The Application of Three-Dimensional-Printed Hydrogels in Bone Tissue Engineering.

IF 5.1 2区医学 Q2 CELL & TISSUE ENGINEERING

Tissue Engineering. Part B, Reviews Pub Date : 2024-10-01 Epub Date: 2024-01-17 DOI:10.1089/ten.TEB.2023.0218

Chengcheng Zhang, Tengbin Shi, Dingwei Wu, Dingxiang Hu, Wenwen Li, Jie Fei, Wenge Liu

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引用次数: 0

Abstract

Bone defects are a prevalent clinical issue that presents a serious medical challenge. Bone tissue engineering (BTE) has emerged as an effective approach for treating large bone defects. Hydrogels, as hydrophilic three-dimensional polymers, are recognized as suitable material for BTE due to their excellent biocompatibility and degradability. However, the submicron and nanoporous structure of hydrogels limits the survival of osteoblasts, hindering bone tissue regeneration. In recent years, 3D printing technology has attracted appreciable attention. The use of hydrogels as 3D-printed ink facilitates the printing of hydrogels in any desired shape, enabling personalized or more complex requirements. This article provides a systematic review of the latest applications of 3D-printed hydrogels in BTE. These hydrogels serve as a multifunctional platform for the next generation technology in treating bone defects. The advantages and limitations of 3D-printed hydrogels in BTE are discussed, and future research directions are explored. This review can form the basis for future hydrogel design.

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三维打印水凝胶在骨组织工程中的应用。

骨缺损是一个普遍存在的临床问题，也是一项严峻的医学挑战。骨组织工程（BTE）已成为治疗大面积骨缺损的有效方法。水凝胶作为亲水性三维聚合物，具有良好的生物相容性和可降解性，是公认的适用于 BTE 的材料。然而，水凝胶的亚微米和纳米多孔结构限制了成骨细胞的存活，阻碍了骨组织的再生。近年来，三维打印技术备受关注。使用水凝胶作为三维打印墨水，可以打印出任何所需形状的水凝胶，从而满足个性化或更复杂的要求。本文系统回顾了三维打印水凝胶在 BTE 中的最新应用。这些水凝胶是治疗骨缺损的下一代技术的多功能平台。文章讨论了三维打印水凝胶在 BTE 中的优势和局限性，并探讨了未来的研究方向。本综述可作为未来水凝胶设计的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tissue Engineering. Part B, Reviews Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

12.80

自引率

1.60%

发文量

150

期刊介绍： Tissue Engineering Reviews (Part B) meets the urgent need for high-quality review articles by presenting critical literature overviews and systematic summaries of research within the field to assess the current standing and future directions within relevant areas and technologies. Part B publishes bi-monthly.