Tissue Engineering. Part B, Reviews最新文献_第10页

Stem Cell-Based Therapies for Auditory Hair Cell Regeneration in the Treatment of Hearing Loss. 基于干细胞的听觉毛细胞再生疗法治疗听力损失。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-08-10 DOI: 10.1089/ten.TEB.2023.0084

Adeline Josephine Cumpata, Luminita Labusca, Luminita Mihaela Radulescu

{"title":"Stem Cell-Based Therapies for Auditory Hair Cell Regeneration in the Treatment of Hearing Loss.","authors":"Adeline Josephine Cumpata, Luminita Labusca, Luminita Mihaela Radulescu","doi":"10.1089/ten.TEB.2023.0084","DOIUrl":"10.1089/ten.TEB.2023.0084","url":null,"abstract":"The incidence and prevalence of hearing loss is increasing globally at an accelerated pace. Hair cells represent the sensory receptors of auditory and vestibular systems. Hair cell absence, loss or degeneration due to congenital diseases, trauma, toxicity, infection or advancing age, results in disabling hearing loss. Regenerative medicine approaches consisting in stem cell-based hair cell rescue or regeneration, gene therapy, as well as cell and tissue engineering are expected to dramatically improve the therapeutic arsenal available for addressing hearing loss. Current strategies that are using different stem cell types to rescue or to induce hair cell proliferation and regeneration are presented. Gene and cell therapy methods that modulates transdifferentiation of surrounding cell types into hair cells are presented, together with their specific advantages and limitations. Several modalities for improving therapeutic targeting to the inner ear such as nanoparticle-mediated cell and gene delivery are introduced. Further steps in building more relevant high-throughput models for testing novel drugs and advanced therapies are proposed as a modality to accelerate translation to clinical settings.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"15-28"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Use of Animal Models in Craniofacial Regenerative Medicine: A Narrative Review. 探索在颅面再生医学中使用动物模型：叙述性综述。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-08-16 DOI: 10.1089/ten.TEB.2023.0038

Seyed Ali Mosaddad, Ahmed Hussain, Hamid Tebyaniyan

{"title":"Exploring the Use of Animal Models in Craniofacial Regenerative Medicine: A Narrative Review.","authors":"Seyed Ali Mosaddad, Ahmed Hussain, Hamid Tebyaniyan","doi":"10.1089/ten.TEB.2023.0038","DOIUrl":"10.1089/ten.TEB.2023.0038","url":null,"abstract":"The craniofacial region contains skin, bones, cartilage, the temporomandibular joint (TMJ), teeth, periodontal tissues, mucosa, salivary glands, muscles, nerves, and blood vessels. Applying tissue engineering therapeutically helps replace lost tissues after trauma or cancer. Despite recent advances, it remains essential to standardize and validate the most appropriate animal models to effectively translate preclinical data to clinical situations. Therefore, this review focused on applying various animal models in craniofacial tissue engineering and regeneration. This research was based on PubMed, Scopus, and Google Scholar data available until January 2023. This study included only English-language publications describing animal models' application in craniofacial tissue engineering (in vivo and review studies). Study selection was based on evaluating titles, abstracts, and full texts. The total number of initial studies was 6454. Following the screening process, 295 articles remained on the final list. Numerous in vivo studies have shown that small and large animal models can benefit clinical conditions by assessing the efficacy and safety of new therapeutic interventions, devices, and biomaterials in animals with similar diseases/defects to humans. Different species' anatomical, physiologic, and biological features must be considered in developing innovative, reproducible, and discriminative experimental models to select an appropriate animal model for a specific tissue defect. As a result, understanding the parallels between human and veterinary medicine can benefit both fields.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"29-59"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10011355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in In Vitro Blood-Air Barrier Models and the Use of Nanoparticles in COVID-19 Research. 体外血液-空气屏障模型和纳米颗粒在新冠肺炎研究中的应用进展。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-09-26 DOI: 10.1089/ten.TEB.2023.0117

Neval Sevinc Ozdemir, Dmitry Belyaev, Manuel Nieto Castro, Sascha Balakin, Joerg Opitz, Hevi Wihadmadyatami, Rahmi Anggraeni, Deniz Yucel, Halime Kenar, Natalia Beshchasna, Ika Dewi Ana, Vasif Hasirci

