Tobacco Induced Diseases最新文献

{"title":"Factors associated with smoking cessation among adolescents: A retrospective study in a smoking cessation outpatient clinic.","authors":"Saliha Büşra Aksu, Güzin Zeren Öztürk, Beray Gelmez Taş","doi":"10.18332/tid/221181","DOIUrl":"10.18332/tid/221181","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate smoking cessation status and factors associated with cessation among individuals aged ≤20 years who attended a smoking cessation outpatient clinic during the first month of follow-up.</p><p><strong>Methods: </strong>This was a single-center, descriptive study conducted among adolescents who applied to a Smoking Cessation Outpatient Clinic. Patients' sociodemographic characteristics and smoking histories were recorded, and nicotine dependence was assessed using the Fagerström test for nicotine dependence (FTND). Statistical analyses included descriptive statistics, group comparisons using appropriate parametric or nonparametric tests, and multivariable logistic regression.</p><p><strong>Results: </strong>A total of 229 adolescents were included. At one month, the overall cessation rate was 7.9% (n=18). At one month, adolescents who quit smoking had lower daily cigarette consumption and lower nicotine dependence scores. In multivariable analysis, only the FTND score remained independently associated with cessation (AOR=0.807; 95% CI: 0.660-0.987).</p><p><strong>Conclusions: </strong>Among Turkish adolescents seeking smoking cessation support, lower nicotine dependence was the primary predictor of short-term quitting success. For public health policies, early identification and timely intervention in adolescent smoking are essential to reduce the potential long-term health risks and future healthcare costs, particularly given the increasingly early age of smoking initiation.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking as an independent predictor of long term care certification: The Yamagata cohort study.","authors":"Yoko Matsunami, Masayoshi Souri, Ri Sho, Natsuko Suzuki, Midori Furuse, Tsuneo Konta","doi":"10.18332/tid/224865","DOIUrl":"10.18332/tid/224865","url":null,"abstract":"<p><strong>Introduction: </strong>Smoking has been associated with disease risk; however, whether smoking is an independent predictor of long-term care (LTC) certification remains uninvestigated. Therefore, this study aimed to examine the association between smoking status and LTC certification.</p><p><strong>Methods: </strong>This prospective cohort study was conducted using data from the Yamagata cohort study in Japan. Participants were followed for a mean of 7.6 years (SD=1.8). Individuals with available baseline data on smoking status and relevant covariates were included. The main exposure was baseline smoking status (current, former, and never smokers), and the primary outcome was LTC certification incidence during follow-up. Associations between smoking status and LTC certification were evaluated using Cox proportional hazards models, with sequential adjustment for potential confounders, including demographic factors, lifestyle habits, and comorbidities.</p><p><strong>Results: </strong>At baseline, the overall smoking prevalence rate was 12.4% (22.4% in men, 4.6% in women). At a mean follow-up of 7.6 years (SD=1.8), LTC certification was issued to 262 (2.6%) individuals: 137 men (3.0%), and 125 women (2.1%). Unadjusted analysis using a Cox proportional hazards model indicated a higher hazard ratio (HR) for current smokers (HR=1.44; 95% CI: 1.03-2.02), which remained significant after adjustment for sex and age (AHR=1.81; 95% CI: 1.23-2.66). This persisted even after adjusting for sex, age, physical activity, alcohol consumption, hypertension, diabetes, and dyslipidemia (AHR=1.83; 95% CI: 1.25-2.69), and after accounting for nine factors, including stroke and ischemic heart disease (AHR=1.86; 95% CI: 1.27-2.73). Never and former smokers showed no differences in adjusted models. A sensitivity analysis excluding patients with a history of cardiovascular disease yielded similar AHRs.</p><p><strong>Conclusions: </strong>Overall, current smokers had a higher risk of LTC certification than never smokers, suggesting that smoking may be an independent risk factor.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of e-cigarette use by sex and age in Thailand: The National Health Examination Survey 2024-2025.","authors":"Roengrudee Patanavanich, Wichai Aekplakorn, Suwat Chariyalertsak, Sauwanan Bumrerraj, Polathep Vichitkunakorn, Montakarn Chuemchit, Nareemarn Neelapaichit, Stanton A Glantz","doi":"10.18332/tid/218627","DOIUrl":"10.18332/tid/218627","url":null,"abstract":"<p><strong>Introduction: </strong>Since their introduction in the early 2000s, the prevalence of e-cigarette use has increased globally. E-cigarette use among females, while usually lower than that of males, is rising and typically higher than cigarette use. This study describes the prevalence of e-cigarette use in Thailand stratified by age and sex, including frequency of use, place obtained, preferred flavors, and reasons for use.