Sustainable Chemistry and Pharmacy最新文献

{"title":"Improving the sustainability of Gluconobacter oxydans l-sorbose production using food waste media and recyclable resting cells","authors":"Florencia D. Pirotti ,&nbsp;Nicolás Soriano ,&nbsp;Magdalena Ripoll ,&nbsp;Pablo Domínguez de María ,&nbsp;Colin J. Barrow ,&nbsp;Lorena Betancor","doi":"10.1016/j.scp.2025.102098","DOIUrl":"10.1016/j.scp.2025.102098","url":null,"abstract":"<div><div>Biotransformations offer the potential for sustainable and green syntheses, but a holistic assessment is required to understand their environmental impact, including biocatalyst production, the reaction itself, and downstream processes. This study focuses on the production of <span>l</span>-sorbose, an essential intermediate for the industrial production of vitamin C, from D-sorbitol using <em>Gluconobacter oxydans</em>. To improve the sustainability of the process, two approaches were considered. First, food waste effluents (apple juice from discarded apples as a carbon source, and brewer's spent yeast as a nitrogen source) were incorporated into the growth medium for <em>G. oxydans</em>. The effects on bacterial growth and biomass productivity were evaluated to select optimal waste-based broths, reducing water (less Water Depletion) and wastewater treatment emissions. A broth containing 50 % apple juice was observed to save between 115 and 1000 kg CO₂ · kg biomass⁻¹, depending on wastewater recalcitrance (from mild treatment to incineration). Second, we demonstrated for the first time the biotransformation of D-sorbitol to <span>l</span>-sorbose using resting cells in pure water, the simplest possible medium. Our results demonstrate that cells derived from food waste fermentations efficiently catalyzed the reaction, simplifying downstream processing and contributing to overall process sustainability. The resting cells were reusable across 10 cycles, retaining over 90 % of their initial activity during the first six cycles and approximately 10 % by the tenth. The cumulative productivity reached ∼180 g of <span>l</span>-sorbose per gram of cells. CO₂ emissions during wastewater treatment are estimated at 2–6 kg CO₂ per kg <span>l</span>-sorbose, providing a promising baseline for future improvements.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102098"},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity oriented synthesis of cyano-substituted polycyclic N-heteroaryl compounds in green solvent","authors":"Yuan-Qi Li ,&nbsp;Zhi-Jie Kang ,&nbsp;Ben-Jun Han ,&nbsp;Yan-Chun Zhang ,&nbsp;Fan Teng ,&nbsp;Cheng-Tao Feng","doi":"10.1016/j.scp.2025.102114","DOIUrl":"10.1016/j.scp.2025.102114","url":null,"abstract":"<div><div>Cyanated polycyclic <em>N</em>-heterocycles are vital for pharmaceutical applications; however, their synthesis often relies on unsustainable methods involving non-green solvents, stoichiometric chemical oxidants or mediators, or precious-metal catalysts. In this study, we report a manganese-catalyzed oxidative tandem reaction for synthesizing cyanated polycyclic <em>N</em>-heterocycles from arylacetic acids/aromatic aldehydes, heterocyclic amines, and trimethylsilyl cyanide. This tandem reaction proceeds <em>via</em> a manganese-catalyzed Strecker reaction, followed by oxidative radical cyclization, and aromatization. Notably, this protocol utilizes γ-valerolactone as a green solvent, both Mn catalyst and γ-valerolactone can be recycled multiple times.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102114"},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrothermal carbonization of Colombian plantain peels: Physicochemical properties, thermal behavior, and bioactive potential","authors":"Jenny Marcela Vélez-Gómez ,&nbsp;Lina M. Orozco ,&nbsp;Michael Renz ,&nbsp;Luz Angela Veloza","doi":"10.1016/j.scp.2025.102118","DOIUrl":"10.1016/j.scp.2025.102118","url":null,"abstract":"<div><div>Hydrothermal carbonization (HTC) is a promising technology for the conversion of biomass into high-added-value products, offering an effective treatment for organic waste with high moisture content. In this study, the impact of reaction conditions on the distribution of products generated from Dominico Harton plantain peel, an abundant agro-industrial waste in Colombia, was investigated. The