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Obstetricians and gynaecologists: Suicidal thoughts and burnout rose after pandemic, survey suggests. 妇产科医生：调查显示，大流行后，自杀念头和倦怠感上升。
The BMJ Pub Date : 2025-07-30 DOI: 10.1136/bmj.r1602
Kate Bowie
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引用次数: 0
Our Future Health: consent, clinical risk, and industry issues plague the UK’s biggest ever health research programme 我们未来的健康：同意、临床风险和行业问题困扰着英国有史以来最大的健康研究项目
The BMJ Pub Date : 2025-07-30 DOI: 10.1136/bmj.r1579
Margaret McCartney, Deborah Cohen
{"title":"Our Future Health: consent, clinical risk, and industry issues plague the UK’s biggest ever health research programme","authors":"Margaret McCartney, Deborah Cohen","doi":"10.1136/bmj.r1579","DOIUrl":"https://doi.org/10.1136/bmj.r1579","url":null,"abstract":"The UK’s flagship health research programme promises breakthroughs, but beneath an NHS branded facade, critics are asking who really benefits from this vast database, heavily backed by industry and government. Margaret McCartney and Deborah Cohen investigate As a research programme, Our Future Health (OFH) is a runaway success—at least on paper. Described by one observer as the UK Biobank “on steroids,” OFH has become the UK’s largest ever health research programme, recruiting more than 1.5 million participants in just two years, with a goal of reaching five million.1 Its scale and ambition are praiseworthy, especially for enrolling people from ethnic minority groups and low income backgrounds—communities often overlooked in medical research. Participants are told that their data, along with access to their NHS records, will help researchers make discoveries about conditions such as dementia, cancer, and heart disease. Researchers will use only deidentified data, for purposes only for “the public good.” Participants may later be asked whether they want personal feedback from their samples, including their DNA, that could “reveal health or disease risks.” Behind the headline data, however, concerns persist. To investigate the major issues The BMJ has spoken to the programme’s chief executive, Raghib Ali, as well as its critics. The first issue is consent. Volunteers can sign up through community pharmacies, mobile units, the blood transfusion service, or an NHS branded invitation promising new insights into their blood pressure and disease risk. In exchange for personal details and blood samples they receive a £10 shopping voucher. Privacy campaigners have questioned whether participants truly understand how their genetic material will be used and whether the gift voucher could amount to undue inducement. Others warn of the risks associated with returning complex polygenic risk scores of dubious clinical utility, especially in the absence of a clear NHS plan …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Majority of global liver cancer cases "preventable," Lancet commission finds. 柳叶刀委员会发现，全球大多数肝癌病例是“可以预防的”。
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1587
Kate Bowie
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引用次数: 0
Doctors are dragged into Mexico's drug wars as cartels take over clinics. 由于贩毒集团接管了诊所，医生们被拖入了墨西哥的毒品战争。
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1591
Luke Taylor
{"title":"Doctors are dragged into Mexico's drug wars as cartels take over clinics.","authors":"Luke Taylor","doi":"10.1136/bmj.r1591","DOIUrl":"https://doi.org/10.1136/bmj.r1591","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"5 1","pages":"r1591"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory change could improve biosimilar access in the US 监管改革可能会改善美国生物仿制药的准入
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj-2025-084860
Tiffany E Jiang, Reshma Ramachandran, Joshua J Skydel
{"title":"Regulatory change could improve biosimilar access in the US","authors":"Tiffany E Jiang, Reshma Ramachandran, Joshua J Skydel","doi":"10.1136/bmj-2025-084860","DOIUrl":"https://doi.org/10.1136/bmj-2025-084860","url":null,"abstract":"Tiffany E Jiang , Reshma Ramachandran , and Joshua J Skydel argue that US requirements for interchangeability are not supported by evidence and hamper use of biosimilars Biological medicines (biologics) such as monoclonal antibodies have improved the treatment of numerous cancers, autoimmune diseases, and other conditions. They provide targeted treatment that enables patients to control their disease and lead healthier lives. Biologics are also among the most expensive available medications, accounting for almost one half of US drug spending in 2023 despite representing just 2% of prescriptions.1 Biosimilar products can lower prices and expand access to treatment, much like generic versions of small molecule drugs (box 1). However, whereas generic drugs are readily accepted as alternatives to branded products, biosimilars face challenges that have so far prevented them becoming widely used, especially in the US. Proposed changes to the Food and Drug Administration guidance could relax requirements and improve access to lower cost versions of these transformative therapies, but further changes are needed to maximise the benefits. Box 1 ### Key definitionsRETURN TO TEXT","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nawal Bagaria: GP who set up care homes and helped found a Hindu temple in Edinburgh 纳瓦尔·巴格里亚：全科医生，在爱丁堡建立了养老院，并帮助建立了一座印度教寺庙
