Sustainable Chemistry and Pharmacy最新文献_第7页

Women's satisfaction with their childbirth experiences and hospitals' corporate social responsibility intentions 产妇分娩满意度与医院企业社会责任意愿

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-16 DOI: 10.1016/j.scp.2025.102154

Iris Gertner Moryossef

{"title":"Women's satisfaction with their childbirth experiences and hospitals' corporate social responsibility intentions","authors":"Iris Gertner Moryossef","doi":"10.1016/j.scp.2025.102154","DOIUrl":"10.1016/j.scp.2025.102154","url":null,"abstract":"<div><div>Maternal satisfaction with childbirth is a key determinant of maternal well-being, mother–infant bonding, and postpartum recovery. In Israel, it also affects hospital reimbursement policies, incentivizing improvements in the quality and design of labor and delivery rooms. This study examined the influence of hospitals' corporate social responsibility (CSR) practices, particularly environmentally sustainable infrastructure and eco-conscious organizational policies—on maternal satisfaction, using the 3P service marketing mix: Physical Evidence, Process, and Personal Interaction. Data were collected from 58 mothers who gave birth in seven hospitals in northern Israel. These hospitals were located in six cities, as one city (Haifa) included two separate hospitals with independent maternity wards. The hospitals classified into two groups based on CSR initiatives related to infrastructure (delivery rooms, postpartum amenities), basic green-design features (energy-efficient lighting, natural ventilation, eco-certified materials), sustainable nutrition options, and waste recycling. Results indicate that a hospital's ecofriendly environment has a positive significant influence on maternal satisfaction, especially in the Personal Interaction (<em>r</em> = .64, <em>p</em> < .001) and Process (<em>r</em> = .59, <em>p</em> < .001) dimensions. Personal Interaction was the strongest predictor of maternal satisfaction (β = .71, <em>p</em> < .001), while CSR commitment had no significant effect on satisfaction with Physical Evidence. These findings provide new empirical evidence that a green hospital's organizational environment contributes not only to environmental goals, but also to better childbirth experiences. These insights are valuable for hospital managers, policymakers, and designers aiming to promote sustainable development and patient-centered maternity care. These findings support the integration of CSR into maternity care to enhance patient-centered delivery experiences.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102154"},"PeriodicalIF":5.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green environmental assessment and rating for solvents (GEARS) as an innovative tool for solvent selection 绿色环境评估和溶剂评级（GEARS）作为溶剂选择的创新工具

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-16 DOI: 10.1016/j.scp.2025.102157

Fotouh R. Mansour , Alaa Bedair

{"title":"Green environmental assessment and rating for solvents (GEARS) as an innovative tool for solvent selection","authors":"Fotouh R. Mansour , Alaa Bedair","doi":"10.1016/j.scp.2025.102157","DOIUrl":"10.1016/j.scp.2025.102157","url":null,"abstract":"<div><div>This study introduces the Green Environmental Assessment and Rating for Solvents (GEARS) as a novel metric designed to evaluate the environmental, functional and economic viability of solvents used in research and industrial applications. GEARS integrates comprehensive Environmental Health and Safety (EHS) criteria with Life Cycle Assessment (LCA) to provide a holistic evaluation of solvent efficiency. The metric assesses ten critical parameters: toxicity, biodegradability, renewability, volatility, thermal stability, flammability, environmental impact, efficiency, recyclability, and cost. Each parameter is scored based on specific thresholds, contributing to an overall score that highlights the strengths and weaknesses of each solvent. The effectiveness of GEARS is demonstrated through case studies evaluating methanol, ethanol, acetonitrile, benzene, and glycerol, revealing insights into their overall performance. The results highlight the importance of using a comprehensive assessment tool to facilitate the selection of greener solvents, thereby promoting sustainable practices in the chemical industry. The GEARS software is available as an open-source tool at bit.ly/GEARS2025.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102157"},"PeriodicalIF":5.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of carbon sink for concrete structures: From hydration kinetics to climate-driven carbonation 混凝土结构碳汇建模：从水化动力学到气候驱动的碳化

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-16 DOI: 10.1016/j.scp.2025.102148

Ye Tian , Jia-Cheng Xu , Guo-Yi Zhang , Zu-Shi Tian , Bei Li , Ruo-Yi Zhao , Qiang Zeng , Bo-Tao Huang , Dong-Ming Yan

