Sustainable Chemistry and Pharmacy最新文献

{"title":"Synergistic Cr–Co metal oxide catalysis on molecular sieve support for cascade one-pot conversion of biomass derived cellulose to FDCA","authors":"N.V. Fathima Safeeda ,&nbsp;Vadupu Sai Dharani ,&nbsp;Kalle Indradeep ,&nbsp;M. Karthikeyan ,&nbsp;Jesús Esteban Serrano ,&nbsp;Meera Balachandran","doi":"10.1016/j.scp.2025.102040","DOIUrl":"10.1016/j.scp.2025.102040","url":null,"abstract":"<div><div>2,5-furandicarboxylic acid (FDCA) is an essential precursor compound for the synthesis of polyethylene furanoate (PEF), a biobased polymer offering a more sustainable alternative to its analog polyethylene terephthalate (PET), based on petroleum derived terephthalic acid (TPA). This study explores the one-pot synthesis of FDCA from agro-waste bagasse residue through the dehydration of C6 sugars to HMF and its subsequent oxidation, for which a heterogeneous metal oxide catalyst is employed. Catalysts based on Co, Cr or their combination supported on molecular sieves 5A were investigated for efficiency and selectivity in biomass conversion. Advanced characterization techniques including XRD, FTIR, SEM, BET, TPD, TPR, and XPS provide insights into their structural features and chemical properties that contribute to the catalytic activity. The incorporation of Co and Cr metal oxides into the zeolite framework not only enhances the catalytic activity but also ensures the availability of pores resulting in a maximum yield of 61.74 % FDCA. Even with the use of this real waste stream, the Cr–Co zeolite catalyst exhibited outstanding regeneration and reusability, retaining 99.95 % of its catalytic activity over five reaction cycles. This study presents a sustainable and cost-effective approach, emphasizing the potential of one-pot conversion of agro-waste to value-added chemical.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102040"},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular landscape of therapeutic deep eutectic systems selective toxicity towards colorectal cancer","authors":"Filipe Oliveira ,&nbsp;Joana Pinto ,&nbsp;Filipa Amaro ,&nbsp;Joana Pereira ,&nbsp;Inês Ferreira ,&nbsp;Mário S. Diniz ,&nbsp;Paula Guedes de Pinho ,&nbsp;Ana Rita C. Duarte","doi":"10.1016/j.scp.2025.102037","DOIUrl":"10.1016/j.scp.2025.102037","url":null,"abstract":"<div><div>The foremost modern medicine challenges, such as cancer's high mortality rates, have emphasized the growing need for improved therapeutic agents. Following eutectic systems spotlight due to their remarkable physicochemical and biological properties, while mostly in compliance with the Green Chemistry Principles and sustainability metrics as the Sustainable Development Goals (SDG) from United Nations, we aimed to push forward their understanding as anticancer agents. Considering therapeutic deep eutectic systems (THEDES) promising reports of anticancer activity towards colorectal cancer (CRC) cells, we sought to fill the knowledge gap on these eutectics impact on these cancer cells molecular landscape. For that, an integrated approach was used to study how combining a terpene – as menthol (Me), thymol (Thy), perillyl alcohol (POH) and limonene (Lim) – with ibuprofen (Ibu) as a THEDES, affects permeability, cellular transport, cell viability, reactive oxygen species (ROS), cell metabolome and systemic toxicity. THEDES exposure resulted in increased Ibu cellular uptake, depletion of ROS, and cell dead induction via apoptosis. Moreover, CRC cells experienced alterations in their metabolite landscape with deleterious effects on essential metabolic pathways, such as lipid and anaerobic glycolysis energy production pathways. Furthermore, non-relevant systemic toxicity of these THEDES, within the range of concentrations tested, was observed. These findings underscore THEDES potential as selective anticancer agents, while offering a promising path for the development of therapeutics aligned with the sustainability metrics.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102037"},"PeriodicalIF":5.