Therapie最新文献

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Dapagliflozin-induced leukocytoclastic vasculitis 达帕格列净诱发的白细胞凝集性血管炎
IF 2.2 4区 医学
Therapie Pub Date : 2025-05-01 DOI: 10.1016/j.therap.2024.06.004
Dhouha Sahnoun , Houda Ghardallou , Myriam Agrebi , Mohamed Ben Rejeb , Najet Ghariani , Badreddine Sriha , Mohamed Denguezli , Chaker Ben Salem
{"title":"Dapagliflozin-induced leukocytoclastic vasculitis","authors":"Dhouha Sahnoun , Houda Ghardallou , Myriam Agrebi , Mohamed Ben Rejeb , Najet Ghariani , Badreddine Sriha , Mohamed Denguezli , Chaker Ben Salem","doi":"10.1016/j.therap.2024.06.004","DOIUrl":"10.1016/j.therap.2024.06.004","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":"80 3","pages":"Pages 336-338"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drugs and patient's dissatisfaction reporting: From a disproportionality pharmacovigilance analysis to social pharmacology. 药物与患者不满报告:从不均衡药物警戒分析到社会药理学。
IF 2.2 4区 医学
Therapie Pub Date : 2025-05-01 DOI: 10.1016/j.therap.2025.04.005
Jean-Louis Montastruc
{"title":"Drugs and patient's dissatisfaction reporting: From a disproportionality pharmacovigilance analysis to social pharmacology.","authors":"Jean-Louis Montastruc","doi":"10.1016/j.therap.2025.04.005","DOIUrl":"https://doi.org/10.1016/j.therap.2025.04.005","url":null,"abstract":"<p><strong>Introduction: </strong>Patient satisfaction is a key element in medical practice. Few studies have investigated patient satisfaction or dissatisfaction with their drug treatment.</p><p><strong>Method: </strong>Using the World Health Organization (WHO) global pharmacovigilance database, we investigated, through disproportionality analyses, potential associations between exposure to drugs and \"patient dissatisfaction with treatment\" reports. All reports of \"patient dissatisfaction with treatment\" in adults until 31/12/2024 were included.</p><p><strong>Results/discussion: </strong>Results are expressed as reporting odds ratio (ROR). Among 506 reports, three quarters came from consumers, involving mainly women aged between 45 and 64. The main coreported term was drug inefficacy (before adverse drug reactions). The first anatomical therapeutic chemical (ATC) group was dermatological drugs (25.5%) followed by alimentary tract and metabolism (24.3%), nervous system (22.5%) drugs. A significant association was found with 22 drugs with the highest ROR values for plecanatide, efinaconazole and avatrombopag.</p><p><strong>Conclusion: </strong>Despite its mandatory limitations (underreporting, selective reporting…), this study shows that pharmacovigilance data could help to understand some aspects of social pharmacology, here, patient dissatisfaction with their drug treatment.</p>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report of a slow-metabolism of CYP2D6 which led to a misuse of codeine: How can we detect it and how can we take care? 导致滥用可待因的 CYP2D6 代谢缓慢病例报告:我们如何才能发现它?
IF 2.2 4区 医学
Therapie Pub Date : 2025-05-01 DOI: 10.1016/j.therap.2024.07.002
Deborah Montmeat , Xavier Declèves , Laurence Labat , Alicja Puszkiel , Serge Perrot , Anne-Priscille Trouvin
{"title":"Case report of a slow-metabolism of CYP2D6 which led to a misuse of codeine: How can we detect it and how can we take care?","authors":"Deborah Montmeat ,&nbsp;Xavier Declèves ,&nbsp;Laurence Labat ,&nbsp;Alicja Puszkiel ,&nbsp;Serge Perrot ,&nbsp;Anne-Priscille Trouvin","doi":"10.1016/j.therap.2024.07.002","DOIUrl":"10.1016/j.therap.2024.07.002","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":"80 3","pages":"Pages 338-341"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141789139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of new drug releases on heart failure management and hospitalizations in France: A repeated cross-sectional study between 2014 and 2023 新药发布对法国心衰管理和住院治疗的影响:2014年至2023年间的重复横断面研究。
IF 2.2 4区 医学
Therapie Pub Date : 2025-05-01 DOI: 10.1016/j.therap.2024.07.006
Paul Gautier , Cécile Vindis , Meyer Elbaz , François Montastruc
