Tobacco Induced Diseases最新文献

{"title":"A systematic review on risk factors and reasons for e-cigarette use in adolescents.","authors":"Víctor José Villanueva-Blasco, Lorena Belda-Ferri, Andrea Vázquez-Martínez","doi":"10.18332/tid/196679","DOIUrl":"10.18332/tid/196679","url":null,"abstract":"<p><strong>Introduction: </strong>The aim was to establish EC use risk and protective factors, the reasons for use, associations with tobacco and other substance use, and use for smoking cessation.</p><p><strong>Methods: </strong>A systematic review following PRISMA guidelines was registered in PROSPERO (CRD42024532771). Searches in Web of Science and PubMed/MEDLINE (March-April 2024) used terms like 'electronic cigarette' and 'adolescents' with a PICO framework. Inclusion criteria covered studies on adolescents aged 10-19 years, published in English or Spanish (2018-2024). Three reviewers independently screened studies, achieving 96% inter-rater reliability. Data extraction followed standardized tables, and methodological quality was assessed using MMAT and GRADE tools, ensuring a robust evaluation of evidence on adolescent electronic cigarette use.</p><p><strong>Results: </strong>From 895 studies, 50 met the inclusion criteria. The strongest risk factors for adolescent EC use include social acceptance and use within peer or family circles (13 studies), male gender (10 studies), low risk perception (6 studies), younger age (3 studies), and greater financial resources (3 studies). Motives for use include low perceived risk and appealing flavors, supported by both longitudinal and cross-sectional studies. EC use is significantly associated with smoking initiation (7 studies), cannabis consumption (8 studies), and alcohol use (4 studies). Evidence on the effectiveness of ECs as harm reduction or smoking cessation tools in adolescents remains inconclusive, with some cross-sectional studies supporting their utility and others finding contrary evidence. High-quality research indicates ECs are predominantly used alongside traditional cigarettes, with dual nicotine consumption patterns commonly observed.</p><p><strong>Conclusions: </strong>Evidence on adolescent EC use identifies risk factors, motives, and links to substance use. However, its role in harm reduction and smoking cessation remains insufficient and controversial. High-quality research is needed, as most studies are low quality. Targeted prevention strategies addressing social influences, perceptions, and accessibility are crucial to reduce adolescent EC use.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143012296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study on exposure to secondhand smoke in indoor public places and attitudes of residents towards the smoke control ordinance in public places.","authors":"Xiaowen Wang, Wenjing Zou, Xinyue Zhang, Nongnong Yang, Yuying Zheng, Runtang Meng, Haiyan Ma","doi":"10.18332/tid/196676","DOIUrl":"10.18332/tid/196676","url":null,"abstract":"<p><strong>Introduction: </strong>Secondhand smoke (SHS) exposure is a serious public health problem. This study aims to collect data on tobacco control since the implementation of the new version of the Smoke Control Ordinance in Public Places of Hangzhou (the Ordinance), combined with questionnaire surveys to understand the SHS exposure situation in public places, relevant knowledge and attitudes of residents in Hangzhou.</p><p><strong>Methods: </strong>We used data from a population-based tobacco control survey of 2746 adults aged 15-75 years conducted in Hangzhou, Zhejiang Province in March 2023. Data were collected using a self-administered questionnaire consisting of demographic characteristics, exposure to tobacco, awareness of tobacco hazards, knowledge of the Ordinance, and behaviors and attitudes towards tobacco control in public places. Chi-squared tests were performed to examine the differences in knowledge and attitudes related to tobacco control in indoor public places among residents with different characteristics in Hangzhou. Multivariable logistic regression was used to identify variables affecting satisfaction with the effectiveness of tobacco control in public places.