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable strength improvement of clay soil via steel slag and hydrothermal solidification: A geochemical approach using the role of chemical compositions, Ruxton Ratio, and cementation index","authors":"Shifa Burhan,&nbsp;Ahmed Salih Mohammed","doi":"10.1016/j.scp.2025.102024","DOIUrl":"10.1016/j.scp.2025.102024","url":null,"abstract":"<div><div>Clay soils often exhibit low load-bearing capacity and significant volumetric instability under variable moisture conditions. This study assesses the effectiveness of steel slag as a stabilizing agent for clay soils through hydrothermal solidification, aiming to enhance compressive strength, control shrinkage, and improve resistance to moisture-induced deformation. This study quantified the effect of steel slag on the compressive strength of clay soils with various liquid limits. A total of 71 natural and 164 stabilized soil datasets were analyzed, assessing both chemical composition (SiO₂: 20.1 %–65.7 %, Al₂O₃: 2 %–38.8 %, CaO: 0.21 %–29.8 %) and physical properties (liquid limit: 30 %–65.2 %, plasticity index: 9.2 %–35.4 %, density: 0.78–1.87 g/cm³). Key influencing parameters included steel slag content (0 % % −50 %), Ca (OH)₂ (0 % % % −60 %), curing time (0–120 days), and temperature (20 °C −195 °C). Experimental results demonstrated significant improvements in compressive strength (21–5865 kPa), primarily attributed to pozzolanic reactions and the formation of calcium silicate hydrate (C–S–H). A pure quadratic model demonstrated high predictive accuracy (R² = 0.76 for training and R² = 0.74 for testing), confirming a strong correlation between steel slag content, hydrothermal conditions, and soil strength enhancement. This research highlights the potential of steel slag as a sustainable alternative for soil stabilization, addressing both geotechnical performance and environmental sustainability through the recycling of industrial by-products.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102024"},"PeriodicalIF":5.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular bioeconomy approach for the recovery of polyphenols and dietary fibres from orange pomace waste","authors":"Nupur Srivastava ,&nbsp;Anupama Kumar ,&nbsp;Shilpshri V. Shinde ,&nbsp;Amrat Pal Singh ,&nbsp;Karuna Shanker","doi":"10.1016/j.scp.2025.102038","DOIUrl":"10.1016/j.scp.2025.102038","url":null,"abstract":"<div><div>The orange juice processing industry generates substantial peel and pomace waste, which, if not managed responsibly, poses significant environmental challenges. However, these byproducts are rich in bioactive compounds with notable health benefits. Conventional extraction methods often rely on toxic, non-biodegradable solvents, making them environmentally unsustainable. The present work addresses this using a circular bioeconomy approach, for developing green and scalable methods for valorising orange pomace waste (OPW) using non-toxic, recyclable deep eutectic solvents (DESs). Four DESs and a benchmark solvent (Ethanol: Water 50 % v/v) were used for the extraction of bioactive compounds from OPW under optimized conditions. LP: MA (1:1) DES emerged as the most effective, achieving high total phenolic content (TPC) as confirmed through FTIR spectroscopy, SEM, CHN analyses, and computational modeling. The DES extracts exhibited strong antibacterial and antioxidant properties, validated by DPPH, FRAP, ABTS, and TFC assays, highlighting their potential for sustainable healthcare applications (SDG 3). The solid residue, containing 41–47.98 % dietary fiber, supports a zero-waste approach (SDG 2 &amp; 12), while the recyclability of DESs for four cycles minimizes resource consumption and environmental impact (SDG 13). By integrating green chemistry, waste valorization, and circular bioeconomy principles, this study advances sustainable industrial practices, promoting better resource utilization and environmental pollution mitigation, in alignment with global sustainability goals.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102038"},"PeriodicalIF":5.