Tissue Engineering. Part B, Reviews最新文献

{"title":"Adhesive Hydrogels in Orthopedic Therapy: Design Strategies, Functional Innovations, and Clinical Translation.","authors":"Chunquan Zhu, Zhijun Bi, Bin Liu, Ming Xia, Wei Yan, Lihui Sun, Dongbo Li, Bo Cai, Dongsong Li, Zhiguo Bi","doi":"10.1177/19373341251377104","DOIUrl":"10.1177/19373341251377104","url":null,"abstract":"<p><p>The musculoskeletal system, essential for mobility, structural support, and organ protection, is frequently compromised by trauma, degenerative diseases, or tumors, profoundly impacting patients' quality of life. Adhesive hydrogels have emerged as pivotal biomaterials for orthopedic therapies, offering localized treatment with enhanced biocompatibility, tunable mechanics, and sustained bioactive delivery. While systemic drug administration often suffers from off-target effects, adhesive hydrogels enable precise tissue integration and microenvironmental modulation, addressing challenges such as infection control, tissue regeneration, and mechanical reinforcement. However, achieving optimal adhesion strength, dynamic mechanical matching, and selective tissue targeting remains a critical hurdle. Innovative strategies, including dynamic covalent bonds, stimuli-responsive networks, and multifunctional hybridization, have expanded hydrogel applications in diabetic wound healing, load-bearing bone repair, and spinal cord regeneration. For instance, injectable hydrogels with wet adhesion capabilities facilitate minimally invasive delivery, while drug-eluting systems localize chemotherapeutics to tumor sites, reducing systemic toxicity. Despite these advances, scalability, long-term stability, and clinical translation require further exploration. This review systematically examines the design principles, functional mechanisms, and therapeutic applications of adhesive hydrogels in orthopedics, emphasizing their role in bridging biomechanical demands with biological regeneration. We envision that interdisciplinary innovation in smart hydrogels will unlock personalized solutions, transforming the landscape of precision orthopedic medicine.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373341251377104"},"PeriodicalIF":4.6,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Design and Application of Absorbable Materials for Orbital Fracture Reconstruction.","authors":"Zhangjun Ren, Chao Xiong, Hongfei Liao","doi":"10.1177/19373368261417101","DOIUrl":"https://doi.org/10.1177/19373368261417101","url":null,"abstract":"<p><p>Orbital fractures are a common type of maxillofacial trauma, and their functional and aesthetic reconstruction has long posed challenges in surgical repair. Traditional implant materials (such as autogenous bone, titanium mesh, and porous polyethylene) carry risks of long-term foreign body retention and associated complications. Absorbable materials overcome the drawbacks of permanent implants by providing temporary mechanical support during healing while gradually degrading, representing a significant advancement in orbital fracture repair. This article systematically reviews the design advancements and current applications of resorbable materials in orbital fracture reconstruction. It covers material classification (including properties of poly-L lactic acid [PLLA], polyglycolic acid, polycaprolactone [PCL], and their composites), biomechanical performance, degradation mechanisms, and their integration with precision technologies such as 3D printing, computer navigation, and external endoscopy for preoperative planning and intraoperative procedures. Clinical studies indicate that absorbable implants achieve repair outcomes comparable to permanent implants in small-to-medium and some complex orbital fractures, with the unique advantage of avoiding interference with growth and development in pediatric patients. Despite challenges including delayed inflammatory responses, mechanical strength limitations, and inadequate radiopacity, novel material designs (e.g., uncalcined hydroxyapatite/PLLA composites) and hybrid technologies (e.g., incorporating functional factors such as bone morphogenetic protein-2) are continuously enhancing their performance. Future directions encompass developing smart biomaterials, deepening digital technology integration, advancing long-term multicenter clinical studies, and optimizing cost-effectiveness strategies. Absorbable materials are poised to become a mainstream choice for orbital fracture repair.Impact StatementThis review highlights the transformative role of absorbable materials in orbital fracture reconstruction. By providing temporary support and then degrading, they eliminate long-term risks of permanent implants. The integration of advanced composites (e.g., u-HA/PLLA) and precision technologies such as 3D printing enables superior, patient-specific outcomes. This research consolidates evidence for their efficacy, particularly in pediatric cases, and charts a future course toward smart biomaterials and deeper digital integration, establishing them as a potential new standard of care and significantly advancing the field of maxillofacial surgery.