The Journal of Phytopharmacology最新文献

{"title":"Comparative study on the Antidiabetic activity of the bark extracts of Syzygium caryophyllatum (L.) Alston and Syzygium zeylanicum (L.) DC","authors":"KJ Shilpa, G. Krishnakumar, K. Hegde","doi":"10.31254/phyto.2023.12508","DOIUrl":"https://doi.org/10.31254/phyto.2023.12508","url":null,"abstract":"The study evaluated the potential antidiabetic property of methanol extracts of S. caryophyllatum and S. zeylanicum in alloxan and streptozotocin - induced diabetic rats. Glibenclamide and extract at 5mg/kg, 200 and 400 mg/kg body weight respectively were used. Animals were divided into 7 groups of 6 each. The treatment was carried out in each group of animals for both the models for 21 days. Blood samples were withdrawn under mild anesthesia from retro - orbital of the overnight fasted animals on 1st, 7th, 14th, and 21st day. Estimation of SGPT and SGOT and the intensity of the coloured complex was performed. Body weight of animals in all the groups was recorded at 0, 7th, 15th and 21st day. There was no mortality amongst the dosed groups of animals and the extract did not show toxicity at a dose level of 2000 mg/kg. The extracts of both the species at 400 mg / kg body weight possessed a remarkable fasting blood – glucose lowering potential, significant increase in body weight and reduced levels of SGPT and SGOT in alloxan and streptozotocin induced diabetic rats. The extracts also exhibited improved glucose utilisation. The UPLC analysis of the extract revealed the presence of phenols and flavonoids with antidiabetic potential. The results support the use of Syzygium species in traditional system of medicine to treat diabetes mellitus.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139310840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity of Artemisia annua L and Aloe barbadense miller plant extracts against Staphylococcus aureus","authors":"Lusweti Kituyi, Samson M. Lutta, Steve Barasa","doi":"10.31254/phyto.2023.12503","DOIUrl":"https://doi.org/10.31254/phyto.2023.12503","url":null,"abstract":"Artemisia annua L. and Aloe barbadense miller are medicinal plants applied in treatment of various diseases. Staphylococcus aureus is a gram-negative bacterium found commonly on the skin and in the environment. Phytochemical are plants secondary metabolites with promising medicinal properties as remedy to limitations associated with the conventional drugs. A study was conducted to investigate the anti-microbial properties of bioactive components from natural leave extracts of Artemisia annua L. and Aloe barbadensis miller obtained from methanolic as extractant against Staphylococcus aureus. The phytochemical analysis revealed the leave extracts contained most plant secondary metabolites. The biochemical components from both plants were established to inhibit the growth of Staphylococcus aureus. Artemisia annua L had an inhibition zone of 20.67 mm while Aloe barbadensis miller had 10.33 mm against Staphylococcus aureus. The anti-microbial activity of the combined leaves extracts displayed significant high levels of synergetic properties with an inhibition zone of 23.67 mm. Gentamicin which served as standard for the assay had an inhibition zone of 27.67 mm. The study hence showed Artemisia annua L and Aloe barbadensis miller leaves bioactive components can be applied as an effective alternative medicine in management of Staphylococcus aureus.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139311489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant potential, toxicity, and effect of Calotropis procera extract on milk production in Wistar rats","authors":"D. Maya, T. Basile, D. Leonard, Zabre Généviève, B. Balé, B. G. Raymond","doi":"10.31254/phyto.2023.12501","DOIUrl":"https://doi.org/10.31254/phyto.2023.12501","url":null,"abstract":"Breast-feeding failure is a public health concern, as the use of breast milk substitutes increases the risk of morbidity and mortality among infants in developing countries. In Burkina Faso, people rely on medicinal plant to treat Breast-feeding failure. Indeed, Calotropis procera is medicinal plant used in traditional medicine to treat Breast-feeding failure. The phytochemical components, safety and antioxidant activity of the plant were first determined. Aim of this study was to evaluate the effects of aqueous extract of C. procera on milk supply. The effect of C. procera on milk supply was evaluated in lactating rats by measuring pup weight during suckling period. At the start of the experiment, lactating females weighing 241.22 ± 9.64 g were divided into three lots of five rats each. The lot I was administered with NaCl (0.9%), the lot II was treated with metoclopramide (5 mg/kg b.w.) and lot III received aqueous extract of C. procera at the dose of 200 mg/kg b.w. The drug was administered orally and started from the