Synthetic Communications最新文献_第9页

Iron (II) catalyzed cyclization of ketoxime acetates with triethyl orthoformate: An easy access to symmetrical pyridines 铁（II）催化醋酸酮肟与原甲酸三乙酯的环化：一种容易得到对称吡啶的方法

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-12-01 DOI: 10.1080/00397911.2024.2421364

Kotyada Satishkumar , Podugu Rajitha Lakshmi , Yettula Kumari , Voosala Christopher , Vidavalur Siddaiah

引用次数: 0

Synthesis and spectral characteristics of N-(2,2,2-trichloro-1-((5-(R-amino)-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides N-（2,2,2-三氯-1-（（5-（r -氨基）-1,3,4-噻二唑-2-基）氨基）乙基）羧酰胺的合成及光谱特性

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-12-01 DOI: 10.1080/00397911.2024.2422472

Valeriia V. Pavlova , Pavlo V. Zadorozhnii , Aleksey B. Ryabitsky , Vadym V. Kiselev , Oxana V. Okhtina , Aleksandr V. Kharchenko

{"title":"Synthesis and spectral characteristics of N-(2,2,2-trichloro-1-((5-(R-amino)-1,3,4-thiadiazol-2-yl)amino)ethyl)carboxamides","authors":"Valeriia V. Pavlova , Pavlo V. Zadorozhnii , Aleksey B. Ryabitsky , Vadym V. Kiselev , Oxana V. Okhtina , Aleksandr V. Kharchenko","doi":"10.1080/00397911.2024.2422472","DOIUrl":"10.1080/00397911.2024.2422472","url":null,"abstract":"<div><div>In this paper, we reported the development of an efficient and highly productive synthetic protocol for preparing new 2,5-diamino-1,3,4-thiadiazole derivatives functionalized with <em>N</em>-(2,2,2-trichloroethyl)carboxamide group. The method of their preparation was based on the reaction of oxidative dehydrosulfurization of <em>N</em>-(2,2,2-trichloro-1-(2-(phenylcarbamothioyl)hydrazine-1-carbothioamido)ethyl)carboxamides and <em>N</em>-(1-(2-carbamothioylhydrazine-1-carbothioamido)-2,2,2-trichloroethyl)benzamide under the action of a mixture of iodine and triethylamine in DMF. This reaction took place at room temperature for two hours and allowed obtaining the target products with a 69-75% yield. Using the developed protocol, we obtained ten new derivatives of 1,3,4-thiadiazole. Their structure was proven by IR,<sup>1</sup>H NMR,<sup>13</sup>C NMR, <sup>1</sup>H-<sup>1</sup>H COSY, <sup>1</sup>H-<sup>13</sup>C HSQC, <sup>1</sup>H-<sup>13</sup>C HMBC spectroscopy, and LC/HRMS spectrometry.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 23","pages":"Pages 2076-2087"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing quinoxaline chemistry: Sustainable and green synthesis using L-arabinose as a catalyst 推进喹啉化学：以l -阿拉伯糖为催化剂的可持续绿色合成

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-12-01 DOI: 10.1080/00397911.2024.2419861

Sandip J. Detke , Anuja D. Karwande , Sai Srinivas Ponugoti , Shreerang V. Joshi , Prashant S. Kharkar

{"title":"Advancing quinoxaline chemistry: Sustainable and green synthesis using L-arabinose as a catalyst","authors":"Sandip J. Detke , Anuja D. Karwande , Sai Srinivas Ponugoti , Shreerang V. Joshi , Prashant S. Kharkar","doi":"10.1080/00397911.2024.2419861","DOIUrl":"10.1080/00397911.2024.2419861","url":null,"abstract":"<div><div>In the present study, an innovative and eco-friendly methodology for synthesizing quinoxaline derivatives has been introduced, leveraging L-arabinose as a novel catalyst. This approach not only underscores the feasibility of green chemistry in synthesizing high-purity quinoxaline derivatives but also highlights the enhanced sustainability of the process. Detailed mechanistic investigations revealed the synergistic interactions between L-arabinose and the reactants, providing a deeper understanding of the catalytic process. The synthesized compounds, due to their unique structural and electronic properties, may find promising applications in life and material sciences such as optoelectronics. Furthermore, our environmental impact assessment demonstrated significant reduction in generated waste, solvent use, and overall carbon footprint, aligning with the global agenda for sustainable development. This research marks a significant step forward in quinoxaline chemistry, promoting the adoption of green synthesis pathways while reinforcing the principles of sustainable and environment-friendly chemical practices.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 23","pages":"Pages 2024-2037"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-pot synthesis of new benzo[4,5]imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a] pyrimidines as an eco-friendly and effective method catalyzed by acetic acid with prospective antimicrobial agents 醋酸催化一锅法合成新型苯并[4,5]咪唑[1,2-a]嘧啶和吡唑[1,5-a]嘧啶

