The Journals of Gerontology Series A: Biological Sciences and Medical Sciences最新文献

{"title":"Accelerometer-Measured Multi-dimensional Physical Activity Patterns and Physical Functional Decline: A Prospective National Cohort Study of Aging.","authors":"Lingjie Fan,Junhan Zhao,Jian Wang,Xin Zhou Be,Xiyue Wang,Shengyi Liu,Fengyi Wang,Quan Wei,Tao Lin","doi":"10.1093/gerona/glaf158","DOIUrl":"https://doi.org/10.1093/gerona/glaf158","url":null,"abstract":"BACKGROUND: Physical activity (PA) is crucial for maintaining physical function in older adults, but relationships between multidimensional PA patterns and functional decline remain unclear. This study examined associations between accelerometer-measured PA patterns and physical function decline in older adults.METHODS: We conducted a prospective cohort study with one-year follow-up using data from 586 community-dwelling participants aged ≥65 years in the National Health and Aging Trends Study (2021-2022). Wrist-worn accelerometers measured four PA dimensions: cumulative (total activity counts), peak (maximum intensity), temporal (active and sedentary minutes), and fragmentation. Physical function decline was defined as any decrease in Short Physical Performance Battery score at follow-up. Multivariable logistic regression examined associations between PA dimensions and physical function changes.RESULTS: Higher total activity counts (OR: 0.71, 95% CI: 0.59-0.85), minutes spent active (OR: 0.75, 95% CI: 0.63-0.89), and maximum intensity (OR: 0.67, 95% CI: 0.55-0.83) were associated with lower odds of functional decline, while activity fragmentation showed the opposite relationship (OR: 1.23, 95% CI: 1.03-1.47). Dose-response analyses demonstrated continuous linear relationships. Compared to the lowest activity levels (10th percentile), participants at the 90th percentile showed substantially lower risk: total activity counts (OR: 0.50, 95% CI: 0.29-0.88), active minutes (OR: 0.58, 95% CI: 0.37-0.95), and maximum intensity (OR: 0.54, 95% CI: 0.32-0.75), while activity fragmentation showed progressive risk increase (OR: 1.37, 95% CI: 0.83-2.21). Domain-specific analyses showed consistent patterns.CONCLUSIONS: Multidimensional PA patterns have distinct relationships with functional decline in older adults. Findings support tailored PA recommendations and potential for targeted interventions.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Machine-Learning to Identify Differences in the Association between Blood-Based Biomarkers and Later Life Health Across Race and Ethnicity.","authors":"Mateo P Farina,Eric T Klopack,Eileen M Crimmins","doi":"10.1093/gerona/glaf153","DOIUrl":"https://doi.org/10.1093/gerona/glaf153","url":null,"abstract":"Increasingly, biomarkers are used to understand health and health inequalities among older adults. Combined with advancements in machine-learning approaches, researchers are using predictive algorithms of later life health to identify biomarkers of interest and create biological risk scores. However, these algorithms may select biomarkers that are most important for majority populations, which, in most population-based samples, would reflect the health and aging of White older adults. Understanding how biomarker selection varies across race/ethnicity across different types of health outcomes is paramount to advancing GeroScience research. We used the 2016 Venous Blood Substudy (VBS) of the Health and Retirement Study (HRS). We fit race-stratified boosted decision tree models to predict all-cause mortality, multimorbidity, diabetes, and heart conditions from 54 biomarkers in the 2016 VBS that covered 11 biological systems. We, then, graphed biomarkers that had feature values above .01 for each algorithm to show racial/ethnic differences in biomarker selection. We found more variation in biomarker selection across racial/ethnic groups for all-cause mortality. We found little variation in biomarker selection for heart conditions and diabetes. There was some variation for multimorbidity but with substantial overlap across racial/ethnic groups. While machine-learning approaches for developing biological risk scores and identifying biomarkers linked to later life health will yield additional insight into aging processes in human populations, researchers must consider how these approaches may differ across race/ethnicity for different types of health conditions and its potential implications for Geroscience research.