Tobacco Induced Diseases最新文献

{"title":"Access to tobacco cessation is a human right and essential for the endgame.","authors":"Ashton Thiele, Carolyn Dresler, Hasmeena Kathuria, Megan Arendt-Manning, Carol Southard","doi":"10.18332/tid/203618","DOIUrl":"https://doi.org/10.18332/tid/203618","url":null,"abstract":"","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarette smoke modulates methylation levels of LEF1-AS1 and impedes its expression: An experimental study.","authors":"Bader O Almutairi, Ahmed Rady, Bashayer S Aljuhani, Mikhlid H Almutairi","doi":"10.18332/tid/203507","DOIUrl":"https://doi.org/10.18332/tid/203507","url":null,"abstract":"<p><strong>Introduction: </strong>Cigarette smoke (CS) contains carcinogenic substances and influences genetic regulation and epigenetic modifications, such as DNA methylation. It plays a role in the development of various cancers, including colon, bladder, lung cancer, and leukemia. Long non-coding RNAs play a significant role in controlling several pathways in the cell, including lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1), which is found overexpressed in lung, oral, glioblastoma, and colon cancers and downregulated in leukemias. We investigated the impact of CS on DNA methylation of the promoter region of LEF1-AS1 as well as its expression in endothelial cells.</p><p><strong>Methods: </strong>This experimental study was designed to investigate the effects of cigarette smoke on the methylation status of the promoter region of LEF1-AS1 in smoker and non-smoker samples and its expression in relevant cell models. To measure the alternations of DNA methylation, extracted DNA samples from 64 male subjects (32 smokers and 32 non-smokers) were bisulfite-treated and amplified using polymerase chain reaction (PCR) with methylation-specific PCR primers. Furthermore, to define the impact of CS on LEF1-AS1 expression, human umbilical vein endothelial cells (HUVECs) were fed with media containing CS for 3 and 6 hours. The expression analysis of LEF1-AS1 was performed using the GTEx (Genotype-Tissue Expression) database, including an assessment of its expression in various cancers such as lung and brain cancers. The functional analysis of the LEF1-AS1 gene was conducted across multiple tissues using data from the GENT2 databases, along with meta-survival and functional enrichment analysis.</p><p><strong>Results: </strong>The results indicated an average increase of 19.8% in DNA methylation of the promoter region of LEF1-AS1 in the samples from the smokers compared with those from the non-smokers, as well as a significant reduction of LEF1-AS1 expression level in the HUVECs (45% and 83%) after treatment with CS (3 and 6 Hours), respectively. LEF1-AS1 expression varied significantly across tumor types when compared to their normal counterparts. Some cancers, such as lung and brain, showed increased expression, suggesting cancer-specific overexpression of LEF1-AS1. Variability in expression across cancers and normal tissues implies potential heterogeneity in gene regulation. A meta-survival analysis of the LEF1-AS1 gene (e.g. GSE31546, GSE31548, GSE19188), revealed hazard ratios (HR) ranging widely, with some studies (e.g. GSE31546, HR=12.02) suggesting increased risk, though confidence intervals often included 1, indicating uncertainty. Low heterogeneity (I²=16%, p=0.26) suggests consistency among studies, but the overall findings lack strong statistical significance.</p><p><strong>Conclusions: </strong>Our findings indicate that CS alters LEF1-AS1 DNA methylation and causes an inhibition of LEF1-AS1 expression.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between electronic cigarette use and respiratory symptoms among university students: A cross-sectional study in Saudi Arabia.","authors":"Mawada Q Alsaedi, Abdulmohsen H Al-Zalabani","doi":"10.18332/tid/203454","DOIUrl":"https://doi.org/10.18332/tid/203454","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarette use is on the rise. It is critical to understand the respiratory hazards connected with their use for public health reasons. However, there are limited data concerning this issue in the Middle East and in Saudi Arabia in particular. This study aimed to investigate the association between e-cigarette use and respiratory symptoms among university students in Madinah city, Saudi Arabia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted among university students using a self-administered questionnaire with self-reported respiratory symptoms as the primary outcome; a non-probability convenience sampling strategy was used. Emails were sent to all registered students in undergraduate programs between October and November 2024. Appropriate statistical tests were performed on the data, including multivariable logistic regression.</p><p><strong>Results: </strong>A total of 499 students participated in the study, of which 17.6% were current e-cigarette users and 13.2% were ever users. Respiratory symptoms were most prevalent among current users. Current e-cigarette users and ever users had higher odds of respiratory symptoms than never users (adjusted odds ratio, AOR=2.26; 95% CI: 1.14-4.51 and AOR=2.32; 95% CI: 1.21-4.46, respectively), after adjusting for demographic characteristics, tobacco use, exposure to tobacco and e-cigarettes, and other health factors.