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-12-01 DOI: 10.1080/00397911.2024.2419872

Najla Altwaijry , Asmaa Saleh , Esam A. Ishak , Hamdi M. D. Nasr , Ismail M. M. Othman

{"title":"One-pot synthesis of new benzo[4,5]imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a] pyrimidines as an eco-friendly and effective method catalyzed by acetic acid with prospective antimicrobial agents","authors":"Najla Altwaijry , Asmaa Saleh , Esam A. Ishak , Hamdi M. D. Nasr , Ismail M. M. Othman","doi":"10.1080/00397911.2024.2419872","DOIUrl":"10.1080/00397911.2024.2419872","url":null,"abstract":"<div><div>A novel set chalcones <strong>3a-d</strong> was efficiently synthesized in elevated produces across the condensing process of Claisen-Schmidt. An eco-friendly and efficient process was designed for creating a novel desired products <strong>5a-f</strong> and <strong>7a-f</strong>, respectively with excellent yields. This synthesis was accomplished by reacting acetophenone derivatives <strong>1a-d</strong>, heteroaromatic aldehydes <strong>2a,b</strong> and aminobenzoimidazole <strong>4</strong> or 3-aminopyrazole <strong>6a,b</strong>, using acetic acid as both the catalyst and solvent. Solvent optimization was performed during the synthesis of the desired compounds <strong>5a</strong> or <strong>7a</strong>, highlighting the benefits of using acetic acid that is harmless for the environment, which offers easy procedure, rapid reaction, elevated efficiency and broad tolerance of starting materials. The preferred products were verified through compatible spectroscopic data. The antimicrobial efficacious for all compounds was successfully evaluated against various microorganisms, revealing that <strong>3b</strong> exhibited significant antimicrobial activity across all tested microbes, with measurements of the minimum inhibitory concentrations being between 4.80 to 63.8 μM.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 23","pages":"Pages 2038-2051"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2,3-Diaminonaphthalene-1,4-dione: Versatile precursor for the synthesis of molecular systems 2,3-二氨基萘-1,4-二酮：分子体系合成的多功能前体

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-30 DOI: 10.1080/00397911.2024.2435467

Sherif M. H. Sanad

引用次数: 0

Synthesis and antioxidant activity of 14-Aryl-14H-dibenzo[a,j] xanthene’s and bis(3-hydroxy-5,5′-dimethyl-2-cyclohexene-1-ones) derivatives using silica-tungstosulfonic acid catalyst 使用二氧化硅-钨磺酸催化剂合成 14-芳基-14H-二苯并[a,j]氧杂蒽和双(3-羟基-5,5′-二甲基-2-环己烯-1-酮)衍生物并提高其抗氧化活性

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-21 DOI: 10.1080/00397911.2024.2424487

Reddi Mohan Naidu Kalla , Swetha Kumari Koduru , Sivarama Krishna Lakkboyana , Jaewoong Lee

{"title":"Synthesis and antioxidant activity of 14-Aryl-14H-dibenzo[a,j] xanthene’s and bis(3-hydroxy-5,5′-dimethyl-2-cyclohexene-1-ones) derivatives using silica-tungstosulfonic acid catalyst","authors":"Reddi Mohan Naidu Kalla , Swetha Kumari Koduru , Sivarama Krishna Lakkboyana , Jaewoong Lee","doi":"10.1080/00397911.2024.2424487","DOIUrl":"10.1080/00397911.2024.2424487","url":null,"abstract":"<div><div>The synthesis of biologically active benzoxanthene, and bis(3-hydroxy-5,5’-dimethyl-2-cyclohexene-1-ones) derivatives has been conducted under an environmentally benign method by using an efficient catalyst, silica-tungstosulphonic acid. The benefits of this catalyst include being safe for the environment, low-cost, and simple to construct. It produces good yields and high purity in a short time and facilitates easy cleansing, products are obtained by straightforward recrystallization without the need for column chromatography. The reagent retained its catalytic activity for at least five consecutive cycles of reuse. The catalyst is described by IR, XRD, and SEM-EDX, which clearly shows that sulfonation happens in silica tungstic acid. In addition, the targeted derivatives were studied for anti-oxidant properties such as DPPH, reducing power assay, and H<sub>2</sub>O<sub>2</sub> scavenging activity. The synthesized products such as <strong>3e, 5k, 5 m, 5o,</strong> and <strong>5p</strong> showed good anti-oxidant properties. Among all of these compounds, <strong>5p</strong> showed good activity due to the nitro substitution on the benzene ring.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 24","pages":"Pages 2143-2158"},"PeriodicalIF":1.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142706906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel and efficient process for the synthesis of 1,3,4-oxadiazole containing MBX-4132 as antimicrobial agent in Neisseria gonorrhoeae 合成含 MBX-4132 的 1,3,4-oxadiazole 的新型高效工艺，作为淋病奈瑟菌的抗菌剂