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DunedinPACE Predicts Incident Metabolic Syndrome: Cross-sectional and Longitudinal Data from the Berlin Aging Study II (BASE-II).","authors":"Ilja Demuth,Valentin Max Vetter,Jan Homann,Marit Philine Junge,Vera Regitz-Zagrosek,Denis Gerstorf,Christina M Lill,Lars Bertram","doi":"10.1093/gerona/glaf157","DOIUrl":"https://doi.org/10.1093/gerona/glaf157","url":null,"abstract":"BACKGROUNDAim of the study was a comparative analysis of different epigenetic clocks with regard to their ability to predict a future onset of the Metabolic Syndrome (MetS). In addition, cross-sectional relationships between epigenetic age measures and MetS were investigated.METHODSMetS was diagnosed in participants of the Berlin Aging Study II at baseline (n = 1,671, mean age 68.8 ± 3.7 years, 51.6% women) and at follow-up (n = 1,083; 7.4 ± 1.5 years later). DNA methylation age acceleration (DNAmAA) was calculated for a total of ten epigenetic clocks at baseline. In addition, DunedinPACE, a DNAm-based measure of the pace of aging, was calculated. The relationship between MetS, DNAmAA and DunedinPACE was investigated by fitting regression models adjusted for potential confounders and calculating receiver operating characteristic statistics.RESULTSAmong all biomarkers investigated, DunedinPACE was the only DNAm-based predictor that was significantly associated with incident MetS at follow-up on average 7.4 years later (OR: 9.84, p = 0.028). Logistic regression models predicting MetS that either included solely clinical parameters or solely epigenetic clock estimates (DNAmAA) or DunedinPACE revealed that GrimAge DNAmAA had an area under the curve most comparable to the model considering clinical variables only. Cross-sectional differences between participants with and without MetS remained statistically significant for DunedinPACE only after covariate adjustment (baseline: β = 0.042, follow-up: β = 0.031, p < 0.0001 in both cases).CONCLUSIONComparison of epigenetic clocks in relation to MetS showed strong and consistent associations with DunedinPACE. Our results highlight the potential of using certain DNAm-based measures of biological ageing in predicting the onset of clinical outcomes, such as MetS.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of a Polygenic Lifespan Score With the Risk of Common Age-Related Diseases and Mortality.","authors":"Niko Paavo Tynkkynen,Kaisa Koivunen,Päivi Herranen,Laura Joensuu,Timo Törmäkangas,Elina Sillanpää","doi":"10.1093/gerona/glaf156","DOIUrl":"https://doi.org/10.1093/gerona/glaf156","url":null,"abstract":"BACKGROUNDAging increases the risk of major noncommunicable diseases. Research into the genetics of health-related traits could reveal genetic pathways for robustness against these diseases. We studied how a genetic predisposition for a long lifespan is associated with the risk of all-cause mortality and major age-related noncommunicable diseases.METHODSWe analyzed data from 376 753 participants (mean age = 58.5 years; standard deviation = 13.9 years; 46.3% men) to examine how a polygenic lifespan score (PLS) is associated with the risk of all-cause mortality and major noncommunicable diseases. The associations between all-cause mortality, cancers, femur fracture, dementia, Alzheimer's disease, Parkinson's disease, type 2 diabetes, obesity, cardiovascular diseases, hypertension, ischemic heart diseases, coronary heart disease, stroke, and myocardial infarction were investigated using conventional and time-dependent Cox regression.RESULTSThe PLS was associated with all the above-mentioned outcomes except for Parkinson's disease. Most of the associations were time-dependent, and the hazard ratio (HR) varied over time from protective to risk-increasing. However, the current PLS predicted noncommunicable disease risks with small effect sizes (lowest HR ≈ 0.70, highest HR ≈ 1.20, Cox-Snell pseudo-R2 > 0.01).CONCLUSIONSGenetic predisposition for a longer lifespan was associated with a smaller risk of common age-related noncommunicable diseases suggesting greater robustness against these conditions. The lowest risks were found during periods when the incidences of diseases were greatest. The observed small effects highlight the need to better understand how accumulated environmental factors modify individual lifespans.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex matters: the effect of physical activity on brain perfusion.","authors":"Brittany Intzandt,Safa Sanami,Julia Huck,Louis Bherer,Claudine J Gauthier","doi":"10.1093/gerona/glaf154","DOIUrl":"https://doi.org/10.1093/gerona/glaf154","url":null,"abstract":"Cerebral blood flow (CBF) declines consistently in aging and this decline is a critical component of several late life diseases. Understanding why this occurs in normal aging, prior to pathological changes, is crucial. Physical activity (PA) is a powerful preventative tool to improve vascular health and preserves CBF in both sexes, though females may benefit most throughout the lifespan. There is currently limited knowledge however about what intensity is needed to derive benefit, and if there are sex differences in this relationship with intensity. Here, CBF and PA were investigated according to sex and age. A total of 573 participants aged 36 to 90 years were included from the Human Connectome Lifespan Aging. Linear and quadratic regressions were utilized to investigate relationships among CBF and PA intensities in each of the four groups. Vigorous PA in middle aged males was related to greater CBF (p < 0.05). Older females showed benefit at all intensities (p < 0.05). Middle aged females were least sensitive to the effects of PA. In all groups except older males, hippocampal CBF was only dependent on vigorous PA (p < 0.05). These results highlight the sex-specific relationship between CBF and PA, and the importance of tailoring recommendations to sex and lifespan stage including addressing and updating current public health guidelines to maximize adoption and benefit, specific to brain health.