{"title":"Advances in In Vitro Blood-Air Barrier Models and the Use of Nanoparticles in COVID-19 Research.","authors":"Neval Sevinc Ozdemir, Dmitry Belyaev, Manuel Nieto Castro, Sascha Balakin, Joerg Opitz, Hevi Wihadmadyatami, Rahmi Anggraeni, Deniz Yucel, Halime Kenar, Natalia Beshchasna, Ika Dewi Ana, Vasif Hasirci","doi":"10.1089/ten.TEB.2023.0117","DOIUrl":"10.1089/ten.TEB.2023.0117","url":null,"abstract":"Respiratory infections caused by coronaviruses (CoVs) have become a major public health concern in the past two decades as revealed by the emergence of SARS-CoV in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019. The most severe clinical phenotypes commonly arise from exacerbation of immune response following the infection of alveolar epithelial cells localized at the pulmonary blood-air barrier. Preclinical rodent models do not adequately represent the essential genetic properties of the barrier, thus necessitating the use of humanized transgenic models. However, existing monolayer cell culture models have so far been unable to mimic the complex lung microenvironment. In this respect, air-liquid interface models, tissue engineered models, and organ-on-a-chip systems, which aim to better imitate the infection site microenvironment and microphysiology, are being developed to replace the commonly used monolayer cell culture models, and their use is becoming more widespread every day. On the contrary, studies on the development of nanoparticles (NPs) that mimic respiratory viruses, and those NPs used in therapy are progressing rapidly. The first part of this review describes in vitro models that mimic the blood-air barrier, the tissue interface that plays a central role in COVID-19 progression. In the second part of the review, NPs mimicking the virus and/or designed to carry therapeutic agents are explained and exemplified.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"82-96"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10027102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgment of Reviewers 2023. 鸣谢 2023 年审稿人。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-12-11 DOI: 10.1089/ten.teb.2023.29022.ack

引用次数: 0

Stem Cell-Derived Cardiomyocyte-Like Cells in Myocardial Regeneration. 干细胞衍生的类心肌细胞在心肌再生中的作用

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-07-04 DOI: 10.1089/ten.TEB.2023.0049

Pauline Cheng, Ahmad Rashad, Ankit Gangrade, Natan Roberto de Barros, Ali Khademhosseini, Jonathan Tam, Padmini Varadarajan, Devendra K Agrawal, Finosh G Thankam

{"title":"Stem Cell-Derived Cardiomyocyte-Like Cells in Myocardial Regeneration.","authors":"Pauline Cheng, Ahmad Rashad, Ankit Gangrade, Natan Roberto de Barros, Ali Khademhosseini, Jonathan Tam, Padmini Varadarajan, Devendra K Agrawal, Finosh G Thankam","doi":"10.1089/ten.TEB.2023.0049","DOIUrl":"10.1089/ten.TEB.2023.0049","url":null,"abstract":"Myocardial infarction results in the significant loss of cardiomyocytes (CMs) due to the ischemic injury following coronary occlusion leading to impaired contractility, fibrosis, and ultimately heart failure. Stem cell therapy emerged as a promising regenerative strategy to replenish the otherwise terminally differentiated CM to restore cardiac function. Multiple strategies have been applied to successfully differentiate diverse stem cell populations into CM-like phenotypes characterized by the expression status of signature biomarkers and observable spontaneous contractions. This article discusses the current understanding and applications of various stem cell phenotypes to drive the differentiation machinery toward CM-like lineage. Impact Statement Ischemic heart disease (IHD) extensively affects a large proportion of the population worldwide. Unfortunately, current treatments for IHD are insufficient to restore cardiac effectiveness and functionality. A growing field in regenerative cardiology explores the potential for stem cell therapy following cardiovascular ischemic episodes. The thorough understanding regarding the potential and shortcomings of translational approaches to drive versatile stem cells to cardiomyocyte lineage paves the way for multiple opportunities for next-generation cardiac management.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"1-14"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9810500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxyapatite/Polyurethane Scaffolds for Bone Tissue Engineering. 用于骨组织工程的羟基磷灰石/聚氨酯支架。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-08-21 DOI: 10.1089/ten.TEB.2023.0073

Tianyu Zhang, Jingxuan Li, Yahui Wang, Weimo Han, Yan Wei, Yinchun Hu, Ziwei Liang, Xiaojie Lian, Di Huang

引用次数: 0

Recent Advances in Cell Sheet-Based Tissue Engineering for Bone Regeneration. 基于细胞薄片的骨再生组织工程研究进展。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-09-28 DOI: 10.1089/ten.TEB.2023.0119

