Sustainable Chemistry and Pharmacy最新文献

{"title":"Upcycling of molybdenum tailings, coal gangue and slag into sustainable repaired composites by geopolymerization technology: Workability, embodied carbon and mechanical-microstructural development","authors":"Jun Li , Shuang Cao , Qian Su , Hesong Jin , Chang Cai , Lingkun Chen , Jianxing Liu , Tuan Ngo","doi":"10.1016/j.scp.2024.101836","DOIUrl":"10.1016/j.scp.2024.101836","url":null,"abstract":"<div><div>The major disadvantage of reinforced concrete structure was multi cracks under loading, seriously affecting its normal performance, but using traditional repaired materials to strengthen reinforced concrete structures can bring some side-effects, such as higher carbon oxide and cost. Herein, this study successfully designed an eco-friendly geopolymer repaired composites developed by molybdenum tailings, ground granulated blast-furnace slag and coal gangue. Firstly, the fresh and harden properties of geopolymer repaired composites was systematically studied including water bleeding rate, fluidity, setting time, unconfined compressive strength and bonding strength. The micro performance of geopolymer repaired composites was analyzed via scanning electron microscopy, thermogravimetry-derivative thermogravimetry, X-ray diffraction and fourier transform infrared spectroscopy to give some new viewpoints for revealing the coupled geopolymerization mechanism of molybdenum tailings/coal gangue/ground granulated blast-furnace slag in geopolymer repaired composites. Meanwhile, the gray level of concrete contact surface is calculated. The results show that the properties of geopolymer repaired composites with 5% NaOH designed by 1:3 binder/sand, 0.5 w/c and 1:3 molybdenum tailings/ground granulated blast-furnace slag were optimal properties with 1.73% water bleeding rate, 192 mm fluidity, 58 min and 178 min the initial and final setting time, respectively, 21.443 MPa 28-d unconfined compressive strength and 2.642 MPa bonding strength. Excessive NaOH amount would inhibit the unconfined compressive strength and bonding strength of geopolymer repaired composites, while the increase of ground granulated blast-furnace slag would improve unconfined compressive strength and bonding strength. The primary hydration products of geopolymer repaired composites were C–S–H and C-A-S-H gels. Molybdenum tailings, coal gangue, and ground granulated blast-furnace slag showed an important synergistic effect, improving its geopolymerization reaction and strength. Besides, bonding strength of geopolymer repaired composites was highly correlated with unconfined compressive strength and fractal dimension of surface roughness. The relation coefficients are 0.92005 and 0.94006, respectively. With the higher the unconfined compressive strength of geopolymer repaired composites and the larger fractal dimension of the concrete contact surface, the bonding strength of geopolymer repaired composites is higher and the bond between geopolymer repaired composites and concrete is denser. The increase in the amount of NaOH and the increase in ground granulated blast-furnace slag have an increasing and decreasing trend on the carbon emissions of geopolymer repaired composites, respectively. The most obvious increasing and decreasing trends are that the carbon emissions of GRC increase from 66.41 kg CO<sub>2</sub>-e/m<sup>3</sup> to 96.28 kg CO<sub>2</sub>-e/m<sup>3</sup> and decrease","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101836"},"PeriodicalIF":5.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and green synthesis of asymmetric 3,4,5-trimethoxyphenyl-inspired 1,5-diaryl-1,4-pentadien-3-ones as potent anti-gastric cancer agents through ROS and JNK-triggered apoptosis","authors":"Jianzhang Wu ,&nbsp;Song Yao ,&nbsp;Danjie Wang ,&nbsp;Mengke Han ,&nbsp;Yingwen Liu ,&nbsp;Shuo Ren ,&nbsp;Liping Chen ,&nbsp;Min Zhu ,&nbsp;Qian Li ,&nbsp;Tao Wu ,&nbsp;Yujia Li ,&nbsp;Jiabing Wang ,&nbsp;Qing Xu ,&nbsp;Tao Wei","doi":"10.1016/j.scp.2024.101837","DOIUrl":"10.1016/j.scp.2024.101837","url":null,"abstract":"<div><div>Asymmetric 1,5-diheteroarylpenta-1,4-dien-3-one skeleton and 3,4,5-trimethoxy- phenyl group could be regarded as potent elements for designing chemotherapy agents, respectively. With the disadvantages of previous synthesis, a greener and simple procedure was developed for one-step synthesis of (E)-4(3,4,5- trimethoxypheyl)but-3-en-2-one intermediate under the Cs₂CO₃/EtOH/H₂O system. Hence, a series of asymmetric 1,5-diaryl-1,4-pentadien-3-ones inspired 