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261417101"},"PeriodicalIF":4.6,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Landscape of the Role of Exosomes in Diabetic Wound Management: Bibliometric Perspective.","authors":"Yungang Hu, Feng Xiong, Muzi Huang, Xiaohua Hu, Yuming Shen, Weili Du","doi":"10.1177/19373368261419657","DOIUrl":"https://doi.org/10.1177/19373368261419657","url":null,"abstract":"<p><p>Diabetic wounds significantly present clinical difficulties on account of high prevalence, recurrence rates, and substantial health care burden. Traditional treatment approaches to these wounds remain suboptimal, emphasizing the urgent demand for new therapeutic strategies. As an emerging therapeutic modality, exosomes (Exos) have garnered increasing attention for their prospect for diabetic wound healing (DWH). Nevertheless, in this domain, a systematic bibliometric analysis of research trends remains insufficient. In this study, we retrieved 441 publications on Exos-based diabetic wound treatment from 2005 to 2024 from the Web of Science Core Collection database. Bibliometric tools comprising CiteSpace and VOSviewer were employed for visualization and bibliometric analysis, including publication trends, national and institutional contributions, author collaboration networks, and keyword co-occurrence patterns. In this domain, the quantity of publications has shown a stable upward trend, with China leading in research output (77.3%), before the United States (12.2%) and India (4.3%). Keyword co-occurrence analysis revealed that research hotspots primarily focus upon the effect of Exos in inflammation modulation and angiogenesis. Notably, integrating Exos with hydrogels has emerged as a key research frontier, presenting a prospective strategy for DWH through sustained Exos release and targeted delivery of therapeutic agents. This study systematically mapped the global research landscape of Exos-based treatments for DWH, clarifying the critical role of Exos in wound recovery and emphasizing the potential of Exos-loaded hydrogels as a future research direction. These findings provided valuable insights into both fundamental research and clinical practices, contributing to the progress in diabetic wound management.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261419657"},"PeriodicalIF":4.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrophage Polarization-Targeted Hydrogels for Bone Regeneration.","authors":"Xiaonan Wang, Yu Sun, Xin Zhao, Aobo Zhang","doi":"10.1177/19373368261420996","DOIUrl":"https://doi.org/10.1177/19373368261420996","url":null,"abstract":"<p><p>Bone regeneration is a multifaceted process involving inflammation and tissue remodeling, which are tightly regulated by the immune response. Macrophages, central players in bone regeneration, exhibit remarkable functional plasticity, transitioning between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. The regulation of macrophage polarization, specifically guiding the shift from the M1 to M2 phenotype, has emerged as a critical therapeutic target to enhance bone regeneration. This review explores the emerging field of macrophage-targeted hydrogels, a novel class of biomaterials designed to modulate macrophage polarization for enhanced bone regeneration. These hydrogels integrate bioactive agents such as growth factors, exosomes, peptides, and nanozymes to influence macrophage behavior, thereby creating a favorable microenvironment for tissue healing. By incorporating specific bioactive molecules that engage macrophage receptors, these hydrogels promote a shift toward the reparative M2 phenotype, facilitating osteogenesis, angiogenesis, and tissue remodeling. Despite their potential, challenges remain, including optimizing the precise control over macrophage polarization, improving targeted delivery, and ensuring the long-term safety and stability of these materials. This review provides a comprehensive overview of the mechanisms, applications, and therapeutic potential of macrophage-targeted hydrogels, highlighting their promise as an innovative strategy for bone regeneration.