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability performance of one-part alkali-activated self-compacting concrete mixes under aggressive and elevated temperature conditions","authors":"Kaku Mahendra,&nbsp;Mattur C. Narasimhan,&nbsp;Srikanth Rathod,&nbsp;Amit Kumar Das,&nbsp;Gundupalli Bhanu Prakash","doi":"10.1016/j.scp.2025.102025","DOIUrl":"10.1016/j.scp.2025.102025","url":null,"abstract":"<div><div>The growing demand for sustainable, high-performance materials in modern construction has driven the development of advanced concrete technologies. This study introduces one-part alkali-activated self-compacting concrete (OPASC) as a practical, safe, and user-friendly alternative to conventional Portland cement-based concretes. Selected mixes with compressive strengths exceeding 70 MPa were evaluated for durability under aggressive conditions, including extended exposure to 5 % sulfuric acid and 5 % magnesium sulfate up to 180 days. The thermal stability of these candidate mixes was also assessed by subjecting the mixes to sustained temperatures ranging from 200 °C to 800 °C. Chloride-ion resistance of these mixes was examined under bulk diffusion tests. Key durability indicators, including water absorption, permeable voids, and sorptivity, were quantified to evaluate matrix impermeability. The results revealed compressive strength losses of 25–32 % under acid exposure, 7–15 % under sulfate exposure, and 30–42 % under thermal exposure, with chloride diffusion coefficients ranging from 0.21 × 10⁻¹² to 0.32 × 10⁻¹² m²/s, indicating high resistance to ionic ingress. The mixes also exhibited low water absorption (3–4.5 %), lower soptivities (0.0024–0.0013 mm/s^1/2), and much reduced permeable voids (4.3–5.5 %), reflecting an impermeable, dense matrix. Microstructural analyses using SEM-EDS and XRD revealed that degradation under acid and sulfate conditions is primarily attributable to the decalcification of C/N-A-S-H gels, accompanied by the recrystallization of stable aluminosilicate phases. Finally, the environmental sustainability evaluation, which considered both embodied energy and carbon footprint, verified the superior environmental friendliness of OPASC mixes relative to conventional concrete. These findings confirm that OPASC exhibits superior chemical and thermal durability, reduced permeability, and enhanced resilience, thereby establishing it as a sustainable and practical solution for modern infrastructure applications.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102025"},"PeriodicalIF":5.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insight into peroxidase-mediated Pinus massoniana resin browning, and browning inhibition strategy","authors":"Hanxiao Liu,&nbsp;Xiaopeng Chen,&nbsp;Dandan Yu,&nbsp;Siheng Zhang,&nbsp;Jiezhen Liang,&nbsp;Xin Li,&nbsp;Xiaojie Wei,&nbsp;Linlin Wang","doi":"10.1016/j.scp.2025.102035","DOIUrl":"10.1016/j.scp.2025.102035","url":null,"abstract":"<div><div>Pine resin is an important non-wood forestry product and has been postulated as an ideal candidate to replace petroleum-derived chemicals and fuels. During crude pine resin storage, peroxidase-mediated enzymatic browning leads to significant color deterioration and quality degradation. This study aimed to discover the browning mechanisms in crude pine resin and improve its quality. Peroxidase (PNmPOD) was extracted from the Pinus massoniana needle and characterised for its browning kinetic properties. The enzymatic browning mechanisms in crude pine resin were analyzed. This investigation employed a simulated system containing hydrogen peroxide, ferulic acid, epicatechin, PNmPOD, and crude resin. The results revealed that the peroxidase activity was optimal at pH 5.6 and 65 °C, with an activation energy of 193.41 kJ/mol. The simulated storage system revealed that epicatechin and ferulic acid undergo peroxidase-driven reactions: oxidation/dismutation-isomerization, demethylation-free radical coupling, and dehydration condensation. These processes correlate directly with chromatic shifts in the experimental model; pine resin's main constituents (resin acids and terpenoids) remain inert in enzymatic browning reactions. To effectively deactivate peroxidase activity with minimal resin chromatic alteration, heat treatment at 75 °C/20 min or adding <span>l</span>-cysteine as an inhibitor emerged as the optimized protocol. This study establishes fundamental strategies for enzymatic browning control and quality enhancement in post-harvest pine resin preservation.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102035"},"PeriodicalIF":5.