IF 12.1 2区材料科学

Small Pub Date : 2026-05-04 DOI: 10.1002/smll.202514355

Yilin Wang, Zhifang Liu, Maoheng Fei, Jiejun Li, Caiyu Ge, Xiang Ye, Yixi Xie, Pengcheng Zhao, Junjie Fei

{"title":"Integration of MOF-on-MOF-Derived Core-Shell CoFe@Fe3Mo3C with Graphene Oxide@Carbon Nanobubbles for Highly Selective Detection of Flutamide.","authors":"Yilin Wang, Zhifang Liu, Maoheng Fei, Jiejun Li, Caiyu Ge, Xiang Ye, Yixi Xie, Pengcheng Zhao, Junjie Fei","doi":"10.1002/smll.202514355","DOIUrl":"https://doi.org/10.1002/smll.202514355","url":null,"abstract":"Flutamide (Flu) is an antiandrogen drug associated with various side effects at high concentrations. A core-shell composite, MoG@ZIF-67@MIL-101, was synthesized through an in situ growth method using Mo-glycerate (MoG) solid spheres as the core and a MOF-on-MOF structure (ZIF-67@MIL-101) as the shell. After controlled carbonization, a CoFe bimetallic alloy nanoparticles @ metal carbide material (CoFe@Fe3Mo3C) with a unique core-shell structure was successfully obtained, in which strong electronic coupling was formed, exhibiting excellent electrocatalytic synergy. The successful construction of the MOF-on-MOF structure and the composite material was confirmed through various physical characterizations. Subsequently, the material was integrated with graphene oxide @ carbon nanobubbles (GO@CNB) to develop a CoFe@Fe3Mo3C/GO@CNB/GCE electrochemical sensor for Flu detection. Owing to the composite's outstanding conductivity and electrocatalytic activity, the sensor exhibited a wide linear range of 5.0 nm-10.0 µm and an ultralow detection limit of 3.4 nm. Density functional theory calculations showed that the composite possesses the strongest adsorption energy for Flu (-1.50 eV) and elucidated the electrochemical reaction mechanism. The sensor achieved recoveries of 96%-105% in water sample analysis, demonstrating its practical applicability. This study highlights the significant potential of integrating core-shell MOF-on-MOF-derived alloy carbide materials with 2D conductive carbon nanomaterials for environmental analysis.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e14355"},"PeriodicalIF":12.1,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breathable, Stretchable Electroporation Patches for Drug Delivery. 可呼吸、可拉伸的药物输送电穿孔贴片。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73624

Zhuoran Li, Haitao Guo, Zanxin Zhou, Xinkai Xu, Guosheng Wang, Jie Cheng, Wenjun Li, Luying Zhao, Xueren Wang, Jian Li, Xuecheng Ping, Shuang Li, Qi Gu, Yewang Su

{"title":"Breathable, Stretchable Electroporation Patches for Drug Delivery.","authors":"Zhuoran Li, Haitao Guo, Zanxin Zhou, Xinkai Xu, Guosheng Wang, Jie Cheng, Wenjun Li, Luying Zhao, Xueren Wang, Jian Li, Xuecheng Ping, Shuang Li, Qi Gu, Yewang Su","doi":"10.1002/smll.73624","DOIUrl":"https://doi.org/10.1002/smll.73624","url":null,"abstract":"Arthritis has become a widespread global health issue with the aging population. Wearable transdermal drug delivery offers a promising treatment with high bioavailability and sustained drug concentrations. However, current technologies struggle with issues such as high cost, low comfort, risk of infection, or tissue pain and damage. Here, we present a breathable, stretchable electroporation patch (BSEP) that seamlessly integrates the traditional drug patch with electroporation-enhanced transdermal drug delivery technology in a low-cost manner. Conductive ink was patterned and deposited onto a breathable and stretchable non-woven fabric substrate using screen printing. A unique serpentine interdigitated design for stretchable electrodes was adopted to precisely localize the electric field within the superficial layers of the skin, reducing voltage in deep tissues by >50% and minimizing potential damage. Cytotoxicity tests and histological analyses confirmed the biocompatibility and safety of the materials and device. Finally, animal experiments validated the effectiveness of the BSEP in enhancing drug delivery, achieving a two-threefold increase in skin penetration compared to the control group. These findings collectively suggest that the developed BSEP holds significant promise for transdermal drug delivery applications.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73624"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogenization of Fe³⁺ Ions on Chiral Carbon Dots With Enhanced Activity and Stability in DOPA Oxidation. 手性碳点上Fe3+离子的异质化对DOPA氧化活性和稳定性的增强