{"title":"Impact of new drug releases on heart failure management and hospitalizations in France: A repeated cross-sectional study between 2014 and 2023","authors":"Paul Gautier ,&nbsp;Cécile Vindis ,&nbsp;Meyer Elbaz ,&nbsp;François Montastruc","doi":"10.1016/j.therap.2024.07.006","DOIUrl":"10.1016/j.therap.2024.07.006","url":null,"abstract":"<div><div>Real-life data on the impact of sacubitril-valsartan and sodium-glucose cotransporter type 2 (SGLT-2) inhibitors on heart failure (HF) in France is lacking. Using French health insurance databases, we examined the ten-year evolution in HF medication use, focusing on SGLT-2 inhibitors and sacubitril/valsartan, and incidence of HF hospitalizations during the same period. We conducted a repeated cross-sectional study using medical-administrative data from French health insurance databases between 2014 and 2023. These included “OpenMedic” for outpatient medication reimbursements and “ScanSanté” for annual hospitalization data. Medications were classified using ATC codes, and hospitalizations were identified using ICD-10 codes. Statistical analyses encompassed annual rates of users and boxes dispensed for HF medications, along with HF, ischemic heart disease and ischemic stroke hospitalization rates. Prevalence of SGLT-2 inhibitors and sacubitril-valsartan use was also studied regionally, with direct standardization by age and sex, with the French population as the standard population. Between 2014 and 2023, HF drug use increased significantly, with beta-blockers and ACE inhibitors/ARBs leading in prevalence of use. ARNi and SGLT-2 inhibitors, introduced later, showed remarkable rises: +506% and +3766% in users since their market introduction, respectively. Meanwhile, HF hospitalizations slightly increased by +3.6% between 2016 and 2019, followed by a notable decline of −12.5% during 2019–2023, coinciding with the introduction of SGLT-2 inhibitors. In contrast, hospitalizations for ischemic heart disease rose by 11.6% over the period 2016–2019 and by +5.2% over the period 2019–2023, and hospitalizations for ischemic stroke rose by 8.2% over the period 2016–2019 and declined by −0.6% over the period 2019–2023. We observed regional disparities in SGLT-2 inhibitors use, with prevalence ranging from 0.9% in Bretagne to 1.5% in Hauts-de-France. The data suggests a temporal correlation between the increase in SGLT-2 inhibitors use and the decline in HF hospitalizations since 2019. More studies are needed to measure real life effectiveness of SGLT-2 inhibitors in heart failure.</div></div>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":"80 3","pages":"Pages 253-258"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142037105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Spontaneous splenic rupture concomitant with serum sickness induced by infliximab. 病例报告:英夫利昔单抗致自发性脾破裂伴血清病。
IF 2.2 4区 医学
Therapie Pub Date : 2025-04-30 DOI: 10.1016/j.therap.2025.04.004
Thomas Darque, Arthur Dubernet, Chloé Martineau, Julia Goossens, Marie-Laure Jullie, Nathalie Sultan
{"title":"Case report: Spontaneous splenic rupture concomitant with serum sickness induced by infliximab.","authors":"Thomas Darque, Arthur Dubernet, Chloé Martineau, Julia Goossens, Marie-Laure Jullie, Nathalie Sultan","doi":"10.1016/j.therap.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.therap.2025.04.004","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood glutamate levels in major depression with antidepressants and benzodiazepines: A 6-month prospective cohort study. 服用抗抑郁药和苯二氮卓类药物的重度抑郁症患者血谷氨酸水平:一项为期6个月的前瞻性队列研究。
IF 2.2 4区 医学
Therapie Pub Date : 2025-04-12 DOI: 10.1016/j.therap.2025.04.003
Kahlil El Asmar, Tala El Ghoul, Romain Colle, Rida Assaf, Séverine Martin, Séverine Trabado, Bruno Feve, Céline Verstuyft, Laurent Becquemont, Emmanuelle Corruble