{"title":"Modeling of carbon sink for concrete structures: From hydration kinetics to climate-driven carbonation","authors":"Ye Tian , Jia-Cheng Xu , Guo-Yi Zhang , Zu-Shi Tian , Bei Li , Ruo-Yi Zhao , Qiang Zeng , Bo-Tao Huang , Dong-Ming Yan","doi":"10.1016/j.scp.2025.102148","DOIUrl":"10.1016/j.scp.2025.102148","url":null,"abstract":"<div><div>Concrete production is estimated to contribute approximately 9 % of global greenhouse gas emissions. However, due to carbonation reactions, concrete buildings absorb CO<sub>2</sub> from the air during their service life. In order to accurately predict the carbon sink of concrete buildings, a carbon sink calculation model was developed. This model is based on a kinetic model that considers the cement hydration process, heat transfer, moisture transport, and carbonation. Moreover, time-varying exposure conditions (TVEC) are considered, including long-term and seasonal variations in climate. In the case study, the model was applied to a school building, and carbonation simulations were conducted under the Representative Concentration Pathway 8.5 (RCP8.5) scenario. The results show that the carbon sink of the building was 99.03 tons over 50 years, equivalent to approximately 27.6 % of the emissions generated during concrete production. In addition, the dynamic evolution of the building's carbon sink and the factors affecting the carbon sink were carefully analyzed.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102148"},"PeriodicalIF":5.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sustainable dispersive liquid-liquid microextraction optimized by response surface methodology for multiclass emerging contaminants in surface water 响应面法优化地表水中多类新发污染物的液液分散微萃取

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-15 DOI: 10.1016/j.scp.2025.102153

Nawaltul Akma Ahmad Sabri , Fahren Fazzer Sukatis , Muhammad Qusyairi Jori Roslan , Muhammad Raznisyafiq Razak , Ahmad Zaharin Aris

{"title":"Sustainable dispersive liquid-liquid microextraction optimized by response surface methodology for multiclass emerging contaminants in surface water","authors":"Nawaltul Akma Ahmad Sabri , Fahren Fazzer Sukatis , Muhammad Qusyairi Jori Roslan , Muhammad Raznisyafiq Razak , Ahmad Zaharin Aris","doi":"10.1016/j.scp.2025.102153","DOIUrl":"10.1016/j.scp.2025.102153","url":null,"abstract":"<div><div>A green and efficient analytical method was developed for the simultaneous determination of 22 multiclass emerging contaminants (ECs) in surface water using dispersive liquid-liquid microextraction (DLLME) coupled with chromatographic analysis. Targeted compounds include pharmaceuticals, endocrine-disrupting chemicals (EDCs), pesticides, and perfluoroalkyl substances (PFAS), which are rarely addressed collectively in a single DLLME workflow. The method was optimized using Response Surface Methodology (RSM), enabling the robust modelling of parameter interactions with reduced experimental runs. Environmentally benign, low-toxicity solvents were selected to enhance the greenness of the method without compromising extraction performance. The method exhibited satisfactory performance, including low detection limits reaching up to 0.01 ng/mL range and good repeatability. Its environmental sustainability, assessed via the AGREE metric, yielded a high score of 0.64 versus 0.43 for conventional approaches, validating its alignment with Green Analytical Chemistry (GAC) principles. Application to real surface water samples confirmed its effectiveness for the comprehensive, green monitoring of trace-level ECs in aquatic environments.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102153"},"PeriodicalIF":5.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic defect and doping engineering of novel green phosphorene for enhanced spatial carrier separation: A DFT-based strategy for high-efficiency overall water splitting 新型绿色磷烯增强空间载流子分离的协同缺陷和掺杂工程：一种基于dft的高效整体水分解策略

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-15 DOI: 10.1016/j.scp.2025.102156