</p><p><strong>Methods: </strong>This cross-sectional study used the seventh Thai National Health Examination Survey (NHES), conducted between 2024 and 2025. Weighted percentages with 95% confidence intervals (CIs) were used to describe self-reported e-cigarette use patterns across age groups and sex, accounting for survey weights and the complex survey design. We also used multivariable logistic regression models to examine the factors associated with e-cigarette use.</p><p><strong>Results: </strong>Current e-cigarette use was highest among males aged 20-29 years (13.4%; 95% CI 10.7-16.1). Among current e-cigarette users, dual use was higher among males than females (50.3%; 95% CI: 45.1-55.5 vs 18.8%; 95% CI: 11.7-26.0; p<0.01). Never smoking cigarettes among participants who currently use e-cigarettes was higher among females <30 years than males (64.7%; 95% CI: 55.4-74.1 vs 22.5%; 95% CI: 17.4-27.6; p<0.001). Fruit flavors were the most preferred among e-cigarette users across age groups and sexes. Females were more likely to use e-cigarettes to relieve stress and generally initiated using e-cigarettes at a younger age than males. Multivariable logistic regression revealed that age and sex were significantly (p<0.001) associated with ever, current, and daily e-cigarette use.</p><p><strong>Conclusions: </strong>This study describes patterns of e-cigarette use in a country where e-cigarettes are prohibited. The high proportion of dual use and the high prevalence of e-cigarette use among younger adults who never smoked, suggest that e-cigarette use is not primarily motivated by cessation among younger users. Health initiatives should dispel e-cigarette harm reduction claims and denormalize social norms that encourage their use.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13355163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between knowledge of electronic cigarettes and HTPs and intentions to use among university students: A cross-sectional study.","authors":"Canan Arslan","doi":"10.18332/tid/224358","DOIUrl":"10.18332/tid/224358","url":null,"abstract":"<p><strong>Introduction: </strong>Electronic cigarettes and heated tobacco products (HTPs) have become increasingly visible among young adults. This study examines the association between university students' level of knowledge about these products and their intention to use them.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among 382 university students aged 18-25 years in Türkiye. Participants were recruited using a convenience sampling method. Knowledge of electronic cigarettes and HTPs was assessed using true, false, or 'I don't know' items. Intention to use was measured with Likert-type items. Group differences were analyzed using the Mann-Whitney U test, and associations were examined using Kendall's tau-b correlation coefficient. Multivariable ordinal logistic regression analyses were performed to adjust for potential confounding factors. Statistical significance was set at 0.05.</p><p><strong>Results: </strong>Awareness of electronic cigarettes was high (94.2%), whereas current use was low (0.8%). For HTPs, awareness was 34.8%, and current use was 3.7%. The mean knowledge scores were 3.25 ± 2.22 for electronic cigarettes and 2.22 ± 2.51 for HTPs. Students who indicated that they might consider trying an HTP if offered by a friend had higher knowledge scores (p=0.047). Weak but statistically significant positive correlations were observed between knowledge of electronic cigarettes and intention to use within the next six months (τ-b=0.143; p<0.001), as well as overall propensity to use (τ-b=0.165; p<0.001). However, in multivariable analyses, knowledge was not independently associated with intention to use either electronic cigarettes or HTPs, while conventional cigarette use and peer use were significantly associated with intention outcomes.</p><p><strong>Conclusions: </strong>Knowledge level was not independently associated with intention to use electronic cigarettes or HTPs. Knowledge alone may not be sufficient to explain differences in intentions among young adults, and behavioral and social factors may play a more prominent role.