</p><p><strong>Conclusions: </strong>We found a significant association between e-cigarette use and adverse respiratory symptoms among university students, independent of tobacco use.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the association between anhedonia and nicotine dependence: A study among female undergraduate students in Saudi Arabia.","authors":"Mai B Alwesmi, Sana Hawamdeh, Sondus F Alotaibi, May A Alfohaid, Futun M Alharbi, Nourah A Alghamdi, Jumanah K Alghamdi, Fai A Aseeri, Raghad A Alqhatani, Adam Saleh","doi":"10.18332/tid/203551","DOIUrl":"https://doi.org/10.18332/tid/203551","url":null,"abstract":"<p><strong>Introduction: </strong>Nicotine dependence and its psychological foundations, including anhedonia, are major public health issues, especially among young adults. There is a dearth of knowledge regarding nicotine dependence and anhedonia especially among female young adults. Thus, this study aimed to investigate the associations between anhedonia and nicotine dependence among female undergraduate students.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in March 2024, among 449 female undergraduate students, in Saudi Arabia. Data were collected using the Fagerström test for nicotine dependence (FTND) and the Snaith-Hamilton Pleasure Scale (SHAPS).</p><p><strong>Results: </strong>A total of 449 female undergraduate students participated in the study. The majority were aged 18-20 years (62.8%). The study found that 11.4% of participants reported nicotine use, primarily e-cigarettes (66.7%). Nicotine users reported higher parental [45.1% vs 26.4%, χ²(1)=7.770, p=0.005] and sibling nicotine use [52.9% vs 30.7%, χ²(1)=17.992, p=0.001]. Mental health conditions were more prevalent in nicotine users [39.2% vs 15.1%, χ²(1)=17.992, p<0.001]. Logistic regression identified mental health conditions (OR=4.44, p<0.001), sibling nicotine use (OR=2.37, p=0.006), and parental nicotine use (OR=2.27, p=0.01) as key predictors of nicotine use. Anhedonia was present in 19.8% of participants, associated with mental health conditions [38.2% vs 12.8%, χ²(1)=31.501, p<0.001], nicotine use [27% vs 7.5%, χ²(1)=8.309, p=0.005] and sibling nicotine use [46.1% vs 30%, χ²(1)=26.857, p<0.001]. Mental health conditions (OR=3.47, p<0.001) and nicotine use (OR=3.34, p<0.001) strongly predicted anhedonia.</p><p><strong>Conclusions: </strong>The study's results support the notion that psychological discomfort influences nicotine use, demonstrating a substantial association between anhedonia and nicotine use. Given the influence of familial nicotine use, there is an immediate need for targeted interventions that address both social and psychological aspects.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with smoking and e-cigarette use statuses among individuals with chronic diseases after hurricanes Helene and Milton.","authors":"Francis Dalisay, Young-Rock Hong, Haoran Chu, Ramzi G Salloum","doi":"10.18332/tid/203427","DOIUrl":"https://doi.org/10.18332/tid/203427","url":null,"abstract":"<p><strong>Introduction: </strong>Natural disasters increase health risks for individuals with chronic diseases and may worsen substance use behaviors as a coping mechanism. The present study examined post-disaster intentions to use and past 30-day use of cigarettes and e-cigarettes and associated factors among individuals with chronic diseases who experienced hurricanes Helene and Milton.</p><p><strong>Methods: </strong>We conducted online panel surveys in US Federal Emergency Management Agency (FEMA)-declared disaster counties in Georgia, North Carolina, and South Carolina following hurricane Helene, and in Florida following Helene/Milton (October-November 2024). Study participants (n=418) included adults with self-reported diagnoses of diabetes, heart disease, lung/respiratory disease, or cancer. We employed validated measures of hurricane stressors, psychological distress (depression/anxiety), and climate change anxiety. Multiple logistic regression models were used to examine factors associated with intentions to use and past 30-day use of cigarettes and e-cigarettes.</p><p><strong>Results: </strong>Hurricane stressors were consistently associated with increased intentions and current use of both cigarettes and e-cigarettes (AORs ranging from 1.21 to 1.36, all p<0.001). Depression/anxiety symptoms were associated with increased post-disaster intentions to use cigarettes (AOR=1.91; 95% CI: 1.38-2.64, p<0.001) and e-cigarettes (AOR=1.66; 95% CI: 1.21-2.28, p<0.01), and past 30-day use of cigarettes (AOR=1.49; 95% CI: 1.10-2.02, p<0.05). Climate change anxiety (AOR=1.41; 95% CI: 1.07-1.85, p<0.05) was associated with increased past 30-day e-cigarette use.</p><p><strong>Conclusions: </strong>In addition to hurricane stressors and depression and anxiety symptoms, climate change anxiety appears to be a factor associated with tobacco use, particularly, e-cigarettes. Post-disaster health assessments should incorporate substance use interventions for vulnerable populations with chronic conditions.