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HPV positive oropharyngeal cancer HPV阳性口咽癌
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj-2025-086142
Dominic McKenna, Richard Mayne, Carrie Carson, Sarah Collins, Ekambar Reddy
{"title":"HPV positive oropharyngeal cancer","authors":"Dominic McKenna, Richard Mayne, Carrie Carson, Sarah Collins, Ekambar Reddy","doi":"10.1136/bmj-2025-086142","DOIUrl":"https://doi.org/10.1136/bmj-2025-086142","url":null,"abstract":"### What you need to know A man in his 50s presents with a 4 week history of a lump on the right side of his neck, initially noticed while shaving. The lump was associated with a mild sore throat radiating to his right ear that persisted despite antibiotics. He is a lifelong non-smoker, who rarely drinks alcohol. On examination he had a firm, fixed 3 cm mass in the right anterior triangle, anterior to the upper third of the sternocleidomastoid muscle. Oropharyngeal exam revealed an irregularly enlarged right tonsil with a hard consistency. Squamous cell carcinoma is the most common malignancy affecting the oropharynx (fig 1), specifically the lymphoid tissue of the palatine tonsils and base of the tongue.1 The causal association between HPV, particularly the HPV 16 subtype, and oropharyngeal squamous cell carcinoma (OPSCC) was recognised by the International Agency for Research against Cancer in 2007. This is a clinically and pathologically distinct disease entity from HPV negative OPSCC. It has a markedly different epidemiology, typically affecting …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaza: Over 50 000 preschool children are acutely malnourished, study finds, as ceasefire deal progresses. 加沙：研究发现，随着停火协议的推进，5万多名学龄前儿童严重营养不良。
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2137
Elisabeth Mahase
{"title":"Gaza: Over 50 000 preschool children are acutely malnourished, study finds, as ceasefire deal progresses.","authors":"Elisabeth Mahase","doi":"10.1136/bmj.r2137","DOIUrl":"https://doi.org/10.1136/bmj.r2137","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"17 1","pages":"r2137"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Painful purpura in systemic lupus erythematosus 系统性红斑狼疮引起的疼痛性紫癜
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r1901
Yan-jia Shu, Zheng-bang Dong
{"title":"Painful purpura in systemic lupus erythematosus","authors":"Yan-jia Shu, Zheng-bang Dong","doi":"10.1136/bmj.r1901","DOIUrl":"https://doi.org/10.1136/bmj.r1901","url":null,"abstract":"A woman in her late 50s presented with a two month history of a scattered macular rash on her back, which progressively merged into painful purpura. She had a history of systemic lupus erythematosus treated with prednisone and hydroxychloroquine. Physical examination showed violaceous, reticular purpura with dusky central discoloration (fig 1 …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are more dissatisfied UK doctors really moving abroad? 越来越多不满意的英国医生真的搬到国外了吗？
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2113
Elisabeth Mahase
{"title":"Are more dissatisfied UK doctors really moving abroad?","authors":"Elisabeth Mahase","doi":"10.1136/bmj.r2113","DOIUrl":"https://doi.org/10.1136/bmj.r2113","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"86 1","pages":"r2113"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UK considers drug price changes as European leaders warn "unnecessary clinical trials" are sending wrong message to big pharma. 英国考虑调整药品价格，欧洲领导人警告称，“不必要的临床试验”正在向大型制药公司传递错误信息。
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2132
Kate Bowie
{"title":"UK considers drug price changes as European leaders warn \"unnecessary clinical trials\" are sending wrong message to big pharma.","authors":"Kate Bowie","doi":"10.1136/bmj.r2132","DOIUrl":"https://doi.org/10.1136/bmj.r2132","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"70 1","pages":"r2132"},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where genocide, healthocide, and atrocities start, medical neutrality ends 种族灭绝、健康灭绝和暴行在哪里开始，医疗中立就在哪里结束
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2120
Kamran Abbasi
{"title":"Where genocide, healthocide, and atrocities start, medical neutrality ends","authors":"Kamran Abbasi","doi":"10.1136/bmj.r2120","DOIUrl":"https://doi.org/10.1136/bmj.r2120","url":null,"abstract":"The medical community must play a role in ending atrocities—so say editorialists Joseph Amon and Shatha Elnakib. They reflect on the Rwandan genocide, when 800 000 to a million people were killed in 100 days (doi:10.1136/bmj.r2101).1 They challenge the notion of medical neutrality and advocate active engagement to prevent and stop genocide (doi:10.1136/bmj.r1994).2 The medical community includes professionals, leaders, and organisations—all of whom have a responsibility. Many professionals, like the public, face difficulties in understanding what “constitutes evidence of genocide” and how to intervene. Amon and Elnakib offer two concrete actions. The first is to bear witness. The second is to collaborate—with human rights organisations, legal experts, grassroots activists, and affected communities—to overcome political inertia. Medicolegal partnerships are crucial, they argue, to influence political intervention and to ensure accountability and justice. Health professionals have borne witness, and their verdict is a damning one on Israel’s actions. A landmark study from the front line, using data collected by health professionals about the injuries they observed in Gaza, paints a horrific picture (doi:10.1136/bmj-2025-087524).3 The data are imperfect—inevitably, given the circumstances—but the study …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145255600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low dose oral semaglutide for obesity . . . and other research 低剂量口服西马鲁肽治疗肥胖…还有其他研究
