{"title":"非吸烟者暴露于二手烟和身体残疾：一项使用NHANES 2013-2018可替宁测量值的全国性横断面研究。","authors":"Jiahui He, Zhounan Wu, Yuhang Liang, Jinshen He","doi":"10.18332/tid/200546","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Secondhand smoke (SHS) exposure is a significant health risk, but current research often overlooks its broader impact on functional impairments in the general public.</p><p><strong>Methods: </strong>This study utilized serum cotinine levels (SCL) from the 2013-2018 NHANES dataset to investigate physical disabilities associated with SHS exposure. SCL represents the combined concentration of cotinine and hydroxycotinine. The physical disabilities assessed include difficulties with hearing, vision, concentration, walking, dressing or bathing independently, and running errands alone. Logistic regression was applied to evaluate the relationship between SCL and physical disabilities in adults, with stratified analyses by age, gender, and race. A p<0.05 was considered significant.</p><p><strong>Results: </strong>Logistic regression analyses showed that SHS exposure was significantly associated with walking difficulty. Participants in the highest quartile of SCL (Q4) had significantly higher odds of walking difficulty compared to those in the lowest quartile (Q4 vs Q1, AOR=2.03; 95% CI: 1.24-3.31, p-trend=0.010). Higher hydroxycotinine were associated with increased walking difficulty (AOR=1.48; 95% CI: 1.06-2.08, p=0.030). Individuals in the highest quartile of hydroxycotinine (Q4) faced more difficulty running errands (AOR=2.09; 95% CI: 1.13-3.88, p-trend=0.036). Among males, the highest quartiles of cotinine and hydroxycotinine were more strongly associated with walking difficulty than in females (cotinine: AOR=2.92 vs 1.49; hydroxycotinine: AOR=3.23 vs 1.78). In adults aged ≥60 years, higher SCL, cotinine, and hydroxycotinine levels were significantly associated with walking difficulty (SCL, AOR=1.58; 95% CI: 1.24-2.02); cotinine, AOR=1.80; 95% CI: 1.21-2.67; hydroxycotinine, AOR=4.57; 95% CI: 1.92-10.89). An 'L'-shaped association was observed for ln(hydroxycotinine) and walking difficulty, with a significant association beyond -1.306 (AOR=2.57; 95% CI: 1.33-4.96, p=0.005).</p><p><strong>Conclusions: </strong>Higher SHS is significantly associated with various physical disabilities, especially in men and older adults.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843551/pdf/","citationCount":"0","resultStr":"{\"title\":\"Exposure to secondhand smoke and physical disabilities in non-smokers: A national cross-sectional study with cotinine measurements from NHANES 2013-2018.\",\"authors\":\"Jiahui He, Zhounan Wu, Yuhang Liang, Jinshen He\",\"doi\":\"10.18332/tid/200546\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Secondhand smoke (SHS) exposure is a significant health risk, but current research often overlooks its broader impact on functional impairments in the general public.</p><p><strong>Methods: </strong>This study utilized serum cotinine levels (SCL) from the 2013-2018 NHANES dataset to investigate physical disabilities associated with SHS exposure. SCL represents the combined concentration of cotinine and hydroxycotinine. The physical disabilities assessed include difficulties with hearing, vision, concentration, walking, dressing or bathing independently, and running errands alone. Logistic regression was applied to evaluate the relationship between SCL and physical disabilities in adults, with stratified analyses by age, gender, and race. A p<0.05 was considered significant.</p><p><strong>Results: </strong>Logistic regression analyses showed that SHS exposure was significantly associated with walking difficulty. Participants in the highest quartile of SCL (Q4) had significantly higher odds of walking difficulty compared to those in the lowest quartile (Q4 vs Q1, AOR=2.03; 95% CI: 1.24-3.31, p-trend=0.010). Higher hydroxycotinine were associated with increased walking difficulty (AOR=1.48; 95% CI: 1.06-2.08, p=0.030). Individuals in the highest quartile of hydroxycotinine (Q4) faced more difficulty running errands (AOR=2.09; 95% CI: 1.13-3.88, p-trend=0.036). Among males, the highest quartiles of cotinine and hydroxycotinine were more strongly associated with walking difficulty than in females (cotinine: AOR=2.92 vs 1.49; hydroxycotinine: AOR=3.23 vs 1.78). In adults aged ≥60 years, higher SCL, cotinine, and hydroxycotinine levels were significantly associated with walking difficulty (SCL, AOR=1.58; 95% CI: 1.24-2.02); cotinine, AOR=1.80; 95% CI: 1.21-2.67; hydroxycotinine, AOR=4.57; 95% CI: 1.92-10.89). An 'L'-shaped association was observed for ln(hydroxycotinine) and walking difficulty, with a significant association beyond -1.306 (AOR=2.57; 95% CI: 1.33-4.96, p=0.005).</p><p><strong>Conclusions: </strong>Higher SHS is significantly associated with various physical disabilities, especially in men and older adults.</p>\",\"PeriodicalId\":23202,\"journal\":{\"name\":\"Tobacco Induced Diseases\",\"volume\":\"23 \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-02-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843551/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tobacco Induced Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18332/tid/200546\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tobacco Induced Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18332/tid/200546","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Exposure to secondhand smoke and physical disabilities in non-smokers: A national cross-sectional study with cotinine measurements from NHANES 2013-2018.
Introduction: Secondhand smoke (SHS) exposure is a significant health risk, but current research often overlooks its broader impact on functional impairments in the general public.
Methods: This study utilized serum cotinine levels (SCL) from the 2013-2018 NHANES dataset to investigate physical disabilities associated with SHS exposure. SCL represents the combined concentration of cotinine and hydroxycotinine. The physical disabilities assessed include difficulties with hearing, vision, concentration, walking, dressing or bathing independently, and running errands alone. Logistic regression was applied to evaluate the relationship between SCL and physical disabilities in adults, with stratified analyses by age, gender, and race. A p<0.05 was considered significant.
Results: Logistic regression analyses showed that SHS exposure was significantly associated with walking difficulty. Participants in the highest quartile of SCL (Q4) had significantly higher odds of walking difficulty compared to those in the lowest quartile (Q4 vs Q1, AOR=2.03; 95% CI: 1.24-3.31, p-trend=0.010). Higher hydroxycotinine were associated with increased walking difficulty (AOR=1.48; 95% CI: 1.06-2.08, p=0.030). Individuals in the highest quartile of hydroxycotinine (Q4) faced more difficulty running errands (AOR=2.09; 95% CI: 1.13-3.88, p-trend=0.036). Among males, the highest quartiles of cotinine and hydroxycotinine were more strongly associated with walking difficulty than in females (cotinine: AOR=2.92 vs 1.49; hydroxycotinine: AOR=3.23 vs 1.78). In adults aged ≥60 years, higher SCL, cotinine, and hydroxycotinine levels were significantly associated with walking difficulty (SCL, AOR=1.58; 95% CI: 1.24-2.02); cotinine, AOR=1.80; 95% CI: 1.21-2.67; hydroxycotinine, AOR=4.57; 95% CI: 1.92-10.89). An 'L'-shaped association was observed for ln(hydroxycotinine) and walking difficulty, with a significant association beyond -1.306 (AOR=2.57; 95% CI: 1.33-4.96, p=0.005).
Conclusions: Higher SHS is significantly associated with various physical disabilities, especially in men and older adults.
期刊介绍：
Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community.
The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.
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