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73631

Wenwen Li, Mengling Zhang, Huiwen Shu, Jiahui Dong, Tao Hu, Cheng Zhu, Hui Huang, Yang Liu, Zhenhui Kang

{"title":"Heterogenization of Fe3+ Ions on Chiral Carbon Dots With Enhanced Activity and Stability in DOPA Oxidation.","authors":"Wenwen Li, Mengling Zhang, Huiwen Shu, Jiahui Dong, Tao Hu, Cheng Zhu, Hui Huang, Yang Liu, Zhenhui Kang","doi":"10.1002/smll.73631","DOIUrl":"https://doi.org/10.1002/smll.73631","url":null,"abstract":"The heterogenization of homogeneous catalysts represents a major research direction in modern green catalysis, as it combines the high activity and selectivity features of molecular catalysts with the high stability and facile recyclability benefits of solid materials. A common drawback in most heterogenized catalyst systems is the significant decrease in catalytic activity compared to their homogeneous counterparts. Herein, we propose a facile strategy to heterogenize Fe3+ ions through coordination with the terminal ─COO- groups of serine-derived chiral carbon dots (C-CDs), forming a heterogeneous catalyst with COO-─Fe3+ active sites. The resulting Fe-CDs exhibit excellent stability across a broad pH range and display markedly enhanced peroxidase-like catalytic activity toward dihydroxyphenylalanine (DOPA) oxidation by 278.53% in average compared to the homogeneous Fe3+ catalyst. By combining excellent catalytic efficiency with well-resolved active-site architectures, the CDs-based ion-coordination-driven transition from homogeneous to heterogeneous catalysis successfully avoids the activity loss commonly linked to catalyst heterogenization.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73631"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stabilizing the Structure and Enhancing the Kinetics of O3-Type Layered Cathodes for High-Performance Sodium-Ion Batteries via Targeted Multi-Element Synergistic Doping. 定向多元素协同掺杂稳定高性能钠离子电池o3型层状阴极结构并增强其动力学。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73623

Feiyan Yu, Ying He, Yiyue He, Wei Luo, Lishun Bai, Yue Liu, Kuhang Liu, Yueying Yu, Sijie Li, Xiaobo Ji, Zhi Chang

{"title":"Stabilizing the Structure and Enhancing the Kinetics of O3-Type Layered Cathodes for High-Performance Sodium-Ion Batteries via Targeted Multi-Element Synergistic Doping.","authors":"Feiyan Yu, Ying He, Yiyue He, Wei Luo, Lishun Bai, Yue Liu, Kuhang Liu, Yueying Yu, Sijie Li, Xiaobo Ji, Zhi Chang","doi":"10.1002/smll.73623","DOIUrl":"https://doi.org/10.1002/smll.73623","url":null,"abstract":"Despite their high specific capacity, O3-type layered oxides face challenges of structural instability and sluggish kinetics as cathode materials for sodium-ion batteries (SIBs). Herein, we report a targeted synergistic strategy involving dual-element (Cu2+/Ti4+) doping at the transition metal (TM) sites and Ca2+ introduction into the Na sites of O3-type NaNi1/3Fe1/3Mn1/3O2 (NFM) to address their inherent defects. This multi-site modification effectively stabilizes the crystal structure, alleviates the phase transition amplitude, suppresses irreversible oxygen loss even at high voltage (up to 4.2 V vs. Na+/Na), and enhances Na+ migration by reducing the migration barrier and interfacial impedance. As a result, the optimized cathode (CCT) delivers a high reversible capacity of 125.3 mAh g-1 with 76.9% capacity retention after 300 cycles (vs. 64.1% for NFM). Even at a high current density of 2000 mA g-1 (∼13 C), the CCT cathode cycled at 4.2 V delivers a remarkable capacity of 94.3 mAh g-1, demonstrating excellent rate capability. The CCT//HC full-cell demonstrates excellent performance, achieving a high initial capacity (123.5 mAh g-1) and outstanding cycling stability (76.2% capacity retention) over 300 cycles. This work underscores the efficacy of multi-site synergistic doping strategy in designing high-performance layered oxide cathodes for practical SIBs.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73623"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precursor-Modulated Synthesis Enables a Stable and Activatable Mn(III) Formate With the ReO₃-Type Topology. 前驱体调制合成具有reo3型拓扑结构的稳定可活化甲酸锰。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73587