3,4,5-trimethoxyphenyl were designed, optimized synthesized and investigated the anti-gastric cancer activity. Among them, most compounds showed good anti-gastric cancer activity. The quantitative structure-activity relationship models (QSAR) of compounds were constructed through by random forest algorithm and R² in two tumor cells were greater than 0.88. Compound <strong>7c</strong> was elucidated to inhibit tumor growth, migration, and trigger death of SGC-7901 cells by up-regulating the generation of ROS and JNK-related apoptosis. In total, a greener system for synthesizing intermediates is provided, and compound <strong>7c</strong> may serve as a potential chemotherapy agent for gastric cancer.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101837"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manufacturing bioprocess of novel cream formulations based on polysaccharides “ulvans” from green seaweed Ulva lactuca: Effect of extraction procedures and concentrations on the optical and rheological properties of ulvan creams","authors":"Mariem Guidara ,&nbsp;Hela Yaich ,&nbsp;Raul Petrut ,&nbsp;Aurore Richel ,&nbsp;Christophe Blecker ,&nbsp;Hamadi Attia ,&nbsp;Haikel Garna","doi":"10.1016/j.scp.2024.101852","DOIUrl":"10.1016/j.scp.2024.101852","url":null,"abstract":"<div><div>This paper investigates a new manufacturing bioprocess for making of creams based on the sulphated polysaccharide “Ulvan” extracted from the green seaweed <em>Ulva lactuca</em> using different extraction processes and added at varying concentration from 1 to 5% (w/w).</div><div>Regardless of the extraction procedure and concentration, the bio-macromolecule ulvan can produce successful cream formulations with and suitable materials that exhibit excellent rheology and optical properties, due to its molecular flexibility and self-aggregation behavior. Depending on the extraction procedures, we declare that the creams prepared with low concentrations from 1 to 3 % (w/w) of enzymatic-chemical extract (EE) and acidic extract (CA1), can successfully enhance the lightness, stability, thixotropic and viscoelastic behaviors, which are usually correlated to the physical properties and cross-linking characteristics of ulvans. Additionally, these creams demonstrate high skin absorption at temperatures between 5 and 29 °C. Interestingly, high concentrations of these ulvan extracts at beyond 3% (w/w) in the creams lead to more outstanding storage stability, increased strength and firmness, and enhanced lightness and pseudoplastic behavior, along with excellent skin absorption. These results have important implications for the industrial sector in the production and optimization of ulvan-based creams, especially cream based on CA1 incorporated at 3 % (w/w), as an efficient green-sustainable strategy.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101852"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of pH-Sensitive intelligent films incorporating betacyanin from dragon fruit peel and TiO2 nanoparticles for monitoring fish fillet freshness","authors":"Huimin Du ,&nbsp;Nurul Saadah Said ,&nbsp;Won-Young Lee","doi":"10.1016/j.scp.2024.101839","DOIUrl":"10.1016/j.scp.2024.101839","url":null,"abstract":"<div><div>This study aimed to develop novel pH-sensitive intelligent films for monitoring food freshness by incorporating betacyanin extracted from dragon fruit peel, pectin, sodium alginate, and titanium dioxide (TiO₂) nanoparticles. Pectin and betacyanin were simultaneously extracted from dragon fruit peel and combined with sodium alginate and TiO₂ nanoparticles to create composite and double-layer films. The films were comprehensively characterized to evaluate their physical, mechanical, structural, and functional properties. Additionally, their effectiveness in monitoring the freshness of mackerel fillets was assessed. The incorporation of TiO₂ nanoparticles significantly enhanced film properties, with tensile strength increasing from 3.55-13.42 MPa to 13.85–14.90 MPa, water vapor permeability decreasing from 1.58 to 3.00 × 10⁻⁹ g/msPa to 1.54–3.00 × 10⁻⁹ g/msPa, and swelling degree reducing from 294-330% to 260–261%. TiO₂ nanoparticles effectively immobilized and protected betacyanin from photodegradation, crucial for maintaining color stability. The subjected films demonstrated color changes from reddish-violet to brownish-yellow, correlating with increasing TVB-N levels in mackerel fillets. The double-layer film exhibited superior stability under both dark and light conditions compared to the composite film. This study uniquely combines dragon fruit peel-derived pectin and betacyanin with TiO₂ nanoparticles, addressing the growing demand for eco-friendly packaging solutions by utilizing food waste and developing biodegradable alternatives to synthetic pH indicators.