{"title":"Blood glutamate levels in major depression with antidepressants and benzodiazepines: A 6-month prospective cohort study.","authors":"Kahlil El Asmar, Tala El Ghoul, Romain Colle, Rida Assaf, Séverine Martin, Séverine Trabado, Bruno Feve, Céline Verstuyft, Laurent Becquemont, Emmanuelle Corruble","doi":"10.1016/j.therap.2025.04.003","DOIUrl":"https://doi.org/10.1016/j.therap.2025.04.003","url":null,"abstract":"<p><strong>Aim of the study: </strong>Our study aims at analyzing blood glutamate levels at three time points in patients on antidepressants and benzodiazepines across different subgroups.</p><p><strong>Methods: </strong>In the 6-month METADAP cohort study, blood glutamate levels were measured in 60 patients with major depression at baseline, 3 months (M3), and 6 months (M6) after starting antidepressant treatment. All patients received a co-prescription with benzodiazepines. Mixed-effect linear regression models were used to analyze the correlation of glutamate levels over time among responders, non-responders, remitters, and non-remitters, adjusting for multiple confounders.</p><p><strong>Results: </strong>Glutamate blood levels showed a significant decrease. Glutamate levels decreased from M0 to M3 across all subgroups. Responders and remitters showed a further decline from M3 to M6 while they increased non-significantly from M3 to M6 among non-responders and non-remitters. Responders showed a decrease of 3.38μmol/L [95% CI (-4.94; -1.82), P<0.001], while remitters showed a decrease of 1.34μmol/L [95% CI (-2.41; -0.27), P=0.014].</p><p><strong>Conclusion: </strong>Glutamate blood levels decreased from M0 to M3 across all groups but varied from M3 to M6: responders and remitters continued to decline, while non-responders and non-remitters showed a non-significant increase. These results should be replicated and further explained.</p>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subcutaneous rituximab in indolent primary cutaneous B cell lymphoma: A case series of 5 patients with the evaluation of the medico economic impact. 皮下美罗华治疗原发性无痛性皮肤B细胞淋巴瘤:5例患者的医学经济影响评价
IF 2.2 4区 医学
Therapie Pub Date : 2025-04-10 DOI: 10.1016/j.therap.2025.04.001
Carla Fassanaro, Laurent Mortier, Olivier Carpentier, Inès Arib, Benoit Dervaux, Sarah Faiz
{"title":"Subcutaneous rituximab in indolent primary cutaneous B cell lymphoma: A case series of 5 patients with the evaluation of the medico economic impact.","authors":"Carla Fassanaro, Laurent Mortier, Olivier Carpentier, Inès Arib, Benoit Dervaux, Sarah Faiz","doi":"10.1016/j.therap.2025.04.001","DOIUrl":"https://doi.org/10.1016/j.therap.2025.04.001","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid desensitization to insulin in a patient with diabetic ketoacidosis and insulin allergy. 糖尿病酮症酸中毒及胰岛素过敏患者的胰岛素快速脱敏。
IF 2.2 4区 医学
Therapie Pub Date : 2025-04-03 DOI: 10.1016/j.therap.2025.03.004
Emna Chtourou, Fatma Charfi, Imen Chabchoub, Hanen Ghozzi, Ahmed Hakim, Kammoun Thouraya, Khaled Zeghal, Lobna Ben Mahmoud
{"title":"Rapid desensitization to insulin in a patient with diabetic ketoacidosis and insulin allergy.","authors":"Emna Chtourou, Fatma Charfi, Imen Chabchoub, Hanen Ghozzi, Ahmed Hakim, Kammoun Thouraya, Khaled Zeghal, Lobna Ben Mahmoud","doi":"10.1016/j.therap.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.therap.2025.03.004","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preventing shingles starts with vaccinating against chickenpox. 预防带状疱疹从接种水痘疫苗开始。
IF 2.2 4区 医学
Therapie Pub Date : 2025-03-31 DOI: 10.1016/j.therap.2025.03.003
Michaël Rochoy
{"title":"Preventing shingles starts with vaccinating against chickenpox.","authors":"Michaël Rochoy","doi":"10.1016/j.therap.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.therap.2025.03.003","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reintroduction of cotrimoxazole in a Stevens-Johnson case with other antibacterial sulfonamide (sulfadiazine) among suspects. 在一起史蒂文斯-约翰逊病例中重新使用复方新诺明,嫌疑犯中还有其他抗菌磺胺(磺胺嘧啶)。
IF 2.2 4区 医学
Therapie Pub Date : 2025-03-26 DOI: 10.1016/j.therap.2025.03.002
Ilaria Matei, Valérie Beaulieu, Camille Ollivier, Bénédicte Lebrun-Vignes, Kamar Bel Hareth, Saskia Ingen-Housz-Oro, Haudrey Assier
{"title":"Reintroduction of cotrimoxazole in a Stevens-Johnson case with other antibacterial sulfonamide (sulfadiazine) among suspects.","authors":"Ilaria Matei, Valérie Beaulieu, Camille Ollivier, Bénédicte Lebrun-Vignes, Kamar Bel Hareth, Saskia Ingen-Housz-Oro, Haudrey Assier","doi":"10.1016/j.therap.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.therap.2025.03.002","url":null,"abstract":"","PeriodicalId":23147,"journal":{"name":"Therapie","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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