null,"abstract":"","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of laryngeal cancer in China caused by smoking from 1990 to 2021 and predictions for 2035: An age-period-cohort analysis of global burden of disease study 2021.","authors":"Xue Gu, Xiaopeng Sun, Xiao Ren, Yu Li, Yingying Fang, Hui Song, Pingli Luo, Mengfan Yuan","doi":"10.18332/tid/202875","DOIUrl":"https://doi.org/10.18332/tid/202875","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking is a major risk factor for laryngeal cancer (LC). Understanding the impact of smoking on the changing disease burden of LC is crucial for LC prevention in China and provides a scientific basis for formulating targeted LC prevention and control strategies, contributing to the achievement of the 'Healthy China 2030' goals.</p><p><strong>Methods: </strong>Data on LC attributable to smoking in China, stratified by sex, age, and year, were obtained from the 2021 Global Burden of Disease (GBD) study to conduct a secondary data analysis. Joinpoint regression was used to analyze trends in the burden of LC attributable to smoking in China from 1990 to 2021. Age-period-cohort (APC) analysis was employed to compare and analyze trends in the age, period, and cohort effects on the disease burden. Finally, Bayesian age-period-cohort (BAPC) analysis was used to predict trends in LC mortality and disability-adjusted life years (DALYs) from 2022 to 2035.</p><p><strong>Results: </strong>From 1990 to 2021, the overall burden of LC attributable to smoking in China increased. The number of deaths in males rose from 9128 to 14219, and in females from 790 to 1054. DALYs increased by 39.85% in males and 22.21% in females. Despite the rise in absolute burden, age-standardized mortality rates (ASMR) and age-standardized DALY rates (ASDR) declined, with reductions exceeding 50% in females. Joinpoint regression analysis revealed a decline-stabilization-decline trend in age-standardized rates among males, while females exhibited a continuous decline. According to the APC model, the age effect on disease burden increased with age, while period and cohort risk ratios generally declined. Net drift analysis showed a decline in mortality and DALY rates attributable to smoking, more pronounced in females than males, with local drift values <0 for both sexes. Predictions indicate that by 2035, male LC deaths will reach 17205, and female deaths 1373; however, ASMR and ASDR will continue to decline, with male ASMR dropping to 2.44 per 100000 and female ASMR to 0.16 per 100000.</p><p><strong>Conclusions: </strong>Over the past three decades, the burden of LC attributable to smoking in China has shown an increasing trend, with sex and age disparities. This burden is expected to continue rising over the next fourteen years. Therefore, it is imperative to strengthen smoking prevention and cessation efforts, particularly targeting high-risk groups. Additionally, continued emphasis on education and awareness regarding LC is necessary to facilitate early detection and intervention, thereby effectively reducing the disease burden attributable to smoking.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of hybrid virtual consultation for a smoking cessation program in Klang Valley, Malaysia.","authors":"Nurkhaledatul Falah Bin Nuzma Adil, Jaya Kumar Murthy, Isa Bin Naina Mohamed, Teh Rohaila Binti Jamil, Rashidi Mohamed Bin Pakri Mohamed","doi":"10.18332/tid/200071","DOIUrl":"10.18332/tid/200071","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking has become a leading preventable cause of premature death and morbidity worldwide, with 8 million people dying each year because of tobacco. In Malaysia, a 24-week standard smoking cessation program is available to help smokers. Teleconsultation was introduced into this program during the COVID-19 pandemic by using internet-based video counseling to reduce the number of clinic visits. This study aimed to evaluate the outcomes of hybrid virtual consultation for smoking cessation programs among patients with nicotine dependence.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted where all the active smokers registered in the smoking cessation program from 2018 to 2023 were recruited. They were grouped into face-to-face interventions and hybrid virtual consultations. All data were obtained from the smoking cessation program registry. The primary outcome was point abstinence (PA) at week 7 (1-month post-quit date), biochemically verified with carbon monoxide (CO) Smokerlyzer for both face-to-face and hybrid groups.