Xuhui Yang , Luteng Luo , Min-Quan Yang , Qingrong Qian

{"title":"Synergistic defect and doping engineering of novel green phosphorene for enhanced spatial carrier separation: A DFT-based strategy for high-efficiency overall water splitting","authors":"Xuhui Yang , Luteng Luo , Min-Quan Yang , Qingrong Qian","doi":"10.1016/j.scp.2025.102156","DOIUrl":"10.1016/j.scp.2025.102156","url":null,"abstract":"<div><div>Green phosphorene (GP), a novel two-dimensional (2D) allotrope of phosphorus, has emerged as a promising photocatalyst for overall water splitting due to its layer-tunable band structure and exceptional charge carrier mobility. However, its practical application is severely limited by rapid electron-hole recombination, insufficient visible-light absorption, and catalytically inert surfaces. To address these challenges, we propose a synergistic defect and doping engineering strategy, systematically investigated through density functional theory (DFT) simulations. By introducing Stone-Wales (SW) defects and subsequent Bi doping (termed SW-1-GP@Bi), the modified GP exhibited remarkable photocatalytic enhancements, including an extended visible-light absorption with a redshifted spectrum, a near-optimal hydrogen evolution reaction (HER) Gibbs free energy (<span><math><mo>Δ</mo><msub><mi>G</mi><mi>H</mi></msub><mo>=</mo><mn>0.05</mn><mspace></mspace><mi>eV</mi></math></span>), and a significantly reduced oxygen evolution reaction (OER) overpotential of 0.51 V at pH = 9 under illumination. The enhanced performance originates from two key mechanisms: (1) SW defects spatially separate electron-hole pairs, suppressing recombination, and (2) Bi doping tailors the surface electronic structure, optimizing hydrogen and oxygen intermediates adsorption. Our work demonstrates that defect-dopant synergy can effectively activate inert basal planes of GP, achieving balanced HER/OER activities for standalone water splitting. This strategy provides a universal framework for designing high efficiency 2D photocatalysts toward scalable solar hydrogen production.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102156"},"PeriodicalIF":5.8,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking Agave bracteosa Saponins: Optimized green extraction through Box-Behnken design 解锁龙舌兰皂苷：通过Box-Behnken设计优化绿色提取

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-14 DOI: 10.1016/j.scp.2025.102162

Francesca Guzzo , María José Aliaño-González , Nuria Chinchilla , Ceferino Carrera , Francisco A. Macías , Alexandra G. Durán , Ana M. Simonet

{"title":"Unlocking Agave bracteosa Saponins: Optimized green extraction through Box-Behnken design","authors":"Francesca Guzzo , María José Aliaño-González , Nuria Chinchilla , Ceferino Carrera , Francisco A. Macías , Alexandra G. Durán , Ana M. Simonet","doi":"10.1016/j.scp.2025.102162","DOIUrl":"10.1016/j.scp.2025.102162","url":null,"abstract":"<div><div>Ultrasound-assisted extraction has emerged as an eco-friendly and efficient alternative for the recovery of bioactive compounds from plant matrices. The present study aimed to optimize the UAE conditions for obtaining saponin-enriched extracts from <em>Agave bracteosa</em> leaves. To this end, a Box-Behnken design coupled with response surface methodology was employed to evaluate the influence of the following factors on saponin yield: ethanol concentration, extraction temperature, sample-to-solvent ratio, ultrasound cycle, and amplitude. The optimal conditions were as follows: 71 % ethanol in water, 34 °C, a sample-to-solvent ratio of 0.02 g/20 mL, a 0.3 s on/0.7 s off cycle, 20 % amplitude, and 5 min. The extracts were analyzed using UPLC-QTOF/MS<sup>E</sup>, leading to the identification of saponins recently reported for <em>Agave bracteosa</em>. The optimized method demonstrated high repeatability and applicability across different <em>Agave</em> species (<em>A. americana</em> and <em>A. lophanta</em>). An extraction efficiency (%EE) of 2739 was achieved compared with preliminary UAE extractions. This study highlights the potential of ultrasound-assisted extraction as a sustainable and effective technique for saponin extraction with important advantages such as reduced energy consumption and processing time.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102162"},"PeriodicalIF":5.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-carbon cement development via synergistic use of lead–zinc smelting slag and magnesium-rich lime mud 铅锌冶炼渣与富镁石灰泥协同开发低碳水泥

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-14 DOI: 10.1016/j.scp.2025.102150

Xiaowei Gu , Bohan Yang , Zhijun Li , Zhihang Hu , Ying Wang , Jianping Liu , Qing Wang