HTC of plantain peels was investigated at various temperatures (150–230 °C), biomass moisture content (50–85%), and residence times (2–4 h). The yield of hydrochar decreased with increasing temperature, ranging from 41.59 to 82.30% at 85% moisture content, 25.19–60.29% at 65% moisture content, and 26.29–49.07% at 50% moisture content. The results indicated that the energy and mass performance of hydrochar are influenced mainly by the moisture content of the biomass and the reaction temperature. At 230 °C and 85% moisture content, the energy densification (ED) ratio and the higher calorific value (HHV) of hydrochar reached maximum values of 1.69 and 27.70 MJ kg⁻¹, respectively. The relationships among the elemental compositions (H/C and O/C) observed in the Van Krevelen diagram suggest that the carbonization process was influenced mainly by dehydration reactions. Thermogravimetric analysis confirmed the increased thermal stability of hydrochar compared with that of fresh raw material. HTC process water analysis revealed acidic pH values (3.76–5.00), high chemical oxygen demand (24447–92963 mg O₂ L⁻¹), and increased electrical conductivity (11.45–18.55 mS cm⁻¹) with increasing temperature. The concentration of 5-hydroxymethylfurfural (5-HMF) reached maxima of 980.9 and 1418.3 μg mL⁻¹ at 190 °C for 2 h and 4 h, respectively. The total phenolic content and antioxidant activity were highest at 170–190 °C, suggesting the potential for valuable bioactive compounds in HTC process water. Principal component analysis (PCA) indicated that the physicochemical properties of the hydrochar remained stable within certain temperature ranges, particularly between 210 and 230 °C, where improved energy characteristics were noted. This suggests that operating within this range is both energy efficient and cost effective for process optimization. These findings highlight the effectiveness of HTC in managing plantain residues in Colombia, producing hydrochar with desirable fuel properties, and generating process water for potential applications in health, fine chemicals, and agriculture.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102118"},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone digital image colorimetry combined with deep eutectic vs supramolecular solvents liquid-liquid microextraction for cleanup and preconcentration of zinc in fish and vegetable samples","authors":"Salihu Isma'il ,&nbsp;Bashir Ismail Ahmad ,&nbsp;Isa Baba Koki ,&nbsp;Aliyu B. Abdullahi ,&nbsp;Yahaya A. Danmaraya","doi":"10.1016/j.scp.2025.102116","DOIUrl":"10.1016/j.scp.2025.102116","url":null,"abstract":"<div><div>Smartphone digital image colorimetry (SDIC) was combined with deep eutectic and supramolecular solvent liquid-liquid microextractions for the determination of zinc chelating with 1-(2-pyridylazo)-2-naphthol. A colored extract contained in a UV cuvette was placed in a locally designed colorimetric box, and the image was captured at optimum SDIC conditions. Sample cleanup and preconcentration were achieved with optimum complexation and extraction parameters. The suggested method has a limit of detection (LOD) between 3.46 and 19.43 ng mL⁻¹, an enrichment factor (EF) between 10.9 and 15.5, and a linear dynamic range between 100 and 500 ng mL⁻¹. The method shows good consistency, with a coefficient of determination (R²) between 0.9955 and 0.9998, and its precision, measured by the percentage relative standard deviation (%RSD), ranges from 1.4 to 4.2 for the same day and from 3.4 to 6.3 across different days. The accuracy of the method was also checked using a single-factor analysis of variance (ANOVA) by comparing its results with those from another independent UV–visible spectrophotometric technique, and both methods showed similar results (P &gt; 0.05). A score of &gt;0.62 on a scale of 0.0–1.0 for the analytical greenness when evaluated through the application of four green analytical tools indicates excellent analytical results. Additionally, promising greenness performance was also recorded with the AGREE tool when compared to other methods reported in the literature. The proposed method was employed for the determination of zinc in fish and vegetable samples, and the percentages of relative recoveries were recorded between 83.1 and 108.3 %.