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261420996"},"PeriodicalIF":4.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid Models of the Oral Mucosa for Precision Medicine.","authors":"Ahmed Atwa, Al-Hassan Soliman Wadan, Seham I Hallool, Ali A Shati, Serag Eldin I Elbehairi, Mohammad Y Alfaifi, Ahmed M Hussein","doi":"10.1177/19373368261420588","DOIUrl":"https://doi.org/10.1177/19373368261420588","url":null,"abstract":"<p><p>Patient-derived organoids (PDOs) have emerged as advanced bioengineered platforms for modeling oral mucosal tissues, offering unprecedented opportunities to interrogate disease mechanisms and evaluate therapeutic responses in a clinically relevant context. This article provides a critical and integrative assessment of recent advances in organoid technologies applied to oral mucosal disorders, with particular emphasis on oral squamous cell carcinoma (OSCC), oral lichen planus, and oral mucositis. Despite significant progress in therapeutic development, the clinical management of OSCC remains challenging due to pronounced inter- and intratumoral heterogeneity and unpredictable treatment responses. Conventional two-dimensional (2D) culture systems and traditional animal models often fail to recapitulate the complex cellular architecture, stromal interactions, and microenvironmental cues that govern oral mucosal pathophysiology, thereby limiting their translational predictive value. In contrast, organoid systems preserve key genetic, epigenetic, and phenotypic features of patient tissues, enabling more faithful <i>ex vivo</i> modeling of disease progression and therapeutic sensitivity. This article critically evaluates the engineering principles underlying oral organoid generation, including stem cell sources, extracellular matrix scaffolds, and microenvironmental modulation, and discusses their implications for disease modeling, drug screening, and personalized therapeutic stratification. Furthermore, current limitations, such as variability in culture conditions, incomplete immune and vascular components, and challenges in standardization, are examined alongside emerging strategies to enhance organoid complexity and translational relevance. Collectively, this article positions organoid-based platforms as a pivotal component of next-generation tissue engineering approaches for oral health research. By bridging fundamental biological insights with clinically actionable applications, organoid technologies hold substantial promise for advancing precision medicine and improving outcomes in patients with complex oral mucosal disorders.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261420588"},"PeriodicalIF":4.6,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Landscape of Tooth Regeneration Research: A Dual-Database Bibliometric Analysis.","authors":"Nurbaeva K Meerim, Gulnara Dzhunushalieva","doi":"10.1177/19373368251405710","DOIUrl":"10.1177/19373368251405710","url":null,"abstract":"<p><p>Tooth regeneration is an exciting frontier in regenerative medicine, yet comprehensive cross-disciplinary analysis of its research landscape remains limited. This study presents the bibliometric analysis, integrating data from Web of Science (WOS) and Scopus, to quantify publication dynamics, journal influence, thematic structure, and translational priorities. Following PRISMA guidelines, we conducted a comprehensive search using keywords related to tooth regeneration, dental tissue engineering, and regenerative dentistry. After systematic screening and quality assessment, 925 articles were analyzed using descriptive statistics to identify publication trends, the most active and cited journals, and VOSviewer co-occurrence analysis to visualize the thematic mapping. The analysis revealed robust field growth. Among the 395 journals that published articles, the top 10 contributed 20% of publications, with the Journal of Dental Research (<i>n</i> = 35) and the Journal of Endodontics (<i>n</i> = 31) leading in productivity. The journals Scientific Reports and Biomaterials achieved the highest Eigenfactor score, while the Science Translational Medicine demonstrated the greatest journal prestige (SJR = 6.722). Co-occurrence analysis identified 384 unique keywords, revealing the presence of four research clusters: Biomaterials and Advanced Scaffold Design; Cellular and Experimental Foundations; Clinical Endodontics and Periodontal Regeneration; Developmental Biology and Tooth Morphogenesis. Stem cell