天然深层共晶系统为基础的银杏叶提取物：一个自然和可持续的解决方案的皮肤护理

IF 5.8 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Sustainable Chemistry and Pharmacy Pub Date : 2025-10-07 DOI:10.1016/j.scp.2025.102230

Marta Marques , Ana Rita Jesus , Ana Rita C. Duarte , Alexandre Paiva

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引用次数: 0

摘要

本研究不仅探索了亲水性天然深层共晶体系（NADES）作为可持续提取银杏叶中生物活性化合物的培养基的潜力，而且还探讨了这些提取物在开发具有抗氧化性能的护肤品中的潜力。对3种NADES的总酚含量（TPC）提取率和抗氧化活性进行了评价。NADES LA:Glc:W（5:1:3）表现出更高的TPC提取率和抗氧化活性，甚至优于传统溶剂的提取。化学性质鉴定奎宁酸和莽草酸为主要化合物，以LA:Glc:W萃取奎宁酸的效率最高。当浓度达到50 mg/mL时，提取物对角质形成细胞无细胞毒性。经H2O2和紫外光诱导后，提取物能够抑制活性氧（ROS）的形成，突出了其护肤应用潜力。稳定性研究表明，Bet:Suc:Gly:W提取物在360天内保持稳定，保持一致的TPC和抗氧化活性，表明其在长期储存和天然护肤配方中有效使用的潜力。根据绿色分析化学原则，通过绿色分析工具AGREEprep和ComplexMoGAPI确认了我们提取方法的可持续性。本文提出的结果强调了NADES作为提取和稳定生物活性化合物的环保替代品的潜力，它不仅在化妆品科学中应用，而且在食品和制药等其他领域也有应用的机会。这项工作证明了溶剂选择在提高萃取效率、稳定性和应用特性方面的关键重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Natural deep eutectic systems-based Ginkgo biloba extracts: A natural and sustainable solution for skin care

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Natural deep eutectic systems-based Ginkgo biloba extracts: A natural and sustainable solution for skin care

This study explores not only the potential of hydrophilic Natural Deep Eutectic Systems (NADES) as sustainable extraction media for bioactive compounds from Ginkgo biloba L. leaves but also the potential of these extracts to be used in the development of skin care products with antioxidant properties. Three NADES were evaluated for their efficiency regarding total phenolic content (TPC) extraction yield and antioxidant activity. NADES LA:Glc:W (5:1:3) exhibited higher TPC extraction yield and antioxidant activity, surpassing even extraction with conventional solvent. Chemical characterization identified quinic acid and shikimic acid as the predominant compounds, with LA:Glc:W achieving the highest efficiency for quinic acid extraction. The extracts showed no cytotoxicity towards keratinocytes cells up to 50 mg/mL. The extracts were able to inhibit the formation of reactive oxygen species (ROS) after induction with H₂O₂ and UV light, highlighting their potential for skin care applications. The stability study showed that Bet:Suc:Gly:W extract was stable over 360 days, maintaining consistent TPC and antioxidant activity, demonstrating its potential for use in long-term storage and effective use in natural skincare formulations. Sustainability of our extraction method was confirmed through green analysis tools, AGREEprep and ComplexMoGAPI, in accordance with Green Analytical Chemistry principles.

The results presented herein, underscore the potential of NADES as eco-friendly alternatives for extracting and stabilizing bioactive compounds, with applications not only in cosmetic sciences but it also opens the opportunity to be used in other fields such as food and pharmaceuticals. This work demonstrates the critical importance of solvent selection in enhanced extraction efficiency, stability, and application-specific properties.

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来源期刊

Sustainable Chemistry and Pharmacy Environmental Science-Pollution

CiteScore

8.20

自引率

6.70%

发文量

274

审稿时长

37 days

期刊介绍： Sustainable Chemistry and Pharmacy publishes research that is related to chemistry, pharmacy and sustainability science in a forward oriented manner. It provides a unique forum for the publication of innovative research on the intersection and overlap of chemistry and pharmacy on the one hand and sustainability on the other hand. This includes contributions related to increasing sustainability of chemistry and pharmaceutical science and industries itself as well as their products in relation to the contribution of these to sustainability itself. As an interdisciplinary and transdisciplinary journal it addresses all sustainability related issues along the life cycle of chemical and pharmaceutical products form resource related topics until the end of life of products. This includes not only natural science based approaches and issues but also from humanities, social science and economics as far as they are dealing with sustainability related to chemistry and pharmacy. Sustainable Chemistry and Pharmacy aims at bridging between disciplines as well as developing and developed countries.