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13340086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences for tobacco control health education among Chinese university students: A discrete choice experiment embedded in a randomized controlled trial.","authors":"Yu Chen, Jie Li, Xinjie Zhao, Guanmin Chen, Zhangyan Li, Ziliang Wang, Kin-Sun Chan, Xiaojing Guan","doi":"10.18332/tid/220332","DOIUrl":"10.18332/tid/220332","url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use prevention among university students requires evidence on which educational program features students prefer. This study used a discrete choice experiment (DCE) embedded in a randomized controlled trial (RCT) to quantify Chinese never-tobacco-using university students' preferences for attributes of a tobacco control health education program.</p><p><strong>Methods: </strong>A DCE with six two-level attributes (organizer, content format, organization mode, frequency, educational content, delivery location) was administered to 260 never-tobacco-using university students enrolled in a Protection Motivation Theory (PMT)-based RCT. Seven choice sets, each containing two unlabeled alternatives, were presented via an online survey platform. Conditional logit models with cluster-robust standard errors estimated attribute preferences; Wald interaction tests assessed preference heterogeneity by trial arm, sex, parental smoking, and peer smoking.</p><p><strong>Results: </strong>Of the 260 respondents, 192 (73.8%) were female, and 243 (93.5%) were undergraduates. Students significantly preferred video-based content (β= -0.1899; 95% CI: -0.2723 - -0.1074), online delivery (β= -0.1698; 95% CI: -0.2525 - -0.0872), and comprehensive cigarette-plus-e-cigarette content (β= -0.1320, 95% CI: -0.2147 - -0.0493). Content format (32.0%), delivery location (28.6%), and educational content (22.2%) together accounted for 82.8% of relative attribute importance. DCE preferences did not differ between trial arms (all Wald interaction p>0.33). A significant sex × delivery location interaction was observed (p=0.019).</p><p><strong>Conclusions: </strong>Chinese never-tobacco-using university students prefer video-based, online, comprehensive tobacco and e-cigarette education. These demand-side preferences may inform the design of future campus-based prevention programs. The absence of trial arm differences supports the validity of the embedded DCE-RCT design.</p><p><strong>Clinical trial registration: </strong>The study is registered on the official website of Chinese Clinical Trial Registry.</p><p><strong>Identifier: </strong>ChiCTR2300068240.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13332694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MiR-129-5p is associated with chronic obstructive pulmonary disease status and alleviates cigarette smoke extract-induced human bronchial epithelial cell injury.","authors":"Dan Liu, Jingfan Wang, Ping Zhang, Yonggang Qin, Yunchang Pan","doi":"10.18332/tid/221191","DOIUrl":"10.18332/tid/221191","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic obstructive pulmonary disease (COPD) is a common progressive respiratory disease with persistent airflow limitation, chronic airway inflammation, and limited early diagnostic biomarkers and targeted therapies. MicroRNAs (miRNAs) are involved in COPD pathogenesis, but the role of microRNA-129-5p (miR-129-5p) in COPD is unclear. This study investigated miR-129-5p's association with COPD susceptibility, its regulation on cigarette smoke extract (CSE)-induced bronchial epithelial cell injury, and the mechanism involving intercellular cell adhesion molecule 1 (ICAM1) and RELA.</p><p><strong>Methods: </strong>The study included a cross-sectional study and in vitro experiments. The cross-sectional study (Hanyang Hospital, March 2022-May 2024) collected serum from 126 COPD patients and 120 controls to detect miR-129-5p, ICAM1, and RELA via quantitative real-time polymerase chain reaction (qRT-PCR). Receiver operating characteristic (ROC) curve area (AUC), multivariate logistic regression, and Pearson correlation were used for analysis. In vitro, human bronchial epithelial cells (BEAS-2B) were divided into 6 groups for the CSE-induced injury model; Cell Counting Kit-8 (CCK-8), flow cytometry, enzyme-linked immunosorbent assay (ELISA), and dual-luciferase assay detected cell functions and miR-129-5p-ICAM1 targeting.</p><p><strong>Results: </strong>Serum miR-129-5p was significantly downregulated in COPD patients, with elevated ICAM1, RELA, and inflammatory factors. It distinguished COPD from controls (AUC=0.88; 95% CI: 0.84-0.92, p<0.001) and was an independent susceptibility factor (adjusted odds ratio, AOR=0.15; 95% CI: 0.08-0.26, p<0.001). miR-129-5p was negatively associated with inflammatory factors and positively associated with pulmonary function. CSE inhibited miR-129-5p and induced injury; its overexpression reversed injury, knockdown exacerbated it, and it targeted ICAM1, whose overexpression abrogated miR-129-5p's protection.