Smoking may be a risk factor for carpal tunnel syndrome: Insights from Mendelian randomization analysis.

IF 2.2 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2025-01-30 eCollection Date: 2025-01-01 DOI:10.18332/tid/199930

Wei Shi, Kaixuan Wu, Hui Li, Huafeng Zhang

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引用次数: 0

Abstract

Introduction: It is currently uncertain whether smoking is a risk factor for carpal tunnel syndrome (CTS). This study aims to elucidate association between smoking and CTS using Mendelian randomization (MR) analysis.

Methods: This study was a secondary analysis of publicly available GWAS data, using four smoking phenotypes (smoking initiation, smoking status, lifetime smoking, and never smoking) as exposures, and two CTS datasets (discovery and validation sets) as outcomes for MR analysis. The discovery set (n=480201) was used to explore the causal relationship between smoking and CTS, while the validation set (n=385304) was used to confirm the results. The effects of smoking on CTS were assessed using inverse variance weighted (IVW), MR-Egger, and weighted median methods. Cochran's Q test was used to detect heterogeneity, and MREgger to test for pleiotropy. Finally, a meta-analysis was performed on the IVW results from both the discovery and validation sets.

Results: IVW results showed that in both the discovery and validation sets, smoking initiation, smoking status, and lifetime smoking are risk factors for CTS. The summary results from the meta-analysis are as follows: smoking initiation (OR=1.17; 95% CI: 1.08-1.27, p<0.001), smoking status (OR=1.87; 95% CI: 1.56-2.24, p<0.001), and lifetime smoking (OR=2.46; 95% CI: 2.03-3.00, p<0.001). Conversely, never smoking is a protective factor against CTS, with the summary result of the meta-analysis being: OR=0.55; 95% CI: 0.42-0.71, p<0.001.

Conclusions: Based on genetic evidence, smoking may be a risk factor for CTS. Further clinical trials are needed to confirm this causal relationship.

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吸烟可能是腕管综合征的一个危险因素：来自孟德尔随机分析的见解。

目前尚不清楚吸烟是否是腕管综合征（CTS）的危险因素。本研究旨在利用孟德尔随机化（MR）分析阐明吸烟与CTS之间的关系。方法：本研究是对公开可用的GWAS数据的二次分析，使用四种吸烟表型（吸烟开始、吸烟状态、终生吸烟和从不吸烟）作为暴露，并使用两个CTS数据集（发现和验证集）作为MR分析的结果。发现集（n=480201）用于探讨吸烟与CTS之间的因果关系，验证集（n=385304）用于确认结果。吸烟对CTS的影响采用逆方差加权（IVW）、MR-Egger和加权中位数法进行评估。采用Cochran’s Q检验检测异质性，MREgger检验多效性。最后，对来自发现集和验证集的IVW结果进行荟萃分析。结果：IVW结果显示，在发现组和验证组中，吸烟起始、吸烟状态和终生吸烟是CTS的危险因素。荟萃分析的总结结果如下：吸烟起始(OR=1.17；结论：基于遗传证据，吸烟可能是CTS的一个危险因素。需要进一步的临床试验来证实这种因果关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.