</p><p><strong>Results: </strong>Of the 2155 non-smokers, 1006 (46.68%) had been exposed to SHS in public places. More than 89.00% of participants supported the Ordinance. Satisfaction with effectiveness of tobacco control in public places in Hangzhou was 68.54%, and the subcomponents that influenced it were satisfaction with tobacco control publicity campaigns (AOR=1.85; 95% CI: 1.19-2.88), satisfaction with tobacco control surveillance and enforcement (AOR=3.91; 95% CI: 2.43-6.30), satisfaction with the smoke-free demonstration for government departments (AOR=5.79; 95% CI: 3.96-8.47), and satisfaction with individual tobacco control behavior (AOR=11.68; 95% CI: 8.53-15.99).</p><p><strong>Conclusions: </strong>It is necessary to strengthen tobacco control publicity to increase the participation of residents and to gain a deeper understanding of the subjective willingness and needs of residents to participate in tobacco control campaigns in order to improve residents' individual satisfaction.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with tobacco use among Saudi Arabian youth: Application of the Theory of Planned Behavior.","authors":"Mosa A Shubayr, Anwar S Alhazmi, Mervat M El Dalatony, Eman D El Desouky, Abdulmohsen H Al-Zalabani, Sarah S Monshi, Ahmed A Elkhobby, Shaikha K Aldukhail, Mohammed M Alqahtani, Mohammed S Aldossary","doi":"10.18332/tid/196678","DOIUrl":"10.18332/tid/196678","url":null,"abstract":"<p><strong>Introduction: </strong>The epidemic of tobacco use poses one of the most severe public health challenges globally, responsible for over 8 million deaths annually according to the World Health Organization (WHO). This study investigates the factors associated with tobacco use among Saudi Arabian youth using the Theory of Planned Behavior (TPB) framework.</p><p><strong>Methods: </strong>A cross-sectional study used the 2022 Global Youth Tobacco Survey (GYTS) to assess tobacco use among 5610 Saudi students aged 13-15 years. The structured, anonymous questionnaire collected demographic data and TPB constructs (e.g. attitudes, subjective norms, perceived behavioral control, and intentions) were derived from the validated GYTS questionnaire, with items grouped and scored to represent each construct. One-way ANOVA, t-tests, and logistic regression analyses were conducted, with a significance level set at 0.05.</p><p><strong>Results: </strong>Of the surveyed students, 5610 (80.4%) aged 13-15 years met the inclusion criteria. Tobacco use was prevalent, with 31.3% having ever used tobacco and 8.78% currently using it. Negative attitudes toward tobacco were inversely associated with usage (AOR=0.97; 95% CI: 0.970-0.974). Subjective norms, reflecting perceived social pressure, were positively associated with tobacco use (AOR=1.17; 95% CI: 1.170-1.176). Perceived behavioral control, indicating the ease of quitting or avoiding tobacco, was strongly associated with use (AOR=1.87; 95% CI: 1.848-1.888). Stronger behavioral intentions to use tobacco were also associated with a higher likelihood of use (AOR=1.24; 95% CI: 1.226-1.246).</p><p><strong>Conclusions: </strong>The high prevalence of tobacco use among Saudi Arabian youth, early initiation, and significant social influences highlight the need for comprehensive public health strategies. Targeted education, reduced tobacco accessibility, and programs to shift social norms and attitudes are essential. Addressing these factors can help prevent initiation and support cessation efforts among young people.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of human metabolism to ultra-low and high nicotine cigarettes based on urine metabolomics and bioinformatic analysis.","authors":"Mengyue Zhang, Chunting Yang, Lingling Gao, Yuanyuan Zhao, Hongzhi Shi","doi":"10.18332/tid/196677","DOIUrl":"10.18332/tid/196677","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the metabolomic profiles of urine samples obtained from smokers who smoked cigarettes with low and high nicotine content.</p><p><strong>Methods: </strong>Three smokers participated in this study. They were given low-nicotine (LN) cigarettes, and urine was collected at the end of the third day for the LN group. After 1 week of not smoking, they were given high-nicotine (HN) cigarettes, and urine was collected for the HN group. Untargeted metabolomics and bioinformatic analysis methods were used for urine analysis.