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco carcinogen NNK promotes pancreatic cancer proliferation via LINC00857/β-catenin.","authors":"Cancan Zhou, Ruiqi Cao, Qiqi Wang, Jiantao Mo, Weikun Qian, Zhengyuan Feng, Shengzhan Zhang, Xin Chen, Jie Hao, Qingyong Ma, Zheng Wu, Zheng Wang","doi":"10.18332/tid/203455","DOIUrl":"https://doi.org/10.18332/tid/203455","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking is a key risk factor for pancreatic cancer (PC). Nicotine-derived nitrosamine ketone (NNK), a major tobacco smoke constituent, has been shown to promote cancer growth, but its specific role in PC progression remains unclear. While long non-coding RNA LINC00857 (lnc RNA) is implicated in cancer progression, its regulation by NNK is unknown. This study aims to investigate whether NNK can drive PC growth and elucidate the underlying mechanisms.</p><p><strong>Methods: </strong>Employing an experimental methodology, this investigation treated human pancreatic cancer cell lines (CFPAC-1 and Panc-1) with NNK and utilized various assays (CCK-8, colony formation, and EdU cell proliferation) to assess the effects on cell proliferation. The interplay between LINC00857 expression profiles, PC, and smoking was systematically investigated through cross-database bioinformatic interrogation encompassing public resources and institutional biobank data. Experiments were performed to knock down LINC00857 in PC cells using siRNA technology. We used Western blotting and quantitative real-time PCR (qRT-PCR) to assess β-catenin expression and elucidate the mechanism by which the tobacco carcinogen NNK promotes PC formation.</p><p><strong>Results: </strong>Some evidence that NNK enhanced the proliferative capacity of PC cells was found. Bioinformatic analysis of public databases, combined with data from our center's database, revealed that LINC00857 was up-regulated in PC and correlated with smoking. Moreover, we discovered that knockdown of LINC00857 inhibited PC cell proliferation, with β-catenin identified as a potential downstream molecule. Importantly, after LINC00857 knockdown, we observed suppression of NNK-induced β-catenin upregulation at both protein and transcriptional levels.</p><p><strong>Conclusions: </strong>NNK potentially induces PC progression through the LINC00857/β-catenin axis. These findings provide new perspectives on the mechanisms of PC progression and highlight the clinical relevance of smoking cessation for preventing PC.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal smoking around birth as a risk factor for offspring chronic obstructive pulmonary disease: Evidence from Mendelian randomization.","authors":"Qiliang Jian, Huyan Huo, Fangxiang Mu, Fang Wang","doi":"10.18332/tid/203186","DOIUrl":"https://doi.org/10.18332/tid/203186","url":null,"abstract":"<p><strong>Introduction: </strong>Previous observational studies suggested that exposure of the fetus to maternal smoking during pregnancy may increase the likelihood of chronic obstructive pulmonary disease (COPD). Hence, following the STROBE-MR guidelines, we carried out a two-sample MR analysis to explore the association between maternal smoking around birth and offspring COPD.</p><p><strong>Methods: </strong>We used independent single nucleotide polymorphisms (SNPs) related to maternal smoking around birth, obtained from genome-wide association study summary data, as instrumental variables (IVs). The dataset included 121634 controls and 276098 cases. The selected outcome was chronic obstructive pulmonary disease (COPD) in offspring, with 454945 controls and 13530 cases. We performed analyses using inverse variance weighting (IVW), weighted median, and MR-Egger regression methods. Multivariate MR included maternal illnesses (high blood pressure and heart disease) as covariates to address potential mediators. Sensitivity analysis was conducted using leave-one-out analysis, Cochran's Q test, and MR-Egger intercept test.</p><p><strong>Results: </strong>In the univariate MR analysis, it was found that maternal smoking around birth significantly increased the likelihood of offspring COPD (IVW, OR=35.13; 95% CI: 10.18-121.20; p<0.001). Furthermore, after adjusting the variates for maternal illnesses, the relationship between maternal smoking around birth and offspring COPD remained statistically significant (adjusted odds ratio, AOR= 62.11; 95% CI: 16.60-232.46; p<0.001).</p><p><strong>Conclusions: </strong>The study provides MR evidence of a potential association between maternal smoking around birth and increased COPD risk in offspring.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping indicators of tobacco and related product use: Unveiling challenges and variations in the Eurobarometer surveys over three decades.","authors":"Ayaka Teshima, Cristina Martínez, Filippos T Filippidis, Anthony A Laverty, Constantine I Vardavas, Ariadna Feliu, Armando Peruga, Esteve Fernandez","doi":"10.18332/tid/202651","DOIUrl":"10.18332/tid/202651","url":null,"abstract":"<p><strong>Introduction: </strong>The European Commission's Special Eurobarometer surveys on tobacco are widely used as comparable and representative data across the European Union for monitoring consumption patterns. Despite their broad use, certain challenges persist, including inconsistencies in survey timelines and variations in the collected information across waves. This study aims to identify available tobacco and related product indicators, and assess their temporal comparability, to support researchers to better understand the potential uses of these data and their alignment with other sources.