The BMJ最新文献

{"title":"Eating disorders: Doctors and patients left in “nightmare situation” amid long waits, unsafe care, and preventable deaths","authors":"Emma Wilkinson","doi":"10.1136/bmj-2026-100634","DOIUrl":"https://doi.org/10.1136/bmj-2026-100634","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"72 1","pages":"e100634"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing the conversation on maternity safety","authors":"Carolyn Hastie","doi":"10.1136/bmj-2026-100782","DOIUrl":"https://doi.org/10.1136/bmj-2026-100782","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"8 1","pages":"e100782"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lenacapavir: Gilead is urged to change price after NHS rejects HIV drug owing to cost","authors":"Elisabeth Mahase","doi":"10.1136/bmj-2026-100825","DOIUrl":"https://doi.org/10.1136/bmj-2026-100825","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"51 1","pages":"e100825"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wales risks raising “one of the unhealthiest generations in decades,” doctors warn","authors":"Gareth Iacobucci","doi":"10.1136/bmj-2026-100823","DOIUrl":"https://doi.org/10.1136/bmj-2026-100823","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"20 1","pages":"e100823"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot drinks and oesophageal cancer: the facts behind the headlines","authors":"Jane Feinmann","doi":"10.1136/bmj-2026-100840","DOIUrl":"https://doi.org/10.1136/bmj-2026-100840","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"5 1","pages":"e100840"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous derivation, validation, and comparison of predictor hazard ratios for cardiovascular risk prediction equations in patients with diabetes from high versus non-high income countries: cohort study","authors":"Jingyuan Liang,Yeunhyang Choi,Peng Shen,Susan Wells,Katrina Poppe,Zhangping Fu,Matire Harwood,Xiaofei Liu,Sue Crengle,Ting Wang,Corina Grey,Hongbo Lin,Suneela Mehta,Xun Tang,Rod Jackson,Pei Gao","doi":"10.1136/bmj-2026-100535","DOIUrl":"https://doi.org/10.1136/bmj-2026-100535","url":null,"abstract":"Abstract Objective To directly test the generalisability of cardiovascular disease (CVD) risk predictor effects across populations in a high income versus non-high income country, derive comparable risk equations, and identify more effective strategies for prediction across populations. Design Population based cohort study. Setting Primary prevention cohorts in New Zealand and China. Participants Equivalent New Zealand and Chinese cohorts of people aged 30-74 years with diabetes and no CVD based on electronic health records. Main outcome measures Country specific five year equations were derived using standardised methods to predict first cardiovascular events; predictor hazard ratios were compared. New Zealand equations were applied to the Chinese cohort, with performance assessed before and after standard recalibration, followed by the updating of predictor hazard ratios that differed statistically significantly. Results Between 2004 and 2018, 47 958 New Zealand participants had 5622 (11.7%) first CVD events. Between 2010 and 2018, 46 558 Chinese participants had 3650 (7.8%) first CVD events. Sex specific equations included 16 predictors. Hazard ratios for most predictors were similar between New Zealand and Chinese equations but differed markedly for age (eg, women: 1.61, 95% confidence interval 1.51 to 1.71 per 10 years in New Zealand, 2.51 (2.32 to 2.72) per 10 years in China). Standard recalibration of New Zealand equations did not improve calibration in the Chinese cohort (expected to observed ratio: 0.938 in men, 0.809 in women). Replacing New Zealand age coefficients with Chinese coefficients noticeably improved calibration (expected to observed ratio 1.027 in men, 1.025 in women). Conclusions Applying a high income country derived CVD risk prediction equation to a population from a non-high income country with diabetes may introduce systematic errors, primarily driven by differences in the effect of age. Moving beyond simple recalibration to updating key predictor coefficients, particularly age, should be considered for more accurate risk stratification. This study highlights potential limitations of high income country equation updating practices and proposes a feasible approach to improve their accuracy when used in populations from non-high income countries.","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"76 1","pages":"e100535"},"PeriodicalIF":0.0,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alzheimer’s prevention drug trial: is a “statin for the brain” on the horizon?","authors":"Jacqui Wise","doi":"10.1136/bmj-2026-100822","DOIUrl":"https://doi.org/10.1136/bmj-2026-100822","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"172 1","pages":"e100822"},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wegovy: GPs are told not to prescribe GLP semaglutide for heart health without funding guarantee","authors":"Gareth Iacobucci","doi":"10.1136/bmj-2026-100816","DOIUrl":"https://doi.org/10.1136/bmj-2026-100816","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"19 1","pages":"e100816"},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the diagnosis and management of skin and soft tissue infections","authors":"Brit Long,Krishan Yadav,Megan A Rech,Michael Gottlieb","doi":"10.1136/bmj-2026-100580","DOIUrl":"https://doi.org/10.1136/bmj-2026-100580","url":null,"abstract":"Abstract Skin and soft tissues infections (SSTIs) are common conditions, affecting millions worldwide. SSTIs range from uncomplicated cellulitis to necrotizing fasciitis and can be divided into non-purulent and purulent forms. Non-purulent SSTI is most commonly associated with beta-haemolytic streptococci, while purulent SSTI is typically associated with Staphylococcus aureus . Cellulitis most commonly presents with acute warmth, pain, tenderness to palpation, erythema, and oedema. Skin abscess typically presents with a fluctuant tender area with erythema. Laboratory testing is of limited use in most patients. Point-of-care ultrasound is useful for distinguishing cellulitis from abscess if the diagnosis is unclear. Management of SSTI includes antibiotics such as penicillin VK, dicloxacillin, or a cephalosporin, while treatment for skin abscess includes incision and drainage, with antibiotics recommended in select patients. Patients should elevate the affected extremity when possible, and non-steroidal anti-inflammatory drugs may reduce pain and inflammation. The effectiveness of decolonization for patients with recurrent cellulitis or skin abscess is controversial. While most patients with cellulitis or skin abscess are appropriate for discharge with follow-up, patients with sepsis and those with challenges adhering to therapy, immunosuppression, or failed outpatient therapy should be referred to the emergency department. Novel antibiotics such as tedizolid, delafloxacin, omadacycline, and ceftaroline may be considered in select cases.","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"40 1","pages":"e100580"},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Government announces £32m to strengthen hospitals’ resilience to extreme heat","authors":"Jacqui Wise","doi":"10.1136/bmj-2026-100819","DOIUrl":"https://doi.org/10.1136/bmj-2026-100819","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"12 1","pages":"e100819"},"PeriodicalIF":0.0,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}