evening (18:00) of day 3 of lactation to day 17. The phytochemical components such as steroids and triterpenoids, flavonoids, cardenolids, tannins, saponosids and reducing sugars were detected in the plant extracts. The aqueous and hydro-ethanolic extracts showed a weak antioxidant activity. In the acute test no signs of toxicity and mortality were recorded. In the Sub-acute test, any signs of toxicity were observed in rat during the period of treatment. There was no significant change in Hematological and biochemical parameters between the lots treated with extract and the control lot. The aqueous extract (200 mg/kg) of C. procera increased milk production significantly (p < 0.01) compared to blank control (NaCl, 0.9%). The milk production increased by 39%. Conclusion: Aqueous extract of C. procera can stimulate milk supply in rats and therefore confirm its use in traditional medicine in the treatment of mother’s milk insufficiency.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial activity, cytotoxicity, and phytochemical assays of organic and aqueous extracts from Sarcophyte piriei","authors":"","doi":"10.31254/phyto.2023.12502","DOIUrl":"https://doi.org/10.31254/phyto.2023.12502","url":null,"abstract":"Traditional medicine practice systems employ plants in the era of rising antimicrobial resistance. The current research investigates the antimicrobial activities of Sarcophyte piriei, whose tuber is utilized to manage diseases. There are limited studies on the efficacy, safety, and chemical composition of the Sarcophyte piriei. The objective was to investigate the antimicrobial activity, cytotoxicity, and phytochemical components. The powdered material was extracted by maceration using water and organic solvents progressively from petroleum ether (100%), dichloromethane (100%), dichloromethane: methanol (1:1) and methanol (100%) and water. Disk diffusion method was used to investigate antimicrobial activity at 100 mg/ml and minimum inhibitory concentration determined. Cytotoxicity of the extracts were evaluated using brine shrimp lethality assay. Phytochemical screening was done using standard procedures. The extracts revealed varied antimicrobial effects, the methanol: dichloromethane (1:1) extracts revealed the highest zone of inhibition 18.0 ± 0.0 mm against S. aureus while aqueous had a zone of 10.0 ± 0.0 mm against C. albicans. The lowest minimum inhibitory concentration of the active dichloromethane: methanol (1:1) against Bacillus cereus, Pseudomonas aeruginosa and Staphylococcus aureus. Minimum inhibitory concentration values obtained were: 18.75 + 00, 14.06 + 4.7 and 28. 13 + 9.4 mg/ml respectively. The minimum bactericidal concentrations values were: 62.5 + 12.5, 20.31 + 9.5 and 40.63 + 19 mg/ml respectively. The petroleum ether and dichloromethane extracts had the highest cytotoxic effects against brine shrimp with LC50 value of 55.0 µg/ml while the aqueous extract was nontoxic. Alkaloids, terpenoids, amino acids, carbohydrates, flavonoids, saponins, tannins, cardiac glycosides, diterpenes, xanthoproteins, anthocyanins, coumarins and oxalates were detected. It was concluded that the extracts of Sarcophyte piriei has antimicrobial activity and the water extracts is safe. Therefore, the secondary metabolites responsible for antimicrobial activity require to be isolated.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139310349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Analysis of Ginger Raisin Wine and its Fermentation Process: Investigating Antibacterial Properties","authors":"Shreeya Das Mahapatra, Pritam Kumar Sahoo, Koyel De, Subhabrata Goswami, Satyabrata Manna, Somnath De","doi":"10.31254/phyto.2023.12506","DOIUrl":"https://doi.org/10.31254/phyto.2023.12506","url":null,"abstract":"Due to its nutritional benefits, wine is a popular alcoholic beverage that is widely recognized, consumed, and flavored. Wine can be fortified with particular ingredients that may be good for our health to improve its nutritional value. Rhizomes of ginger are widely utilized in the food, beverage, and confectionary sectors as flavorings and are consumed all over the world. Terpenes and oleoresin are just two of the many active components found in ginger. In the lab raisins, sugar and yeast were used to try to make wine from ginger rhizome. 21 days were spent fermenting it at 250C. The alcohol was then detached from its sediments and keep for around 300 days to mature. The ginger wine’s hue, pH, acidity, brix, and alcohol content were noted. When the wine sample underwent phytochemical analysis, different components including flavonoids, alkaloids, terpenoids, carbohydrates and proteins were discovered to be present. In comparison to ethanol and ginger extracts, wine had the largest zone of inhibition when its antibacterial ability was evaluated against the test pathogens. As a result, ginger can be useful for the creation of an herbal wine due to its significant phytochemical components are preserved in the wine and can therefore be made in big quantities as a heath beverage.