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102116"},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coconut shell biochar–Bacillus cereus DKBovi-5 based biocomposite as a sustainable additive for cement mortar: Effect of pyrolysis temperature on characterization, strength, hydration, and healing","authors":"P.P. Anoop,&nbsp;T. Palanisamy","doi":"10.1016/j.scp.2025.102112","DOIUrl":"10.1016/j.scp.2025.102112","url":null,"abstract":"<div><div>Although biochar–bacteria composites have been explored for self-healing in cementitious materials, the influence of pyrolysis temperature on microbial compatibility and healing performance has been insufficiently investigated. This study addresses this gap by examining how pyrolysis temperature affects the physicochemical properties of coconut shell biochar and its effectiveness as a microbial carrier in mortar. Biochar produced at 300 °C, 400 °C, and 500 °C was characterized, and <em>Bacillus cereus</em> DKBovi-5 was immobilized onto it to form biocomposites. The biocomposites were incorporated into mortar to evaluate mechanical, microstructural, and crack healing performances. Characterization of biochar showed enhanced crystallinity at 500 °C as indicated by XRD, development of primary and secondary pores confirmed by FESEM, and increased micronutrient concentrations due to thermal enrichment observed through ICP-MS. Compressive strength restoration increased from 80.21 % to 91.23 % between 300 °C and 500 °C temperatures. TGA analysis, interpreted using Bhatty's method, indicated an increase in the degree of hydration from 61.65 % to 65.33 %. Rietveld refinement of XRD data revealed a rise in calcite content from 24 % to 51 %. FESEM imaging confirmed the deposition of hydration products within the biochar pores. Healing evaluation showed closure of cracks up to 0.762 mm and 0.920 mm in mortars with 300 °C and 500 °C biocomposites, respectively, corresponding to healed areas of 92.49 % and 100 %. The healed products in all biocomposites were confirmed as calcite through FESEM-EDS and XRD analyses. Optimized pyrolysis at 500 °C yielded a biocomposite with superior microbial healing performance, establishing its suitability as a self-healing admixture in bio-mortar applications.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102112"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solar-powered biodiesel production from waste cooking oils: A sustainable waste valorization prototype for the Saharan environment","authors":"Ahmed Boulal ,&nbsp;Zeineb Hamden ,&nbsp;Mostefa Khelafi ,&nbsp;Kamel Hadri","doi":"10.1016/j.scp.2025.102121","DOIUrl":"10.1016/j.scp.2025.102121","url":null,"abstract":"<div><div>This study presents the development of a solar-powered transesterification system for biodiesel production from waste cooking oil (WCO), using potassium hydroxide (KOH) as a homogeneous catalyst. The autonomous prototype integrates a solar water heater (up to 60 °C) and a 200 W photovoltaic (PV) generator to meet both thermal and electrical energy needs.</div><div>Prior to scaling up, laboratory experiments were conducted to determine the optimal reaction conditions. The best results were obtained at 60 °C, with a methanol-to-oil molar ratio of 6:1 and 1 wt% KOH. Under these conditions, the semi-pilot system achieved a biodiesel yield of 90 % per 50-L batch. GC–MS and FTIR analyses confirmed the effective conversion of WCO into fatty acid methyl esters (FAMEs). The resulting biodiesel met ASTM D6751 and EN 14214 standards, with a density of 0.8858 g/cm³, kinematic viscosity of 5.84 mm²/s at 40 °C, flash point of 188.2 °C, cetane index of 46.6, sulfur content of 0.0395 wt%, and an acid value of 0.35 mg KOH/g.</div><div>The system's energy demand, approximately 90 Wh per hour, is fully supplied by a 100 W PV panel coupled with a 100 Wh rechargeable battery, ensuring complete energy autonomy. These results underscore the potential of the proposed solar-integrated reactor as a scalable, eco-friendly, and cost-effective solution for decentralized biodiesel production in arid, solar-rich regions.