</p><p><strong>Methods: </strong>We explored questionnaires and reports in these surveys on tobacco from the Eurobarometer official website since its inception (1992, 2002, 2005, 2006, 2008, 2009, 2012, 2014, 2017, 2020 and 2023 waves). We extracted and compared questions and responses on use of tobacco and related products, as well as on sociodemographic variables. Finally, we compared all indicators, including frequency and wording, and further mapped the consistency of the indicators and type of product used across the different waves.</p><p><strong>Results: </strong>Current, daily, former and never use of conventional cigarettes has been consistently assessed across all waves, enabling temporal comparisons. From 2009, the surveys have expanded to include e-cigarette use; since 2012, the surveys include various combusted products such as cigars, pipes, cigarillos, and waterpipes, and from 2020, heated tobacco products. By contrast, detailed data on product-specific use intensity and initiation remain limited. While indicators for secondhand smoke exposure and smoking cessation were present in multiple waves, their comparability is hindered by variations in question-wording and responses.</p><p><strong>Conclusions: </strong>Some challenges exist in using Eurobarometer surveys for temporal estimation of tobacco-related burden. Nonetheless, these surveys remain a valuable and unique tool for monitoring tobacco and related product use across the European Union. To further enhance their utility, periodic re-evaluation by tobacco control experts is recommended to ensure that the surveys maintain comparability with past data while capturing effectively emerging products and trends.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WHO FCTC: How we got here and where we are going.","authors":"Laurent Huber, Megan Arendt-Manning","doi":"10.18332/tid/203569","DOIUrl":"https://doi.org/10.18332/tid/203569","url":null,"abstract":"","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of laryngeal cancer in China caused by smoking from 1990 to 2021 and predictions for 2035: An age-period-cohort analysis of global burden of disease study 2021.","authors":"Xue Gu, Xiaopeng Sun, Xiao Ren, Yu Li, Yingying Fang, Hui Song, Pingli Luo, Mengfan Yuan","doi":"10.18332/tid/202875","DOIUrl":"https://doi.org/10.18332/tid/202875","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking is a major risk factor for laryngeal cancer (LC). Understanding the impact of smoking on the changing disease burden of LC is crucial for LC prevention in China and provides a scientific basis for formulating targeted LC prevention and control strategies, contributing to the achievement of the 'Healthy China 2030' goals.</p><p><strong>Methods: </strong>Data on LC attributable to smoking in China, stratified by sex, age, and year, were obtained from the 2021 Global Burden of Disease (GBD) study to conduct a secondary data analysis. Joinpoint regression was used to analyze trends in the burden of LC attributable to smoking in China from 1990 to 2021. Age-period-cohort (APC) analysis was employed to compare and analyze trends in the age, period, and cohort effects on the disease burden. Finally, Bayesian age-period-cohort (BAPC) analysis was used to predict trends in LC mortality and disability-adjusted life years (DALYs) from 2022 to 2035.</p><p><strong>Results: </strong>From 1990 to 2021, the overall burden of LC attributable to smoking in China increased. The number of deaths in males rose from 9128 to 14219, and in females from 790 to 1054. DALYs increased by 39.85% in males and 22.21% in females. Despite the rise in absolute burden, age-standardized mortality rates (ASMR) and age-standardized DALY rates (ASDR) declined, with reductions exceeding 50% in females. Joinpoint regression analysis revealed a decline-stabilization-decline trend in age-standardized rates among males, while females exhibited a continuous decline. According to the APC model, the age effect on disease burden increased with age, while period and cohort risk ratios generally declined. Net drift analysis showed a decline in mortality and DALY rates attributable to smoking, more pronounced in females than males, with local drift values <0 for both sexes. Predictions indicate that by 2035, male LC deaths will reach 17205, and female deaths 1373; however, ASMR and ASDR will continue to decline, with male ASMR dropping to 2.44 per 100000 and female ASMR to 0.16 per 100000.</p><p><strong>Conclusions: </strong>Over the past three decades, the burden of LC attributable to smoking in China has shown an increasing trend, with sex and age disparities. This burden is expected to continue rising over the next fourteen years. Therefore, it is imperative to strengthen smoking prevention and cessation efforts, particularly targeting high-risk groups. Additionally, continued emphasis on education and awareness regarding LC is necessary to facilitate early detection and intervention, thereby effectively reducing the disease burden attributable to smoking.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}