Rajesh Das, Zeyu Deng, Dan Zhao, Anthony K Cheetham

引用次数: 0

Biomedical Applications of Nucleic Acid Materials in Targeted Protein Degradation Systems. 核酸材料在靶向蛋白质降解系统中的生物医学应用。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73622

Hanyin Zhu, Xintong Li, Huarui Liu, Dandan Li, Changping Yang, Hong Wang, Jianbing Liu, Baoquan Ding

引用次数: 0

Recent Advances in Flexible Hybrid Hydrogel-Based Sensors for Human Health Monitoring. 用于人体健康监测的柔性混合水凝胶传感器的最新进展。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73580

Wei Shi, Yern Chee Ching, Fuhao Mo, Cheng Hock Chuah

{"title":"Recent Advances in Flexible Hybrid Hydrogel-Based Sensors for Human Health Monitoring.","authors":"Wei Shi, Yern Chee Ching, Fuhao Mo, Cheng Hock Chuah","doi":"10.1002/smll.73580","DOIUrl":"https://doi.org/10.1002/smll.73580","url":null,"abstract":"The rapid development of flexible health monitoring systems is driven by high-performance functional materials engineered with application-oriented sensing functions. Hybrid hydrogels formed through the organic integration of natural polymers, synthetic polymers, or functional components in various combinations have emerged as one of the most promising candidates for flexible sensing applications. This review summarizes recent advances in the design and application of hybrid hydrogel-based flexible sensors for health monitoring. It first discusses representative natural and synthetic polymers used in hybrid hydrogel construction and their controllable chemical modification strategies for property optimization. Subsequently, various crosslinking mechanisms, including irreversible covalent, reversible covalent, and non-covalent crosslinking, are reviewed in terms of their design principles, structure-property relationships, and roles in achieving specific functions such as self-healing, conductivity, and stretchability through molecular-level synergistic regulation. Furthermore, two typical categories of hybrid hydrogel sensors, double network (DN) hydrogels and nanocomposite hydrogels, are outlined, covering their structural characteristics, fabrication approaches, and functional design strategies. The representative applications of hybrid hydrogels in pressure, strain, and temperature sensing, and wound management are also summarized. Finally, the key challenges facing hybrid hydrogel-based flexible sensors are discussed, along with perspectives on future trends toward health monitoring systems.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73580"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanosecond-Response and Low-Thermal-Diffusion Micro-LED Arrays for High-Speed Optogenetic Modulation With Artifact Suppression. 用于高速光遗传调制的纳秒响应和低热扩散微led阵列与伪影抑制。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73620

Jinyu Ye, Huichen Fan, Yibin Lin, Qian Lu, Tailiang Guo, Yongai Zhang, Jie Sun, Chaoxing Wu, Qun Yan, Xiongtu Zhou