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loop diuretics and subsequent use of urinary symptom medications in older adults: evaluation of a possible prescribing cascade.","authors":"Matthew E Growdon,Bocheng Jing,W James Deardorff,Earl J Morris,W John Boscardin,Leah J Blank,Tasce Bongiovanni,Kenneth S Boockvar,Michael A Steinman","doi":"10.1093/gerona/glaf150","DOIUrl":"https://doi.org/10.1093/gerona/glaf150","url":null,"abstract":"BACKGROUNDLoop diuretic (LD) use may lead to a prescribing cascade whereby urinary symptoms are ascribed to genitourinary syndromes and treated with urinary symptom medications (USMs). We investigated if LDs lead to increased USM use among older adults and whether this potential prescribing cascade varies across key characteristics.METHODSThis was a prescription sequence symmetry analysis of Veterans Administration data, involving veterans ≥66 years who initiated treatment with LD (2010-2019). USMs were antimuscarinics, beta-3 adrenergic agonists, peripheral alpha-1 blockers, and 5-alpha reductase inhibitors. We calculated the adjusted sequence ratio (aSR), assessing the cascade signal while adjusting for secular trends, and stratified by key variables.RESULTSThere were 17,735 veterans who initiated USM within 6 months after LD and 25,190 who initiated USM within 6 months before LD; 99% were male. Unexpectedly, the aSR was 0.74 (95% CI, 0.73-0.76), meaning patients were 26% less likely to initiate USM within 6 months after initiating LD vs 6 months before. This inverse relationship held in men (aSR, 0.74, 95% CI, 0.72-0.76) but was null in women (aSR, 1.00, 95% CI, 0.80-1.26). In men without baseline urinary symptoms, we observed the LD-USM cascade in patients with heart failure (aSR 1.52, 95% CI, 1.41-1.63) and multimorbidity (e.g., Charlson 4th quartile, aSR 1.24, 95% CI, 1.10-1.39).CONCLUSIONSWe did not find evidence for a LD-USM cascade among predominantly male older adults overall. Clinicians may under-prescribe USMs in patients receiving LDs, perhaps due to strong attribution of urinary symptoms to LD use.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Taxonomy to Characterize Stressor Variation in Studies of Physical Resilience and its Illustration in Total Knee Replacement.","authors":"Frederick Sieber,Mallak K Alzahrani,Qian-Li Xue,Ravi Varadhan,Thomas Laskow,Charles Brown,Brian Buta,Julius Oni,Fangyu Liu,Jeremy Walston,Karen Bandeen-Roche","doi":"10.1093/gerona/glaf151","DOIUrl":"https://doi.org/10.1093/gerona/glaf151","url":null,"abstract":"BACKGROUNDThis study aimed to develop a conceptual framework and empirical measures to characterize stressor magnitude and type in the context of total knee replacement (TKR) and to investigate their relationship with resilience phenotypes.METHODSA sequential elicitation process was used to identify key stressor characteristics, categorized as exogenous or endogenous. Resilience phenotypes were created as (post-surgery - (baseline, or pre-surgery)) changes in four measures of physical function/symptoms selected based on their relevance to TKR outcomes. These measures included: the Short Physical Performance Battery score (SPPB), the Pittsburgh fatigability scale (PFS), the Short Form-36 (SF-36) physical component summary score, and the knee injury and osteoarthritis outcome score (KOOS) quality of life subscale.RESULTSAnalyses revealed few associations between baseline phenotype measurements and stressor characteristics. Several consistent adjusted associations were observed between stressor characteristics and six-month resilience phenotypes. All endogenous measurements analyzed exhibited the expected direction of association with PFS change from baseline to 6 months, indicating higher stress levels predicted a diminished return of vigor post-surgery; intraoperative blood loss exhibited the strongest association. Outpatient vs inpatient procedures were associated with more beneficial change from baseline to 6 months of all resiliency phenotypes; SPPB score recovery exhibited the strongest association. Other individual strong associations were observed, but with less consistency across phenotypic trajectories or stressor characteristics.CONCLUSIONSThe study highlights the importance of considering stressor variation in resilience research. The conceptual framework and empirical measures developed provide a foundation for future investigations into the factors influencing resilience to physical stressors in older adults.