dynamics emphasizes three groups of stem cells: dental-derived cells, specialized cell types and non-dental derived cells. Our bibliometric analysis provides a comprehensive review of the tooth regeneration landscape. Thematic synthesis of stem cells led to an understanding of the field's current limitations, challenges, and cutting-edge trends. This manuscript represents the first dual-database bibliometric and visualization-driven analysis of tooth regeneration research. It quantifies global publication dynamics, highlights the pivotal contributions of leading journals, and delineates four critical thematic clusters: Biomaterials and Advanced Scaffold Design, Cellular and Experimental Foundations, Clinical Endodontics and Periodontal Regeneration, and Developmental Biology and Tooth Morphogenesis. By systematically mapping stem cell applications into dental-derived, specialized, and non-dental populations, this study provides a novel cellular framework for evaluating translational readiness. Furthermore, it underscores emerging frontiers such as 3D bioprinting, bioactive scaffolds, exosome-based therapies, and genetic modulation, while identifying persistent challenges in vascularization, innervation, enamel regeneration, and clinical scalability. Collectively, this analysis offers clinicians, researchers, and policymakers a strategic roadmap for advancing functional tooth regeneration from laboratory innovation to clinical application.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368251405710"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145858115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteonecrosis and Bone Regeneration: A Bibliometric Odyssey over 24 Years.","authors":"Ziyang Min, Yizhou Cao, Jun Liu","doi":"10.1177/19373368261419996","DOIUrl":"https://doi.org/10.1177/19373368261419996","url":null,"abstract":"<p><strong>Background: </strong>Osteonecrosis is a pathological condition characterized by disturbances in microcirculation, osteolysis, and subsequent bone collapse, leading to significant pain and motor impairments that severely affect the quality of life of affected individuals. The primary therapeutic goal in osteonecrosis is the restoration of bone integrity, typically through bone grafting or the use of tissue-engineered constructs. Despite the critical importance of these approaches, a systematic and comprehensive review of the field remains lacking. This study aims to provide a thorough bibliometric analysis of the current state and key research trends in bone regeneration for osteonecrosis.</p><p><strong>Methods: </strong>A systematic search of the Web of Science Core Collection, Scopus, and OpenAlex was conducted for studies published between 2001 and 2024, yielding a total of 1,548 publications related to \"osteonecrosis and bone regeneration.\" Bibliometric tools, including VOSviewer, CiteSpace, and the R package \"bibliometrix,\" were utilized for data analysis.</p><p><strong>Results: </strong>The analysis revealed a notable increase in the number of publications over the years, with China leading the global output at 38.6%, followed by the United States (16.4%) and Japan (5.2%). Shanghai Jiao Tong University and researcher Ling Qin were identified as key contributors to the field. The journal <i>International Orthopaedics</i> emerged as a highly active outlet, while <i>Bone</i> was recognized for its significant impact. Research efforts have primarily focused on bone grafts, tissue engineering, and mesenchymal stem cells, with emerging interest in the integration of exosomes, apoptosis, oxidative stress, and immunomodulation in regenerative therapy.</p><p><strong>Conclusion: </strong>This bibliometric review highlights the leading contributors to the field of osteonecrosis research and identifies key trends in bone regeneration strategies. The findings underscore the progressive advancements in the field and suggest promising avenues for future research.