</p><p><strong>Conclusions: </strong>Serum miR-129-5p was downregulated in COPD patients, while cellular evidence indicated that it potentially alleviates CSE-induced injury by targeting ICAM1 and downregulating RELA, providing preliminary evidence for COPD pathogenesis; further large-scale studies are needed to verify its clinical value.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148370005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking inequalities among culturally diverse populations in Australia: A secondary dataset analysis of the HILDA survey 2002-2019.","authors":"Lin Aung, Karen Block, Humaira Maheen, Upul Cooray, Ankur Singh","doi":"10.18332/tid/217085","DOIUrl":"10.18332/tid/217085","url":null,"abstract":"<p><strong>Introduction: </strong>Given that over 7 million Australians are born overseas, this study aimed to examine smoking prevalence, trends, and inequalities across major cultural subpopulations in Australia from 2002 to 2019, using a causal weighting method.</p><p><strong>Methods: </strong>This was a secondary analysis of repeated cross-sectional data from 18 waves (2002-2019) of the Household, Income and Labour Dynamics in Australia (HILDA) survey. Respondents aged ≥15 years with smoking status and region of birth were grouped into six cultural subpopulations. Inverse probability of treatment weighting (IPTW) was applied to adjust for sociodemographic characteristics across six cultural subpopulations. Inequalities in never, current, and ex-smokers were assessed using prevalence differences and ratios, stratified by sex, with Australian-born individuals as the reference group.</p><p><strong>Results: </strong>Absolute differences (per 100 people) in never smoking prevalence between the group with the poorest smoking prevalence and the Australian-born group, decreased from -16.53% (95% CI: -18.17 - -14.89) to -10.84% (95% CI: -12.24 - -9.43), and from -7.56% (95% CI: -11.88 - -3.24) to -4.01% (95% CI: -8.16-0.14) in ex-smoking prevalence. However, absolute differences in current smoking increased from 3.49% (95% CI: -0.70-7.68) to 9.09% (95% CI: 5.52-12.66). Men from the Middle East and Africa and women from Europe, the Middle East, and Africa had the poorest outcomes, with increasing current smoking and declining never smoking prevalence.</p><p><strong>Conclusions: </strong>While inequalities in never and ex-smoking prevalence have narrowed, inequalities in current smoking persist or have worsened among specific subgroups. These findings indicate persistent smoking inequalities among certain immigrant subgroups, suggesting the need for further research to understand better the social, cultural, and structural factors that may underlie these patterns and guide future equity-focused tobacco control strategies.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13320934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cigarette smoking, e-cigarette, and heated tobacco product use and associated factors among a nationally representative sample of adult Malaysians: An online survey.","authors":"Chandrashekhar T Sreeramareddy, Fateen-Izzah Haziqah Parlan, Palanisamy Sivanandy, Pathiyil R Shankar","doi":"10.18332/tid/221104","DOIUrl":"10.18332/tid/221104","url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to estimate the prevalence of cigarette smoking, e-cigarette, and heated tobacco product use behaviors and their associated factors among adult Malaysians.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted in December 2024 among a nationally representative sample of 1000 adult Malaysians (≥18 years). We used a questionnaire adapted from the Global Adult Tobacco Survey. Binary logistic regression analyses were performed to identify factors associated with tobacco and nicotine product use.</p><p><strong>Results: </strong>The overall prevalence of current smoking was 28.6% (95% CI: 25.8-31.4), with a mean age of smoking initiation of 21.5 years. Awareness of e-cigarettes was high (92.4%), with 14.6% (95% CI: 12.5-17.0) and 13.4% (95% CI: 11.4-15.8) reporting current daily and non-daily use, respectively. Fewer respondents were aware of heated tobacco products (HTPs, 548.5%), with 4.5% (95% CI: 3.4-6.1) and 10.0% (95% CI: 8.2-12.1) reporting current daily and non-daily use, respectively. Current smoking (AOR=44.19; 95% CI: 24.78-78.81 for e-cigarettes; AOR=31.0; 95% CI: 13.58-73.57 for HTPs), male sex, younger age, and exposure to advertisements were significantly associated with e-cigarette and HTP use. A smoke-free home environment was a protective factor against e-cigarette (AOR=0.44; 95% CI: 0.24-0.80) and HTP use (AOR=0.27; 95% CI: 0.13-0.55).</p><p><strong>Conclusions: </strong>Continued surveillance of nicotine product use is essential. Tobacco control measures under the new Public Health Act should include specific regulations for e-cigarettes and heated tobacco products, particularly targeting younger populations.