{"title":"Low-carbon cement development via synergistic use of lead–zinc smelting slag and magnesium-rich lime mud","authors":"Xiaowei Gu , Bohan Yang , Zhijun Li , Zhihang Hu , Ying Wang , Jianping Liu , Qing Wang","doi":"10.1016/j.scp.2025.102150","DOIUrl":"10.1016/j.scp.2025.102150","url":null,"abstract":"<div><div>Lead-zinc smelting slag (LZSS) presents potential as a supplementary cementitious material (SCM); however, its limited intrinsic reactivity and detrimental influence on hydration restrict its widespread application. This study proposes a sustainable strategy for low-carbon cement development by incorporating magnesium-rich lime mud (LM), a by-product of industrial water treatment, to enhance the performance of LZSS-based cement. The influence of LM on cement hydration behavior, mechanical strength development, and phase evolution was comprehensively evaluated. Experimental results revealed that incorporating 5 wt% LM markedly improved compressive strength from early to later curing ages, primarily attributed to the alkaline activation of LZSS and the formation of beneficial hydration products such as carboaluminates and hydrotalcite. In contrast, a higher LM dosage (15 wt%) significantly reduced strength despite enhanced clinker hydration, indicating an optimal LM content threshold. Leaching tests, conducted under neutral water conditions, indicated negligible release of heavy metals from the blended cements, confirming their environmental safety. While hydrotalcite formation may improve resistance to chloride ingress, comprehensive durability evaluation is still needed. Additionally, carbon footprint analysis demonstrated a substantial reduction in the global warming potential (GWP) of the blended cements. Notably, the LM15 formulation achieved a GWP reduction of up to 43 % relative to ordinary Portland cement. These findings highlight the potential of co-utilizing LZSS and LM to improve cement performance, ensure environmental safety, and reduce carbon emissions, thereby advancing the development of low-carbon and resource-efficient cementitious materials.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102150"},"PeriodicalIF":5.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioconversion of vine shoots into renewable products using ohmic heating extraction and autohydrolysis 利用欧姆加热提取和自水解将藤茎转化为可再生产品

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-13 DOI: 10.1016/j.scp.2025.102155

Diego Cardoza , Joana S. Gomes-Dias , Sara G. Pereira , Inmaculada Romero , Eulogio Castro , Cristina M.R. Rocha

{"title":"Bioconversion of vine shoots into renewable products using ohmic heating extraction and autohydrolysis","authors":"Diego Cardoza , Joana S. Gomes-Dias , Sara G. Pereira , Inmaculada Romero , Eulogio Castro , Cristina M.R. Rocha","doi":"10.1016/j.scp.2025.102155","DOIUrl":"10.1016/j.scp.2025.102155","url":null,"abstract":"<div><div>The valorization of vine shoots (VS), a lignocellulosic waste from the viticulture industry, was evaluated using different alternative and sustainable extraction processes. An innovative biorefinery approach, sequentially combining ohmic heating extraction (OHE) and autohydrolysis (AH), was selected for the extraction of nutraceutical compounds and bioethanol production. Overall, the use of both technologies improved the extraction yield of target compounds, modulated their profiles (due to the affinity of each solvent used), and improved the saccharification of the residual biomass when compared to non-sequential processing, reinforcing the advantages of the novel approach proposed. An optimal combination of OHE (80 °C for 60 min) followed by AH at 200 °C for 30 min showed the highest recovery of phenolic compounds (31.3 mg GAE/g VS) and antioxidant activity (48.5 mg TE/g VS with FRAP methodology). Simultaneously, the recovery of glucose in the solid fraction (96.3 %) was promoted, making it suitable for simultaneous saccharification and fermentation, with ethanol yields of up to 61.26 % (achieving 20.57 g/L after 72 h). The novel cascading valorization process applied in this work maximizes the extraction of value-added products and aligns with circular economy principles by promoting the efficient use of this agro-industrial waste, reinforcing the importance of environmentally-friendly processing in the production of nutraceuticals, biofuels and bioproducts.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102155"},"PeriodicalIF":5.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel green and sustainable solvent system based on the synergistic effect of natural deep eutectic solvent and surfactant micelles for the separation and determination of acrylamide from various foodstuffs 基于天然深层共晶溶剂和表面活性剂胶束协同作用的新型绿色可持续溶剂体系，用于分离和测定各种食品中的丙烯酰胺

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-13 DOI: 10.1016/j.scp.2025.102164