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2050
Tom Nolan
{"title":"Low dose oral semaglutide for obesity . . . and other research","authors":"Tom Nolan","doi":"10.1136/bmj.r2050","DOIUrl":"https://doi.org/10.1136/bmj.r2050","url":null,"abstract":"Tom Nolan reviews this week’s research Multicancer detection (MCD) tests are available to buy—although may set you back more than a thousand pounds. Websites offering the tests, that usually detect fragments of DNA released by cancer cells, seem to imply an established evidence base for them, such as that they’ve been validated on over 40 000 participants. A systematic review suggests there is still a way to go: the authors searched for controlled studies in screening populations and found no controlled studies that report benefits of screening with MCD tests. The NHS-Galleri trial should change that and is expected to report its findings next year. Ann Intern Med doi:10.7326/ANNALS-25-01877 Countless headlines exalt the life changing benefits of newer …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The implications of the Make Our Children Healthy Again report for child health and obesity in the US 《让我们的孩子再次健康》报告对美国儿童健康和肥胖的影响
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2116
Juliana F W Cohen, Leah E Chapman, Marlene B Schwartz
{"title":"The implications of the Make Our Children Healthy Again report for child health and obesity in the US","authors":"Juliana F W Cohen, Leah E Chapman, Marlene B Schwartz","doi":"10.1136/bmj.r2116","DOIUrl":"https://doi.org/10.1136/bmj.r2116","url":null,"abstract":"Federal funding policies should align with priorities to improve child health, say Juliana Cohen and colleagues On 9 September 2025, the Make America Healthy Again (MAHA) Commission released a strategy report on child health, Make Our Children Healthy Again .1 The commission organised its recommendations around four root causes of poor health among children in the US: poor diet, exposure to environmental chemicals, lack of physical activity and chronic stress, and overmedicalisation. Although reactions among US public health and medical leaders have been mixed—with particular concern about the government’s approach to vaccines—there is potential to find common ground and bipartisan support for many of the commission’s recommendations on nutrition.23 To improve children’s diets and reduce their risk of obesity, federal funding decisions must also be coordinated with an evidence based approach to developing policies and supporting programmes. The original MAHA report (published in May 2025) explicitly recommended that Americans reduce their consumption of ultra-processed foods (UPFs).4 This recommendation marked a notable shift away from the traditional nutrient based system of the Dietary Guidelines for Americans (DGA) that categorises foods into groups and …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute abdominal pain in a young woman 一名年轻女子出现急性腹痛
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj-2025-086952
Wenwen Ni, Timothy Shao Ern Tan
{"title":"Acute abdominal pain in a young woman","authors":"Wenwen Ni, Timothy Shao Ern Tan","doi":"10.1136/bmj-2025-086952","DOIUrl":"https://doi.org/10.1136/bmj-2025-086952","url":null,"abstract":"A woman in her 20s presented to the emergency department with a one day history of severe lower abdominal pain and vaginal bleeding. Her previous menstrual period was 5 weeks earlier. She was not using any form of contraception, and had no relevant medical, gynaecological, or surgical history apart from a previous caesarean section. On admission, her temperature was 37.4°C. Her heart rate was 100 bpm with a blood pressure of 102/65 mm Hg. Abdominal examination revealed tenderness over the suprapubic region on deep palpation. Speculum examination showed a closed cervical os with no bleeding or retained product of conception. A urine pregnancy test was positive and her serum β human chorionic gonadotropin (hCG) level was 1724.2 IU/L (normal range <5 IU/L). Other laboratory tests showed a haemoglobin level of 114 g/L (normal range 120-160 g/L), white blood cell count of 17.27×10 …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rupa Tewari: classical Indian singer and sexual health doctor who championed women and children 鲁帕·特瓦里：印度古典歌手和性健康医生，她支持妇女和儿童
The BMJ Pub Date : 2025-10-09 DOI: 10.1136/bmj.r2094
Rebecca Wallersteiner
{"title":"Rupa Tewari: classical Indian singer and sexual health doctor who championed women and children","authors":"Rebecca Wallersteiner","doi":"10.1136/bmj.r2094","DOIUrl":"https://doi.org/10.1136/bmj.r2094","url":null,"abstract":"In the 1990s, when there were few female Indian doctors in Scotland, Rupasree Tewari wore a sari to work every day, describing it as her version of a business suit. Although she found attitudes towards immigrant doctors challenging, she persisted. For more than 20 years she worked in sexual and reproductive health, child protection, and school medicine. She led clinics for contraception, family planning, and menopause and pre-termination counselling. She trained in video colposcopy for the medical examination of victims of sexual abuse and organised Saturday morning drop-in clinics for teenagers. She also served as senior clinical medical officer in community child health, overseeing the care of around 5000 children as school doctor of institutions around Kirkcaldy. Her former colleague Linda Gillespie, a school nurse, said, “I remember Rupa as a professional and compassionate person. The young people often commented on how kind and gentle she was.” Tewari also tutored medical students, GP trainees, and nurses from the universities of Edinburgh, Dundee, St Andrews, and Sheffield in contraceptive counselling, intrauterine device and implant …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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