无过渡金属条件下通过氧化交叉脱氢偶联（CDC）反应对 C（sp3）-H 键进行选择性官能化的说明

IF 5.5 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy Pub Date : 2025-02-26 DOI:10.1016/j.scp.2025.101955

Sreya Gupta , Sarmistha Pal

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引用次数: 0

摘要

考虑到游离过渡金属（TM） sp3碳氢键功能化相对于传统TM催化的C-X （X = Cl, Br， I, OTf）键活化的合成价值，有机化学家们越来越重视开发氧化交叉脱氢偶联（CDC）反应的方法。本文介绍了近年来一些重要的协议，并根据底物类型进行了分类。在一些选定的病例中，强调了一些CDC反应产物的药学重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An account on selective functionalization of C(sp3)-H bonds by oxidative cross dehydrogenative coupling (CDC) reactions under transition-metal free condition

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An account on selective functionalization of C(sp3)-H bonds by oxidative cross dehydrogenative coupling (CDC) reactions under transition-metal free condition

Considering the synthetic utility of Transition-metal (TM) free sp³ C–H bond functionalization over traditional TM catalysed C-X (X = Cl, Br, I, OTf) bond activation, organic chemists have paid more attention in developing methods for the oxidative cross dehydrogenative coupling (CDC) reactions. Some recent, important protocols are described in the review with classification according to the substrate types. Pharmaceutical importance of some of the CDC reaction products have been highlighted in some selected cases.

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来源期刊

Sustainable Chemistry and Pharmacy Environmental Science-Pollution

CiteScore

8.20

自引率

6.70%

发文量

274

审稿时长

37 days

期刊介绍： Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.