Tuğçe Özköylü, Seçkin Fesliyan, Nail Altunay

{"title":"Novel green and sustainable solvent system based on the synergistic effect of natural deep eutectic solvent and surfactant micelles for the separation and determination of acrylamide from various foodstuffs","authors":"Tuğçe Özköylü, Seçkin Fesliyan, Nail Altunay","doi":"10.1016/j.scp.2025.102164","DOIUrl":"10.1016/j.scp.2025.102164","url":null,"abstract":"<div><div>The present study introduces the analytical procedure developed for the separation of acrylamide (AA) from different food samples by surfactant-modulated natural deep eutectic solvent-based sonication-assisted liquid-liquid microextraction (SM-NADES-SA-LLME) and subsequent determination by ultraviolet–visible spectrophotometry (UV–Vis). A new solvent system was used for the separation of AA, which reveals the synergistic effect achieved by the combination of natural deep eutectic solvent (NADES) and surfactant micelles. <span>l</span>-proline is one of the 20 amino acids that make up proteins, while malic acid is involved in the Krebs cycle. The use of these components of biological origin is important for the application of environmental sustainability principles in chemistry and for meeting the criteria of Green Analytical Chemistry. The interaction between NADES (<span>l</span>-proline:malic acid) and Triton X-114 (as nonionic surfactant) molecules reduced the critical micelle concentration, resulting in rapid and efficient micelle formation. To the best of our knowledge, this solvent system was used for the first time for the separation of AA. When the SM-NADES-SA-LLME procedure was applied under optimal conditions, efficient analytical parameters were obtained. Certified reference materials (CRMs) have also confirmed the high accuracy of the method. The green profile and applicability of the SM-NADES-SA-LLME procedure were demonstrated using specific software tools. The SM-NADES-SA-LLME procedure comprises a green, selective, sensitive and accurate analytical method including a novel solvent system for the determination of AA.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102164"},"PeriodicalIF":5.8,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microplastics in sustainable pharmaceutical manufacturing 微塑料在可持续制药生产中的应用

IF 5.8 2区化学

Sustainable Chemistry and Pharmacy Pub Date : 2025-08-12 DOI: 10.1016/j.scp.2025.102158

Priyanka Patakam, K. Selvakumar, Hiriyanna Ganesh Bhat, Ranit Bandyopadhyay

{"title":"Microplastics in sustainable pharmaceutical manufacturing","authors":"Priyanka Patakam, K. Selvakumar, Hiriyanna Ganesh Bhat, Ranit Bandyopadhyay","doi":"10.1016/j.scp.2025.102158","DOIUrl":"10.1016/j.scp.2025.102158","url":null,"abstract":"<div><div>Microplastics (MPs), plastic particles smaller than 5 mm, are emerging contaminants of concern in both environmental and pharmaceutical fields. Within pharmaceutical manufacturing, MPs typically originate from the breakdown of plastic-based equipment, packaging materials, and leachates, and can enter drug products during production, handling, or storage. This review explores these contamination pathways through the perspective of sustainable manufacturing and green chemistry principles. The presence of MPs in formulations particularly liquid and semi-solid dosage forms can compromise drug efficacy by affecting the stability, solubility, and bioavailability of active pharmaceutical ingredients (APIs). MPs may also serve as carriers of toxic substances, such as heavy metals and endocrine-disrupting chemicals, increasing potential risks to human health and the environment. Incorporating bio-circular economy concepts, the review evaluates advanced detection techniques including FTIR, Raman spectroscopy, and SEM, along with sustainable sample preparation methods. It also highlights contamination control measures aligned with Good Manufacturing Practices (GMP), such as the use of non-plastic processing tools, cleanroom improvements, and eco-friendly packaging all aimed at reducing MPs contamination and supporting circular material use. This multidisciplinary approach emphasizes the need for sustainable, system-based solutions that align with the United Nations Sustainable Development Goals. To advance these efforts, future research should focus on standardizing detection methods, studying long-term impacts of MPs on drug safety, and developing real-time monitoring tools. Additionally, clear regulatory guidelines and risk assessment models specific to microplastics in pharmaceuticals are essential for guiding effective industry practices and policy decisions.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"47 ","pages":"Article 102158"},"PeriodicalIF":5.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144830446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0