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101839"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient and green preparation of baicalein from Radix scutellariae with deep eutectic solvent pretreated bioconversion of cellulose-based microreactor","authors":"Shuang Jin ,&nbsp;Yubin Ren ,&nbsp;Yupeng Cheng ,&nbsp;Weili Liu ,&nbsp;Cailiang Peng ,&nbsp;Bingyou Yang ,&nbsp;Haixue Kuang ,&nbsp;Yujie Fu ,&nbsp;Chen Lv ,&nbsp;Hongyao Cai","doi":"10.1016/j.scp.2024.101858","DOIUrl":"10.1016/j.scp.2024.101858","url":null,"abstract":"<div><div>To enhance the bioconversion ratio, an efficient and green bioconversion method for the preparation of baicalein with a microreactor composed of edible microorganisms (<em>Aspergillus oryzae</em> and <em>Yeast)</em> treated with deep eutectic solvent co-immobilized on magnetic cellulose was investigated. Various types of deep eutectic solvents (DES) were screened to obtain a superior biocatalytic effect. NADES (CHCL/EG) harvested the maximum catalytic effect at 1.0 wt% under optimal conditions (concentration of bacterium 1.5 × 10⁷ (C × 10⁷ cells/mL), wet weight of microreactor 12 g, incubation temperature 33 °C and pH 5.0, liquid-solid ratio 30:1 (mL/g), incubation time 48 h), baicalein reached 66.36 mg/g, which increased 3.46-fold to that of normal sample after optimizing. DES could increase the permeability of the cell membrane. The bioconversion rate of baicalin reached 97.2%.</div><div>Moreover, IC₅₀ values of the extracts measured by the DPPH-radical scavenging test were 0.366 mg/mL (control sample 0.674 mg/mL). The residual activity of the microreactor was 80.2 % after using it 14 times. The experimental results showed that bioconversion is an effective method for preparing baicalein from the plants.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101858"},"PeriodicalIF":5.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enviro-economic sustainability of ivy leaf powder extraction process based on Phyto-geographic variation of hederacoside C in Hedera helix L. leaves: A lab scale study","authors":"Shoaib Hussain ,&nbsp;Hina Akram ,&nbsp;Hina Fida ,&nbsp;Talib E. Butt","doi":"10.1016/j.scp.2024.101854","DOIUrl":"10.1016/j.scp.2024.101854","url":null,"abstract":"<div><div>The traditional industrial production of herbal medicines often relies on unsustainable processes that generate significant environmental pollution. This study focuses on developing a more eco-friendly approach to extracting hederacoside C, a key component in cough medicine derived from ivy (<em>Hedera helix</em> L.). By using Ultra High Performance Liquid Chromatography (UHPLC), hederacoside C levels were determined in <em>Hedera helix</em> leaves samples from six different geographical locations and one sample from ivy grown under controlled conditions. The concentration of hederacoside C varies depending on the origin of the ivy leaf samples. The highest concentration is found in samples from Ukraine, while the lowest is found in samples from Pakistan. To optimize extraction, the study investigates the impact of different ethanol concentrations, soaking times, and extraction temperatures. The results show that a 40% ethanol solution, 30 min of soaking, and 45 min of extraction at 72 °C yield the highest hederacoside C content (15.26%) in the powder extract, with a 20.52% yield. This optimized method significantly outperforms the conventional extraction technique, which achieves a hederacoside C content of 8.68% in the powder extract. The enrichment of hederacoside C content by conventional method achieved is 2.22 times in powder extract produced with starting herb having hederacoside C content of 3.91%. The proposed sustainable extraction method not only enhances hederacoside C content but also reduces energy consumption and environmental impact by minimizing solvent usage and waste generation. This study highlights the potential for optimizing herbal medicine production to create a more sustainable and environmentally responsible industry.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101854"},"PeriodicalIF":5.