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of potential genotoxic NDSRIs (Nitrosamine Drug Substance Related Impurities) in Quetiapine Fumarate – antipsychotic medication: (Q)SAR assessment, UPLC-ESI-MS/MS method development, validation and its analytical greenness evaluation","authors":"Sriram Pepakayala ,&nbsp;Venkata Nadh Ratnakaram ,&nbsp;Yuvaraj Zunjarrao ,&nbsp;Yogesh Kumar Lohia","doi":"10.1016/j.scp.2025.102032","DOIUrl":"10.1016/j.scp.2025.102032","url":null,"abstract":"<div><div>Nitrosamine Drug Substance Related Impurities (NDSRIs) are classified as possible human carcinogens by regulatory authorities. 1,4-Dinitrosopiperazine (DNP), 1-nitrosopiperazine (MNP), 11-(4-Nitrosopiperazin-1-yl)dibenzo[b,f][1,4]thiazepine (NDAQ) and 2-(2-(4-nitrosopiperazin-1-yl)ethoxy)ethan-1-ol (NHEEP) are the prime NDSRIs in Quetiapine Fumarate, an antipsychotic medication. In the current study, SDG3 (Good Health and Well-Being), Targets 3.8 and 3.d. were achieved through calculations involving (Q)-SAR methodologies and CPCA scores. SDG9 (Industry, Innovation, and Infrastructure), Target 9.4 was realized by developing a simple and straightforward UPLC-ESI-MS/MS method for simultaneous determination of four NDSRIs and validated as per ICH (Q2 R2) guidelines. Acquity H-Class UPLC system equipped with Waters Xevo TQ-S Micro MS system was used. Agilent Poroshell 120 PFP column with a dimension of 150 × 4.6 mm, and particle size of 2.7 μm was used. The mobile phase consisting of phases – A and B (0.3 % formic acid in water and methanol respectively) was used in gradient mode with a lower run time of 16 min. The LOQ values, with respect to the sample concentrations, were 42.40 ppb, 42.83 ppb, 41.90 ppb and, 156.45 ppb, for DNP, MNP, NDAQ, and NHEEP respectively. The method's linearity was established from a strong correlation (R² &gt; 0.99). The percent relative standard deviation (%RSD) for six replicates was 1.11 %, 1.09 %, 0.88 %, and 0.37 % for DNP, MNP, NDAQ, and NHEEP, respectively, confirming the method's repeatability. Assessed the method's eco-friendliness by greenness tools like the Green Analytical Procedure Index (GAPI), Analytical GREEnness (AGREE), and Analytical Eco-Scale, and found it to be eco-friendly.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102032"},"PeriodicalIF":5.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbeads from recycled polystyrene yogurt cups for the in-syringe micro solid-phase extraction of four opioids from environmental and biological samples","authors":"Lorenzo Antonelli ,&nbsp;Ángela Inmaculada López-Lorente ,&nbsp;Alessandra Gentili ,&nbsp;Rafael Lucena ,&nbsp;Soledad Cárdenas","doi":"10.1016/j.scp.2025.102036","DOIUrl":"10.1016/j.scp.2025.102036","url":null,"abstract":"<div><div>A novel procedure for the extraction and determination of four opioids from environmental and biological fluids is presented. The main goal of this study is to introduce an innovative method for recycling plastic waste (i.e., polystyrene), aiming to achieve a consistent and dependable microstructure. Polystyrene microbeads, deposited on a rounded piece of paper, have been used as a sorbent material in an in-syringe extraction device. For the preparation of the polymeric sorbent, an emulsion solidification technique was optimized, achieving a regular micro material, obtained from second-hand regenerated polystyrene polymer from yogurt cups. This work presents, for the first time, the use of recycled polystyrene as micro-sorbent integrated into a paper-based support, combining waste valorization with effective analyte extraction. Under the optimum conditions, methadone, tramadol, codeine, and morphine were determined by direct injection mass spectrometry in environmental water as well as biofluids as saliva and urine. Limits of detection lower than 8 μg L⁻¹ and precision better than 14.9 % have been obtained for all the analytes in saliva and environmental water samples. The interference of the endogenous compounds of urine prevents the determination of morphine and codeine in this matrix. The trueness, expressed as relative recovery (RR), ranged from 85 % to 114 %. The extraction device has proved to be a valid and sustainable alternative to traditional sorbents, offering good analytical standards and being transversal for the application to different matrices. The simplicity and environmental friendliness of this approach make it highly adaptable across various research and industrial domains.