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing public responses to Shanghai's strict smoking ban: A data mining study based on 12320 Health Hotline calls.","authors":"Lili Shi, Aksara Regmi, Jiaqi Shao, Zi-An He, Yuyang Cai","doi":"10.18332/tid/218152","DOIUrl":"10.18332/tid/218152","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluates the public response to Shanghai's strict smoking ban through an analysis of calls made to the 12320 Health Hotline. The focus is on identifying the types of violations reported, the locations involved, and how these calls can inform future enforcement strategies.</p><p><strong>Methods: </strong>We collected 41614 call records from March 2016 to March 2019 and used natural language processing (NLP) techniques to analyze these data. Calls containing tobacco-related complaints, consultations, help-seeking requests, or suggestions were included.</p><p><strong>Results: </strong>Following the implementation of the amended regulations, tobacco-related hotline activity peaked in March 2017. During this month, 6937 eligible calls were recorded, of which 4705 (68%) were complaints, 1212 (17%) were consultations, and 829 (12%) were help-seeking requests, while only 172 calls (2%) involved suggestions. Workplaces accounted for the largest proportion of reported locations (35%; n=2399), followed by food and beverage establishments (14%; n=960) and leisure or hospitality venues (13%; n=902), with schools least frequently reported (1%; n=86).</p><p><strong>Conclusions: </strong>Hotline-based surveillance provides a practical approach for characterizing public concerns related to smoking ban enforcement. Further studies are needed to examine demographic predictors of call patterns, assess long-term trends beyond the initial implementation period, and explore how such data sources may complement conventional tobacco control monitoring systems.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of nicotine exposure on depression: An integrative analysis combining network toxicology, molecular docking, and Mendelian randomization.","authors":"Daoyuan Li, Yuli Huang, Tanyue Zhou, Zhen Wang, Cailing Ren","doi":"10.18332/tid/220849","DOIUrl":"10.18332/tid/220849","url":null,"abstract":"<p><strong>Introduction: </strong>Depression is a globally prevalent affective disorder closely associated with environmental factors and neurological dysfunction, affecting over 300 million people worldwide and imposing a heavy burden on families and healthcare systems. As the core addictive bioactive component in tobacco, nicotine is intimately linked to an increased risk of depression, but its underlying molecular mechanisms remain unclear. This study aimed to explore the molecular mechanisms of nicotine-induced depression and identify the core molecular targets and pathways involved.</p><p><strong>Methods: </strong>This study integrated network toxicology, molecular docking, and Mendelian randomization (MR). Nicotine's structure and SMILES were retrieved from PubChem for toxicity analysis via ADMETlab 3.0 and Protox3.0. Potential targets of nicotine and depression-related genes were screened from databases including GeneCards, OMIM, and ChEMBL. Common targets were obtained via Venny for PPI network construction, core target screening, GO/KEGG enrichment analysis, and molecular docking of the top 5 targets. MR verified causal associations with depression.</p><p><strong>Results: </strong>Nicotine exhibited significant neurotoxicity (probability=0.951), respiratory, hepatotoxic, and nephrotoxic effects. A total of 69 common targets were identified, including DRD2, CHRNA4, and STAT3. GO enrichment involved biological processes like excitatory postsynaptic potential and KEGG pathways such as cAMP signaling. Molecular docking showed favorable binding affinity (binding energies < -5.0 kcal/mol). MR confirmed that higher CHRNA4 expression in the Nucleus Accumbens increased depression risk (IVW, OR=1.02; 95% CI: 1.01-1.04, p=0.003).</p><p><strong>Conclusions: </strong>This study demonstrated that nicotine exacerbates depressive-like behaviors by binding to core targets, including DRD2 and CHRNA4, and regulating dopaminergic and cholinergic pathways. These findings provide mechanistic insights for elucidating the underlying molecular mechanisms of nicotine-induced depression, while the identified targets and pathways offer potential directions for subsequent mechanistic validation and targeted studies of depression associated with nicotine exposure.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"24 ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148353761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}