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102121"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile preparation of three-dimensional macroporous network structured modified wood flour for efficient Pb(II) removal from aqueous solution: mechanism and economic assessment","authors":"Zhirong Chen ,&nbsp;Jinfeng Tang ,&nbsp;Nana Wang ,&nbsp;Mingdong Chang","doi":"10.1016/j.scp.2025.102115","DOIUrl":"10.1016/j.scp.2025.102115","url":null,"abstract":"<div><div>Utilizing plant wastes to treat Pb(II)-polluted water bodies offers a sustainable solution, but concerns over adsorption ability and separation efficiency limit its application. This study investigates the preparation and application of three-dimensional macroporous network-structured modified wood flour (WTX and TZX) for efficient Pb(II) removal. The adsorbents were synthesized through xanthate modification of defatted (TZ) and non-defatted (WT) wood flour, followed by lyophilization to achieve a stable porous structure. The optimal preparation condition involved mixing 1.0 g of original wood flour with 2 mL of CS₂ in a strong base environment at 25 °C for 3 h. Both WTX and TZX exhibited similar three-dimensional structure and good solid-liquid separation performance. Pb(II) removal rates reached 61 % for WTX and 54 % for TZX within 45 min. The maximum adsorption capacities were 221.73 mg/L for WTX and 210.53 mg/g for TZX, significantly higher than untreated wood flour. Despite similar appearances and maximum Pb(II) removal abilities, the defatting pretreatment did not enhance mechanical properties or adsorption performance. Pb(II) immobilization occurred via electrostatic attraction, complexation and precipitation, with functional groups like –O–C (=S)–SNa, –OH, –NH₂ and –COOH playing key roles. An economic assessment highlighted the cost-effectiveness of the adsorbents, with an estimated treatment cost of 3.21 US$/ton of wastewater. The study underscores the potential of waste wood flour biomass as a sustainable, low-cost solution for heavy metal remediation.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102115"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycling bio-waste into durable green mortars: Effects of eggshell powder on strength, microstructure, and durability","authors":"Ahmet Ferdi Şenol,&nbsp;Özlem Çalışkan","doi":"10.1016/j.scp.2025.102119","DOIUrl":"10.1016/j.scp.2025.102119","url":null,"abstract":"<div><div>Calcium-rich eggshell powder (ESP) has gained attention as a sustainable alternative in construction. Similar to fly ash (FA), it can be incorporated into geopolymer systems. This study investigates the effects of replacing FA with ESP at 2.5 %, 5 %, 10 %, and 15 % on the workability, strength, and durability of FA-based geopolymer mortars. Mortars were cured at 70 °C for 24 h and stored at room temperature until day 28. Physical, mechanical, and durability tests were conducted along with regression analysis. Additionally, microstructure was examined using FE-SEM/EDX. Workability decreased with increasing ESP content, with up to a 19 % reduction observed at higher replacement levels. The results showed that 10 % ESP replacement enhanced flexural and compressive strengths by 14.2 % (from 7.87 MPa to 9 MPa) and 20 % (from 41.1 MPa to 49.3 MPa), respectively, while reducing abrasion loss by 32.8 % and sorptivity by up to 50 %. At elevated temperatures, the mixture containing 10 % ESP retained the highest compressive strength after 400 °C exposure (2.4 % loss), while the 2.5 % ESP series showed the lowest strength loss (35.1 %) at 800 °C. Under acid and sulfate exposure, the control (ESP-free) series exhibited the least strength losses (5.6 % and 18 %, respectively), while mixtures with higher ESP content showed greater degradation. Microstructural analysis showed that 10 % ESP improved Ca/Si, Na/Si, and Si/Al ratios, leading to a denser matrix. The results support the use of ESP as a promising bio-based additive in durable and sustainable alkali-activated materials.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102119"},"PeriodicalIF":5.