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to mobilization in hours after surgery for hip fracture and 30-day mortality-A study on 36,229 patients from the Danish Hip Fracture Registry.","authors":"Morten Tange Kristensen,Ina Trolle Andersen,Bjarke Viberg,Alma Becic Pedersen","doi":"10.1093/gerona/glaf147","DOIUrl":"https://doi.org/10.1093/gerona/glaf147","url":null,"abstract":"BACKGROUNDEarly mobilization after hip fracture (HF) is a key indicator in national registries and associated with reduced mortality, but in-depth analysis of time in hours for mobilization is lacking. We described the clinical profile and 30-day mortality by time-intervals in hours for mobilization after HF surgery.METHODSUsing Danish registries, we included HF patients aged ≥65 years (from year 2016-2021). Exposure-time in hours from start of surgery to mobilization. Outcome-mortality within 2-30 days of surgery. Primary mortality analysis-we compared mobilizations >24-36h versus ≤24h by calculating weighted risks, risk differences (RD) and hazard ratios (HR) using inverse probability of treatment weighted method. Secondary mortality analyses-we compared mobilizations >24-36h and >12-24h versus ≤12h.RESULTSWe included 36,229 patients (67.3% women) with a median age of 82.6 years. Patients mobilized ≤24h had similar age, BMI, and marital status, but were slightly more living in own residence, have high pre-fracture mobility, high education, and less comorbidity than patients mobilized >24-36h. The weighted risk of 30-day mortality for mobilization >24-36h versus ≤24h was 10.43% and 7.89% with corresponding RD and HR of 1.67 (0.54,2.80) and 1.22 (1.07,1.38). The weighted RD and HR were 1.62% (0.89, 2.35) and 1.25 (1.12,1.39) for >12-24 versus ≤12h, and 1.33% (0.17-2.49) and 1.16 (1.02,1.31) for >12-24h versus >24-36h.CONCLUSIONThe 30-day mortality increases with the increasing time to mobilization after HF surgery. We suggest focusing on time in hours to mobilization with a 24-hour or even earlier timepoint after surgery.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"End-of-Life Care in Hospitalized Patients with Dementia","authors":"Xin Wen Ong, David G Le Couteur, Louise M Waite, Janani Thillainadesan","doi":"10.1093/gerona/glaf120","DOIUrl":"https://doi.org/10.1093/gerona/glaf120","url":null,"abstract":"Background As the aging population grows, the care provided to patients with dementia at the end of life represents a critical area of geriatric and palliative care. This study aimed to describe the care provided to hospitalized patients with dementia who died during their hospital stay. Methods A retrospective cohort study was conducted at a teaching hospital in Sydney, Australia. The study included patients with dementia who died during hospitalization. Data were collected on demographic characteristics, clinical management, and documentation of key care processes, including advance care planning, resuscitation orders, and discussions about oral nutrition and hydration. Results The study cohort comprised patients with a mean age of 87.2 ± 7.2 years (n = 100), 63% of whom had lived in nursing homes. Geriatric medicine teams cared for a large proportion of patients (63%), and their patients were more likely to be older, from a nursing home, and to die from pneumonia compared to those admitted in palliative care teams. Recommended care processes were implemented in the majority of patients with advance care planning and resuscitation orders being the most frequently documented, and discussions about oral nutrition and hydration the least frequent. Conclusion This study highlights the integral role of geriatrics services in providing end-of-life care for hospitalized patients with dementia, and underscore opportunities to enhance the quality and consistency of care for this population.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Socioeconomic Conditions Across the Life Course on Epigenetic Age Acceleration: Evidence from a Longitudinal Cohort","authors":"Leah Moubadder, Junyu Chen, Elizabeth S Clausing, Katrina L Kezios, Karen N Conneely, Pam Factor-Litvak, Diddier Prada, Andrea Baccarelli, Rachel C Shelton, Bruce G Link, Shakira F Suglia","doi":"10.1093/gerona/glaf139","DOIUrl":"https://doi.org/10.1093/gerona/glaf139","url":null,"abstract":"Background We investigated whether adulthood socioeconomic status (SES) mediates the association between childhood SES and biological aging in a longitudinal cohort (N = 359). Methods SES was measured using composite scores from prospective measures in childhood and at age 50. Peripheral blood DNA methylation (DNAm) was measured at approximately 50 years of age. DNAm age acceleration (AA) was quantified for DNAm “clocks” (Horvath, Hannum, PhenoAge, GrimAge) and a DNAm pace-of-aging measure (DunedinPACE). Linear regression was used to evaluate the associations between SES at each life stage and DNAm AA. Adulthood SES was evaluated as a mediator between childhood SES and DNAm AA using marginal structural models. Results Compared to high childhood SES, low childhood SES was associated with AA for GrimAge (β=0.99, 95% confidence interval [CI]: 0.08, 1.91) and DunedinPACE (β=0.05, 95% CI: 0.02, 0.08). Low adulthood SES, compared to high adulthood SES, was also associated with AA for GrimAge (β=2.31, 95% CI: 1.35, 3.28) and DunedinPACE (β=0.05, 95% CI: 0.02, 0.08). The association between childhood SES and both clocks were partially mediated by adulthood SES. No other clocks were associated with SES. Conclusion Early and late-life socioeconomic conditions accelerate biological aging. Larger studies exploring mediators and interventions are needed for equitable aging mitigation.","PeriodicalId":22892,"journal":{"name":"The Journals of Gerontology Series A: Biological Sciences and Medical Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}