茶叶茜草(L. Alston)和泽兰茜草(L. DC)树皮提取物的抗糖尿病活性比较研究

KJ Shilpa, G. Krishnakumar, K. Hegde
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引用次数: 0

摘要

该研究评估了 S. caryophyllatum 和 S. zeylanicum 甲醇提取物对阿脲和链脲佐菌素诱导的糖尿病大鼠的潜在抗糖尿病特性。使用格列本脲和提取物,剂量分别为 5 毫克/千克、200 毫克和 400 毫克/千克体重。动物被分为 7 组,每组 6 只。对每组动物进行为期 21 天的治疗。在轻度麻醉下,分别于第 1 天、第 7 天、第 14 天和第 21 天从隔夜禁食动物的眼眶后抽取血液样本。测定 SGPT 和 SGOT 以及有色复合物的强度。在第 0 天、第 7 天、第 15 天和第 21 天记录各组动物的体重。在 2000 毫克/千克的剂量水平下,各剂量组的动物都没有死亡,提取物也没有显示出毒性。两种植物的提取物在 400 毫克/千克体重的剂量下都具有显著的空腹血糖降低潜力,体重显著增加,并降低了阿脲和链脲佐菌素诱导的糖尿病大鼠的 SGPT 和 SGOT 水平。提取物还能提高葡萄糖的利用率。提取物的 UPLC 分析显示,其中含有具有抗糖尿病潜力的酚类和黄酮类化合物。这些结果支持在传统医学体系中使用茜草来治疗糖尿病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative study on the Antidiabetic activity of the bark extracts of Syzygium caryophyllatum (L.) Alston and Syzygium zeylanicum (L.) DC
The study evaluated the potential antidiabetic property of methanol extracts of S. caryophyllatum and S. zeylanicum in alloxan and streptozotocin - induced diabetic rats. Glibenclamide and extract at 5mg/kg, 200 and 400 mg/kg body weight respectively were used. Animals were divided into 7 groups of 6 each. The treatment was carried out in each group of animals for both the models for 21 days. Blood samples were withdrawn under mild anesthesia from retro - orbital of the overnight fasted animals on 1st, 7th, 14th, and 21st day. Estimation of SGPT and SGOT and the intensity of the coloured complex was performed. Body weight of animals in all the groups was recorded at 0, 7th, 15th and 21st day. There was no mortality amongst the dosed groups of animals and the extract did not show toxicity at a dose level of 2000 mg/kg. The extracts of both the species at 400 mg / kg body weight possessed a remarkable fasting blood – glucose lowering potential, significant increase in body weight and reduced levels of SGPT and SGOT in alloxan and streptozotocin induced diabetic rats. The extracts also exhibited improved glucose utilisation. The UPLC analysis of the extract revealed the presence of phenols and flavonoids with antidiabetic potential. The results support the use of Syzygium species in traditional system of medicine to treat diabetes mellitus.
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