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pandemic protection to fuel production: Conversion of waste personal protective equipment-kits to high-quality hydro-processed fuels","authors":"Naresh Kathula ,&nbsp;Karan Sharma ,&nbsp;Syed Md Razak ,&nbsp;Chandan K. Munagala ,&nbsp;Vineet Aniya","doi":"10.1016/j.scp.2024.101851","DOIUrl":"10.1016/j.scp.2024.101851","url":null,"abstract":"<div><div>The advent of COVID-19 has heightened apprehensions within the plastic waste management sector, particularly due to the increased adoption of single-use personal protective equipment (PPE)-kits at the domestic level and hospitals for protection against contagious diseases. This study addresses the issue by focusing on the hydro-processing of pyrolytic oil derived from thermally catalysed cracking of sterilized waste PPE kits. Employing an indigenously prepared FCC-supported Ni catalyst, the investigation delves into the effects of hydrogenation process parameters-temperature, catalyst composition, and catalyst loadings—maintaining a constant pressure of 70 bar H₂ on fuel quality. Experimental results indicate that oil upgraded at a higher temperature of 240 °C with a 10% Ni/FCC catalyst at a 20 wt% loading demonstrates a remarkable selectivity of 76.51 wt% compounds in the C_5-12 range, signifying a substantial gasoline fraction. The hydrogenated oil exhibits 57.05 wt% paraffinic content and a desirable 24.5 wt% yield of aromatics. GC-MS analysis reveals the presence of 25 wt% C_5-7 iso-alkanes, 9.33 wt% toluene, and 12.35 wt% benzene, closely resembling the composition of commercial gasoline. Moreover, the physicochemical properties of the hydrogenated oil meet specifications for commercial gasoline suitable for automobile applications, making it a viable substitute or complement for blending with commercial gasoline.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101851"},"PeriodicalIF":5.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A sustainable approach for the determination of pacritinib in biological samples with dispersive liquid-liquid microextraction and using hydrophobic natural deep eutectic solvents","authors":"Natalia Treder ,&nbsp;Adrianna Kowal ,&nbsp;Anna Roszkowska ,&nbsp;Tomasz Bączek","doi":"10.1016/j.scp.2024.101841","DOIUrl":"10.1016/j.scp.2024.101841","url":null,"abstract":"<div><div>The work demonstrates the viability of using hydrophobic natural deep eutectic solvents (NADES) as extraction solvents in dispersive liquid-liquid microextraction (DLLME). To this aim, a menthol-thymol mixture is employed to develop, for the first time, a hydrophobic NADES-based DLLME method for determining novel anticancer drug, pacritinib (PAC), in serum samples prior to LC-UV analysis. In addition, critical aspects of the sample preparation protocol are optimized, including the molar ratio of the hydrogen bond donor and acceptor in the hydrophobic NADES, the amount of extraction solvent, the dispersion method, the pH, the salting-out effect, and the extraction time. The interactions between the hydrophobic NADES components were investigated <em>via</em> FT-IR analysis, with the validation parameter results confirming the assay's acceptable performance. The proposed method's linearity ranged between 0.1 and 3.5 μg mL⁻¹ (<em>R</em>^<em>2</em> = 0.9936), with an LOD and LOQ of 0.025 μg mL⁻¹ and 0.1 μg mL⁻¹, respectively. Furthermore, the method's precision and accuracy ranged between 3.45-10.98% and 100.88–111.01%, respectively. Significantly, all values obtained using the hydrophobic NADES-DLLME-LC-UV method complied with ICH requirements for bioanalytical methods. Moreover, the proposed method's greenness and practicality were also assessed using the sample-preparation metric of sustainability (SPMS) and Blue Applicability Grade Index (BAGI). The resultant SPMS score of 8.21 confirmed the method's excellent greenness, and the total BAGI score of 62.5 confirmed the method's practicality.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101841"},"PeriodicalIF":5.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometric-assisted spectrophotometric methods for simultaneous drug determination in new Helicobacter pylori treatment regimens - Environmental sustainability assessment","authors":"Khanda F.M. Amin ,&nbsp;Reem H. Obaydo ,&nbsp;Hayam M. Lotfy","doi":"10.1016/j.scp.2024.101849","DOIUrl":"10.1016/j.scp.2024.101849","url":null,"abstract":"<div><div>The recent FDA approval of VOQUEZNA™ TRIPLE PAK™ 7-day therapy, which includes vonoprazan (VON), amoxicillin (AMO), and clarithromycin (CLA), marks a significant advancement in the treatment of <em>Helicobacter pylori</em> (<em>H. pylori</em>) infections. Accurate quantification of these active