</p><p><strong>Results: </strong>PCA showed a high degree of similarity between samples within the group and a large distance between samples between groups, indicating a significant difference between the two groups. A total of 1150 significantly differential metabolites were selected between the HN and LN groups, such as cotinine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol-N-glucuronide. Two-way hierarchical clustering analysis also suggested noticeable differences between the two comparison groups Enrichment analysis indicates that the differential metabolites between the two groups were mainly enriched in 19 pathways, such as the protein kinase G (cGMP)-protein kinase G (PKG) signaling pathway, adenosine monophosphate (AMP)-activated protein kinase signaling pathway, mammalian target of rapamycin signaling pathway, and Parkinson's disease.</p><p><strong>Conclusions: </strong>Cigarettes with different nicotine content may alter the metabolism of smokers. A total of 1150 significantly different metabolites were identified between the HN and LN groups, which were mainly enriched in ABC transporters, protein kinase G (cGMP)-protein kinase G (PKG) signaling pathway, caffeine metabolism, and arginine biosynthesis pathways.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in retail cigarette price after tax increase: Findings from the 2018-2020 ITC Vietnam surveys.","authors":"Thi Phuong Thao Tran, Thi Ngoc Phuong Nguyen, Thu Trang Vu, Thai Uyen Tran, Don Nguyen, Thi Hai Phan, Son Dao The, Min Kyung Lim, Anne C K Quah, Jin-Kyoung Oh, Hoang Van Minh","doi":"10.18332/tid/196675","DOIUrl":"10.18332/tid/196675","url":null,"abstract":"<p><strong>Introduction: </strong>No longitudinal study has investigated the impact of cigarette tax increases on retail prices in Vietnam. This study aims to describe changes in the purchase price of cigarettes following an excise tax increase from 70% to 75% in January 2019.</p><p><strong>Methods: </strong>Data were collected from people who currently smoke cigarettes in the longitudinal ITC Vietnam surveys: 1870 participants in Wave 1 (pre-increase), 1564 in Wave 2 (post-increase), and 1308 in Wave 3 (post-increase). Weighted mean self-reported prices of a cigarette pack (with standard error) were calculated for participants who were successfully followed up across three waves. These mean prices were calculated for domestic and international brands, categorized by specific cigarette brands. Percentage changes in mean prices were also measured, and significant differences in mean prices between follow-up waves (Waves 2 and 3) and the baseline (Wave 1) were assessed using paired t-tests. For brands with very small sample sizes, we used non-parametric tests, specifically the Wilcoxon signed-rank test instead of paired t-tests.</p><p><strong>Results: </strong>The weighted mean price of a cigarette pack remained low and stable: VND 12330 (US$0.54) in 2018, VND 12700 (US$0.55) in 2019, and VND 12120 (US$0.53) in 2020 (1000 Vietnamese Dongs about US$0.04345, at 2018). International brands were substantially more expensive than domestic brands, but prices for both remained constant across all waves. Among domestic brands, Thang Long and Sai Gon showed slight price increases of around 3% and 5%, respectively (p<0.05). Among international brands, no statistically significant increase in mean prices was observed.</p><p><strong>Conclusions: </strong>The retail price of cigarettes remains low, indicating that the slight tax increase was insufficient to raise the current retail price significantly. Therefore, a substantial increase in cigarette prices by adding a specific tax is necessary.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of heated tobacco products on metabolic syndrome: A cohort study.","authors":"Yongho Jee, Sang Yop Shin, Mikyung Ryu, Jonathan M Samet","doi":"10.18332/tid/194490","DOIUrl":"10.18332/tid/194490","url":null,"abstract":"<p><strong>Introduction: </strong>Evidence concerning the health effects of using heated tobacco products is needed. The aim of the present study is to investigate the effects of conventional cigarettes (CCs), electronic vaping cigarettes (EVCs), and heated tobacco products (HTPs) on the development of metabolic syndrome.</p><p><strong>Methods: </strong>We conducted a cohort study in South Korea using data from the Korea Medical Institute. The study included 183870 people who visited the Korea Medical Institute, responded to a smoking status questionnaire in 2019, and were followed up in 2020 - ever and current use of CCs, EVCs, and HTPs. We defined the main outcome as incident metabolic syndrome among participants with at least two health checkups separated by a follow-up period of at least a year.