The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)最新文献_第6页

The application of a new beam-rigid body MEMS gyroscope in the frequency-modulation mode 一种新型波束刚体MEMS陀螺仪在调频模式下的应用

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908880

S. A. M. Lajimi, G. Heppler, E. Abdel-Rahman

引用次数: 4

A novel micromixer with multimixing mechanisms for high mixing efficiency at low Reynolds number 一种低雷诺数下具有高混合效率的混合机制的新型微混合器

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908896

H. L. The, N. Tran-Minh, H. Le-Thanh, F. Karlsen

{"title":"A novel micromixer with multimixing mechanisms for high mixing efficiency at low Reynolds number","authors":"H. L. The, N. Tran-Minh, H. Le-Thanh, F. Karlsen","doi":"10.1109/NEMS.2014.6908896","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908896","url":null,"abstract":"In this paper, we propose a novel passive micromixer structure for high mixing efficiency based on the combination of multimixing principles. With a special structure, our proposed micromixer can create vortices, transversal flows and chaotic advections to provide high mixing efficiency event at low Reynolds number. Moreover, two narrow slits at two ends of each mixing unit remarkably reduce pressure drop, making it easy to be built into micro-devices. We conduct intensive simulation to evaluate the performance of our proposed micromixer by numerically solving the governing Navier-Stokes equation and convection-diffusion equation using COMSOL Multiphysics package. The simulation results indicate that our proposed micromixer may achieve stable mixing efficiency of 80% or above for a wide Reynolds number range from 0.5 to 100. Especially, at Reynolds number (Re) > 30, mixing efficiency is less dependent on Reynolds number. The mixing efficiency of our micromixer is two times higher than mixing efficiency of micromixer based on unbalanced splits and collisions of fluid at the same mixing channel length of 5mm. At Re = 30, our proposed micromixer has high mixing efficiency of 85% with moderate pressure drop ΔP = 12,600Pa.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"98 1","pages":"651-654"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80910491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A low-noise CMOS interface circuit for resonant pressure sensor 一种用于谐振压力传感器的低噪声CMOS接口电路

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908791

Xiaodong Sun, W. Yuan, Sen Ren, Jinjun Deng, C. Jiang

引用次数: 1

An Aluminum Nano-Spike electroporation chip for low voltage delivery of molecules to cancer cells 一种用于向癌细胞低压输送分子的铝纳米尖刺电穿孔芯片

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908779

K. Riaz, S. Leung, S. Tripathi, Gursimran Singh Sethi, H. Shagoshtasbi, Z. Fan, Y.-K. Lee

{"title":"An Aluminum Nano-Spike electroporation chip for low voltage delivery of molecules to cancer cells","authors":"K. Riaz, S. Leung, S. Tripathi, Gursimran Singh Sethi, H. Shagoshtasbi, Z. Fan, Y.-K. Lee","doi":"10.1109/NEMS.2014.6908779","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908779","url":null,"abstract":"Micro electroporation (EP) devices with high efficiency and cell viability are useful for various biomedical applications, such as drug delivery and screening. However, these devices usually have low reliability due to undesirable electrochemical reactions. In this study, an Aluminum Nano-Spike EP (ANS-EP) chip was fabricated using nano-imprint lithography, electrochemical anodization and MEMS technology. The fabricated device was characterized using cervical cancer cell line (HeLa cells). The EP efficiency and cell viability as functions of electric pulse amplitude and duration were measured using digital fluorescent microscopy with Propidium Iodide (PI) dye. Numerical simulations of electric field strength indicated enhanced localized electric field at the tip due to high aspect ratio of nano-spikes. Systematic experiments revealed EP can be achieved with high efficiency and cell viability using ANS-EP chips without bubble generation at the critical applied voltage of 2.5 V, much smaller than the micro and conventional electroporators.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"12 1","pages":"147-151"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78990960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Silicon substrate strength enhancement depending on nanostructure morphology 硅衬底强度增强取决于纳米结构形态

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908834

Kunal Kashyap, Amarendra Kumar, Chung-Yao Yang, M. T. Hou, J. Yeh

引用次数: 0

Filling through-silicon vias with conductive ferromagnetic silver-iron composite 用导电铁磁银铁复合材料填充硅通孔

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908828

C. Lu, Kerwin Wang

引用次数: 0

An integrated microfluidic system for screening of peptides specific to colon cancer cells and colon cancer stem cells using the phage display technology 利用噬菌体展示技术筛选结肠癌细胞和结肠癌干细胞特异性肽的集成微流控系统

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908845

Yu-Jui Che, Huei-Wen Wu, Lein-Yu Hung, Hwan-You Chang, Kuan Wang, Gwo-Bin Lee

{"title":"An integrated microfluidic system for screening of peptides specific to colon cancer cells and colon cancer stem cells using the phage display technology","authors":"Yu-Jui Che, Huei-Wen Wu, Lein-Yu Hung, Hwan-You Chang, Kuan Wang, Gwo-Bin Lee","doi":"10.1109/NEMS.2014.6908845","DOIUrl":"https://doi.org/10.1109/NEMS.2014.6908845","url":null,"abstract":"Reagents binding specifically to target molecules are essential tools for clinical diagnosis and targeted therapy. Screening of target cell-surface specific affinity reagents with bench-top methods has some drawbacks, including time-consuming, labor-intensive and requirement of large-scale instrument. Microfluidic platforms may overcome these drawbacks because they could automate and complete the screening process within a shorter period of time. Phage display is a promising technology in selection of cell-surface specific peptides. In recent years, a subpopulation of tumor cells named cancer stem cells is believed to be the tumorigenic cells and closely associated with metastasis. A specific peptide that can recognize and differentiate cancer stem cells from the rest of cancer cell population is therefore useful for early diagnosis and targeted therapy. In this study, selection of M13 phage displayed peptides that bind with colon cancer cells and colon cancer stem cells using an integrated microfluidic system was successfully demonstrated. Compared with the traditional methods, the total selection process was shortened to 36 hours while traditional method needs almost a month. More importantly, the screening process can be automated and performed on a single microfluidic chip. The developed technique may be promising for early diagnosis of cancer and target therapeutics.","PeriodicalId":22566,"journal":{"name":"The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)","volume":"52 1","pages":"440-443"},"PeriodicalIF":0.0,"publicationDate":"2014-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87538907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Super hydrophobic/super hydrophilic transparent nanostructured glass fabricated by wet etching 湿法蚀刻制备超疏水/超亲水透明纳米结构玻璃

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908771

Amarendra Kumar, Kunal Kashyap, K. Liao, M. T. Hou, J. Yeh

引用次数: 0

SOI technology-based microfiltration system for circulating tumor cells isolation and enumeration 基于SOI技术的循环肿瘤细胞分离与计数微滤系统

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908820

Wei Ma, Ronghao Zeng, Dayu Liu, Y. Zohar, Yi-Kuen Lee

引用次数: 2

Experimental investigation of 3D plasmon talbot effect 三维等离子体talbot效应的实验研究

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS) Pub Date : 2014-04-13 DOI: 10.1109/NEMS.2014.6908866

Yiting Yu, H. Zappe

引用次数: 1