{"title":"Nanosecond-Response and Low-Thermal-Diffusion Micro-LED Arrays for High-Speed Optogenetic Modulation With Artifact Suppression.","authors":"Jinyu Ye, Huichen Fan, Yibin Lin, Qian Lu, Tailiang Guo, Yongai Zhang, Jie Sun, Chaoxing Wu, Qun Yan, Xiongtu Zhou","doi":"10.1002/smll.73620","DOIUrl":"https://doi.org/10.1002/smll.73620","url":null,"abstract":"A fundamental challenge within the field of optogenetics is the attainment of simultaneous high spatial resolution, multi-site addressability, and precise temporal control. Conventional optical instruments, such as optical fibers, present restricted scalability and suboptimal spatial control. This study introduces an innovative optogenetic apparatus that surmounts these limitations through the integration of thousands of blue micro-light-emitting diodes by means of a novel ion-implantation pixelation strategy, enabling selective activation via a flexible driver. Operating at a low voltage of 2.9 V, it efficiently stimulates cells with minimal light attenuation within the tissue and low heat production during extended use. Significantly, the device showcases a nanosecond-scale rise time of 49.2 ns, substantially enhancing temporal resolution for high-speed neural modulation. By utilizing a WO3 metal-semiconductor-metal device as a surrogate optoelectronic platform to emulate cellular response, we demonstrate high-fidelity response recording and notably improved post-stimulation activity. Moreover, we characterize artifacts stemming from various light pulses and achieve substantially reduced-artifact stimulation using 100 ms short pulses.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73620"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sandwich Structure Design for Coordinated Enhancement of Polarization and Breakdown in Lead-Free Energy Storage Ceramics. 无铅储能陶瓷极化与击穿协同增强的夹层结构设计。

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73647

Tong Wang, Yulu Zhang, Jiahao Chen, Luo Kong, Haibo Yang, Fei Yan, Haijun Wang, Ting Wang, Weiping Gong, Song Li, Chunchun Li, Li Jin

{"title":"Sandwich Structure Design for Coordinated Enhancement of Polarization and Breakdown in Lead-Free Energy Storage Ceramics.","authors":"Tong Wang, Yulu Zhang, Jiahao Chen, Luo Kong, Haibo Yang, Fei Yan, Haijun Wang, Ting Wang, Weiping Gong, Song Li, Chunchun Li, Li Jin","doi":"10.1002/smll.73647","DOIUrl":"https://doi.org/10.1002/smll.73647","url":null,"abstract":"High-energy-density ceramic capacitors that do not rely on lead critical for mitigating environmental pollution and addressing the growing energy demand. However, electromechanical coupling often prevents the simultaneous enhancement of maximum polarization (Pmax) and breakdown field strength (Eb), which limits further advances in energy storage performance (ESP). To overcome this constraint, we adopt a macroscopic structural design strategy and fabricate sandwich-structured ceramics using a tape-casting process. This architecture enables concurrent regulation of polarization and breakdown strength, effectively alleviating their intrinsic trade-off and substantially increasing the energy density. Consequently, lead-free ceramics with a sandwich configuration deliver a recoverable energy density (Wrec) of 6.83 J·cm-3 accompanied by a high efficiency (η) of 92.0% under 487 kV·cm-1. The η remains above 93.3% over frequencies from 1 to 100 Hz and temperatures from 20°C to 140°C, while the variation in Wrec stays within ±5.2%. In addition, the ceramics exhibit a high power density (PD) of 78.52 MW·cm-3. These results highlight sandwich-structured lead-free ceramics as promising candidates for high-performance energy-storage capacitors.","PeriodicalId":228,"journal":{"name":"Small","volume":" ","pages":"e73647"},"PeriodicalIF":12.1,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147809204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "[Ligand-Engineering MoS₂-Osmium Heterostructure as Highly Active and Specific Peroxidase-Mimic Nanozyme for Interference-Free and Multimode Biosensing]". 更正“[配体工程mos2 -锇异质结构作为高活性和特异性过氧化物酶模拟纳米酶的无干扰和多模式生物传感]”

IF 12.1 2区材料科学

Small Pub Date : 2026-05-03 DOI: 10.1002/smll.73604

引用次数: 0

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