</p><p><strong>Results: </strong>The association of using HTPs with risk for metabolic syndrome was estimated after controlling for age, sex, exercise, drinking history, and smoking regular cigarettes and using EVCs, with the Cox proportional hazards model. The risk of incident metabolic syndrome was increased by 68% (HR=1.68; 95% CI: 1.25-2.26) for current HTP users compared to never users. Among HTP users who did not currently smoke conventional cigarettes, the risk was doubled (HR=2.17; 95% CI: 1.31-3.62) when their smoking duration was ≥3 years. The risk of metabolic syndrome increased by 33% (HR=1.33; CI: 1.18-1.49) among HTP users who used them more than 16 times a day. The use of HTP was found to increase the risk of developing metabolic syndrome, with a particularly elevated risk observed among those who used HTPs for more than three years. The risk was higher than that observed in conventional cigarette users.</p><p><strong>Conclusions: </strong>Our findings indicate that HTP use poses comparable risks in relation to metabolic syndrome development.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142839829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: Association of cigarette smoking with cardiometabolic risk factors: A cross-sectional study.","authors":"Samar Sultan, Fouzy Lesloom","doi":"10.18332/tid/196812","DOIUrl":"https://doi.org/10.18332/tid/196812","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.18332/tid/191246.].</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11635948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-period-cohort analysis of smoking prevalence trends among career military personnel in South Korea.","authors":"Sunju Jung, Heewon Kang, Sung-Il Cho","doi":"10.18332/tid/196477","DOIUrl":"10.18332/tid/196477","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluated smoking trends among career military personnel in South Korea. After a tobacco tax increase in 2015, the tobacco control program for career military personnel expanded significantly. This study explores long-term smoking trends among career military personnel through age-period-cohort (APC) analysis within the context of targeted tobacco control policies.</p><p><strong>Methods: </strong>This secondary data analysis utilized data from 12052 individuals aged 19--54 years, identified as career military personnel in the Korea Community Health Survey (KCHS) from 2008 to 2022. APC analysis with the intrinsic estimator (IE) method was conducted to address multicollinearity and accurately assess the contributions of age, period, and birth cohort to smoking prevalence.</p><p><strong>Results: </strong>Smoking prevalence significantly decreased among career military personnel, from 46.2% in 2008 to 34.1% in 2022. The highest prevalence of smoking was initially observed in the age group of 22-24 years. Although overall prevalence declined, a slight increase was observed in the age group of mid-30s to early 40s, suggesting that smoking behavior varied across age groups. A significant decrease occurred between 2014 and 2016, with individuals born in the 1970s exhibiting the highest smoking prevalence, and those born after 1980 demonstrating a notably lower smoking prevalence.</p><p><strong>Conclusions: </strong>Although smoking prevalence has declined, the distinct age, period, and cohort characteristics of career military personnel necessitate tailored tobacco control policies that consider the various aspects of military life.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total serum bilirubin levels as mediators of anti-atherosclerosis mechanisms with consideration of smoking status.","authors":"Shigemasa Tani, Kazuhiro Imatake, Yasuyuki Suzuki, Tsukasa Yagi, Atsuhiko Takahashi","doi":"10.18332/tid/195378","DOIUrl":"https://doi.org/10.18332/tid/195378","url":null,"abstract":"<p><strong>Introduction: </strong>Cigarette smoking is a significant risk factor for atherosclerotic cardiovascular diseases (ASCVDs). Mildly elevated total serum bilirubin (TSB) levels can exert anti-atherosclerotic effects and may regulate inflammation. We explore the relationship between TSB levels, smoking, and inflammation.