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"143 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening and antimicrobial activity of the plant extracts Andrographis paniculata against selected microbes","authors":"Salma Fathima, Pruthvi Charan Jambiga, Ramya Thumma, Samreen Ahmadi, Srinitha Askani, Bushra Sumayya Mohammed, Poornesh Sutramay, S. Dharavath, S. Taduri","doi":"10.31254/phyto.2023.12505","DOIUrl":"https://doi.org/10.31254/phyto.2023.12505","url":null,"abstract":"Background: Andrographis paniculata is a medicinal plant with a long history of traditional use in various herbal medicine systems. Objective: This study aims to conduct aphytochemical screening and antibacterial activity from leaf, stem and root parts of Andrographis paniculata. Methods: The preliminary screening was done by cold maceration technique using chloroform, butanol, methanol, ethanol and aqueous solvents. This phytochemical screening showed the presence of alkaloids, glycosides, flavonoids, terpenoids, phenols, tannins and saponins. Antibacterial activity was performed by using well diffusion method from leaf, stem and root butanolic extracts of A. paniculata. Results: Glycosides are abundantly present in leaf, stem and root explant extracts. Whereas, alkaloids and flavonoids are moderately present in leaf, stem and root explant extracts and followed by less presence of tannins, phenols and saponins. The maximum zone of bacterial inhibition was observed in leaf butanolic extracts against of the E.Coli, for stem butanolic extract against of B. subtilis and for root butanolic extract against B. sphaericus. Conclusion: This study revealed the potential photochemical constituents and antibacterial activity in A.Paniculata. The presence of these bioactive substances they use in treatment.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139309978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicinal uses, phytochemical, pharmacological and pharmacokinetics properties of Cumin (Cuminum cyminum)","authors":"H. Shaheen, Samuelson Martin Luther King Boum Bindebe, J. Nyemb, Jean Pierre Abdou, Jennifer George, Vishwanath R. Patil, N. Segueni, G. Batiha","doi":"10.31254/phyto.2023.12507","DOIUrl":"https://doi.org/10.31254/phyto.2023.12507","url":null,"abstract":"A well-known plant for its distinctive scent is cumin [Cuminum cyminum Linn.]. It is a herbaceous annual plant in the Umbellifereae family. Many traditional cuisines have been prepared with cumin seeds as a spice or a key component. In various cultural contexts in the Middle East, cumin has also been said to have significant culinary and therapeutic purposes. The chemical make-up, nutritional value, ethnomedical applications, and traditional usage of cumin seeds were all covered in this review. The review discussed the isolated and discovered bioactive components evaluated and validated therapeutic qualities in addition to describing the pharmacological properties of cumin based on publications that are currently accessible. The most current research on drug bioavailability, pharmacokinetics, and potential negative effects are also reported.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139310629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congestive Heart Failure in the Light of Ancient Wisdom of Unani Medicine: A Review","authors":"Hina Muqeem, BD Khan, Mohd Mohsin, M. N. Mannan","doi":"10.31254/phyto.2023.12509","DOIUrl":"https://doi.org/10.31254/phyto.2023.12509","url":null,"abstract":"Congestive heart failure is a complex clinical syndrome that causes functional impairment of ventricular filling and ejection of blood. It can cause dyspnea, fatigue, and fluid retention, affecting exercise tolerance and causing pulmonary and peripheral edema. Moreover, it is a burgeoning and life-threatening syndrome characterized by significant morbidity and mortality, poor functional capacity and quality of life, and high costs. Worldwide congestive heart failure affects more than 64 million people. Nowadays: congestive heart failure is correlated with Suqūṭ-e-Qalb Imtilāʼī, by modern Unani physicians. However, the disease is mentioned in classical Unani literature under the headings of Ikhtilāj-e-qalbi (arrhythmia), Rabw (cardiac asthma), Buhr (cardiac asthma), Khafaqān (palpitation), Istisqā’ Laḥmī (anasarca), Du‘f al-Qalb (weakness of heart), Intiṣāb al-Nafas (orthopnoea), Sudda-e-Urooq-e-Qalb (coronary artery obstruction), Ghashī (syncope), Tasallub-al- Sharāyīn (arteriosclerosis) and Imtilā’ bi Hasbil Aw’iya (congestion of blood vessels). Congestive heart failure and mortality are on the rise despite the significant advancements in contemporary medicine and guidelines