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261419996"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147317846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Stromal Cell Therapy for Premature Ovarian Insufficiency: Mechanisms and Perspectives.","authors":"Yao Fu, Xu Qin, Xinyuan Liang, Wen Lin, Jingxin Yao","doi":"10.1177/19373368261420531","DOIUrl":"https://doi.org/10.1177/19373368261420531","url":null,"abstract":"<p><p>Premature ovarian insufficiency (POI) is a clinically heterogeneous disorder characterized by ovarian dysfunction occurring before the age of 40, leading to infertility and increased long-term health risks. Current management strategies alleviate symptoms but fail to restore ovarian function or fertility, thereby prompting an urgent demand for regenerative therapies for POI. Mesenchymal stromal cells (MSCs) have emerged as a promising regenerative strategy due to their multifunctional capabilities, including paracrine effects, immunomodulation, and cytoprotection effects. This review systematically synthesizes preclinical and clinical evidence supporting the efficacy of MSCs in mitigating ovarian damage, enhancing folliculogenesis, restoring hormonal balance, and promoting the restoration of fertility in both POI models and patients. In addition, this article examines ongoing challenges, such as cellular heterogeneity, the determination of optimal transplantation strategies, and ensuring long-term safety. It also highlights innovative approaches, including biomaterial-enhanced transplantation, genetic engineering, and exosome-based therapies. The integration of these advanced strategies within personalized medicine frameworks holds significant potential to transform the clinical management of POI.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368261420531"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergistic Applications of Microneedling and Nanomaterials: Attaining Cutaneous Repair.","authors":"Guotao Wei, Yihao Yuan, Jiapeng Li, Miaohan Qiu, Ruohan Wang, Zhengtai Mao, Linfei Zuo, Dezhi Zhao, Jiawei Wu","doi":"10.1177/19373368251412766","DOIUrl":"https://doi.org/10.1177/19373368251412766","url":null,"abstract":"<p><p>Environmental stressors delay cutaneous wound healing and significantly impact patient survival rates. Traditional wound medications suffer from low delivery efficiency and susceptibility to degradation. Microneedle technology, characterized by its minimally invasive nature and high efficiency, significantly enhances transdermal drug delivery capabilities, while nanomaterials improve therapeutic efficacy through superior drug protection and controlled-release properties. The combination of these two technologies synergistically enables rapid wound repair and reduces the risk of complications. Current research predominantly focuses on single-component analyses (with only nine related studies indexed in Web of Science from 2014 to 2025), lacking systematic investigation into their synergistic mechanisms. This review innovatively establishes a classification system for microneedle-nanomaterial combinations, elucidating their fabrication processes, functional characteristics, and synergistic enhancement mechanisms, thereby providing a critical theoretical reference for the field of cutaneous repair.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368251412766"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Trends in Biomaterials for Bone Regeneration: A Bibliometric Perspective.","authors":"Avin Dadvand, Saeed Farzad-Mohajeri, Mohammad Mehdi Dehghan","doi":"10.1177/19373368251414028","DOIUrl":"https://doi.org/10.1177/19373368251414028","url":null,"abstract":"<p><p>Natural bone regeneration often falls short for complex or large defects, making costly bone grafting procedures a necessary intervention. Tissue engineering provides promising alternatives, and biomaterial selection is strongly crucial for its success. This study provides a bibliometric analysis from 2000 to 2024, comparing research trends on 35 biomaterials or regenerative strategies in bone regeneration, as well as active countries, clinical trials, and both animal and bone defect models. Our findings reveal declining trends for some calcium phosphate materials (i.e., biphasic calcium phosphate and tricalcium phosphate), stable trends for hydroxyapatite, and increasing research engagement for bioactive glasses and several natural polymers (i.e., silk fibroin, chitosan, alginate, gelatin, hyaluronic acid, and cellulose). However, collagen showed a declining research interest. From synthetic polymers, polycaprolactone is gaining research interest, while polylactic-co-glycolic acid and poly(methyl methacrylate) are declining. Newer advancements (i.e., exosomes, polydopamine coating, and graphene-based materials), gene therapy strategies, and peptides showed growth. Conversely, calcium sulfate, bone morphogenetic proteins, and platelet-rich plasma are declining. These comparative insights inform future research and biomaterial selection in bone regeneration.</p>","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"19373368251414028"},"PeriodicalIF":4.6,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}