</p><p><strong>Methods: </strong>This cross-sectional study evaluated health screening participants with no history of ASCVD between 1 April 2019 and 31 March 2020. TSB was compared between non-smokers and smokers using the Kruskal-Wallis test, and the influencing factors of TSB levels were identified using multivariable logistic regression with TSB levels above the 75th percentile set as the dependent variable. Mediation analysis was performed to determine whether TSB levels mediated the association between smoking and inflammation.</p><p><strong>Results: </strong>A total of 8337 participants (mean age: 46.6 ± 13.0 years; 58.9% men) were included. TSB levels were significantly lower in smokers (n=1353) than in non-smokers (n=6984) [median (IQR): 0.72 (0.56-0.92) vs 0.76 (0.60-0.97) mg/dL, p<0.0001]. Multivariable logistic regression analysis demonstrated that smoking was an independent determinant of lower TSB levels (adjusted odds ratio, AOR=0.81; 95% CI: 0.70-0.93, p=0.003). Leukocyte counts and C-reactive protein levels significantly decreased as TSB levels increased (p<0.0001). Moreover, the relationship between the duration of smoking cessation and TSB levels showed a positive correlation. Mediation analysis indicated that cigarette smoking had significant indirect effects on higher leukocyte counts and higher CRP levels (coefficient=0.014; 95% CI: 0.008-0.021; and coefficient=0.002; 95% CI: 0.001-0.003, respectively].</p><p><strong>Conclusions: </strong>Lower TSB levels related to a smoking habit may be associated with higher inflammation, thereby increasing the ASCVD risk. TSB may regulate inflammation and exert antioxidant effects. Furthermore, smoking cessation may lead to higher TSB levels and lower inflammation.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11607641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between the serum cotinine and trabecular bone score in the adult population: A cross-sectional study.","authors":"Shifu Bao, Weibu Jimu, Nai Mu, Fang Yan, Shuxing Xing, Zheng Zhou","doi":"10.18332/tid/194680","DOIUrl":"10.18332/tid/194680","url":null,"abstract":"<p><strong>Introduction: </strong>Trabecular bone score (TBS) is gaining attention as a novel approach for evaluating bone quality, as it provides insights into skeletal microarchitecture. We aimed to investigate the possible relationship between serum cotinine and TBS in the US population.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES). A total of 6961 adults aged ≥20 years with complete data on TBS and serum cotinine were included. Serum cotinine levels were measured using isotope-dilution high-performance liquid chromatography coupled with tandem mass spectrometry. TBS was derived from lumbar spine DXA images using the Med-Imap SA TBS Calculator. Weighted multivariable linear regression analyses were conducted, adjusting for age, sex, race, BMI, poverty income ratio (PIR), total spine bone mineral density (TSBMD), smoking status, C-reactive protein (CRP), total protein, blood urea nitrogen, serum creatinine, serum uric acid, serum calcium, alkaline phosphatase, and serum phosphorus. Subgroup analyses were stratified by sex, race, BMI, and PIR.</p><p><strong>Results: </strong>A total of 6961 individuals were included in the analysis, with a mean (± SE) age of 45.20 ± 0.39 years, comprising 49.21% males and 50.79% females. The serum level of cotinine was negatively associated with TBS in the fully adjusted model. Specifically, for each unit increase in the log2-cotinine score, there was a corresponding 0.01 unit decrease in TBS (β= -0.01; 95% CI: -0.02 - -0.01, p=0.002). Participants in the highest tertile of serum cotinine had a significantly lower TBS compared to those in the lowest tertile (β= -0.01; 95% CI: -0.02 - -0.01, p=0.002). Subgroup analysis revealed a significant negative association between serum cotinine and TBS in females (β= -0.021; 95% CI: -0.03 - -0.01), but not in males. No significant associations were found when stratified by race, BMI, and PIR.</p><p><strong>Conclusions: </strong>Serum cotinine was negatively associated with TBS in US adults. Further large-scale prospective studies are still needed to explore the associative relationship of cotinine in TBS.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"22 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}