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-11 DOI: 10.1080/00397911.2024.2424995

Prachi Ramteke , M.S. Gill

引用次数: 0

Novel Schiff bases of quinolin-4(1h)-one: Synthesis, antiproliferative evaluation, apoptosis, cell cycle, autophagy and molecular docking studies in human colon cancer cells 喹啉-4(1h)-酮的新型希夫碱：在人类结肠癌细胞中进行合成、抗增殖评估、细胞凋亡、细胞周期、自噬和分子对接研究

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-06 DOI: 10.1080/00397911.2024.2424486

Tarik E. Ali , Mohammed A. Assiri , Mohamed Hussien , Ali A. Shati , Mohammad Y. Alfaifi , Serag E. I. Elbehairi

{"title":"Novel Schiff bases of quinolin-4(1h)-one: Synthesis, antiproliferative evaluation, apoptosis, cell cycle, autophagy and molecular docking studies in human colon cancer cells","authors":"Tarik E. Ali , Mohammed A. Assiri , Mohamed Hussien , Ali A. Shati , Mohammad Y. Alfaifi , Serag E. I. Elbehairi","doi":"10.1080/00397911.2024.2424486","DOIUrl":"10.1080/00397911.2024.2424486","url":null,"abstract":"<div><div>A green and efficient ultrasound-mediated protocol was developed for the synthesis of a series of novel Schiff bases derived from quinoline-4-one. The synthetic strategy involved the condensation of 4-oxo-1,4-dihydro-quinoline-3-carboxaldehyde with diverse anilines and heteroaryl amines. The synthesized compounds were characterized using spectroscopic techniques. A comprehensive in <em>vitro</em> cytotoxicity evaluation against HCT116 and HT-29 human colon cancer cell lines revealed that several compounds exhibited potent anticancer activity. Notably, compounds <strong>3c</strong> and <strong>3e</strong> demonstrated superior cytotoxicity compared to the clinical standard doxorubicin. Mechanistic studies indicated that these lead compounds induced apoptosis, necrosis, and cell cycle arrest at G1 and G2 phases. Furthermore, autophagy induction was observed. <em>In silico</em> ADMET predictions support the potential of compounds <strong>3c</strong> and <strong>3e</strong> as promising anticancer drug candidates. The molecular docking studies revealed that the Schiff bases <strong>3c</strong> and <strong>3e</strong> displayed good interaction with VEGFR-2 receptor. These findings underscore the quinoline-4-one scaffold as a valuable template for the development of novel antitumor agents.</div></div>","PeriodicalId":22119,"journal":{"name":"Synthetic Communications","volume":"54 24","pages":"Pages 2130-2142"},"PeriodicalIF":1.8,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of an improved and facile synthesis route of the FGFR inhibitor erdafitinib 开发表皮生长因子受体抑制剂厄达非替尼的改进型简易合成路线

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-05 DOI: 10.1080/00397911.2024.2423897

Shuang Wang , Nanxin Peng , Liping Yin , Wei Wang , Yue Wu , Di Zhang , Zongjie Gan

引用次数: 0

An efficient and practical synthesis of ferroptosis inducer erastin 一种高效实用的铁色素沉着诱导剂麦拉宁合成方法

IF 1.8 3区化学

Synthetic Communications Pub Date : 2024-11-01 DOI: 10.1080/00397911.2024.2423363

Xinxin Cui , Chenghan Zhuang , Siyu Liang , Xingxian Zhang

引用次数: 0