</p><p><strong>Results: </strong>A total of 156 participants were included in this study, including face-to-face (99 participants) and hybrid virtual consultation (57 participants). The mean age of face-to-face and hybrid group participants was 51 and 48 years, respectively. In general, hybrid virtual consultation was more feasible, as evidenced by a lower defaulter rate and a higher rate of participants graduating at the end of the program than face-to-face consultation. The effectiveness of smoking cessation was also higher in hybrid consultation, with a higher abstinence rate at weeks 4 and 7, with percentages of 42.1% and 56.1%, respectively. Additionally, the hybrid group maintained a high continuous abstinence rate (CAR) from week 7 to 24, with a percentage of 56.1%.</p><p><strong>Conclusions: </strong>Hybrid virtual consultation was more effective, as evidenced by higher smoking cessation at week 7 (1-month post-quit date) and CAR from week 7 to week 24 compared to the face-to-face group. Telemedicine or teleconsultation should be easily available for smoking cessation programs, and healthcare providers should consider incorporating hybrid models into them to fully utilize the program and improve outcomes.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in academic research on thirdhand smoke using bibliometric analysis.","authors":"Joseph K Ahialey, Yubin Lee, Myung-Bae Park, Jimi Huh","doi":"10.18332/tid/201402","DOIUrl":"10.18332/tid/201402","url":null,"abstract":"<p><strong>Introduction: </strong>This study used quantitative analysis to explore the current landscape of thirdhand smoke (THS) research by identifying gaps and emerging trends. Despite growing evidence of health risks associated with THS, research remains sparse, and no public policies address THS exposure. This analysis aimed to inform future studies and policies, in order to mitigate THS-related health risks.</p><p><strong>Methods: </strong>Using a bibliometric approach, our literature search identified 227 academic articles and reviews indexed in PubMed between 2009 and 2023. We used Biblioshiny, a bibliometrix R package, VOSviewer, and Excel to analyze the bibliographic data.</p><p><strong>Results: </strong>Since 2009, an average growth of 14.09% annually has been observed in THS-related publications. Additionally, we found that US institutions are major contributors to THS research. At the country level, studies conducted in the US, China, Spain, Italy, and South Korea are the most prevalent in the THS literature. Our findings indicate that THS research mainly focuses on human participants, health promotion, nicotiana/chemistry, air pollution/indoor analysis, tobacco smoke pollution, adolescent health, odorants/analysis, surface properties, carcinogens, and disease models/animals.</p><p><strong>Conclusions: </strong>We analyzed THS research trends and identified the most impactful authors, journals, institutions, and countries. Considering the findings of this study, policymakers should continue policy development and implementation efforts to address THS exposure. The findings of this study can serve as basic reference material for scholars to guide future research directions regarding THS research.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of smoking to the global burden of bladder cancer from 1990 to 2021 and projections to 2046.","authors":"Kai Qi, Honghui Cheng, Yiwei Jiang, Yichun Zheng","doi":"10.18332/tid/202237","DOIUrl":"10.18332/tid/202237","url":null,"abstract":"<p><strong>Introduction: </strong>Based on the results extracted from the Global Burden of Disease (GBD) 2021, the objective of this research is to examine the spatiotemporal trends of bladder cancer attributable to smoking from 1990 to 2021, and to make projections up to the year 2046.</p><p><strong>Methods: </strong>This study conducted a secondary dataset analysis of smoking-attributable bladder cancer data extracted from GBD 2021. Bladder cancer was classified using the International Classification of Diseases 10th Revision (ICD-10) in GBD, and smoking exposure was defined as both current and past use of smoked tobacco products. By employing a Bayesian age-period-cohort (BAPC) model, the average annual percentage change (AAPC) was determined to examine trends over time.</p><p><strong>Results: </strong>From 1990 to 2021, the number of deaths and disability-adjusted life years (DALYs) due to smoking-attributable bladder cancer increased significantly. The age-standardized death rate (ASDR) decreased, with an AAPC of -1.54 (95% CI: -1.62 - -1.46). The age-standardized DALY rate (ASDLR) also showed a decline, with an AAPC of -1.68 (95% CI: -1.81 - -1.56). The regions that experienced the most significant age-standardized rate (ASR) burden were Central Europe and Western Europe. Regions with high-medium sociodemographic index (SDI) values had the highest number of deaths and DALYs, as well as the highest ASR for both indicators. The heaviest global disease burden is concentrated among males and individuals aged ≥70 years. Smoking-attributable bladder cancer deaths are projected to rise over the next 25 years, reaching 90021.45 by 2046.