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102036"},"PeriodicalIF":5.5,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143878587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart and sustainable PVA/cellulose-ZnO/anthocyanin Films: Dual-action packaging for extended shelf life and real-time freshness detection","authors":"Neenu K. V ,&nbsp;Michael Badawi ,&nbsp;Jyotishkumar Parameswaranpillai ,&nbsp;Hiba K ,&nbsp;Annu Laya Abraham ,&nbsp;P.M. Sabura Begum ,&nbsp;Midhun Dominic C D","doi":"10.1016/j.scp.2025.102033","DOIUrl":"10.1016/j.scp.2025.102033","url":null,"abstract":"<div><div>Sustainable sensing films for intelligent packaging applications are the need of the hour. Herein, for the first time, cellulose nanofibers (CNFs) from pineapple pomace are used as the host polymer for preparing cellulose-ZnO (C–ZnO) powder. The structural and dimensional properties of the C–ZnO powder were confirmed using different characterization techniques. Red cabbage-derived anthocyanin and C–ZnO were infused with polyvinyl alcohol (PVA) to make the antibacterial sensing films (C–ZnO/PVA (CPVA) and C–ZnO/anthocyanin/PVA (CAPVA)). The effective bonding between the PVA and the fillers is studied using the AT-FTIR analysis. The incorporation of C-ZnO and C–ZnO/anthocyanin resulted in the improving the UV screening ability of the developed films. The tensile strengths of the CPVA and CAPVA films were 14 and 11 % greater than that of the neat PVA film. The interaction with water was significantly reduced when C–ZnO was added to PVA making the material more hydrophobic. This was further confirmed using wettability studies. In 100 days, in wet conditions, the PVA, CPVA, and CAPVA showed biodegradability of 17, 37, and 39 %, respectively. As a packaging material, CPVA and CAPVA films increased the shelf life of fresh shrimp by up to 4 days as they have significant water barrier properties and antibacterial activity with an inhibitory zone of 28 and 20 mm (for CAPVA) against <em>S. aureus</em> and <em>E. coli</em> respectively. Furthermore, the release of volatile amines from shrimp spoilage caused the color of the CAPVA films to change over time from pink to yellow, indicating the possibility of using these films for real-time freshness monitoring.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102033"},"PeriodicalIF":5.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the Horizon of eco-friendly Poly(glycolic acid) to the packaging industry: Synthesis and modification","authors":"Hojun Shin,&nbsp;Jongchul Seo","doi":"10.1016/j.scp.2025.102023","DOIUrl":"10.1016/j.scp.2025.102023","url":null,"abstract":"<div><div>The increase in packaging waste and resulting environmental pollution have emerged as global problems, and the development and practical use of bioplastics have been suggested as key solutions. Consequently, numerous efforts have been made to introduce bioplastics as packaging materials. Important factors include securing sufficient physical properties and industrial production processes to replace petroleum-based plastics. However, bioplastics generally exhibit inadequate thermal stability, mechanical strength, and barrier properties compared to engineering plastics, limiting their application as packaging materials. Polyglycolic acid (PGA) is a notable material because it is bio-based, rapidly biodegradable, biocompatible, and exhibits high mechanical strength and exceptional barrier properties owing to its dense chemical structure. However, the PGA production process—including its synthesis and manufacturing conditions—and PGA's properties have not yet been fully examined owing to its inherent characteristics such as hydrophilicity, narrow melting windows, and insolubility in many organic solvents. Consequently, practical attempts are needed to develop PGA-based packaging materials. In this paper, we summarize the PGA synthesis and modification methods in the sustainable packaging industry before discussing the applicability and future strategies for using PGA as a packaging material.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"45 ","pages":"Article 102023"},"PeriodicalIF":5.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}