directed medical therapy for congestive heart failure. Congestive heart failure hospitalizations make up 1-2% of Western hospital admissions, with the highest 30-day readmission rate (20-25%) in congestive heart failure patients reflecting due to high comorbidity burden. Unani drugs, despite advancements in modern medicine, still significantly impact patient health. They are traditionally used for cardiac ailments like palpitations, coronary artery disease, heart weakness, and cardiotonic. Unani medicine especially Khamīrajat (fermented confections) used in various cardiac diseases is cardio-protective and cardiotonic. According to reports, complementary and alternative medicine is used by up to 61% of cardiac patients with coronary artery disease and those at risk for arteriosclerosis. Therefore, a thorough evaluation of the Unani literature on cardiac illness and its treatment in the Unani system of medicine is needed to decrease congestive heart failure social and economic burdens have become a major global public health priority. This review is an effort to summarize the Unani classical literature on congestive heart failure.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139310845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC-MS Analysis of Chemical Substances from Ethanolic Extract of Prosopis juliflora Leaves","authors":"R Sundhararajan, None Sabarisenthil, Ahamed Salam N, MF Rilvan, B Sathish, Sathish Kumar R, Shakeel Ahmed H, Diptimayee Jena","doi":"10.31254/phyto.2023.12407","DOIUrl":"https://doi.org/10.31254/phyto.2023.12407","url":null,"abstract":"The nutraceuticals in leaves are among the major contributors of their therapeutic relevance to human. This study evaluates the relevance of nutraceuticals obtained from the GC-MS analyses of ethanolic extracts of leaves of Prosopis juliflora. Leaves of Prosopis juliflora harvested from their natural territory and identified at the Plant Science Department of Mohmed Sathak A.J. College of Pharmacy, Sholinganallur, Chennai. Ethanol was used for extracting the crushed plant leaves (5 g) in order. Hot continuous soxhlet extraction was used to complete the extraction. The resulting extracts were kept at -4 °C until their next usage. The current investigation made use of ethanol extract. In the present investigation, the phytocomponents in the extracted substances were identified using the GC-MS method. Results shows 72 phytoconstituents in leaves of Prosopis juliflora, with gamma-Sitosterol, Epilupeol, Benzene methanol, 2-hydroxy-5-methyl-, as highest nutraceutical components with percentage concentrations of 12.94, 11.92 and 10.07 respectively. In order to improve human health, broad-spectrum pharmaceutical formulations are being developed that take advantage of the multiple therapeutic potentials of the main nutraceuticals found in Prosopis juliflora.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135990427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiproliferative effect of methanolic extract of Tamarindus indica in C127I cell line","authors":"Nisaath Begum, Sujith Samraj, AR Nisha, B Devu","doi":"10.31254/phyto.2023.12406","DOIUrl":"https://doi.org/10.31254/phyto.2023.12406","url":null,"abstract":"Investigation of natural bioactive compounds that possess antioxidant and anticancer properties have drawn interest in scientific and industrial perspectives. The current study was conducted to assess the antiproliferative action of methanolic extract of seed coat of Tamarindus indica in C127I mouse mammary tumour cell line. 3-(4,5-dimethyl thazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay is performed to assess the cytotoxicity of methanolic extracts of T. indica in the C127I cell line at concentrations of 320, 160, 80, 40, 20, and 10 µg/mL. The half maximal inhibitory concentration (IC50) was then calculated using Graph Pad Prism 5.0. Doxorubicin was used as positive control. After determining IC50, the cells were treated with extract of T. indica at half, IC50 and double IC50 concentrations after being seeded at a concentration of 1x105 cells/mL in 6 well plates. After 24 hours the cells were trypsinised and stained with acridine orange-ethidium bromide (AOEB) to assess the morphology of apoptosis. When the cells were exposed to various doses of the extract, a dose-dependent decrease in cell viability was observed, and the IC50 value of T. indica was estimated to be 13 µg/ml. In the control cells, AO/EB labelling revealed proliferating cells with green fluorescence, but the T. indica extract-treated cells displayed dose dependent shift from orange to red fluorescence. In conclusion, methanolic extract of Tamarindus indica was found to possess antiproliferative effect in C127I cell line comparable to doxorubicin.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136035755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}