pharmaceutical ingredients (APIs) is critical for ensuring therapeutic efficacy and safety. However, conventional analytical methods often require extensive sample pretreatment and separation, which can be time-consuming and environmentally burdensome. This study presents the first simultaneous quantification of VON, AMO, and CLA using innovative chemometric-assisted spectrophotometric methods aligned with Green Analytical Chemistry (GAC) principles. Our methods eliminate the need for pretreatment or separation, thereby enhancing both analytical efficiency and environmental sustainability. We developed orthogonal partial least squares (OPLS), principal component regression (PCR), and Artificial Neural Network (ANN) models, utilizing the Design of Experiment (DoE) approach to minimize solvent use and waste.</div><div>Model validation was achieved through Orthogonal Array-based Latin Hypercube Sampling (OALHS), ensuring robust performance evaluation. The models demonstrated high precision, with recovery percentages ranging from 98.00% to 102.00%. The calibration set model fitting was assessed using the determination coefficient (R²), and the cross-validation coefficient (Q²), all model's R² and Q² values were close to 1.0, indicating the calibration samples' high capacity for explanation and prediction, while the root mean square error of calibration (RMSEC) values were found to be less than 0.1. The prediction of the validation set was employed by the root mean square error of prediction (RMSEP) and relative root mean square errors of prediction (RRMSEP), the values were found (0.0335–0.0613) and (0.7207–0.5287) for RMSEP and RRMSEP, respectively, while the bias-corrected mean square error of prediction (BCMSEP) was found to be between 0.0014 and 0.0001. To evaluate and enhance the sustainability of the methods, comprehensive tools were utilized: SPIDER Solvent Tool, RGB12 Algorithm, AGREE, and the Need Quality Sustainability (NQS) Index. This work supports the Sustainable Development Goals (SDGs) by demonstrating advancements in environmentally sustainable analytical methods.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101849"},"PeriodicalIF":5.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability of the European Commission’s framework on safe and sustainable by design to the pharmaceutical sector","authors":"Neele Puhlmann ,&nbsp;Elisabetta Abbate ,&nbsp;Klaus Kümmerer ,&nbsp;Agnes G. Oomen ,&nbsp;Ad M.J. Ragas ,&nbsp;Caroline Moermond","doi":"10.1016/j.scp.2024.101845","DOIUrl":"10.1016/j.scp.2024.101845","url":null,"abstract":"<div><div>The chemical sector contributes significantly to anthropogenic impacts on planetary health. Thus, there is a need for a green transformation. The same holds for the pharmaceutical sector. To assist with this transformation, European Commission’s Joint Research Centre (JRC) developed a framework on <em>Safe and Sustainable by Design</em> (SSbD) for chemicals and materials (“SSbD framework”). The general structure of the SSbD framework leaves room for sector-specific priorities and practices. This study explores the applicability of the SSbD framework to the pharmaceutical sector; more specifically to the development, production and use of Human Medicinal Products (HMPs). We show that the stage-gate process in R&amp;D of HMPs fits very well with the design-assessment process of the SSbD framework, making the framework conceptually applicable to pharmaceutical R&amp;D. Future efforts should focus on the development of i) methods to predict environmental safety and sustainability based on the limited data available during R&amp;D, ii) a pragmatic procedure integrating SSbD into HMPs innovation, and iii) a weighing system considering also environmental safety and sustainability parameters alongside patient safety and medical efficacy. Although the assessment phase of the JRC’s SSbD framework has specifically been developed for innovation purposes, we propose an expansion of its scope to pharmaceutical products already on the market. The reason is its applicability by healthcare actors to guide safer and more sustainable choices regarding the use of marketed HMPs. We call this approach <em>Safe and Sustainable by Comparison</em> (SSbC) and show that the assessment principles of the SSbD framework can be applied to SSbC.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"42 ","pages":"Article 101845"},"PeriodicalIF":5.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142653034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}