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1541
Tim Bullamore
{"title":"Nawal Bagaria: GP who set up care homes and helped found a Hindu temple in Edinburgh","authors":"Tim Bullamore","doi":"10.1136/bmj.r1541","DOIUrl":"https://doi.org/10.1136/bmj.r1541","url":null,"abstract":"The opening of Edinburgh Hindu Mandir and Cultural Centre in a former church in 2015 was a joyous occasion, attended by more than 1300 people. This was thanks in no small part to Nawal Bagaria, who was president until February this year, overseeing a thriving congregation that meets twice weekly for prayer, meditation, and community worship. Bagaria and his wife, Sheela, a gynaecologist-turned-psychiatrist, had made their home in Scotland since 1975, when he became a GP in the new town of Livingston. He recalled being asked at his interview what guarantee there was that he would stay in the area; he responded by committing to provide for the local community for the rest of his life. He was true to his word. Increasingly, the couple found that their interests lay in caring for the elderly and in 1988 they approached Livingston Development Corporation for a site where they could provide accommodation for older people unable to live at home. Overcoming objections from residents worried about additional traffic close to a primary school, they opened the 40 bed Peacock Nursing Home in 1989. Two years later it expanded to 80 beds, this second phase being opened …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Half of resident doctors finishing training are set for unemployment next month, BMA warns. 英国医学协会警告说，完成培训的住院医生中有一半将在下个月失业。
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1592
Kate Bowie
{"title":"Half of resident doctors finishing training are set for unemployment next month, BMA warns.","authors":"Kate Bowie","doi":"10.1136/bmj.r1592","DOIUrl":"https://doi.org/10.1136/bmj.r1592","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"215 1","pages":"r1592"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Core GRADE 4: rating certainty of evidence—risk of bias, publication bias, and reasons for rating up certainty 核心GRADE 4：评价证据的确定性-偏倚风险，发表偏倚，以及提高确定性评级的原因
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1468
British Medical Journal Publishing Group
{"title":"Core GRADE 4: rating certainty of evidence—risk of bias, publication bias, and reasons for rating up certainty","authors":"British Medical Journal Publishing Group","doi":"10.1136/bmj.r1468","DOIUrl":"https://doi.org/10.1136/bmj.r1468","url":null,"abstract":"An error occurred in figure 2 of this paper by Guyatt and colleagues ( BMJ 2025;389:e083864, doi:10.1136/bmj-2024-083864, published 13 May 2025). …","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Doctors' strike: Tories vow to ban strikes as Streeting says NHS staff are "picking up slack" of ongoing action. 医生罢工：托利党誓言禁止罢工，因为斯特里廷说，NHS的工作人员正在“收拾残局”。
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1588
Adrian O'Dowd
{"title":"Doctors' strike: Tories vow to ban strikes as Streeting says NHS staff are \"picking up slack\" of ongoing action.","authors":"Adrian O'Dowd","doi":"10.1136/bmj.r1588","DOIUrl":"https://doi.org/10.1136/bmj.r1588","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"722 1","pages":"r1588"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
South Korean government restarts talks with trainee doctors after mass resignation in medical school places row. 韩国政府重启与实习医生的谈判，此前医学院出现大量学生辞职的情况。
The BMJ Pub Date : 2025-07-29 DOI: 10.1136/bmj.r1590
Flynn Murphy
{"title":"South Korean government restarts talks with trainee doctors after mass resignation in medical school places row.","authors":"Flynn Murphy","doi":"10.1136/bmj.r1590","DOIUrl":"https://doi.org/10.1136/bmj.r1590","url":null,"abstract":"","PeriodicalId":22388,"journal":{"name":"The BMJ","volume":"6 1","pages":"r1590"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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