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144611922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zwitterionic resorcinarene bifunctional organocatalyst for the cycloaddition of carbon dioxide to epoxide","authors":"Yongzhu Hu,&nbsp;Haoyu Wang,&nbsp;Zhenjiang Li,&nbsp;Jiahui Ma,&nbsp;Yue Xu,&nbsp;Ziqi Liu,&nbsp;Yanqi Shi,&nbsp;Xiaolong Huang,&nbsp;Hui Zhao,&nbsp;Kai Guo","doi":"10.1016/j.scp.2025.102102","DOIUrl":"10.1016/j.scp.2025.102102","url":null,"abstract":"<div><div>The cycloaddition of carbon dioxide (CO₂) to epoxide (CCE) reaction is a highly attractive sustainable process due to its high atom economy and the versatility applications of the resulting cyclic carbonates. Conventional catalysts for CCE reactions were indispensable of halide cocatalyst, however, halides posed risk of corrosion to process steel equipment and the residue halide was environmentally harmful. To obviate halide, a new halide-free resorcinarene-based zwitterion (<strong>RES-Z</strong>) catalyst was designed and synthesized as organocatalyst for CCE reactions. The <strong>RES-Z</strong> catalyst exhibited excellent performance at 120 °C and 0.5 mol% catalyst loading under 1.0 MPa CO₂ pressure for 12 h, the commercially epoxide bisphenol A diglycidyl ether and 12 terminal epoxides were converted into the corresponding cyclic carbonates with 73–99 % conversion and 99 % selectivity. Bifunctional catalytic mechanism was proposed and validated by NMR titrations where the cationic moiety activated the epoxide and the anionic moiety activated the CO₂. Moreover, the catalyst demonstrated exceptional recyclability, exhibiting no decline in catalytic activity over five consecutive reaction cycles. These findings not only substantiate the efficacy of resorcinarene-based organocatalysts in halide-free catalytic systems but also advance the sustainable utilization of CO₂ in chemical synthesis.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102102"},"PeriodicalIF":5.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-dimensional sustainability assessment framework for micellar UPLC and spectrophotometric analysis of a three-drug combination and its genotoxic impurity","authors":"Ahmed Emad F. Abbas ,&nbsp;Lateefa A. Al-Khateeb ,&nbsp;Noha S. Katamesh ,&nbsp;Michael K. Halim ,&nbsp;Ibrahim A. Naguib ,&nbsp;Mohammed Alqarni ,&nbsp;Basmat Amal M. Said ,&nbsp;Mohamed A. Ali","doi":"10.1016/j.scp.2025.102113","DOIUrl":"10.1016/j.scp.2025.102113","url":null,"abstract":"<div><div>This study introduces an innovative framework for comprehensive sustainability assessment of analytical methods, applied to the simultaneous determination of acebrophylline, montelukast, fexofenadine, and the genotoxic impurity bromobenzene. A newly developed micellar ultra-performance liquid chromatography (UPLC) method, employing a Kinetex HILIC column and an eco-friendly mobile phase of sodium dodecyl sulfate and 18 % 1-pentanol, offers reduced organic solvent use while achieving robust separation. Additionally, we report the first implementation of a suite of green spectrophotometric methods (direct zero-order, ratio subtraction, second and third derivative, and double-divisor ratio derivative) using only water as solvent for this four-component system. All methods demonstrated excellent analytical performance with appropriate linearity ranges (r² ≥ 0.999), recovery (98.5–101.5 %), and precision (RSD ≤2 %). The sustainability profile was assessed through a novel multi-dimensional approach integrating environmental impact (NEMI, ComplexGAPI, AGREE), practical applicability (BAGI), innovation potential (VIGI), and overall sustainability (RGB12). Carbon footprint analysis showed minimal environmental impact (0.002 and 0.039 kg CO₂ equivalent per sample for spectrophotometric and UPLC methods, respectively). The newly introduced Need, Quality, Sustainability (NQS) index quantified holistic sustainability, with the proposed methods achieving superior scores across all metrics compared to existing techniques. The NQS Index assessment confirmed strong alignment with SDGs, including SDGs 3 (Good Health), 6 (Clean Water), 9 (Innovation), 12 (Responsible Consumption), 13 (Climate Action), 14 (Life Below Water), and 15 (Life on Land). This integrated assessment framework advances analytical methodology evaluation beyond traditional performance metrics, introducing a holistic approach to quantify and visualize multiple sustainability dimensions in microanalytical chemistry.</div></div>","PeriodicalId":22138,"journal":{"name":"Sustainable Chemistry and Pharmacy","volume":"46 ","pages":"Article 102113"},"PeriodicalIF":5.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}