Guoding Cao, Liling Ren, Dongyang Ma

{"title":"Recent Advances in Cell Sheet-Based Tissue Engineering for Bone Regeneration.","authors":"Guoding Cao, Liling Ren, Dongyang Ma","doi":"10.1089/ten.TEB.2023.0119","DOIUrl":"10.1089/ten.TEB.2023.0119","url":null,"abstract":"In conventional bone tissue engineering, cells are seeded onto scaffolds to create three-dimensional (3D) tissues, but the cells on the scaffolds are unable to effectively perform their physiological functions due to their low density and viability. Cell sheet (CS) engineering is expected to be free from this limitation. CS engineering uses the principles of self-assembly and self-organization of endothelial and mesenchymal stem cells to prepare CSs as building blocks for engineering bone grafts. This process recapitulates the native tissue development, thus attracting significant attention in the field of bone regeneration. However, the method is still in the prebasic experimental stage in bone defect repair. To make the method clinically applicable and valuable in personalized and precision medicine, current research is focused on the preparation of multifunctionalized building blocks using CS technologies, such as 3D layered CSs containing microvascular structures. Considering the great potential of CS engineering in repairing bone defects, in this review, the types of cell technologies are first outlined. We then summarize the various types of CSs as building blocks for engineering bone grafts. Furthermore, the specific applications of CSs in bone repair are discussed. Finally, we present specific suggestions for accelerating the application of CS engineering in the clinical treatment of bone defects.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"97-127"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10113177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Senescence in Craniofacial Tissue Regeneration: Inducers, Biomarkers, and Interventions. 颅面组织再生中的细胞衰老：诱导因素、生物标志物和干预措施。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-09-11 DOI: 10.1089/ten.TEB.2023.0136

Weibing Tang, Fangjun Huo, Jie Long, Siyuan Zhang, Weidong Tian

{"title":"Cellular Senescence in Craniofacial Tissue Regeneration: Inducers, Biomarkers, and Interventions.","authors":"Weibing Tang, Fangjun Huo, Jie Long, Siyuan Zhang, Weidong Tian","doi":"10.1089/ten.TEB.2023.0136","DOIUrl":"10.1089/ten.TEB.2023.0136","url":null,"abstract":"Craniofacial defects and dental tissue loss have significant negative impacts on the structure and function of jaws and face, often resulting in psychological issues in patients, emphasizing the urgent need for effective craniofacial tissue reconstruction. Unfortunately, natural regeneration of these tissues is limited. Dental-derived mesenchymal stem cells (MSCs) have emerged as a promising resource for tissue engineering-based therapeutic approaches. However, the clinical outcomes of MSC-based transplantation have not met expectations due to various complex reasons, and cellular senescence is recognized as one of the potential mechanisms contributing to the suboptimal results. The quality of MSC decreases during large-scale in vitro expansion, and it is also influenced by the age and the health status of donors. To address these challenges, extensive efforts have been made to developing strategies to combat senescence in tissue engineering, leveraging on current knowledge of underlying mechanisms. This review aims to elucidate the impact of cell senescence in craniofacial and dental regeneration and provides an overview of state-of-the-art antisenescence strategies. We first discuss the potential factors that trigger cell senescence in craniofacial tissue engineering. Then we describe senescence biomarkers, monitoring methods for senescent MSCs, and their underlying molecular mechanisms. The primary focus of this review is on current strategies to inhibit and alleviate cell senescence in tissue engineering. We summarize the strategies concerning the prevention of cell senescence, senolysis, modulation of the senescent associated secretory phenotype, and reversal of senescent MSCs, offering promising opportunities to overcome the challenges associated with cell senescence in craniofacial tissue engineering.","PeriodicalId":23134,"journal":{"name":"Tissue Engineering. Part B, Reviews","volume":" ","pages":"128-141"},"PeriodicalIF":6.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Host Response to Autogenous, Allogeneic, and Xenogeneic Treated Dentin Matrix/Demineralized Dentin Matrix-Oriented Tissue Regeneration. 自体、异体和异种牙本质基质/脱矿牙本质基质导向组织再生的宿主反应。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2024-02-01 Epub Date: 2023-08-16 DOI: 10.1089/ten.TEB.2023.0065

Tianyi Wang, Yongwen Guo

引用次数: 0

Three-Dimensional Bioprinting of Biocompatible Photosensitive Polymers for Tissue Engineering Application. 用于组织工程应用的生物相容性光敏聚合物三维生物打印。

IF 6.4 2区医学

Tissue Engineering. Part B, Reviews Pub Date : 2023-12-01 Epub Date: 2023-07-06 DOI: 10.1089/ten.TEB.2023.0072

Joshua Lim, Sasinan Bupphathong, Wei Huang, Chih-Hsin Lin

引用次数: 0