</p><p><strong>Conclusions: </strong>Despite a decrease in the ASRs of smoking-attributable bladder cancer, the absolute burden has increased and is expected to continue growing. Therefore, continuous and targeted tobacco control measures and medical strategies are needed, especially for developed regions, the elderly, and male populations. And due to the unique mechanisms by which tobacco causes disease, the youth and female populations should not be neglected.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking attitudes, self-reported practices, and COPD knowledge among adults aged 20-59 years: Insights from a Japanese sample.","authors":"Yolanda De Fatima De Oliveira Graca, Liu Yang, Cui Mingyu, Afsari Banu Alpona, Taeko Watanabe, Yuko Sawada, Emiko Tanaka, Tokie Anme","doi":"10.18332/tid/200855","DOIUrl":"10.18332/tid/200855","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking remains a significant public health issue globally, despite efforts to reduce tobacco use. In Japan, smoking persists, particularly among certain groups.</p><p><strong>Methods: </strong>This study investigates smoking attitudes, self-reported practices, and COPD knowledge among Japanese adults aged 20-59 years to identify intervention targets for reducing smoking prevalence and improving public health. Data from the 2020 'Community Empowerment and Well-Being and Healthy Long-term Care: Evidence from a Cohort Study (CEC)' project were analyzed, including 537 participants categorized as smokers, former smokers, or non-smokers.</p><p><strong>Results: </strong>This study shows that gender (male) is a strong predictor of current smoking across all age groups. Individuals with higher smoking awareness are less likely to smoke, especially in older adults. While COPD awareness is significantly associated with smoking only in the 20-29 age group. Among smokers who attempted to quit, 27.7% expressed willingness to quit, but only 3.0% were interested in cessation programs.</p><p><strong>Conclusions: </strong>A proportion of participants had a smoking history, highlighting tobacco use prevalence. Despite widespread support for anti-smoking measures, a disconnection between attitudes and behaviors persists. While most participants had heard of COPD, deeper knowledge of the disease and its symptoms was limited. These findings emphasize the need for anti-smoking policies targeting educational interventions and improving COPD awareness to promote behavior change and reduce smoking prevalence.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends, differences, and future projections of lung cancer attributable to secondhand smoke across 204 countries and territories from 1990 to 2036.","authors":"Yulong Yu, Aifeina Aili, Bili Wu, Weiheng Zhao, Mu Yang, Xianglin Yuan","doi":"10.18332/tid/202228","DOIUrl":"10.18332/tid/202228","url":null,"abstract":"<p><strong>Introduction: </strong>Secondhand smoke (SHS) has long been identified as a significant risk factor for lung cancer, yet the precise magnitude of its contribution to the global lung cancer burden remains unclear. Our study aims to elucidate the harms associated with lung cancer caused by secondhand smoke while emphasizing the importance of avoiding SHS.</p><p><strong>Methods: </strong>The annual deaths and disability-adjusted life years (DALYs) data were obtained from the Global Burden of Disease Study (GBD) 2021 for this secondary dataset analysis. Trends in mortality and DALYs were evaluated, along with correlations with the sociodemographic index (SDI). Projections from 2021 to 2036 utilized a Bayesian age-period-cohort model.</p><p><strong>Results: </strong>In 1990, SHS-related lung cancer was responsible for approximately 0.058 million deaths and 1.599 million DALYs, globally. By 2021, these numbers had increased to approximately 0.098 million deaths and 2.356 million DALYs worldwide. Between 1990 and 2021, SHS-related lung cumulatively caused 2.428 million deaths and 62.785 million DALYs. From 1990 to 2021, deaths and DALYs increased significantly, while age-standardized mortality rates (ASMR) and age-standardized DALY rates (ASDR) decreased. Specifically, ASMR decreased from 1.45 to 1.14, and ASDR dropped from 38.40 to 26.93. The high-middle SDI region bore the largest burden, accounting for nearly 40% of global deaths and DALYs. East Asia held the highest burden of lung cancer attributable to secondhand smoke in 2021, while Oceania had the lowest burden. Projections suggest that male ASMR will decline to 1.18 by 2036, while female ASMR is expected to rise to 0.91 by 2029 before decreasing to 0.89 by 2036.</p><p><strong>Conclusions: </strong>The considerable burden of lung cancer attributable to secondhand smoke underscores the urgent need for targeted public health interventions, particularly in high-risk demographics and regions. To mitigate disparities and enhance global health outcomes, it is crucial to prioritize the avoidance of SHS and the establishment of smoke-free environments.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}